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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2,2-trichloroethanol
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Accession:CHEBI:28094 term browser browse the term
Definition:A chloroethanol that has formula C2H3Cl3O.
Synonyms:related_synonym: 2,2,2-trichloro-1-ethanol;   Formula=C2H3Cl3O;   InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2;   InChIKey=KPWDGTGXUYRARH-UHFFFAOYSA-N;   SMILES=OCC(Cl)(Cl)Cl;   Trichloroethanol
 alt_id: CHEBI:27098;   CHEBI:9685
 xref: Beilstein:1697495;   CAS:115-20-8;   Gmelin:2407;   KEGG:C07490
 xref_mesh: MESH:C005849
 xref: UM-BBD_compID:c0015


show annotations for term's descendants           Sort by:
2,2,2-trichloroethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding ISO 2,2,2-trichloroethanol binds to ESR2 protein CTD PMID:12224631 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 2,2,2-trichloroethanol results in increased expression of IL1A protein CTD PMID:23041168 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of IL1B protein] CTD PMID:36423715 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions 		ISO 2,2,2-trichloroethanol results in increased expression of IL6 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [2,2,2-trichloroethanol results in increased expression of IL6 protein] 		CTD PMID:23041168 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
increases activity 		ISO 2,2,2-trichloroethanol results in increased expression of MMP9 mRNA; 2,2,2-trichloroethanol results in increased expression of MMP9 protein
2,2,2-trichloroethanol results in increased activity of MMP9 protein 		CTD PMID:21741468 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of MYD88 protein CTD PMID:36423715 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in decreased expression of NFKBIA protein CTD PMID:36423715 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB8 protein] CTD PMID:36423715 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of PSMB9 protein] CTD PMID:36423715 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of and affects the localization of RELA protein] CTD PMID:36423715 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TAP1 protein] CTD PMID:36423715 NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO 2,2,2-trichloroethanol results in increased expression of TIMP1 mRNA; 2,2,2-trichloroethanol results in increased expression of TIMP1 protein CTD PMID:21741468 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR2 protein CTD PMID:36423715 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased expression of TLR4 protein CTD PMID:36423715 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein; pyrrolidine dithiocarbamic acid inhibits the reaction [[HLA-B protein alternative form co-treated with 2,2,2-trichloroethanol] results in increased secretion of TNF protein] CTD PMID:36423715 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    chemical entity 20843
      molecular entity 20842
        polyatomic entity 20786
          heteroatomic molecular entity 20723
            halide 19156
              organohalogen compound 18973
                organochlorine compound 18723
                  chloroethanol 44
                    2,2,2-trichloroethanol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      chalcogen 20477
                        oxygen atom 20443
                          oxygen molecular entity 20443
                            hydroxides 20216
                              organic hydroxy compound 19754
                                alcohol 15938
                                  primary alcohol 14896
                                    ethanols 8997
                                      chloroethanol 44
                                        2,2,2-trichloroethanol 15
paths to the root