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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:papaverine
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Accession:CHEBI:28241 term browser browse the term
Definition:A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Synonyms:exact_synonym: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
 related_synonym: Formula=C20H21NO4;   InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3;   InChIKey=XQYZDYMELSJDRZ-UHFFFAOYSA-N;   SMILES=COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
 alt_id: CHEBI:25852;   CHEBI:7918
 xref: CAS:58-74-2;   DrugBank:DB01113;   Drug_Central:2056;   HMDB:HMDB0015245;   KEGG:C06533;   KEGG:D07425;   KNApSAcK:C00001899;   KNApSAcK:C00027467;   LINCS:LSM-2338
 xref_mesh: MESH:D010208
 xref: MetaCyc:CPD-15742;   PDBeChem:EV1;   PMID:11971205;   PMID:24414229;   Reaxys:312930;   Wikipedia:Papaverine


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papaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression EXP Papaverine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides]
Papaverine results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Papaverine results in decreased expression of CLDN5 protein CTD PMID:20728510 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Papaverine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Papaverine results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] CTD PMID:10894095 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Papaverine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Papaverine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ocln occludin decreases expression EXP Papaverine results in decreased expression of OCLN protein CTD PMID:20728510 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9830022 PMID:12411423 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link

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  CHEBI ontology 19875
    role 19825
      application 19494
        pharmaceutical 19364
          drug 19364
            cardiovascular drug 7663
              vasodilator agent 5805
                papaverine 14
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  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                carbocyclic compound 18305
                                  benzenoid aromatic compound 17344
                                    benzenes 17087
                                      methoxybenzenes 1843
                                        dimethoxybenzene 101
                                          papaverine 14
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