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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alloxanthine
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Accession:CHEBI:28315 term browser browse the term
Definition:A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.
Synonyms:exact_synonym: 1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione
 related_synonym: Formula=C5H4N4O2;   InChI=1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11);   InChIKey=HXNFUBHNUDHIGC-UHFFFAOYSA-N;   Oxipurinol;   Oxoallopurinol;   Oxypurinol;   SMILES=O=c1[nH]c2[nH]ncc2c(=O)[nH]1
 alt_id: CHEBI:22360;   CHEBI:2603
 xref: BPDB:2154;   Beilstein:139956;   CAS:2465-59-0;   HMDB:HMDB0000786;   KEGG:C07599;   KEGG:D02365
 xref_mesh: MESH:D010117
 xref: PMID:18484017;   PMID:23751350;   PMID:24184830;   PMID:24591375;   Reaxys:139956;   Wikipedia:Oxypurinol


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alloxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Oxypurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Oxypurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Oxypurinol results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Oxypurinol results in increased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Dek DEK proto-oncogene increases secretion ISO DEK protein results in increased secretion of Oxypurinol CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Oxypurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Oxypurinol results in increased expression of HMOX1 mRNA CTD PMID:25091725 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Oxypurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions
increases uptake
ISO Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] CTD PMID:16135657 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Oxypurinol results in increased expression of TNF mRNA
Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]
CTD PMID:26641773 PMID:28949055 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Oxypurinol results in decreased activity of XDH protein CTD PMID:26968635 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            xenobiotic metabolite 14478
              human xenobiotic metabolite 13864
                drug metabolite 4439
                  alloxanthine 15
                    7-isobutyl-5-methyl-2-(1-naphthylmethyl)-3-(4-pyridyl)alloxanthine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      pyrazolopyrimidine 5694
                                        alloxanthine 15
                                          7-isobutyl-5-methyl-2-(1-naphthylmethyl)-3-(4-pyridyl)alloxanthine 0
paths to the root