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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pinocembrin
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Accession:CHEBI:28157 term browser browse the term
Definition:A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.
Synonyms:exact_synonym: (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
 related_synonym: (2S)-pinocembrin;   (S)-2,3-Dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one;   (S)-5,7-dihydroxyflavanone;   (S)-pinocembrin;   5,7-Dihydroxyflavanone;   Dihydrochrysin;   Formula=C15H12O4;   Galangin flavanone;   InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1;   InChIKey=URFCJEUYXNAHFI-ZDUSSCGKSA-N;   SMILES=Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccccc1
 alt_id: CHEBI:26139;   CHEBI:69684;   CHEBI:75100;   CHEBI:8221
 xref: CAS:480-39-7;   HMDB:HMDB0030808;   KEGG:C09827;   KNApSAcK:C00000992;   LINCS:LSM-4126;   LIPID_MAPS_instance:LMPK12140214
 xref_mesh: MESH:C016063
 xref: MetaCyc:CPD-6991;   PMID:21973101;   PMID:22050318;   PMID:23179089;   PMID:23212747;   PMID:23594163;   PMID:23611777;   PMID:23669639;   PMID:23697399;   PMID:23725831;   PMID:23725838;   PMID:23847074;   Reaxys:88951;   Wikipedia:Pinocembrin



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pinocembrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein] CTD PMID:33393179 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
CTD PMID:33393179 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pinocembrin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects activity ISO pinocembrin affects the activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased activity of GPT protein] CTD PMID:33393179 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]] CTD PMID:18295389 PMID:33393179 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]] CTD PMID:18295389 PMID:33393179 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]] CTD PMID:33393179 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of pinocembrin CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO pinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; pinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA] CTD PMID:18295389 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53BP1 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TRP53BP1 protein]
CTD PMID:33393179 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      chemical role 19539
        antioxidant 14502
          pinocembrin 12
            (2S)-2-hydroxypinocembrin 0
            (2S)-8-methylpinocembrin 0
            glabranin 0
            pinocembrin 7-rhamnosylglucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic heterocyclic compound 18804
                                  oxacycle 17704
                                    benzopyran 11204
                                      1-benzopyran 10945
                                        flavonoid 6568
                                          flavans 3063
                                            flavanones 326
                                              hydroxyflavanone 313
                                                dihydroxyflavanone 192
                                                  pinocembrin 12
                                                    (2S)-2-hydroxypinocembrin 0
                                                    (2S)-8-methylpinocembrin 0
                                                    glabranin 0
                                                    pinocembrin 7-rhamnosylglucoside 0
paths to the root