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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vitamin K epoxide
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Accession:CHEBI:28371 term browser browse the term
Definition:A phytylnaphthoquinone that has formula C31H46O3.
Synonyms:exact_synonym: 1a-methyl-7a-(-3,7,11,15-tetramethylhexadec-2-en-1-yl)-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione
 related_synonym: (2,3-Epoxyphytyl)menaquinone;   1,4-Naphthoquinone, 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-2,3-Epoxyphylloquinone;   1a,7a-Dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)-naphth[2,3-b]oxirene-2,7-dione;   2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone;   2,3-Epoxyphylloquinone;   Formula=C31H46O3;   InChI=1S/C31H46O3/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-31-29(33)27-19-8-7-18-26(27)28(32)30(31,6)34-31/h7-8,18-20,22-24H,9-17,21H2,1-6H3;   InChIKey=KUTXFBIHPWIDJQ-UHFFFAOYSA-N;   Naphth[2,3-b]oxirene-2,7-dione, 1a,7a-dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)-Phylloquinone oxide;   Phylloquinone epoxide;   Phylloquinone oxide;   Phylloquinone-2,3-epoxide;   SMILES=CC(C)CCCC(C)CCCC(C)CCCC(C)=CCC12OC1(C)C(=O)c1ccccc1C2=O;   Vitamin K 2,3-epoxide;   Vitamin K1 2,3-epoxide;   Vitamin K1 oxide;   Vitamin K1, epoxide
 alt_id: CHEBI:10010;   CHEBI:27302
 xref: CAS:25486-55-9;   KEGG:C05849;   KEGG:C16711
 xref_mesh: MESH:C016186

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vitamin K epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F9 coagulation factor IX multiple interactions ISO [VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein CTD PMID:29581108 NCBI chr  X:143,097,507...143,141,791
Ensembl chr  X:143,097,525...143,141,794 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
increases reduction
affects reduction		 ISO
EXP		 [VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]; fluindione inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
VKORC1 protein affects the reduction of vitamin K1 oxide
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]		 CTD PMID:23928358 PMID:29581108 NCBI chr 1:199,338,785...199,341,306
Ensembl chr 1:199,337,138...199,341,302 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 increases reduction
increases metabolic processing
multiple interactions		 ISO
EXP		 VKORC1L1 protein results in increased reduction of vitamin K1 oxide
VKORC1L1 protein results in increased metabolism of vitamin K1 oxide
[VKORC1L1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; fluindione inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]		 CTD PMID:23710884 PMID:23928358 PMID:29581108 NCBI chr12:30,218,825...30,268,990
Ensembl chr12:30,222,701...30,268,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      molecular entity 19872
        main group molecular entity 19763
          gas molecular entity 17642
            oxirane 5784
              epoxide 5782
                vitamin K epoxide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      ketone 16216
                                        cyclic ketone 13930
                                          quinone 8386
                                            naphthoquinone 1434
                                              phytylnaphthoquinone 51
                                                vitamin K epoxide 3
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