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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aristolochic acid A
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Accession:CHEBI:2825 term browser browse the term
Definition:An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Synonyms:exact_synonym: 8-methoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
 related_synonym: 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid;   8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid;   8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid;   AAA;   Aristolochic acid;   Aristolochic acid I;   Formula=C17H11NO7;   InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20);   InChIKey=BBFQZRXNYIEMAW-UHFFFAOYSA-N;   SMILES=COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O;   aristolochin
 xref: CAS:313-67-7;   KEGG:C08469;   KNApSAcK:C00001526;   KNApSAcK:C00027516;   LINCS:LSM-2373
 xref_mesh: MESH:C000228
 xref: PMID:21558304;   PMID:21719716;   PMID:22071594;   PMID:22118289;   PMID:22126455;   PMID:22245565;   PMID:22373701;   Reaxys:345159;   Wikipedia:Aristolochic_acid

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      CHEBI ontology 19818
        role 19790
          biological role 19788
            biochemical role 19501
              metabolite 19486
                aristolochic acid A 6521
                  aristoloterpenate-I 0
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      CHEBI ontology 19818
        subatomic particle 19816
          composite particle 19816
            hadron 19816
              baryon 19816
                nucleon 19816
                  atomic nucleus 19816
                    atom 19816
                      main group element atom 19761
                        p-block element atom 19761
                          carbon group element atom 19703
                            carbon atom 19698
                              organic molecular entity 19698
                                organic group 18905
                                  organic divalent group 18887
                                    organodiyl group 18887
                                      carbonyl group 18853
                                        carbonyl compound 18853
                                          carboxylic acid 18569
                                            monocarboxylic acid 17903
                                              aristolochic acids 6558
                                                aristolochic acid A 6521
                                                  aristoloterpenate-I 0
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