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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3alpha-hydroxy-5beta-androstan-17-one
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Accession:CHEBI:28195 term browser browse the term
Definition:An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.
Synonyms:related_synonym: (3alpha,5beta)-3-hydroxyandrostan-17-one;   3alpha-Hydroxyetiocholan-17-one;   3alpha-etiocholanolone;   5-isoandrosterone;   5beta-androstan-3alpha-ol-17-one;   5beta-androsterone;   AETIOCHOLANOLONE;   Etiocholan-3alpha-ol-17-one;   Etiocholanolone;   Formula=C19H30O2;   InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18+,19+/m1/s1;   InChIKey=QGXBDMJGAMFCBF-BNSUEQOYSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CCC(=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
 alt_id: CHEBI:11904;   CHEBI:1710;   CHEBI:20236;   CHEBI:40622
 xref: Beilstein:2217625;   CAS:53-42-9;   DrugBank:DB02854;   HMDB:HMDB0000490;   KEGG:C04373;   LIPID_MAPS_instance:LMST02020059
 xref_mesh: MESH:D005043
 xref: PDBeChem:AE2;   PMID:1146492;   PMID:301822;   PMID:663966;   Reaxys:2217625;   Wikipedia:Etiocholanolone



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3alpha-hydroxy-5beta-androstan-17-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions
increases chemical synthesis
ISO [AKR1D1 protein alternative form results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein alternative form results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased metabolism of androstane-3,17-dione] which results in increased chemical synthesis of Etiocholanolone; [AKR1D1 protein results in increased reduction of Androstenedione] which results in increased chemical synthesis of Etiocholanolone
AKR1D1 protein alternative form results in increased chemical synthesis of Etiocholanolone; AKR1D1 protein results in increased chemical synthesis of Etiocholanolone
CTD PMID:30928400 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Etiocholanolone CTD PMID:2429951 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      atom 19836
        nonmetal atom 19764
          carbon atom 19719
            organic molecular entity 19719
              lipid 17990
                steroid 14704
                  androstanoid 4826
                    3alpha-hydroxy-5beta-androstan-17-one 2
                      3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            heteroorganic entity 19474
                              organochalcogen compound 19262
                                organooxygen compound 19153
                                  carbonyl compound 18904
                                    ketone 17170
                                      oxo steroid 10532
                                        17-oxo steroid 267
                                          3alpha-hydroxy-5beta-androstan-17-one 2
                                            3alpha-hydroxy-5beta-androstan-17-one 3-glucosiduronic acid 0
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