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Accession:CHEBI:28329 term browser browse the term
Definition:7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Synonyms:exact_synonym: 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
 related_synonym: 2',4,8-Trimethylpsoralen;   4,5',8-Trimethylpsoralen;   6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone;   Formula=C14H12O3;   InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3;   InChIKey=FMHHVULEAZTJMA-UHFFFAOYSA-N;   SMILES=Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1;   Trimethylpsoralen;   Trioxysalen;   trioxisaleno;   trioxysalene;   trioxysalenum
 alt_id: CHEBI:1758;   CHEBI:20282
 xref: Beilstein:221723 "Beilstein";   CAS:3902-71-4 "ChemIDplus";   CAS:3902-71-4 "KEGG COMPOUND";   CAS:3902-71-4 "NIST Chemistry WebBook";   DrugBank:DB04571;   Drug_Central:2759 "DrugCentral";   KEGG:C09314;   KEGG:D01034;   KNApSAcK:C00002502;   LINCS:LSM-3223
 xref_mesh: MESH:D014307
 xref: Patent:US3201421;   Wikipedia:Trioxsalen

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trioxsalen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19362
        pharmaceutical 19231
          drug 19231
            photosensitizing agent 7647
              trioxsalen 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic molecule 19447
                              organic cyclic compound 19207
                                organic heterocyclic compound 18276
                                  organic heteropolycyclic compound 17584
                                    organic heterotricyclic compound 13736
                                      furochromene 99
                                        furanocoumarin 99
                                          psoralens 91
                                            trioxsalen 3
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