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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-hexachlorocyclohexane
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Accession:CHEBI:28428 term browser browse the term
Definition:The beta-isomer of hexachlorocyclohexane.
Synonyms:exact_synonym: (1r,2t,3c,4t,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane
 related_synonym: (1alpha,2beta,3alpha,4beta,5alpha,6beta)-1,2,3,4,5,6-hexachlorocyclohexane;   Formula=C6H6Cl6;   InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3+,4+,5-,6-;   InChIKey=JLYXXMFPNIAWKQ-CDRYSYESSA-N;   SMILES=Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H](Cl)[C@@H]1Cl;   beta-1,2,3,4,5,6-Hexachlorocyclohexane;   beta-BHC;   beta-HCH;   beta-Lindane;   beta-benzene hexachloride;   trans-1,2,3,4,5,6-hexachlorocyclohexane
 alt_id: CHEBI:22757;   CHEBI:3071
 xref: Beilstein:1907338;   CAS:319-85-7;   KEGG:C06988
 xref_mesh: MESH:C023888
 xref: PMID:19760616;   PMID:23866943;   PMID:24183346;   PMID:24361731;   PMID:32525731;   PMID:32675895;   PMID:32906049;   Reaxys:1907338;   UM-BBD_compID:c0139



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beta-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ABCA1 mRNA CTD PMID:25270620 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCB11 mRNA CTD PMID:28392238 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCC2 mRNA CTD PMID:28392238 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCC3 mRNA CTD PMID:28392238 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ABCG1 mRNA CTD PMID:25270620 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCG8 mRNA; beta-hexachlorocyclohexane results in increased expression of ABCG8 protein CTD PMID:27203212 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACADL mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADL protein CTD PMID:28397872 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACADM mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADM protein CTD PMID:28397872 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACADS mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADS protein CTD PMID:28397872 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACOX1 mRNA CTD PMID:28397872 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing affects response to substance
multiple interactions
ISO ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane
[ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane] which affects the expression of ADIPOQ protein
CTD PMID:27883041 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of AGTR1A mRNA CTD PMID:25270620 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions
ISO beta-hexachlorocyclohexane affects the expression of AHR protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]
CTD PMID:33207735 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap13 A-kinase anchoring protein 13 increases expression ISO beta-hexachlorocyclohexane results in increased expression of AKAP13 mRNA CTD PMID:25270620 NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ALAS1 mRNA CTD PMID:25270620 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alg5 ALG5, dolichyl-phosphate beta-glucosyltransferase increases expression ISO beta-hexachlorocyclohexane results in increased expression of ALG5 mRNA CTD PMID:25270620 NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216
JBrowse link
G Ank1 ankyrin 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ANK1 mRNA CTD PMID:25270620 NCBI chr16:68,876,294...69,054,812
Ensembl chr16:68,877,504...69,054,759
JBrowse link
G Apoa5 apolipoprotein A5 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of APOA5 mRNA CTD PMID:25270620 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Ar androgen receptor multiple interactions
affects expression
ISO beta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bicalutamide affects the reaction [beta-hexachlorocyclohexane affects the expression of AR protein] CTD PMID:26022396 PMID:33207735 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO beta-hexachlorocyclohexane results in increased expression of ATP11B mRNA CTD PMID:25270620 NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
JBrowse link
G Atp7b ATPase copper transporting beta increases expression ISO beta-hexachlorocyclohexane results in increased expression of ATP7B mRNA CTD PMID:25270620 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of BCR mRNA CTD PMID:25270620 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA] CTD PMID:20206645 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Casp3 caspase 3 increases cleavage EXP beta-hexachlorocyclohexane results in increased cleavage of CASP3 protein CTD PMID:19760616 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage EXP beta-hexachlorocyclohexane results in increased cleavage of CASP8 protein CTD PMID:19760616 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein CTD PMID:16046044 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc63 coiled-coil domain containing 63 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CCDC63 mRNA CTD PMID:25270620 NCBI chr12:34,424,388...34,453,080
Ensembl chr12:34,424,344...34,453,085
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA
fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA]
