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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,4'-methylene-bis-(2-chloroaniline)
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Accession:CHEBI:28124 term browser browse the term
Definition:A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.
Synonyms:exact_synonym: 4,4'-methanediylbis(2-chloroaniline)
 related_synonym: Formula=C13H12Cl2N2;   InChI=1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2;   InChIKey=IBOFVQJTBBUKMU-UHFFFAOYSA-N;   MOCA;   Methylenebis(chloroaniline);   SMILES=Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
 alt_id: CHEBI:1741;   CHEBI:20264
 xref: CAS:101-14-4;   KEGG:C10999
 xref_mesh: MESH:D008753
 xref: PMID:19447850;   PMID:21501672;   Reaxys:1882318;   Wikipedia:4\,4'-Methylenebis(2-chloroaniline)


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4,4'-methylene-bis-(2-chloroaniline) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylenebis(chloroaniline) results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Alb albumin affects binding EXP Methylenebis(chloroaniline) binds to ALB protein CTD PMID:2019352 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of Methylenebis(chloroaniline) CTD PMID:2908851 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation
multiple interactions
ISO CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)
alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
CTD PMID:1740010 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Methylenebis(chloroaniline) results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Methylenebis(chloroaniline) results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of Methylenebis(chloroaniline) CTD PMID:9288889 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects binding
ISO NAT2 protein results in increased acetylation of Methylenebis(chloroaniline); NAT2 protein results in increased acetylation of Methylenebis(chloroaniline) analog
Methylenebis(chloroaniline) binds to NAT2 protein
CTD PMID:29180287 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            4,4'-methylene-bis-(2-chloroaniline) 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13701
                                          anilines 12359
                                            substituted aniline 11852
                                              chloroaniline 233
                                                4,4'-methylene-bis-(2-chloroaniline) 15
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