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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:digitogenin
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Accession:CHEBI:28431 term browser browse the term
Definition:A 15beta-hydroxy steroid that has formula C27H44O5.
Synonyms:exact_synonym: (25R)-5alpha-spirostan-2alpha,3beta,15beta-triol
 related_synonym: Formula=C27H44O5;   InChI=1S/C27H44O5/c1-14-7-10-27(31-13-14)15(2)21-24(32-27)23(30)22-17-6-5-16-11-19(28)20(29)12-26(16,4)18(17)8-9-25(21,22)3/h14-24,28-30H,5-13H2,1-4H3/t14-,15+,16+,17-,18+,19-,20-,21+,22-,23+,24-,25-,26+,27-/m1/s1;   InChIKey=COVOPPXLDJVUSC-JPYPKGSXSA-N;   SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])[C@H](O)[C@]3([H])O[C@]5(CC[C@@H](C)CO5)[C@@H](C)[C@]43[H])[C@@]1(C)C[C@@H](O)[C@H](O)C2;   digitonin aglycon
 alt_id: CHEBI:23726;   CHEBI:4547
 xref: Beilstein:94573;   CAS:511-34-2;   Chemspider:390462;   KEGG:C08896;   KNApSAcK:C00003573;   LIPID_MAPS_instance:LMST01080004;   PMID:17135046;   PMID:5545780;   PMID:6097588


show annotations for term's descendants           Sort by:
digitonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 increases expression ISO Digitonin results in increased expression of CCNB1 protein CTD PMID:36030841 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Digitonin results in increased expression of CCND1 protein CTD PMID:36030841 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] CTD PMID:31404653 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Digitonin results in decreased expression of CDKN1A protein CTD PMID:36030841 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Digitonin results in decreased expression of CDKN1B protein CTD PMID:36030841 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Digitonin results in increased expression of CYP2B10 protein CTD PMID:36030841 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Etv2 ETS variant transcription factor 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431 		JBrowse link
G Gata2 GATA binding protein 2 multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Digitonin results in decreased expression of HIF1A protein CTD PMID:34717917 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Nek2 NIMA-related kinase 2 increases expression ISO Digitonin results in increased expression of NEK2 protein CTD PMID:36030841 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression ISO Digitonin results in decreased expression of RBL2 protein CTD PMID:36030841 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Digitonin results in increased expression of SLCO1A4 protein CTD PMID:36030841 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Spn sialophorin multiple interactions ISO Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] CTD PMID:31404653 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        biochemical role 19495
          metabolite 19480
            eukaryotic metabolite 19278
              plant metabolite 17890
                digitogenin 14
                  digitonin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic molecule 19651
                              organic cyclic compound 19457
                                organic polycyclic compound 17199
                                  steroid 14405
                                    steroid fundamental parent 14172
                                      spirostan 151
                                        5alpha-spirostan 14
                                          (25R)-5alpha-spirostan 14
                                            digitogenin 14
                                              digitonin 14
paths to the root