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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorobenzene
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Accession:CHEBI:28097 term browser browse the term
Definition:The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Synonyms:related_synonym: Benzene chloride;   Formula=C6H5Cl;   InChI=1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H;   InChIKey=MVPPADPHJFYWMZ-UHFFFAOYSA-N;   Monochlorbenzol;   Monochlorobenzene;   PhCl;   Phenyl chloride;   SMILES=Clc1ccccc1
 alt_id: CHEBI:23131;   CHEBI:3623
 xref: Beilstein:605632;   CAS:108-90-7;   Gmelin:26704;   HMDB:HMDB0041855;   KEGG:C06990
 xref_mesh: MESH:C031294
 xref: MetaCyc:CHLOROBENZENE;   PDBeChem:8CL;   PMID:23360185;   PMID:23957149;   PMID:24341791;   Reaxys:605632;   UM-BBD_compID:c0105;   Wikipedia:Chlorobenzene


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chlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 increases activity EXP chlorobenzene results in increased activity of ALAS1 protein CTD PMID:6895089 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; bucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]; CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]; SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein] CTD PMID:17993253, PMID:18514500, PMID:18645721, PMID:19800902 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [Phenobarbital results in increased expression of CYP2B1 protein] which results in increased metabolism of chlorobenzene CTD PMID:9010585 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases oxidation
ISO
EXP
dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]
CYP2E1 protein results in increased oxidation of chlorobenzene
[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]
CTD PMID:9010585, PMID:9817075 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO chlorobenzene results in increased expression of DUSP1 mRNA; chlorobenzene results in increased expression of DUSP1 protein CTD PMID:19800902 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO chlorobenzene results in decreased expression of EPHX2 mRNA CTD PMID:19800902 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO chlorobenzene results in increased expression of GPX3 mRNA CTD PMID:19800902 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
ISO bucillamine inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]
chlorobenzene results in increased expression of GSTP1 mRNA; chlorobenzene results in increased expression of GSTP1 protein
CTD PMID:19800902 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
EXP
ISO
chlorobenzene results in increased activity of HMOX1 protein
bucillamine inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]
chlorobenzene results in increased expression of HMOX1 mRNA; chlorobenzene results in increased expression of HMOX1 protein
CTD PMID:6895089, PMID:19800902 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO chlorobenzene results in increased expression of HSPA5 protein CTD PMID:12183065 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il13 interleukin 13 increases expression
multiple interactions
ISO chlorobenzene results in increased expression of IL13 protein
CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]
CTD PMID:18514500 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO chlorobenzene results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO chlorobenzene results in increased phosphorylation of NFKBIA protein CTD PMID:18645721 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO chlorobenzene results in increased expression of PTGS2 mRNA; chlorobenzene results in increased expression of PTGS2 protein CTD PMID:19800902 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO bucillamine inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein] CTD PMID:19800902 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO chlorobenzene results in increased expression of SOD2 mRNA CTD PMID:19800902 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO chlorobenzene results in increased expression of TXNRD1 mRNA CTD PMID:19800902 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        solvent 16459
          chlorobenzene 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                carbocyclic compound 18183
                                  benzenoid aromatic compound 17180
                                    benzenes 16922
                                      chlorobenzenes 12992
                                        monochlorobenzenes 8873
                                          chlorobenzene 17
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