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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:arecoline
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Accession:CHEBI:2814 term browser browse the term
Definition:A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Synonyms:exact_synonym: methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
 related_synonym: Formula=C8H13NO2;   InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3;   InChIKey=HJJPJSXJAXAIPN-UHFFFAOYSA-N;   SMILES=COC(=O)C1=CCCN(C)C1;   arecaidine methyl ester;   arecaline;   arecholine;   arekolin;   methylarecaiden;   methylarecaidin
 xref: CAS:63-75-2;   DrugBank:DB04365;   HMDB:HMDB0030353;   KEGG:C10129;   KNApSAcK:C00002020;   LINCS:LSM-15214
 xref_mesh: MESH:D001115
 xref: PMID:21809341;   PMID:22493525;   PMID:23525646;   PMID:23895157;   Patent:CN101411705;   Patent:CN102464607;   Patent:US2506458;   Reaxys:123045;   Wikipedia:Arecoline


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arecoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO U 0126 inhibits the reaction [Arecoline results in increased expression of ACTA2 protein]
Arecoline results in increased expression of ACTA2 mRNA; Arecoline results in increased expression of ACTA2 protein
CTD PMID:32441858 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:17234337 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 decreases expression ISO Arecoline results in decreased expression of AKR1A1 mRNA CTD PMID:17682004 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester results in decreased phosphorylation of AKT1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein] CTD PMID:30910432 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression ISO Arecoline results in decreased expression of ALDH9A1 mRNA CTD PMID:17682004 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression ISO Arecoline results in decreased expression of APEX1 mRNA CTD PMID:17682004 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Ar androgen receptor increases expression EXP Arecoline results in increased expression of AR mRNA; Arecoline results in increased expression of AR protein CTD PMID:21741983 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Arecoline results in decreased expression of BCL2 protein CTD PMID:22108589 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Arecoline results in decreased expression of BRCA1 mRNA CTD PMID:17682004 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp3 caspase 3 increases activity ISO Arecoline results in increased activity of CASP3 protein CTD PMID:22108589 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression EXP Arecoline analog results in decreased expression of CAT CTD PMID:25056785 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion ISO Arecoline results in increased secretion of CCL5 protein CTD PMID:21297082 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
EXP
ISO
Arecoline results in increased expression of CCND1 mRNA; Arecoline results in increased expression of CCND1 protein
[arecoline hydrobromide results in increased abundance of Arecoline] inhibits the reaction [2-amino-6-chloro-alpha-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester results in decreased expression of CCND1 protein]; [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased expression of CCND1 protein
CTD PMID:21741983, PMID:30910432 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnh cyclin H decreases expression ISO Arecoline results in decreased expression of CCNH mRNA CTD PMID:17682004 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions
decreases expression
ISO [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
Arecoline results in decreased expression of CDC25C protein
CTD PMID:22108589 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
ISO U 0126 inhibits the reaction [Arecoline results in decreased expression of CDH1 protein] CTD PMID:32441858 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 increases expression ISO Arecoline results in increased expression of CDH2 protein CTD PMID:32441858 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases activity
multiple interactions
ISO Arecoline results in decreased activity of CDK1 protein
[[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
CTD PMID:22108589 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Arecoline results in increased expression of CDK4 mRNA; Arecoline results in increased expression of CDK4 protein CTD PMID:21741983 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO Arecoline results in decreased expression of CHAF1A mRNA CTD PMID:17682004 NCBI chr 9:11,000,869...11,027,631
Ensembl chr 9:11,001,129...11,027,506
JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO Arecoline results in decreased expression of CHAF1B mRNA CTD PMID:17682004 NCBI chr11:34,101,248...34,121,371
Ensembl chr11:34,101,197...34,121,378
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding
multiple interactions
ISO CHRM3 protein binds to Arecoline
brucine promotes the reaction [Arecoline binds to CHRM3 protein]
CTD PMID:9224827 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Col4a6 collagen type IV alpha 6 chain increases expression ISO Arecoline results in increased expression of COL4A6 protein CTD PMID:32441858 NCBI chr  X:112,405,647...112,768,337
