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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(+)-dihydromyricetin
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Accession:CHEBI:28429 term browser browse the term
Definition:An optically active form of dihydromyricetin having (2R,3R)-configuration.
Synonyms:exact_synonym: (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2R,3R)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one;   (2R,3R)-3,3',4',5,5',7-hexahydroxy-2,3-dihydroflavanonol;   (2R,3R)-3,5,7,3',4',5'-hexahydroxyflavanone;   (2R,3R)-dihydromyricetin;   Ampelopsin;   Ampeloptin;   Formula=C15H12O8;   InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1;   InChIKey=KJXSIXMJHKAJOD-LSDHHAIUSA-N;   SMILES=O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1cc(O)c(O)c(O)c1
 alt_id: CHEBI:18447;   CHEBI:21
 xref: Beilstein:4331256;   Beilstein:5303758;   CAS:27200-12-0;   KEGG:C02906;   KNApSAcK:C00000938
 xref_mesh: MESH:C106407
 xref: MetaCyc:CPD-7087;   PMID:12889119;   PMID:17059013;   PMID:22693649;   Reaxys:5303758;   Wikipedia:Dihydromyricetin
 cyclic_relationship: is_enantiomer_of CHEBI:48027


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(+)-dihydromyricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein] CTD PMID:21871475 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein] CTD PMID:21871475 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 7:111,539,444...111,557,984 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein] CTD PMID:21871475 NCBI chr18:54,500,002...54,538,843 JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein] CTD PMID:21871475 NCBI chr 3:149,385,587...149,416,330 JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression
decreases activity
ISO ampelopsin results in decreased expression of SPHK1 protein
ampelopsin results in decreased activity of SPHK1 protein
CTD PMID:22251058 NCBI chr10:101,758,567...101,764,240 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      chemical role 19254
        antioxidant 14376
          (+)-dihydromyricetin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  oxacycle 17539
                                    benzopyran 10268
                                      1-benzopyran 9991
                                        flavonoid 6513
                                          flavones 4201
                                            hydroxyflavone 4189
                                              flavonols 4099
                                                7-hydroxyflavonol 4078
                                                  myricetin 112
                                                    dihydromyricetin 6
                                                      (+)-dihydromyricetin 6
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