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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorobenzene
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Accession:CHEBI:28097 term browser browse the term
Definition:The simplest member of the class of monochlorobenzenes, that is benzene in which a single hydrogen has been substituted by a chlorine.
Synonyms:related_synonym: Benzene chloride;   Formula=C6H5Cl;   InChI=1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H;   InChIKey=MVPPADPHJFYWMZ-UHFFFAOYSA-N;   Monochlorbenzol;   Monochlorobenzene;   PhCl;   Phenyl chloride;   SMILES=Clc1ccccc1
 alt_id: CHEBI:23131;   CHEBI:3623
 xref: Beilstein:605632;   CAS:108-90-7;   Gmelin:26704;   HMDB:HMDB0041855;   KEGG:C06990
 xref_mesh: MESH:C031294
 xref: MetaCyc:CHLOROBENZENE;   PDBeChem:8CL;   PMID:23360185;   PMID:23957149;   PMID:24341791;   Reaxys:605632;   UM-BBD_compID:c0105;   Wikipedia:Chlorobenzene



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chlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas1 5'-aminolevulinate synthase 1 increases activity EXP chlorobenzene results in increased activity of ALAS1 protein CTD PMID:6895089 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; bucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]; CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]; SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein] CTD PMID:17993253 PMID:18514500 PMID:18645721 PMID:19800902 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP [Phenobarbital results in increased expression of CYP2B1 protein] which results in increased metabolism of chlorobenzene CTD PMID:9010585 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases oxidation
ISO
EXP
dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene]
CYP2E1 protein results in increased oxidation of chlorobenzene
[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]
CTD PMID:9010585 PMID:9817075 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO chlorobenzene results in increased expression of DUSP1 mRNA; chlorobenzene results in increased expression of DUSP1 protein CTD PMID:19800902 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO chlorobenzene results in decreased expression of EPHX2 mRNA CTD PMID:19800902 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO chlorobenzene results in increased expression of GPX3 mRNA CTD PMID:19800902 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
ISO bucillamine inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]
chlorobenzene results in increased expression of GSTP1 mRNA; chlorobenzene results in increased expression of GSTP1 protein
CTD PMID:19800902 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
EXP
ISO
chlorobenzene results in increased activity of HMOX1 protein
bucillamine inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]
chlorobenzene results in increased expression of HMOX1 mRNA; chlorobenzene results in increased expression of HMOX1 protein
CTD PMID:6895089 PMID:19800902 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO chlorobenzene results in increased expression of HSPA5 protein CTD PMID:12183065 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Il13 interleukin 13 increases expression
multiple interactions
ISO chlorobenzene results in increased expression of IL13 protein
CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]
CTD PMID:18514500 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO chlorobenzene results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation ISO chlorobenzene results in increased phosphorylation of NFKBIA protein CTD PMID:18645721 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO chlorobenzene results in increased expression of PTGS2 mRNA; chlorobenzene results in increased expression of PTGS2 protein CTD PMID:19800902 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO bucillamine inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein] CTD PMID:19800902 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO chlorobenzene results in increased expression of SOD2 mRNA CTD PMID:19800902 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO chlorobenzene results in increased expression of TXNRD1 mRNA CTD PMID:19800902 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19823
    role 19773
      application 19486
        solvent 16640
          chlorobenzene 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                carbocyclic compound 18336
                                  benzenoid aromatic compound 17495
                                    benzenes 17282
                                      chlorobenzenes 13757
                                        monochlorobenzenes 9799
                                          chlorobenzene 17
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