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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4,4'-methylene-bis-(2-chloroaniline)
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Accession:CHEBI:28124 term browser browse the term
Definition:A chloroaniline that consists of two 2-chloroaniline units joined by a methylene bridge.
Synonyms:exact_synonym: 4,4'-methanediylbis(2-chloroaniline)
 related_synonym: Formula=C13H12Cl2N2;   InChI=1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2;   InChIKey=IBOFVQJTBBUKMU-UHFFFAOYSA-N;   MOCA;   Methylenebis(chloroaniline);   SMILES=Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
 alt_id: CHEBI:1741;   CHEBI:20264
 xref: CAS:101-14-4;   KEGG:C10999
 xref_mesh: MESH:D008753
 xref: PMID:19447850;   PMID:21501672;   Reaxys:1882318;   Wikipedia:4\,4'-Methylenebis(2-chloroaniline)


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4,4'-methylene-bis-(2-chloroaniline) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Methylenebis(chloroaniline) results in increased expression of AKR1B10 mRNA CTD PMID:26198647 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Alb albumin affects binding EXP Methylenebis(chloroaniline) binds to ALB protein CTD PMID:2019352 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of Methylenebis(chloroaniline) CTD PMID:2908851 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLC mRNA CTD PMID:26198647 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Methylenebis(chloroaniline) results in increased expression of GCLM mRNA CTD PMID:26198647 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Methylenebis(chloroaniline) results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Methylenebis(chloroaniline) results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of Methylenebis(chloroaniline) CTD PMID:9288889 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects binding
ISO NAT2 protein results in increased acetylation of Methylenebis(chloroaniline); NAT2 protein results in increased acetylation of Methylenebis(chloroaniline) analog
Methylenebis(chloroaniline) binds to NAT2 protein
CTD PMID:29180287 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of Methylenebis(chloroaniline) CTD PMID:11159734 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SQSTM1 mRNA CTD PMID:26198647 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Methylenebis(chloroaniline) results in increased expression of SRXN1 mRNA CTD PMID:26198647 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            4,4'-methylene-bis-(2-chloroaniline) 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        aromatic amine 13616
                                          anilines 12327
                                            substituted aniline 11823
                                              chloroaniline 221
                                                4,4'-methylene-bis-(2-chloroaniline) 14
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