Ensembl chr  X:112,405,647...112,473,822
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of CTNNB1 protein CTD PMID:26464283 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Arecoline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:17234337, PMID:17707585 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity EXP Arecoline analog results in increased activity of CYP1A2 protein CTD PMID:25056785 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 decreases expression ISO Arecoline results in decreased expression of CYP26B1 mRNA CTD PMID:17682004 NCBI chr 4:116,261,796...116,278,615
Ensembl chr 4:116,261,796...116,278,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity EXP Arecoline analog results in increased activity of CYP2E1 protein CTD PMID:25056785 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dclre1b DNA cross-link repair 1B decreases expression ISO Arecoline results in decreased expression of DCLRE1B mRNA CTD PMID:17682004 NCBI chr 2:206,285,085...206,293,599
Ensembl chr 2:206,285,089...206,293,599
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Arecoline results in increased expression of DDIT4 mRNA CTD PMID:17682004 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 increases expression ISO Arecoline results in increased expression of DNAJA1 mRNA CTD PMID:17682004 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO Arecoline results in decreased expression of EEF1E1 mRNA CTD PMID:17682004 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of EGFR protein modified form; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased phosphorylation of EGFR protein] CTD PMID:26464283 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:30910432 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO Arecoline results in decreased expression of ERCC2 mRNA CTD PMID:17682004 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Fancg FA complementation group G decreases expression ISO Arecoline results in decreased expression of FANCG mRNA CTD PMID:17682004 NCBI chr 5:58,448,060...58,456,416
Ensembl chr 5:58,448,822...58,455,819
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Arecoline results in increased expression of FN1 protein CTD PMID:26908192 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the expression of FOS protein; [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the localization of FOS protein CTD PMID:26464283 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Arecoline results in increased expression of FSHB protein CTD PMID:21741983 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Arecoline results in increased expression of GDF15 mRNA CTD PMID:17682004 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gss glutathione synthetase decreases expression ISO Arecoline results in decreased expression of GSS mRNA CTD PMID:17682004 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 decreases expression ISO Arecoline results in decreased expression of GTF2H5 mRNA CTD PMID:17682004 NCBI chr 1:46,978,345...46,985,032
Ensembl chr 1:46,978,458...46,985,032
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Il6 interleukin 6 decreases secretion
decreases expression
ISO Arecoline results in decreased secretion of IL6 protein
Arecoline results in decreased expression of IL6 mRNA
CTD PMID:22108589 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases expression ISO Arecoline results in decreased expression of LCMT1 mRNA CTD PMID:17682004 NCBI chr 1:193,335,629...193,391,620
Ensembl chr 1:193,335,645...193,391,638
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Arecoline results in increased expression of LHB protein CTD PMID:21741983 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Maoa monoamine oxidase A decreases expression ISO Arecoline results in decreased expression of MAOA mRNA CTD PMID:17682004 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK1 protein]
Arecoline results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK1 protein]
CTD PMID:26464283, PMID:32441858 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein; Dinoprostone affects the reaction [[helioxanthin co-treated with Arecoline co-treated with 4-nitroquinolone-1-oxide] affects the phosphorylation of MAPK3 protein]
U 0126 inhibits the reaction [Arecoline results in increased phosphorylation of MAPK3 protein]
CTD PMID:26464283, PMID:32441858 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mir136 microRNA 136 increases expression ISO Arecoline results in increased expression of MIR136 CTD PMID:21750350 NCBI chr 6:133,716,761...133,716,842
Ensembl chr 6:133,716,761...133,716,842
JBrowse link
G Mir143 microRNA 143 increases expression ISO Arecoline results in increased expression of MIR143 CTD PMID:21750350 NCBI chr18:56,971,273...56,971,377
Ensembl chr18:56,971,273...56,971,377
JBrowse link
G Mir145 microRNA 145 increases expression ISO Arecoline results in increased expression of MIR145 CTD PMID:21750350 NCBI chr18:56,969,907...56,969,994
Ensembl chr18:56,969,907...56,969,994
JBrowse link
