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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(2-hydroxyphenyl)acetic acid
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Accession:CHEBI:28478 term browser browse the term
Definition:A hydroxy monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 2-hydroxyphenyl group. It is a metabolite of phenylalanine and is excreted in the urine of patients suffering from diseases like phenylketonuria.
Synonyms:related_synonym: (o-hydroxyphenyl)acetic acid;   2-hydroxybenzeneacetic acid;   2-hydroxyphenylacetic acid;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11);   InChIKey=CCVYRRGZDBSHFU-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1ccccc1O;   o-hydroxyphenylacetic acid
 alt_id: CHEBI:1169;   CHEBI:19655
 xref: CAS:614-75-5;   HMDB:HMDB0000669;   KEGG:C05852
 xref_mesh: MESH:C005756
 xref: PDBeChem:OHP;   PMID:13658992;   PMID:22770225;   Reaxys:908000
 cyclic_relationship: is_conjugate_acid_of CHEBI:62423


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(2-hydroxyphenyl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid CTD PMID:34334558 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acid CTD PMID:34334558 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      application 19622
        food additive 15898
          food acidity regulator 11858
            acetic acid 10952
              (2-hydroxyphenyl)acetic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic group 18905
                              organic divalent group 18887
                                organodiyl group 18887
                                  carbonyl group 18853
                                    carbonyl compound 18853
                                      carboxylic acid 18569
                                        monocarboxylic acid 17903
                                          acetic acid 10952
                                            (2-hydroxyphenyl)acetic acid 2
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