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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:methylcobalamin
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Accession:CHEBI:28115 term browser browse the term
Definition:A cobalamin that has formula C63H91CoN13O14P.
Synonyms:exact_synonym: Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide
 related_synonym: CO-METHYLCOBALAMIN;   Formula=C63H91CoN13O14P;   InChI=1S/C62H90N13O14P.CH3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H3;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;/m1../s1;   InChIKey=JEWJRMKHSMTXPP-WZHZPDAFSA-L;   MeCbl;   SMILES=[H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]4[C@@H](O)[C@H](O[C@@H]4CO)n4c[n+](c5cc(C)c(C)cc45)[Co-3]456(C)N1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O;   mecobalamin;   methylcob(III)alamin
 alt_id: CHEBI:25291;   CHEBI:48831;   CHEBI:6869
 xref: CAS:13422-55-4;   COMe:MOL000085;   DrugBank:DB03614;   Gmelin:124528;   KEGG:C06453;   KEGG:D03246
 xref_mesh: MESH:C019476
 xref: PDBeChem:COB


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methylcobalamin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein] CTD PMID:21237187 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein] CTD PMID:21237187 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions
increases activity
ISO Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        biochemical role 19328
          cofactor 15557
            methylcobalamin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organonitrogen heterocyclic compound 17559
                                    polypyrrole 612
                                      tetrapyrrole 500
                                        cyclic tetrapyrrole 370
                                          metallotetrapyrrole 338
                                            cobalt corrinoid 39
                                              cobalt-corrinoid hexaamide 39
                                                cobamides 39
                                                  cobalamins 39
                                                    cob(III)alamins 38
                                                      alkylcob(III)alamin 38
                                                        methylcobalamin 3
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