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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3alpha-hydroxy-5beta-androstan-17-one
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Accession:CHEBI:28195 term browser browse the term
Definition:An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.
Synonyms:related_synonym: (3alpha,5beta)-3-hydroxyandrostan-17-one;   3alpha-Hydroxyetiocholan-17-one;   3alpha-etiocholanolone;   5-isoandrosterone;   5beta-androstan-3alpha-ol-17-one;   5beta-androsterone;   AETIOCHOLANOLONE;   Etiocholan-3alpha-ol-17-one;   Etiocholanolone;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18+,19+/m1/s1;   InChIKey=QGXBDMJGAMFCBF-BNSUEQOYSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CCC(=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
 alt_id: CHEBI:11904;   CHEBI:1710;   CHEBI:20236;   CHEBI:40622
 xref: Beilstein:2217625;   CAS:53-42-9;   DrugBank:DB02854;   HMDB:HMDB0000490;   KEGG:C04373;   LIPID_MAPS_instance:LMST02020059
 xref_mesh: MESH:D005043
 xref: PDBeChem:AE2;   PMID:1146492;   PMID:301822;   PMID:663966;   Reaxys:2217625;   Wikipedia:Etiocholanolone


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3alpha-hydroxy-5beta-androstan-17-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions
increases chemical synthesis
ISO [AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
AKR1D1 protein alternative form results in increased chemical synthesis of Etiocholanolone; AKR1D1 protein results in increased chemical synthesis of Etiocholanolone
CTD PMID:30928400 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Etiocholanolone CTD PMID:2429951 Ensembl chr14:22,375,955...22,534,720 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          carbon atom 19625
            organic molecular entity 19625
              lipid 17202
                steroid 12810
                  androstanoid 2903
                    3alpha-hydroxy-5beta-androstan-17-one 2
                      3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      ketone 16189
                                        oxo steroid 9287
                                          17-oxo steroid 258
                                            3alpha-hydroxy-5beta-androstan-17-one 2
                                              3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
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