CTD PMID:17640349 PMID:20206645 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd19 CD19 molecule increases expression ISO beta-hexachlorocyclohexane results in increased expression of CD19 mRNA CTD PMID:25270620 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO beta-hexachlorocyclohexane results in increased expression of CDKN1B mRNA CTD PMID:17640349 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cers6 ceramide synthase 6 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of CERS6 mRNA CTD PMID:25270620 NCBI chr 3:53,630,636...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO beta-hexachlorocyclohexane results in increased expression of CES1D mRNA CTD PMID:25270620 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cops8 COP9 signalosome subunit 8 increases expression ISO beta-hexachlorocyclohexane results in increased expression of COPS8 mRNA CTD PMID:25270620 NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of CPT1A mRNA CTD PMID:25270620 PMID:28397872 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Ctss cathepsin S increases expression ISO beta-hexachlorocyclohexane results in increased expression of CTSS mRNA CTD PMID:25270620 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP27A1 mRNA CTD PMID:28392238 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP2B10 mRNA CTD PMID:25270620 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP2C55 mRNA CTD PMID:25270620 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of CYP2C38 mRNA CTD PMID:25270620 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP2C29 mRNA CTD PMID:25270620
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP7A1 mRNA CTD PMID:28392238 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP8B1 mRNA CTD PMID:28392238 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of DAB1 mRNA CTD PMID:25270620 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of DRD2 mRNA CTD PMID:25270620 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of DTL mRNA CTD PMID:25270620 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Dync2i1 dynein 2 intermediate chain 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of DYNC2I1 mRNA CTD PMID:25270620 NCBI chr 6:137,133,418...137,189,937
Ensembl chr 6:137,133,418...137,188,719
JBrowse link
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma increases expression ISO beta-hexachlorocyclohexane results in increased expression of EIF2B3 mRNA CTD PMID:25270620 NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332
JBrowse link
G Emp2 epithelial membrane protein 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of EMP2 mRNA CTD PMID:25270620 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
JBrowse link
G Epb41 erythrocyte membrane protein band 4.1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of EPB41 mRNA CTD PMID:25270620 NCBI chr 5:144,110,010...144,264,037
Ensembl chr 5:144,111,906...144,237,821
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression
multiple interactions
increases activity
ISO beta-hexachlorocyclohexane results in increased expression of ERBB2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]
beta-hexachlorocyclohexane results in increased activity of ERBB2 protein
beta-hexachlorocyclohexane results in increased expression of ERBB2 protein
CTD PMID:9443065 PMID:11222871 PMID:12439862 PMID:12948864 PMID:17640349 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein] CTD PMID:12439862 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ERMP1 mRNA CTD PMID:25270620 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
increases expression
multiple interactions
increases activity
ISO beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA; beta-hexachlorocyclohexane results in decreased expression of ESR1 protein
beta-hexachlorocyclohexane results in increased expression of ESR1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]
beta-hexachlorocyclohexane results in increased expression of ESR1 protein
beta-hexachlorocyclohexane results in increased activity of ESR1 protein
[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of ESR1 mRNA; beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12948864 PMID:15064155 PMID:15541753 PMID:16758953 PMID:20206645 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR2 protein]
beta-hexachlorocyclohexane results in increased activity of ESR2 protein
CTD PMID:15064155 PMID:21278053 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ETV1 mRNA CTD PMID:25270620 NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775
JBrowse link
G Exosc8 exosome component 8 increases expression ISO beta-hexachlorocyclohexane results in increased expression of EXOSC8 mRNA CTD PMID:25270620 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO beta-hexachlorocyclohexane results in increased expression of FABP5 mRNA CTD PMID:28392238 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of FAM107A mRNA CTD PMID:25270620 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of FASLG protein] CTD PMID:19760616 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression ISO beta-hexachlorocyclohexane results in increased expression of FASN protein CTD PMID:27203212 PMID:28397872 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of FGF15 mRNA CTD PMID:28392238 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP beta-hexachlorocyclohexane results in increased activity of G6PD protein CTD PMID:2461408 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of GNRH1 mRNA CTD PMID:16758953 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gpr146 G protein-coupled receptor 146 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of GPR146 mRNA CTD PMID:25270620 NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein CTD PMID:16046044 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to beta-hexachlorocyclohexane CTD PMID:22310945 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO beta-hexachlorocyclohexane results in increased phosphorylation of H2AX protein CTD PMID:33207735 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of HMOX1 mRNA CTD PMID:25270620 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hyal1 hyaluronidase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of HYAL1 mRNA CTD PMID:25270620 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO beta-hexachlorocyclohexane results in increased expression of IGF1R mRNA CTD PMID:17640349 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of IGSF3 mRNA CTD PMID:25270620 NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase increases expression ISO beta-hexachlorocyclohexane results in increased expression of JMJD6 mRNA CTD PMID:25270620 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [beta-hexachlorocyclohexane co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of JUN mRNA
