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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:11-deoxycortisol
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Accession:CHEBI:28324 term browser browse the term
Definition:A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.
Synonyms:related_synonym: 11-desoxy-17-hydroxycorticosterone;   20-Dione 17,21-Dihydroxypregn-4-ene-3;   Formula=C21H30O4;   InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1;   InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   cortodoxone
 alt_id: CHEBI:19124;   CHEBI:714
 xref: Beilstein:2511358;   CAS:152-58-9;   HMDB:HMDB0000015;   KEGG:C05488;   KEGG:D03595;   LIPID_MAPS_instance:LMST02030086
 xref_mesh: MESH:D003350
 xref: PMID:18958601;   PMID:24863084;   Reaxys:2511358;   Wikipedia:Cortexolone


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11-deoxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Cortodoxone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 affects metabolic processing
increases metabolic processing
ISO CYP11B1 protein affects the metabolism of Cortodoxone
CYP11B1 protein results in increased metabolism of Cortodoxone
CTD PMID:15522937 PMID:15780661 PMID:15985365 PMID:16030167 PMID:16054388 PMID:19900470 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases metabolic processing
affects metabolic processing
ISO CYP11B2 protein results in increased metabolism of Cortodoxone
CYP11B2 protein affects the metabolism of Cortodoxone
CTD PMID:15743198 PMID:19900470 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding ISO Cortodoxone binds to NR3C1 protein CTD PMID:15705660 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Cortodoxone results in increased activity of NR3C2 protein CTD PMID:15780662 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        anti-inflammatory agent 15758
          anti-inflammatory drug 13617
            cortisol 155
              deoxycortisol 5
                11-deoxycortisol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      ketone 16825
                                        oxyketone 8656
                                          alpha-oxyketone 8656
                                            alpha-hydroxy ketone 8656
                                              primary alpha-hydroxy ketone 7538
                                                cortisol 155
                                                  deoxycortisol 5
                                                    11-deoxycortisol 5
paths to the root