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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-hydroxytryptophan
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Accession:CHEBI:28171 term browser browse the term
Definition:A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Synonyms:exact_synonym: 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
 related_synonym: 5-HTP;   5-hydroxy-DL-tryptophan;   5-hydroxytryptophan DL-form;   DL-5-HTP;   DL-5-hydroxytryptophan;   Formula=C11H12N2O3;   InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16);   InChIKey=LDCYZAJDBXYCGN-UHFFFAOYSA-N;   SMILES=NC(Cc1c[nH]c2ccc(O)cc12)C(O)=O
 alt_id: CHEBI:20595;   CHEBI:2081
 xref: CAS:114-03-4;   CAS:56-69-9;   KEGG:C01017;   KNApSAcK:C00001371
 xref_mesh: MESH:D006916
 xref: PMID:14563478;   PMID:15617538;   Reaxys:88199;   Wikipedia:5-Hydroxytryptophan


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5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein decreases expression ISO 5-Hydroxytryptophan results in decreased expression of AFP mRNA CTD PMID:32926198 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of GATA4 mRNA CTD PMID:32926198 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO 5-Hydroxytryptophan results in decreased expression of NANOG mRNA CTD PMID:32926198 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA CTD PMID:32926198 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        molecular messenger 18659
          neurotransmitter 11681
            5-hydroxytryptophan 6
              5-hydroxy-D-tryptophan 0
              5-hydroxy-L-tryptophan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino acid 16057
                                          alpha-amino acid 13932
                                            non-proteinogenic alpha-amino acid 3802
                                              hydroxy-amino acid 7
                                                hydroxytryptophan 6
                                                  5-hydroxytryptophan 6
                                                    5-hydroxy-D-tryptophan 0
                                                    5-hydroxy-L-tryptophan 0
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