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ONTOLOGY REPORT - ANNOTATIONS


Term:arecoline
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Accession:CHEBI:2814 term browser browse the term
Definition:A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Synonyms:exact_synonym: methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
 related_synonym: Formula=C8H13NO2;   InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3;   InChIKey=HJJPJSXJAXAIPN-UHFFFAOYSA-N;   SMILES=COC(=O)C1=CCCN(C)C1;   arecaidine methyl ester;   arecaline;   arecholine;   arekolin;   methylarecaiden;   methylarecaidin
 xref: CAS:63-75-2 "ChemIDplus";   CAS:63-75-2 "KEGG COMPOUND";   DrugBank:DB04365;   HMDB:HMDB0030353;   KEGG:C10129;   KNApSAcK:C00002020;   LINCS:LSM-15214
 xref_mesh: MESH:D001115
 xref: PMID:21809341 "Europe PMC";   PMID:22493525 "Europe PMC";   PMID:23525646 "Europe PMC";   PMID:23895157 "Europe PMC";   Patent:CN101411705;   Patent:CN102464607;   Patent:US2506458;   Reaxys:123045 "Reaxys";   Wikipedia:Arecoline


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arecoline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahrr aryl-hydrocarbon receptor repressor JBrowse link 1 31,603,297 31,698,329 RGD:6480464
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 JBrowse link 13 85,580,828 85,597,497 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccnh cyclin H JBrowse link 2 13,593,100 13,613,910 RGD:6480464
G Cdc25c cell division cycle 25C JBrowse link 18 27,528,768 27,550,316 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Chaf1a chromatin assembly factor 1 subunit A JBrowse link 9 11,000,869 11,027,631 RGD:6480464
G Chaf1b chromatin assembly factor 1 subunit B JBrowse link 11 34,101,248 34,121,371 RGD:6480464
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:6480464
G Cryab crystallin, alpha B JBrowse link 8 55,178,543 55,182,546 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 JBrowse link 4 116,261,796 116,278,615 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Dclre1b DNA cross-link repair 1B JBrowse link 2 206,285,085 206,293,599 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 5 57,028,467 57,039,378 RGD:6480464
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 JBrowse link 17 26,785,017 26,795,723 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:6480464
G Fancg FA complementation group G JBrowse link 5 58,448,060 58,456,416 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 16 20,555,395 20,557,978 RGD:6480464
G Gss glutathione synthetase JBrowse link 3 151,076,254 151,106,557 RGD:6480464
G Gtf2h5 general transcription factor IIH subunit 5 JBrowse link 1 46,978,345 46,985,032 RGD:6480464
G Hspa14 heat shock protein family A (Hsp70) member 14 JBrowse link 17 78,735,630 78,756,412 RGD:6480464
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Lcmt1 leucine carboxyl methyltransferase 1 JBrowse link 1 193,335,629 193,391,620 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mir136 microRNA 136 JBrowse link 6 133,716,761 133,716,842 RGD:6480464
G Mir143 microRNA 143 JBrowse link 18 56,971,273 56,971,377 RGD:6480464
G Mir145 microRNA 145 JBrowse link 18 56,969,907 56,969,994 RGD:6480464
G Mir23a microRNA 23a JBrowse link 19 25,318,582 25,318,656 RGD:6480464
G Mir26a microRNA 26a JBrowse link 8 127,714,441 127,714,530 RGD:6480464
G Mir26b microRNA 26b JBrowse link 9 81,675,275 81,675,359 RGD:6480464
G Mir30a microRNA 30a JBrowse link 9 29,542,635 29,542,705 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Mt1 metallothionein 1 JBrowse link 19 11,301,991 11,303,007 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Myog myogenin JBrowse link 13 51,126,459 51,129,048 RGD:6480464
G Nat8 N-acetyltransferase 8 JBrowse link 4 117,525,963 117,527,443 RGD:6480464
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 JBrowse link 19 41,731,845 41,798,451 RGD:6480464
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6480464
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rad1 RAD1 checkpoint DNA exonuclease JBrowse link 2 60,461,513 60,469,646 RGD:6480464
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Smc1a structural maintenance of chromosomes 1A JBrowse link X 21,710,976 21,755,708 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 JBrowse link 9 42,692,156 42,805,680 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          metabolite 19106
            arecoline 73
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic ester 13934
                                        alpha,beta-unsaturated carboxylic ester 837
                                          enoate ester 837
                                            arecoline 73
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.