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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:11-deoxycortisol
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Accession:CHEBI:28324 term browser browse the term
Definition:A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.
Synonyms:exact_synonym: 17,21-dihydroxypregn-4-ene-3,20-dione
 related_synonym: 11-desoxy-17-hydroxycorticosterone;   Cortodoxone;   Formula=C21H30O4;   InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1;   InChIKey=WHBHBVVOGNECLV-OBQKJFGGSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO
 alt_id: CHEBI:19124;   CHEBI:714
 xref: Beilstein:2511358;   CAS:152-58-9;   HMDB:HMDB0000015;   KEGG:C05488;   KEGG:D03595;   LIPID_MAPS_instance:LMST02030086
 xref_mesh: MESH:D003350
 xref: PMID:18958601;   PMID:24863084;   Reaxys:2511358;   Wikipedia:Cortexolone



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11-deoxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Cortodoxone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases metabolic processing
affects metabolic processing
ISO CYP11B1 protein results in increased metabolism of Cortodoxone
CYP11B1 protein affects the metabolism of Cortodoxone
CTD PMID:15522937 PMID:15780661 PMID:15985365 PMID:16030167 PMID:16054388 More... NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases metabolic processing
affects metabolic processing
ISO CYP11B2 protein results in increased metabolism of Cortodoxone
CYP11B2 protein affects the metabolism of Cortodoxone
CTD PMID:15743198 PMID:19900470 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding ISO Cortodoxone binds to NR3C1 protein CTD PMID:15705660 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Cortodoxone results in increased activity of NR3C2 protein CTD PMID:15780662 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      application 19747
        anti-inflammatory agent 16333
          anti-inflammatory drug 14856
            cortisol 169
              deoxycortisol 5
                11-deoxycortisol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      ketone 17090
                                        oxyketone 8732
                                          alpha-oxyketone 8732
                                            alpha-hydroxy ketone 8732
                                              primary alpha-hydroxy ketone 7594
                                                cortisol 169
                                                  deoxycortisol 5
                                                    11-deoxycortisol 5
paths to the root