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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aristolochic acid
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Accession:CHEBI:2825 term browser browse the term
Definition:A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Synonyms:exact_synonym: 8-methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
 related_synonym: 3,4-methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid;   8-methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid;   Aristolochic acid I;   Formula=C17H11NO7;   InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20);   InChIKey=BBFQZRXNYIEMAW-UHFFFAOYSA-N;   SMILES=COc1cccc2c1cc([N+]([O-])=O)c1c(cc3OCOc3c21)C(O)=O;   aristolochic acid A;   aristolochin
 xref: CAS:313-67-7;   KEGG:C08469;   KNApSAcK:C00001526;   KNApSAcK:C00027516;   LINCS:LSM-2373
 xref_mesh: MESH:C000228
 xref: PMID:21558304;   PMID:21719716;   PMID:22071594;   PMID:22118289;   PMID:22126455;   PMID:22245565;   PMID:22373701;   Reaxys:345159;   Wikipedia:Aristolochic_acid

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    Path 1
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      CHEBI ontology 19795
        role 19746
          biological role 19746
            biochemical role 19361
              metabolite 19338
                aristolochic acid 6489
                  aristoloterpenate-I 0
    Path 2
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      CHEBI ontology 19795
        subatomic particle 19794
          composite particle 19794
            hadron 19794
              baryon 19794
                nucleon 19794
                  atomic nucleus 19794
                    atom 19794
                      main group element atom 19693
                        p-block element atom 19693
                          carbon group element atom 19614
                            carbon atom 19604
                              organic molecular entity 19604
                                organic group 18713
                                  organic divalent group 18697
                                    organodiyl group 18697
                                      carbonyl group 18646
                                        carbonyl compound 18646
                                          carboxylic acid 18341
                                            monocarboxylic acid 17618
                                              aristolochic acid 6489
                                                aristoloterpenate-I 0
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