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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(2-hydroxyphenyl)acetic acid
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Accession:CHEBI:28478 term browser browse the term
Definition:A hydroxy monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 2-hydroxyphenyl group. It is a metabolite of phenylalanine and is excreted in the urine of patients suffering from diseases like phenylketonuria.
Synonyms:related_synonym: (o-hydroxyphenyl)acetic acid;   2-hydroxybenzeneacetic acid;   2-hydroxyphenylacetic acid;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11);   InChIKey=CCVYRRGZDBSHFU-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccccc1O;   o-hydroxyphenylacetic acid
 alt_id: CHEBI:1169;   CHEBI:19655
 xref: CAS:614-75-5;   HMDB:HMDB0000669;   KEGG:C05852
 xref_mesh: MESH:C005756
 xref: PDBeChem:OHP;   PMID:13658992;   PMID:22770225;   Reaxys:908000
 cyclic_relationship: is_conjugate_acid_of CHEBI:62423


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(2-hydroxyphenyl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid CTD PMID:34334558 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid CTD PMID:34334558 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        food additive 16122
          food acidity regulator 11943
            acetic acid 11053
              (2-hydroxyphenyl)acetic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      monocarboxylic acid 17966
                                        acetic acid 11053
                                          (2-hydroxyphenyl)acetic acid 2
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