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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-hydroxytryptophan
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Accession:CHEBI:28171 term browser browse the term
Definition:A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Synonyms:exact_synonym: 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
 related_synonym: 5-HTP;   5-hydroxy-DL-tryptophan;   5-hydroxytryptophan DL-form;   DL-5-HTP;   DL-5-hydroxytryptophan;   Formula=C11H12N2O3;   InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16);   InChIKey=LDCYZAJDBXYCGN-UHFFFAOYSA-N;   SMILES=NC(Cc1c[nH]c2ccc(O)cc12)C(O)=O
 alt_id: CHEBI:20595;   CHEBI:2081
 xref: Beilstein:88199;   CAS:114-03-4;   CAS:56-69-9;   KEGG:C01017;   KNApSAcK:C00001371
 xref_mesh: MESH:D006916
 xref: PMID:14563478;   PMID:15617538;   Reaxys:88199;   Wikipedia:5-Hydroxytryptophan



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5-hydroxytryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein decreases expression ISO 5-Hydroxytryptophan results in decreased expression of AFP mRNA CTD PMID:32926198 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ddc dopa decarboxylase multiple interactions EXP [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of GATA4 mRNA CTD PMID:32926198 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Nanog Nanog homeobox decreases expression ISO 5-Hydroxytryptophan results in decreased expression of NANOG mRNA CTD PMID:32926198 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO 5-Hydroxytryptophan results in decreased expression of POU5F1 mRNA CTD PMID:32926198 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions EXP [TPH1 protein results in increased hydroxylation of Tryptophan] which results in increased chemical synthesis of 5-Hydroxytryptophan CTD PMID:32243540 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        molecular messenger 18301
          neurotransmitter 10943
            5-hydroxytryptophan 6
              5-hydroxy-D-tryptophan 0
              5-hydroxy-L-tryptophan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        amino acid 14872
                                          alpha-amino acid 12865
                                            non-proteinogenic alpha-amino acid 1753
                                              hydroxy-amino acid 7
                                                hydroxytryptophan 6
                                                  5-hydroxytryptophan 6
                                                    5-hydroxy-D-tryptophan 0
                                                    5-hydroxy-L-tryptophan 0
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