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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vitamin K epoxide
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Accession:CHEBI:28371 term browser browse the term
Definition:A phytylnaphthoquinone that has formula C31H46O3.
Synonyms:exact_synonym: 1a-methyl-7a-(-3,7,11,15-tetramethylhexadec-2-en-1-yl)-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione
 related_synonym: (2,3-Epoxyphytyl)menaquinone;   1,4-Naphthoquinone, 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-2,3-Epoxyphylloquinone;   1a,7a-Dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)-naphth[2,3-b]oxirene-2,7-dione;   2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone;   2,3-Epoxyphylloquinone;   Formula=C31H46O3;   InChI=1S/C31H46O3/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-31-29(33)27-19-8-7-18-26(27)28(32)30(31,6)34-31/h7-8,18-20,22-24H,9-17,21H2,1-6H3;   InChIKey=KUTXFBIHPWIDJQ-UHFFFAOYSA-N;   Naphth[2,3-b]oxirene-2,7-dione, 1a,7a-dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)-Phylloquinone oxide;   Phylloquinone epoxide;   Phylloquinone oxide;   Phylloquinone-2,3-epoxide;   SMILES=CC(C)CCCC(C)CCCC(C)CCCC(C)=CCC12OC1(C)C(=O)c1ccccc1C2=O;   Vitamin K 2,3-epoxide;   Vitamin K1 2,3-epoxide;   Vitamin K1 oxide;   Vitamin K1, epoxide
 alt_id: CHEBI:10010;   CHEBI:27302
 xref: CAS:25486-55-9;   KEGG:C05849;   KEGG:C16711
 xref_mesh: MESH:C016186


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vitamin K epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F9 coagulation factor IX multiple interactions ISO [VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; [VKORC1L1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein CTD PMID:29581108 NCBI chr  X:138,352,334...138,396,835
Ensembl chr  X:138,352,298...138,396,835 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 multiple interactions
increases reduction
affects reduction		 ISO
EXP		 [VKORC1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; coumachlor inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]; fluindione inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1 protein results in increased reduction of vitamin K1 oxide]
VKORC1 protein affects the reduction of vitamin K1 oxide
Warfarin inhibits the reaction [VKORC1 protein affects the reduction of vitamin K1 oxide]		 CTD PMID:23928358 PMID:29581108 NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008 		JBrowse link
G Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 increases reduction
increases metabolic processing
multiple interactions		 ISO
EXP		 VKORC1L1 protein results in increased reduction of vitamin K1 oxide
VKORC1L1 protein results in increased metabolism of vitamin K1 oxide
[VKORC1L1 protein results in increased reduction of vitamin K1 oxide] which results in increased carboxylation of and results in increased activity of F9 protein; coumachlor inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; fluindione inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin affects the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased metabolism of vitamin K1 oxide]; Warfarin inhibits the reaction [VKORC1L1 protein results in increased reduction of vitamin K1 oxide]		 CTD PMID:23710884 PMID:23928358 PMID:29581108 NCBI chr12:26,717,959...26,768,193 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        main group molecular entity 19698
          gas molecular entity 17919
            oxirane 9768
              epoxide 9767
                vitamin K epoxide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      ketone 16957
                                        cyclic ketone 15522
                                          quinone 8385
                                            naphthoquinone 1438
                                              phytylnaphthoquinone 25
                                                vitamin K epoxide 3
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