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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3alpha-hydroxy-5beta-androstan-17-one
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Accession:CHEBI:28195 term browser browse the term
Definition:An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.
Synonyms:related_synonym: (3alpha,5beta)-3-hydroxyandrostan-17-one;   3alpha-Hydroxyetiocholan-17-one;   3alpha-etiocholanolone;   5-isoandrosterone;   5beta-androstan-3alpha-ol-17-one;   5beta-androsterone;   AETIOCHOLANOLONE;   Etiocholan-3alpha-ol-17-one;   Etiocholanolone;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18+,19+/m1/s1;   InChIKey=QGXBDMJGAMFCBF-BNSUEQOYSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CCC(=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
 alt_id: CHEBI:11904;   CHEBI:1710;   CHEBI:20236;   CHEBI:40622
 xref: Beilstein:2217625;   CAS:53-42-9;   DrugBank:DB02854;   HMDB:HMDB0000490;   KEGG:C04373;   LIPID_MAPS_instance:LMST02020059
 xref_mesh: MESH:D005043
 xref: PDBeChem:AE2;   PMID:1146492;   PMID:301822;   PMID:663966;   Reaxys:2217625;   Wikipedia:Etiocholanolone



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3alpha-hydroxy-5beta-androstan-17-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions
increases chemical synthesis
ISO [AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
AKR1D1 protein alternative form results in increased chemical synthesis of Etiocholanolone; AKR1D1 protein results in increased chemical synthesis of Etiocholanolone
CTD PMID:30928400 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Etiocholanolone CTD PMID:2429951 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              lipid 17493
                steroid 13347
                  androstanoid 4841
                    3alpha-hydroxy-5beta-androstan-17-one 2
                      3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      ketone 16957
                                        oxo steroid 10282
                                          17-oxo steroid 262
                                            3alpha-hydroxy-5beta-androstan-17-one 2
                                              3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
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