Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:butan-2-one
go back to main search page
Accession:CHEBI:28398 term browser browse the term
Definition:A dialkyl ketone that is a four-carbon ketone carrying a single keto- group at position C-2.
Synonyms:related_synonym: 2-Butanon;   3-butanone;   Aethylmethylketon;   C2H5COCH3;   Ethyl methyl ketone;   Ethylmethylketon;   Formula=C4H8O;   InChI=1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3;   InChIKey=ZWEHNKRNPOVVGH-UHFFFAOYSA-N;   MEK;   Methylethylketon;   SMILES=CCC(C)=O;   butanone;   butanone 2;   ethylmethyl ketone;   meetco;   methyl acetone;   methyl ethyl cetone;   methylacetone;   methylethyl ketone;   oxobutane
 alt_id: CHEBI:25249;   CHEBI:6858
 xref: Beilstein:741880;   CAS:78-93-3;   Gmelin:25656;   HMDB:HMDB0000474;   KEGG:C02845;   LIPID_MAPS_instance:LMFA12000043
 xref_mesh: MESH:C005222
 xref: MetaCyc:MEK;   PMID:20403429;   PMID:23050457;   Reaxys:741880;   UM-BBD_compID:c0020;   Wikipedia:Butanone


show annotations for term's descendants           Sort by:
 
butan-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 decreases expression ISO methylethyl ketone results in decreased expression of CACNG6 mRNA CTD PMID:33064461 NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance ISO CYP2E1 gene mutant form affects the susceptibility to methylethyl ketone CTD PMID:21352904 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP
methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO methylethyl ketone results in increased expression of PPARGC1A mRNA CTD PMID:33064461 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases expression ISO methylethyl ketone results in decreased expression of SRSF2 mRNA CTD PMID:33064461 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
buten-2-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO 3-buten-2-one binds to and results in decreased activity of GAPDH protein CTD PMID:22084934 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions EXP [PTGR1 protein co-treated with NADP] affects the reduction of 3-buten-2-one CTD PMID:11524419 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        solvent 16635
          polar solvent 15446
            polar aprotic solvent 584
              butan-2-one 8
                1,3-dihydroxybutan-2-one 0
                1-hydroxybutan-2-one 0
                3-cyano-2-butanone 0
                4-hydroxybutan-2-one 0
                buten-2-one 3
                butyn-2-one 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        dialkyl ketone 46
                                          butan-2-one 8
                                            1,3-dihydroxybutan-2-one 0
                                            1-hydroxybutan-2-one 0
                                            3-cyano-2-butanone 0
                                            4-hydroxybutan-2-one 0
                                            buten-2-one 3
                                            butyn-2-one 0
paths to the root