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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorobenzene
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Accession:CHEBI:28097 term browser browse the term
Definition:The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Synonyms:related_synonym: Benzene chloride;   Formula=C6H5Cl;   InChI=1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H;   InChIKey=MVPPADPHJFYWMZ-UHFFFAOYSA-N;   Monochlorbenzol;   Monochlorobenzene;   PhCl;   Phenyl chloride;   SMILES=Clc1ccccc1
 alt_id: CHEBI:23131;   CHEBI:3623
 xref: Beilstein:605632;   CAS:108-90-7;   Gmelin:26704;   HMDB:HMDB0041855;   KEGG:C06990
 xref_mesh: MESH:C031294
 xref: MetaCyc:CHLOROBENZENE;   PDBeChem:8CL;   PMID:23360185;   PMID:23957149;   PMID:24341791;   Reaxys:605632;   UM-BBD_compID:c0105;   Wikipedia:Chlorobenzene


show annotations for term's descendants           Sort by:
chlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 increases activity EXP chlorobenzene results in increased activity of ALAS1 protein CTD PMID:6895089 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; bucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]; CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]; SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein] CTD PMID:17993253 PMID:18514500 PMID:18645721 PMID:19800902 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO chlorobenzene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:36416909 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [Phenobarbital results in increased expression of CYP2B1 protein] which results in increased metabolism of chlorobenzene CTD PMID:9010585 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases oxidation		 ISO
EXP		 dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]
CYP2E1 protein results in increased oxidation of chlorobenzene
[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]		 CTD PMID:9010585 PMID:9817075 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO chlorobenzene results in increased expression of DUSP1 mRNA; chlorobenzene results in increased expression of DUSP1 protein CTD PMID:19800902 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO chlorobenzene results in decreased expression of EPHX2 mRNA CTD PMID:19800902 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO chlorobenzene results in increased expression of GPX3 mRNA CTD PMID:19800902 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression		 ISO bucillamine inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]
chlorobenzene results in increased expression of GSTP1 mRNA; chlorobenzene results in increased expression of GSTP1 protein		 CTD PMID:19800902 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
multiple interactions		 EXP
ISO		 chlorobenzene results in increased activity of HMOX1 protein
chlorobenzene results in increased expression of HMOX1 mRNA; chlorobenzene results in increased expression of HMOX1 protein
bucillamine inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]		 CTD PMID:6895089 PMID:19800902 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO chlorobenzene results in increased expression of HSPA5 protein CTD PMID:12183065 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO chlorobenzene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 increases expression
multiple interactions		 ISO chlorobenzene results in increased expression of IL13 protein
CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]		 CTD PMID:18514500 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO chlorobenzene results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO chlorobenzene results in increased phosphorylation of NFKBIA protein CTD PMID:18645721 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO chlorobenzene results in increased expression of PTGS2 mRNA; chlorobenzene results in increased expression of PTGS2 protein CTD PMID:19800902 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 ISO bucillamine inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein] CTD PMID:19800902 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO chlorobenzene results in increased expression of SOD2 mRNA CTD PMID:19800902 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO chlorobenzene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] CTD PMID:36416909 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO chlorobenzene results in increased expression of TXNRD1 mRNA CTD PMID:19800902 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      application 19717
        solvent 16903
          chlorobenzene 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic molecule 19751
                              organic cyclic compound 19559
                                carbocyclic compound 18603
                                  benzenoid aromatic compound 17956
                                    benzenes 17806
                                      chlorobenzenes 14845
                                        monochlorobenzenes 11639
                                          chlorobenzene 20
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