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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butan-2-one
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Accession:CHEBI:28398 term browser browse the term
Definition:A dialkyl ketone that is a four-carbon ketone carrying a single keto- group at position C-2.
Synonyms:related_synonym: 2-Butanon;   3-butanone;   Aethylmethylketon;   C2H5COCH3;   Ethyl methyl ketone;   Ethylmethylketon;   Formula=C4H8O;   InChI=1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3;   InChIKey=ZWEHNKRNPOVVGH-UHFFFAOYSA-N;   MEK;   Methylethylketon;   SMILES=CCC(C)=O;   butanone;   butanone 2;   ethylmethyl ketone;   meetco;   methyl acetone;   methyl ethyl cetone;   methylacetone;   methylethyl ketone;   oxobutane
 alt_id: CHEBI:25249;   CHEBI:6858
 xref: Beilstein:741880;   CAS:78-93-3;   Gmelin:25656;   HMDB:HMDB0000474;   KEGG:C02845;   LIPID_MAPS_instance:LMFA12000043
 xref_mesh: MESH:C005222
 xref: MetaCyc:MEK;   PMID:20403429;   PMID:23050457;   Reaxys:741880;   UM-BBD_compID:c0020;   Wikipedia:Butanone


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butan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance ISO CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone CTD PMID:21352904 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP
methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
buten-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO 3-buten-2-one binds to and results in decreased activity of GAPDH protein CTD PMID:22084934 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one CTD PMID:11524419 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        solvent 16459
          polar solvent 15235
            polar aprotic solvent 571
              butan-2-one 5
                1,3-dihydroxybutan-2-one 0
                1-hydroxybutan-2-one 0
                3-cyano-2-butanone 0
                4-hydroxybutan-2-one 0
                buten-2-one 3
                butyn-2-one 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        dialkyl ketone 42
                                          butan-2-one 5
                                            1,3-dihydroxybutan-2-one 0
                                            1-hydroxybutan-2-one 0
                                            3-cyano-2-butanone 0
                                            4-hydroxybutan-2-one 0
                                            buten-2-one 3
                                            butyn-2-one 0
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