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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:papaverine
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Accession:CHEBI:28241 term browser browse the term
Definition:A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Synonyms:exact_synonym: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
 related_synonym: Formula=C20H21NO4;   InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3;   InChIKey=XQYZDYMELSJDRZ-UHFFFAOYSA-N;   SMILES=COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
 alt_id: CHEBI:25852;   CHEBI:7918
 xref: CAS:58-74-2;   DrugBank:DB01113;   Drug_Central:2056;   HMDB:HMDB0015245;   KEGG:C06533;   KEGG:D07425;   KNApSAcK:C00001899;   KNApSAcK:C00027467;   LINCS:LSM-2338
 xref_mesh: MESH:D010208
 xref: MetaCyc:CPD-15742;   PDBeChem:EV1;   PMID:11971205;   PMID:24414229;   Reaxys:312930;   Wikipedia:Papaverine



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papaverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO Papaverine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Papaverine results in increased expression of BDNF mRNA CTD PMID:8601816 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Papaverine promotes the reaction [CFTR protein affects the secretion of Chlorides]
Papaverine results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Cldn5 claudin 5 decreases expression EXP Papaverine results in decreased expression of CLDN5 protein CTD PMID:20728510 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Papaverine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Papaverine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression ISO Papaverine results in decreased expression of HAMP mRNA CTD PMID:25633564 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Papaverine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Papaverine inhibits the reaction [Isoproterenol affects the localization of LIPE protein]; Papaverine inhibits the reaction [Isoproterenol results in increased activity of LIPE protein] CTD PMID:10894095 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Papaverine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Papaverine results in increased expression of NTRK2 mRNA CTD PMID:8601816 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ocln occludin decreases expression EXP Papaverine results in decreased expression of OCLN protein CTD PMID:20728510 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Papaverine inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Papaverine inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
CTD PMID:9830022 PMID:12411423 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link

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                papaverine 16
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                            organic molecule 19835
                              organic cyclic compound 19589
                                carbocyclic compound 18528
                                  benzenoid aromatic compound 17772
                                    benzenes 17582
                                      methoxybenzenes 1918
                                        dimethoxybenzene 131
                                          papaverine 16
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