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G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases activity |
EXP |
chlorobenzene results in increased activity of ALAS1 protein |
CTD |
PMID:6895089 |
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NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases secretion increases expression |
ISO |
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; bucillamine inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein]; CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein]; SB 203580 inhibits the reaction [chlorobenzene results in increased expression of CCL2 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased secretion of CCL2 protein] |
CTD |
PMID:17993253 PMID:18514500 PMID:18645721 PMID:19800902 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
chlorobenzene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] |
CTD |
PMID:36416909 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
[Phenobarbital results in increased expression of CYP2B1 protein] which results in increased metabolism of chlorobenzene |
CTD |
PMID:9010585 |
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NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases oxidation |
ISO EXP |
dihydroxyethyldithiocarbamate inhibits the reaction [CYP2E1 protein results in increased metabolism of chlorobenzene] CYP2E1 protein results in increased oxidation of chlorobenzene [Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene] |
CTD |
PMID:9010585 PMID:9817075 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
chlorobenzene results in increased expression of DUSP1 mRNA; chlorobenzene results in increased expression of DUSP1 protein |
CTD |
PMID:19800902 |
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NCBI chr10:16,680,478...16,683,275
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G |
Ephx2 |
epoxide hydrolase 2 |
decreases expression |
ISO |
chlorobenzene results in decreased expression of EPHX2 mRNA |
CTD |
PMID:19800902 |
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NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Gpx3 |
glutathione peroxidase 3 |
increases expression |
ISO |
chlorobenzene results in increased expression of GPX3 mRNA |
CTD |
PMID:19800902 |
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NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
ISO |
bucillamine inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of GSTP1 protein] chlorobenzene results in increased expression of GSTP1 mRNA; chlorobenzene results in increased expression of GSTP1 protein |
CTD |
PMID:19800902 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hmox1 |
heme oxygenase 1 |
increases activity increases expression multiple interactions |
EXP ISO |
chlorobenzene results in increased activity of HMOX1 protein chlorobenzene results in increased expression of HMOX1 mRNA; chlorobenzene results in increased expression of HMOX1 protein bucillamine inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of HMOX1 protein] |
CTD |
PMID:6895089 PMID:19800902 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
chlorobenzene results in increased expression of HSPA5 protein |
CTD |
PMID:12183065 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
chlorobenzene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] |
CTD |
PMID:36416909 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
increases expression multiple interactions |
ISO |
chlorobenzene results in increased expression of IL13 protein CCL2 protein promotes the reaction [chlorobenzene results in increased expression of IL13 protein] |
CTD |
PMID:18514500 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
chlorobenzene results in increased expression of IL1A protein |
CTD |
PMID:23178550 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation |
ISO |
chlorobenzene results in increased phosphorylation of NFKBIA protein |
CTD |
PMID:18645721 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
chlorobenzene results in increased expression of PTGS2 mRNA; chlorobenzene results in increased expression of PTGS2 protein |
CTD |
PMID:19800902 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions increases expression |
ISO |
bucillamine inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein]; Tiopronin inhibits the reaction [chlorobenzene results in increased expression of SOD1 protein] |
CTD |
PMID:19800902 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Sod2 |
superoxide dismutase 2 |
increases expression |
ISO |
chlorobenzene results in increased expression of SOD2 mRNA |
CTD |
PMID:19800902 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
chlorobenzene inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] |
CTD |
PMID:36416909 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
chlorobenzene results in increased expression of TXNRD1 mRNA |
CTD |
PMID:19800902 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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