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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(2-hydroxyphenyl)acetic acid
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Accession:CHEBI:28478 term browser browse the term
Definition:A hydroxy monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 2-hydroxyphenyl group. It is a metabolite of phenylalanine and is excreted in the urine of patients suffering from diseases like phenylketonuria.
Synonyms:related_synonym: (o-hydroxyphenyl)acetic acid;   2-hydroxybenzeneacetic acid;   2-hydroxyphenylacetic acid;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11);   InChIKey=CCVYRRGZDBSHFU-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccccc1O;   o-hydroxyphenylacetic acid
 alt_id: CHEBI:1169;   CHEBI:19655
 xref: CAS:614-75-5;   HMDB:HMDB0000669;   KEGG:C05852
 xref_mesh: MESH:C005756
 xref: PDBeChem:OHP;   PMID:13658992;   PMID:22770225;   Reaxys:908000
 cyclic_relationship: is_conjugate_acid_of CHEBI:62423



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(2-hydroxyphenyl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid CTD PMID:34334558 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid CTD PMID:34334558 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20069
    role 20021
      application 19757
        food additive 15232
          food acidity regulator 11827
            acetic acid 10918
              (2-hydroxyphenyl)acetic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20069
    subatomic particle 20068
      composite particle 20068
        hadron 20068
          baryon 20068
            nucleon 20068
              atomic nucleus 20068
                atom 20068
                  main group element atom 19969
                    p-block element atom 19969
                      carbon group element atom 19892
                        carbon atom 19885
                          organic molecular entity 19885
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18898
                                    carbonyl compound 18898
                                      carboxylic acid 18596
                                        monocarboxylic acid 17847
                                          acetic acid 10918
                                            (2-hydroxyphenyl)acetic acid 2
paths to the root