CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 5-hydroxytryptophan
Accession: CHEBI:28171
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Definition: A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Synonyms: exact_synonym: 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
related_synonym: 5-HTP; 5-hydroxy-DL-tryptophan; 5-hydroxytryptophan DL-form; DL-5-HTP; DL-5-hydroxytryptophan; Formula=C11H12N2O3; InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16); InChIKey=LDCYZAJDBXYCGN-UHFFFAOYSA-N; SMILES=NC(Cc1c[nH]c2ccc(O)cc12)C(O)=O
alt_id: CHEBI:20595; CHEBI:2081
xref: CAS:114-03-4; CAS:56-69-9; KEGG:C01017; KNApSAcK:C00001371
xref_mesh: MESH:D006916
xref: PMID:14563478; PMID:15617538; Reaxys:88199; Wikipedia:5-Hydroxytryptophan
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Afp
alpha-fetoprotein
decreases expression
ISO
5-Hydroxytryptophan results in decreased expression of AFP mRNA
CTD
PMID:32926198
NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
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Ddc
dopa decarboxylase
multiple interactions
EXP
[DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin
CTD
PMID:32243540
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Gata4
GATA binding protein 4
decreases expression
ISO
5-Hydroxytryptophan results in decreased expression of GATA4 mRNA
CTD
PMID:32926198
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
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Nanog
Nanog homeobox
decreases expression
ISO
5-Hydroxytryptophan results in decreased expression of NANOG mRNA
CTD
PMID:32926198
NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
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Pou5f1
POU class 5 homeobox 1
decreases expression
ISO
5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA
CTD
PMID:32926198
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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Tph1
tryptophan hydroxylase 1
multiple interactions
EXP
[TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan
CTD
PMID:32243540
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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