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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butan-2-one
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Accession:CHEBI:28398 term browser browse the term
Definition:A dialkyl ketone that is a four-carbon ketone carrying a single keto- group at position C-2.
Synonyms:related_synonym: 2-Butanon;   3-butanone;   Aethylmethylketon;   C2H5COCH3;   Ethyl methyl ketone;   Ethylmethylketon;   Formula=C4H8O;   InChI=1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3;   InChIKey=ZWEHNKRNPOVVGH-UHFFFAOYSA-N;   MEK;   Methylethylketon;   SMILES=CCC(C)=O;   butanone;   butanone 2;   ethylmethyl ketone;   meetco;   methyl acetone;   methyl ethyl cetone;   methylacetone;   methylethyl ketone;   oxobutane
 alt_id: CHEBI:25249;   CHEBI:6858
 xref: Beilstein:741880;   CAS:78-93-3;   Gmelin:25656;   HMDB:HMDB0000474;   KEGG:C02845;   LIPID_MAPS_instance:LMFA12000043
 xref_mesh: MESH:C005222
 xref: MetaCyc:MEK;   PMID:20403429;   PMID:23050457;   Reaxys:741880;   UM-BBD_compID:c0020;   Wikipedia:Butanone


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butan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance ISO CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone CTD PMID:21352904 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP
methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
buten-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO 3-buten-2-one binds to and results in decreased activity of GAPDH protein CTD PMID:22084934 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        solvent 16489
          polar solvent 15280
            polar aprotic solvent 571
              butan-2-one 5
                1,3-dihydroxybutan-2-one 0
                1-hydroxybutan-2-one 0
                3-cyano-2-butanone 0
                4-hydroxybutan-2-one 0
                buten-2-one 3
                butyn-2-one 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16173
                                        dialkyl ketone 42
                                          butan-2-one 5
                                            1,3-dihydroxybutan-2-one 0
                                            1-hydroxybutan-2-one 0
                                            3-cyano-2-butanone 0
                                            4-hydroxybutan-2-one 0
                                            buten-2-one 3
                                            butyn-2-one 0
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