beta-hexachlorocyclohexane results in increased expression of JUN mRNA
CTD PMID:18481421 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kank3 KN motif and ankyrin repeat domains 3 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of KANK3 mRNA CTD PMID:25270620 NCBI chr 7:14,594,358...14,607,675
Ensembl chr 7:14,594,422...14,607,675
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of KCND2 mRNA CTD PMID:25270620 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of KDELR2 mRNA CTD PMID:25270620 NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153
JBrowse link
G Kif24 kinesin family member 24 increases expression ISO beta-hexachlorocyclohexane results in increased expression of KIF24 mRNA CTD PMID:25270620 NCBI chr 5:56,561,019...56,628,040
Ensembl chr 5:56,561,154...56,628,025
JBrowse link
G Krt19 keratin 19 increases expression ISO beta-hexachlorocyclohexane results in increased expression of KRT19 mRNA CTD PMID:17640349 NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Lcn8 lipocalin 8 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of LCN8 mRNA CTD PMID:25270620 NCBI chr 3:8,467,934...8,473,691
Ensembl chr 3:8,467,934...8,470,918
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions
ISO beta-hexachlorocyclohexane results in decreased expression of MAPK1 protein
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD PMID:12948864 PMID:20206645 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions
ISO beta-hexachlorocyclohexane results in decreased expression of MAPK3 protein
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD PMID:12948864 PMID:20206645 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein]
CTD PMID:19760616 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK9 protein] CTD PMID:19760616 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of MGME1 mRNA CTD PMID:25270620 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MMP12 mRNA CTD PMID:17640349 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MMP13 mRNA CTD PMID:17640349 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MMP9 protein CTD PMID:12948864 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mroh9 maestro heat-like repeat family member 9 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MROH9 mRNA CTD PMID:25270620 NCBI chr13:75,387,800...75,443,118
Ensembl chr13:75,387,746...75,443,092
JBrowse link
G Mylip myosin regulatory light chain interacting protein decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of MYLIP mRNA CTD PMID:25270620 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
JBrowse link
G Myo1e myosin IE decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of MYO1E mRNA CTD PMID:25270620 NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169
JBrowse link
G Nadk NAD kinase increases expression ISO beta-hexachlorocyclohexane results in increased expression of NADK mRNA CTD PMID:25270620 NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression ISO beta-hexachlorocyclohexane results in increased expression of NR1H4 mRNA CTD PMID:28392238 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO beta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr2c1 nuclear receptor subfamily 2, group C, member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of NR2C1 mRNA CTD PMID:25270620 NCBI chr 7:28,715,347...28,768,624
Ensembl chr 7:28,715,562...28,767,160
JBrowse link
G Ntsr2 neurotensin receptor 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of NTSR2 mRNA CTD PMID:25270620 NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PDGFRB mRNA CTD PMID:25270620 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PFKFB1 mRNA CTD PMID:25270620 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; beta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]
beta-hexachlorocyclohexane results in increased expression of PGR; beta-hexachlorocyclohexane results in increased expression of PGR mRNA
CTD PMID:2479123 PMID:16242299 PMID:20206645 PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression ISO beta-hexachlorocyclohexane results in increased expression of PLA2G12A mRNA CTD PMID:25270620 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pla2g15 phospholipase A2, group XV decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PLA2G15 mRNA CTD PMID:25270620 NCBI chr19:34,050,685...34,068,070
Ensembl chr19:34,050,694...34,068,063
JBrowse link
G Polr1b RNA polymerase I subunit B decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of POLR1B mRNA CTD PMID:25270620 NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA CTD PMID:16758953 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO beta-hexachlorocyclohexane results in increased expression of POR mRNA CTD PMID:25270620 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA] CTD PMID:8968093 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prpf18 pre-mRNA processing factor 18 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PRPF18 mRNA CTD PMID:25270620 NCBI chr17:73,630,560...73,661,210
Ensembl chr17:73,630,571...73,690,979
