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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer
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Accession:CHEBI:28175 term browser browse the term
Definition:A sialotetraosylceramide consisting of a branched hexasaccharide made up from two sialyl residues, two galactose residues, one N-acetylglucosamine residue and a glucose residue at the reducing end attached to the ceramide portion via a beta-linkage.
Synonyms:exact_synonym: (2S,3R,4E)-2-(acylamino)-3-hydroxyoctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->8)-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-[beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->4)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside
 related_synonym: (Gal)2 (GalNAc)1 (Glc)1 (Neu5Ac)2 (Cer)1;   Formula=C67H113N4O39R;   GD1b;   Gal(beta1-3)GalNAc(beta1-4)[NeuAc(alpha2-8)NeuAc(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer;   Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)Gal-beta1->4Glc-beta1->1'Cer;   Gal-beta1->3GalNAc-beta1->4(Neu5Ac-alpha2->8Neu5Ac-alpha2->3)LacCer;   Galbeta1-3GalNAcbeta1-4(NeuAcalpha2-8NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer;   II(3)(Neuaca2-8NeuAc)Gg4Cer;   II(3)Neu5Ac2GgOse4Cer;   SMILES=[H][C@]1(O[C@@](C[C@H](O)[C@H]1NC(C)=O)(O[C@H](CO)[C@@H](O)[C@]1([H])O[C@@](C[C@H](O)[C@H]1NC(C)=O)(O[C@@H]1[C@@H](O)[C@@H](O[C@H](CO)[C@@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H]1NC(C)=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](OC[C@H](NC([*])=O)[C@H](O)\\C=C\\CCCCCCCCCCCCC)O[C@@H]1CO)C(O)=O)C(O)=O)[C@H](O)[C@H](O)CO;   beta-Galp-(1->3)-beta-GalpNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Galp-(1->4)-beta-Glcp-(1<->1')-Cer;   disialo GD1b;   disialoganglioside GD1b;   ganglioside GD1b
 alt_id: CHEBI:21150;   CHEBI:5209
 xref: CAS:19553-76-5;   KEGG:C06141;   KEGG:G00115;   LIPID_MAPS_instance:LMSP0601AQ00
 xref_mesh: MESH:C033851
 xref: PMID:10949532;   PMID:1371229;   PMID:1567198;   PMID:16341241;   PMID:1724444;   PMID:17855742;   PMID:19221437;   PMID:19726417;   PMID:2303428;   PMID:2448252;   PMID:24841627;   PMID:25748038;   PMID:25867522;   PMID:26050638;   PMID:27485170;   PMID:27938;   PMID:28188832;   PMID:28416698;   PMID:6204642;   PMID:7534889;   PMID:7691279;   PMID:7693874;   PMID:8857725;   Reaxys:10056853
 cyclic_relationship: is_conjugate_acid_of CHEBI:87785


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beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites] CTD PMID:31202640 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 21763
    role 21742
      biological role 21740
        epitope 7136
          alpha-Neup5Ac-(2->8)-alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group 1
            beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer 1
              beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer 1(II''),9(II')-lactone 0
              beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer(d18:1/18:0) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21763
    subatomic particle 21749
      composite particle 21749
        hadron 21749
          baryon 21749
            nucleon 21749
              atomic nucleus 21749
                atom 21749
                  main group element atom 21666
                    p-block element atom 21666
                      carbon group element atom 21478
                        carbon atom 21379
                          organic molecular entity 21379
                            heteroorganic entity 21059
                              organochalcogen compound 20372
                                organooxygen compound 20302
                                  carbohydrates and carbohydrate derivatives 12920
                                    carbohydrate 12920
                                      monosaccharide 4344
                                        aldose 2720
                                          aldohexose 2356
                                            glucose 2317
                                              D-glucose 2317
                                                D-glucopyranose 1757
                                                  beta-D-glucose 1625
                                                    beta-D-glucosyl group 1
                                                      alpha-Neup5Ac-(2->8)-alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group 1
                                                        beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer 1
                                                          beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer 1(II''),9(II')-lactone 0
                                                          beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer(d18:1/18:0) 0
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