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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,4'-methylene-bis-(2-chloroaniline)
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Accession:CHEBI:28124 term browser browse the term
Definition:A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.
Synonyms:exact_synonym: 4,4'-methanediylbis(2-chloroaniline)
 related_synonym: Formula=C13H12Cl2N2;   InChI=1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2;   InChIKey=IBOFVQJTBBUKMU-UHFFFAOYSA-N;   MOCA;   Methylenebis(chloroaniline);   SMILES=Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
 alt_id: CHEBI:1741;   CHEBI:20264
 xref: CAS:101-14-4;   KEGG:C10999
 xref_mesh: MESH:D008753
 xref: PMID:19447850;   PMID:21501672;   Reaxys:1882318;   Wikipedia:4\,4'-Methylenebis(2-chloroaniline)


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4,4'-methylene-bis-(2-chloroaniline) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylenebis(chloroaniline) results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Alb albumin affects binding EXP Methylenebis(chloroaniline) binds to ALB protein CTD PMID:2019352 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of Methylenebis(chloroaniline) CTD PMID:2908851 NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases oxidation
multiple interactions 		ISO CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)
alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] 		CTD PMID:1740010 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Methylenebis(chloroaniline) results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Methylenebis(chloroaniline) results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of Methylenebis(chloroaniline) CTD PMID:9288889 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects binding 		ISO NAT2 protein results in increased acetylation of Methylenebis(chloroaniline); NAT2 protein results in increased acetylation of Methylenebis(chloroaniline) analog
Methylenebis(chloroaniline) binds to NAT2 protein 		CTD PMID:29180287 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        biochemical role 20261
          metabolite 20243
            4,4'-methylene-bis-(2-chloroaniline) 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          hydrides 19691
                            inorganic hydride 18601
                              pnictogen hydride 18587
                                nitrogen hydride 18502
                                  azane 18261
                                    ammonia 18260
                                      organic amino compound 18260
                                        aromatic amine 15828
                                          anilines 14561
                                            substituted aniline 14194
                                              chloroaniline 234
                                                4,4'-methylene-bis-(2-chloroaniline) 15
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