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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:11-deoxycortisol
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Accession:CHEBI:28324 term browser browse the term
Definition:A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.
Synonyms:exact_synonym: 17,21-dihydroxypregn-4-ene-3,20-dione
 related_synonym: 11-desoxy-17-hydroxycorticosterone;   Cortodoxone;   Formula=C21H30O4;   InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1;   InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
 alt_id: CHEBI:19124;   CHEBI:714
 xref: CAS:152-58-9;   HMDB:HMDB0000015;   KEGG:C05488;   KEGG:D03595;   LIPID_MAPS_instance:LMST02030086
 xref_mesh: MESH:D003350
 xref: PMID:18958601;   PMID:24863084;   Reaxys:2511358;   Wikipedia:Cortexolone



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11-deoxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Cortodoxone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases metabolic processing
affects metabolic processing
ISO CYP11B1 protein results in increased metabolism of Cortodoxone
CYP11B1 protein affects the metabolism of Cortodoxone
CTD PMID:15522937 PMID:15780661 PMID:15985365 PMID:16030167 PMID:16054388 More... NCBI chr 7:108,719,349...108,726,024 JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases metabolic processing
affects metabolic processing
ISO CYP11B2 protein results in increased metabolism of Cortodoxone
CYP11B2 protein affects the metabolism of Cortodoxone
CTD PMID:15743198 PMID:19900470 NCBI chr 7:106,808,559...106,814,048 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding ISO Cortodoxone binds to NR3C1 protein CTD PMID:15705660 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Cortodoxone results in increased activity of NR3C2 protein CTD PMID:15780662 NCBI chr19:47,619,853...47,964,089 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      application 19715
        anti-inflammatory agent 16695
          anti-inflammatory drug 14979
            cortisol 277
              deoxycortisol 5
                11-deoxycortisol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic polycyclic compound 17315
                                  steroid 14736
                                    hydroxy steroid 14484
                                      17-hydroxy steroid 14120
                                        17alpha-hydroxy steroid 5442
                                          17alpha-hydroxy-C21-steroid 281
                                            cortisol 277
                                              deoxycortisol 5
                                                11-deoxycortisol 5
paths to the root