digitogenin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	digitogenin	go back to main search page
Accession:	CHEBI:28431	browse the term
Definition:	A 15beta-hydroxy steroid that has formula C27H44O5.
Synonyms:	exact_synonym:	(25R)-5alpha-spirostan-2alpha,3beta,15beta-triol
	related_synonym:	Formula=C27H44O5; InChI=1S/C27H44O5/c1-14-7-10-27(31-13-14)15(2)21-24(32-27)23(30)22-17-6-5-16-11-19(28)20(29)12-26(16,4)18(17)8-9-25(21,22)3/h14-24,28-30H,5-13H2,1-4H3/t14-,15+,16+,17-,18+,19-,20-,21+,22-,23+,24-,25-,26+,27-/m1/s1; InChIKey=COVOPPXLDJVUSC-JPYPKGSXSA-N; SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])[C@H](O)[C@]3([H])O[C@]5(CC[C@@H](C)CO5)[C@@H](C)[C@]43[H])[C@@]1(C)C[C@@H](O)[C@H](O)C2; digitonin aglycon
	alt_id:	CHEBI:23726; CHEBI:4547
	xref:	Beilstein:94573; CAS:511-34-2; Chemspider:390462; KEGG:C08896; KNApSAcK:C00003573; LIPID_MAPS_instance:LMST01080004; PMID:17135046; PMID:5545780; PMID:6097588

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Rat (6) Mouse (6) Human (6) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (6)

digitonin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 5

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

ETS variant transcription factor 2

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]

NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431

G

GATA binding protein 2

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]

NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761

G

hypoxia inducible factor 1 subunit alpha

decreases expression

Digitonin results in decreased expression of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

solute carrier family 22 member 2

multiple interactions

Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

sialophorin

multiple interactions

Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20056
role	20008
biological role	20007
biochemical role	19640
metabolite	19623
eukaryotic metabolite	19326
plant metabolite	17657
digitogenin	6
digitonin	6
Path 2
Term	Annotations
CHEBI ontology	20056
subatomic particle	20054
composite particle	20054
hadron	20054
baryon	20054
nucleon	20054
atomic nucleus	20054
atom	20054
main group element atom	19956
p-block element atom	19956
carbon group element atom	19882
carbon atom	19875
organic molecular entity	19875
organic molecule	19822
organic cyclic compound	19575
organic polycyclic compound	17176
steroid	14380
steroid fundamental parent	14144
spirostan	131
5alpha-spirostan	6
(25R)-5alpha-spirostan	6
digitogenin	6
digitonin	6

paths to the root