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO beta-hexachlorocyclohexane results in increased expression of PSMD12 mRNA CTD PMID:25270620 NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO beta-hexachlorocyclohexane results in increased expression of PTGES mRNA CTD PMID:25270620 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
EXP Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane affects the localization of RELA protein] CTD PMID:19760616 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs3 regulator of G-protein signaling 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of RGS3 mRNA CTD PMID:25270620 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO beta-hexachlorocyclohexane results in increased expression of SCD1 mRNA; beta-hexachlorocyclohexane results in increased expression of SCD1 protein CTD PMID:27203212 PMID:28397872 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Sh3d21 SH3 domain containing 21 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SH3D21 mRNA CTD PMID:25270620 NCBI chr 5:138,429,180...138,444,540
Ensembl chr 5:138,429,180...138,444,407
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SLC10A1 mRNA CTD PMID:28392238 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC10A2 mRNA CTD PMID:28392238 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc27a1 solute carrier family 27 member 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC27A1 mRNA CTD PMID:25270620 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SLC29A1 mRNA CTD PMID:25270620 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP beta-hexachlorocyclohexane results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC51A mRNA CTD PMID:28392238 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC51B mRNA CTD PMID:28392238 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Sntb2 syntrophin, beta 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SNTB2 mRNA CTD PMID:25270620 NCBI chr19:34,831,657...34,922,325
Ensembl chr19:34,831,584...34,914,113
JBrowse link
G Spag16 sperm associated antigen 16 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SPAG16 mRNA CTD PMID:25270620 NCBI chr 9:71,333,005...72,252,772
Ensembl chr 9:71,332,992...72,252,708
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:20206645 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srcap Snf2-related CREBBP activator protein increases expression ISO beta-hexachlorocyclohexane results in increased expression of SRCAP mRNA CTD PMID:25270620 NCBI chr 1:182,123,562...182,172,643
Ensembl chr 1:182,118,416...182,176,610
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases expression
ISO beta-hexachlorocyclohexane results in decreased expression of SREBF1 mRNA
beta-hexachlorocyclohexane results in increased expression of SREBF1 mRNA; beta-hexachlorocyclohexane results in increased expression of SREBF1 protein
CTD PMID:25270620 PMID:27203212 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TACC1 mRNA CTD PMID:25270620 NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733
JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA] CTD PMID:8968093 PMID:16242299 PMID:20206645 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Thumpd2 THUMP domain containing 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of THUMPD2 mRNA CTD PMID:25270620 NCBI chr 6:13,924,742...13,976,657
Ensembl chr 6:13,924,765...13,976,657
JBrowse link
G Tns1 tensin 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TNS1 mRNA CTD PMID:25270620 NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225
JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TPM3 mRNA CTD PMID:25270620 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Trim42 tripartite motif-containing 42 increases expression ISO beta-hexachlorocyclohexane results in increased expression of TRIM42 mRNA CTD PMID:25270620 NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO beta-hexachlorocyclohexane affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tssc4 tumor suppressing subtransferable candidate 4 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TSSC4 mRNA CTD PMID:25270620 NCBI chr 1:198,251,986...198,254,810
Ensembl chr 1:198,235,487...198,254,980
JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B increases expression ISO beta-hexachlorocyclohexane results in increased expression of TTC39B mRNA CTD PMID:25270620 NCBI chr 5:97,603,329...97,708,103
Ensembl chr 5:97,609,392...97,736,270
JBrowse link
G Zfp113 zinc finger protein 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ZFP113 mRNA CTD PMID:25270620 NCBI chr12:17,022,104...17,033,776
Ensembl chr12:17,022,279...17,033,709
JBrowse link
G Zfp597 zinc finger protein 597 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ZFP597 mRNA CTD PMID:25270620 NCBI chr10:11,653,169...11,658,843
Ensembl chr10:11,653,127...11,660,675
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        pesticide 17304
          organochlorine pesticide 6377
            beta-hexachlorocyclohexane 135
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            organic hydride 18675
                              organic fundamental parent 18657
                                hydrocarbon 18408
                                  cyclic hydrocarbon 17206
                                    monocyclic hydrocarbon 6061
                                      cycloalkane 513
                                        cyclohexane 508
                                          chlorocyclohexane 508
                                            hexachlorocyclohexane 508
                                              beta-hexachlorocyclohexane 135
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