G Mir23a microRNA 23a increases expression ISO Arecoline results in increased expression of MIR23A CTD PMID:21750350 NCBI chr19:25,318,582...25,318,656
Ensembl chr19:25,318,582...25,318,656
JBrowse link
G Mir26a microRNA 26a increases expression ISO Arecoline results in increased expression of MIR26A1 CTD PMID:21750350 NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
JBrowse link
G Mir26b microRNA 26b increases expression ISO Arecoline results in increased expression of MIR26B CTD PMID:21750350 NCBI chr 9:81,675,275...81,675,359
Ensembl chr 9:81,675,275...81,675,359
JBrowse link
G Mir30a microRNA 30a increases expression ISO Arecoline results in increased expression of MIR30A CTD PMID:21750350 NCBI chr 9:29,542,635...29,542,705
Ensembl chr 9:29,542,635...29,542,705
JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO Arecoline results in decreased expression of MLH1 mRNA CTD PMID:17682004 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases secretion ISO Arecoline results in decreased secretion of MMP2 protein CTD PMID:16311067 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Arecoline results in decreased expression of MSH2 mRNA CTD PMID:17682004 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions
ISO Arecoline results in increased expression of MT1A mRNA
Benzo(a)pyrene promotes the reaction [Arecoline results in increased expression of MT1A mRNA]
CTD PMID:17418620 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of MTOR protein CTD PMID:30910432 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myog myogenin decreases expression ISO Arecoline results in decreased expression of MYOG protein CTD PMID:23933062 NCBI chr13:51,126,459...51,129,048
Ensembl chr13:51,126,459...51,129,048
JBrowse link
G Nat8 N-acetyltransferase 8 decreases expression ISO Arecoline results in decreased expression of NAT8 mRNA CTD PMID:17682004 NCBI chr 4:117,525,963...117,527,443 JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 multiple interactions ISO [arecoline hydrobromide results in increased abundance of Arecoline] which results in increased expression of PHLPP2 mRNA; PHLPP2 protein affects the reaction [[arecoline hydrobromide results in increased abundance of Arecoline] which results in decreased phosphorylation of AKT1 protein] CTD PMID:30910432 NCBI chr19:41,731,845...41,798,451
Ensembl chr19:41,731,646...41,798,383
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression EXP Arecoline results in increased expression of PIK3R1 mRNA CTD PMID:20724125 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO Arecoline results in decreased expression of PRKDC mRNA CTD PMID:17682004 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Arecoline results in increased expression of PTGS2; Arecoline results in increased expression of PTGS2 mRNA
[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein; Dinoprostone inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]; helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [helioxanthin inhibits the reaction [[Arecoline co-treated with 4-nitroquinolone-1-oxide] results in increased expression of PTGS2 protein]]
CTD PMID:16311067, PMID:17682004, PMID:26464283 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease decreases expression ISO Arecoline results in decreased expression of RAD1 mRNA CTD PMID:17682004 NCBI chr 2:60,461,513...60,469,646
Ensembl chr 2:60,461,551...60,469,685
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO Arecoline results in increased expression of RAD50 mRNA CTD PMID:17682004 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Arecoline results in increased expression of SERPINE1 protein CTD PMID:26908192 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Arecoline results in increased expression of SLC2A4 mRNA CTD PMID:20724125 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression ISO Arecoline results in decreased expression of SMC1A mRNA CTD PMID:17682004 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Arecoline results in increased expression of TIMP1 mRNA; Arecoline results in increased expression of TIMP1 protein CTD PMID:16311067 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [[Arecoline results in decreased expression of CDC25C] co-treated with [Arecoline results in increased expression of TP53]] results in decreased activity of CDK1 protein
Arecoline results in increased expression of TP53 protein
CTD PMID:22108589 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Uggt1 UDP-glucose glycoprotein glucosyltransferase 1 decreases expression ISO Arecoline results in decreased expression of UGGT1 mRNA CTD PMID:17682004 NCBI chr 9:42,692,156...42,805,680
Ensembl chr 9:42,692,105...42,805,673
JBrowse link
G Vim vimentin increases expression
multiple interactions
ISO Arecoline results in increased expression of VIM protein
U 0126 inhibits the reaction [Arecoline results in increased expression of VIM protein]
CTD PMID:32441858 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            arecoline 77
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        alpha,beta-unsaturated carboxylic ester 871
                                          enoate ester 871
                                            arecoline 77
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.