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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pinocembrin
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Accession:CHEBI:28157 term browser browse the term
Definition:A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.
Synonyms:exact_synonym: (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2S)-pinocembrin;   (S)-2,3-Dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one;   (S)-5,7-dihydroxyflavanone;   (S)-pinocembrin;   5,7-Dihydroxyflavanone;   Dihydrochrysin;   Formula=C15H12O4;   Galangin flavanone;   InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1;   InChIKey=URFCJEUYXNAHFI-ZDUSSCGKSA-N;   SMILES=Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccccc1
 alt_id: CHEBI:26139;   CHEBI:69684;   CHEBI:75100;   CHEBI:8221
 xref: CAS:480-39-7;   HMDB:HMDB0030808;   KEGG:C09827;   KNApSAcK:C00000992;   LINCS:LSM-4126;   LIPID_MAPS_instance:LMPK12140214
 xref_mesh: MESH:C016063
 xref: MetaCyc:CPD-6991;   PMID:21973101;   PMID:22050318;   PMID:23179089;   PMID:23212747;   PMID:23594163;   PMID:23611777;   PMID:23669639;   PMID:23697399;   PMID:23725831;   PMID:23725838;   PMID:23847074;   Reaxys:88951;   Wikipedia:Pinocembrin


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pinocembrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pinocembrin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] CTD PMID:18295389 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] CTD PMID:18295389 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of pinocembrin CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO pinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; pinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA] CTD PMID:18295389 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      chemical role 19255
        antioxidant 14274
          pinocembrin 5
            (2S)-2-hydroxypinocembrin 0
            (2S)-8-methylpinocembrin 0
            glabranin 0
            pinocembrin 7-rhamnosylglucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic heterocyclic compound 18510
                                  oxacycle 17548
                                    benzopyran 10280
                                      1-benzopyran 10002
                                        flavonoid 6514
                                          flavans 3013
                                            flavanones 317
                                              hydroxyflavanone 304
                                                dihydroxyflavanone 184
                                                  pinocembrin 5
                                                    (2S)-2-hydroxypinocembrin 0
                                                    (2S)-8-methylpinocembrin 0
                                                    glabranin 0
                                                    pinocembrin 7-rhamnosylglucoside 0
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