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G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions |
EXP |
crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] |
CTD |
PMID:30580027 |
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NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007
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G |
Akt2 |
thymoma viral proto-oncogene 2 |
multiple interactions |
EXP |
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA] |
CTD |
PMID:30580027 |
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NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
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G |
Bambi |
BMP and activin membrane-bound inhibitor |
multiple interactions |
ISO |
crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA] |
CTD |
PMID:32259551 |
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NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404
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G |
Bax |
BCL2-associated X protein |
multiple interactions increases expression |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein] crocin results in increased expression of BAX mRNA |
CTD |
PMID:23523949 PMID:27353299 PMID:32886819 PMID:32920515 PMID:35274200 |
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions decreases expression |
EXP ISO |
[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA crocin results in decreased expression of BCL2 mRNA crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein] |
CTD |
PMID:31911963 PMID:32886819 PMID:32920515 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bdnf |
brain derived neurotrophic factor |
increases expression |
ISO |
crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein |
CTD |
PMID:24401376 |
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NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
crocin results in decreased expression of BIRC5 mRNA |
CTD |
PMID:32886819 |
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NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage increases expression increases activity |
ISO EXP |
crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein] Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein] crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA] crocin results in increased expression of CASP3 mRNA |
CTD |
PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 PMID:30672053 PMID:31911963 PMID:32886819 PMID:32920515 PMID:35085590 PMID:35274200 More...
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
crocin results in increased activity of CASP8 protein |
CTD |
PMID:32886819 |
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NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein] crocin results in increased activity of CASP9 protein |
CTD |
PMID:27353299 PMID:32886819 PMID:35274200 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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G |
Cat |
catalase |
multiple interactions increases activity decreases activity |
ISO EXP |
crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein] crocin results in increased activity of CAT protein crocin inhibits the reaction [Patulin results in increased activity of CAT protein] crocin results in decreased activity of CAT protein |
CTD |
PMID:25899501 PMID:26584762 PMID:29409856 PMID:32886819 PMID:32920515 |
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
crocin results in decreased expression of CCND1 mRNA |
CTD |
PMID:32886819 |
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NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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G |
Ckm |
creatine kinase, muscle |
multiple interactions |
ISO |
crocin inhibits the reaction [Diazinon results in increased activity of CKM protein] |
CTD |
PMID:23523949 |
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NCBI chr 7:19,145,019...19,155,508
Ensembl chr 7:19,138,701...19,156,766
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G |
Col2a1 |
collagen, type II, alpha 1 |
multiple interactions |
ISO |
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein] |
CTD |
PMID:24709313 |
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NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
crocin results in increased expression of and results in increased phosphorylation of CREB1 protein |
CTD |
PMID:24401376 |
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NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
crocin inhibits the reaction [Diazinon affects the localization of CYCS protein] |
CTD |
PMID:23523949 |
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NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions decreases activity |
ISO |
crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein] crocin results in decreased activity of CYP2E1 protein |
CTD |
PMID:25899501 |
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NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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G |
Foxp2 |
forkhead box P2 |
increases expression |
ISO |
crocin results in increased expression of FOXP2 protein |
CTD |
PMID:36988377 |
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NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976
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G |
Glo1 |
glyoxalase 1 |
multiple interactions |
EXP |
crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein] |
CTD |
PMID:30580027 |
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NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845
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G |
Gpt |
glutamic pyruvic transaminase, soluble |
multiple interactions |
ISO |
crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein] |
CTD |
PMID:32259551 |
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NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein] |
CTD |
PMID:32920515 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Hspa1l |
heat shock protein 1-like |
multiple interactions |
ISO |
crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] |
CTD |
PMID:25637687 |
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NCBI chr17:35,191,679...35,198,204
Ensembl chr17:35,191,679...35,198,261
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein] |
CTD |
PMID:26807765 |
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NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] |
CTD |
PMID:24709313 PMID:26807765 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions decreases expression |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] crocin results in decreased expression of IL6 mRNA |
CTD |
PMID:25637687 PMID:25899501 PMID:29409856 PMID:32886819 PMID:32920515 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Ins1 |
insulin I |
multiple interactions |
ISO |
crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] |
CTD |
PMID:29409856 |
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NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
ISO |
crocin affects the expression of and affects the phosphorylation of JAK2 protein |
CTD |
PMID:32886819 |
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NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
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G |
Keap1 |
kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein] |
CTD |
PMID:32920515 |
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NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
ISO |
crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA] |
CTD |
PMID:24132704 |
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NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein] crocin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:24132704 PMID:28689058 PMID:32886819 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO EXP |
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein] crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA] crocin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819 |
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Mir122 |
microRNA 122 |
multiple interactions decreases expression |
ISO |
crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA] crocin results in decreased expression of MIR122 |
CTD |
PMID:28689058 PMID:36988377 |
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NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997
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G |
Mir29b-1 |
microRNA 29b-1 |
multiple interactions increases expression |
ISO |
Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA] |
CTD |
PMID:32259551 |
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NCBI chr 6:31,039,958...31,040,028
Ensembl chr 6:31,039,958...31,040,028
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G |
Mir34a |
microRNA 34a |
multiple interactions |
ISO |
MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein] |
CTD |
PMID:35085590 |
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NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
crocin inhibits the reaction [Ethanol results in increased activity of MPO protein] |
CTD |
PMID:25637687 |
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NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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G |
Myc |
myelocytomatosis oncogene |
decreases expression |
ISO |
crocin results in decreased expression of MYC mRNA |
CTD |
PMID:32886819 |
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NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
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G |
Mycn |
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived |
multiple interactions decreases response to substance decreases expression |
ISO |
crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein] MYCN results in decreased susceptibility to crocin crocin results in decreased expression of MYCN protein |
CTD |
PMID:30672053 |
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NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915
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G |
Myd88 |
myeloid differentiation primary response gene 88 |
multiple interactions |
ISO |
crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein] |
CTD |
PMID:32259551 |
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NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
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G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein] |
CTD |
PMID:32259551 PMID:32920515 |
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NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
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G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein] |
CTD |
PMID:32920515 |
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NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
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G |
Ostm1 |
osteopetrosis associated transmembrane protein 1 |
multiple interactions |
EXP |
[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA] |
CTD |
PMID:30580027 |
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NCBI chr10:42,554,912...42,578,458
Ensembl chr10:42,459,818...42,578,455
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G |
Parp1 |
poly (ADP-ribose) polymerase family, member 1 |
multiple interactions increases cleavage |
ISO |
MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein] |
CTD |
PMID:30672053 |
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NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
ISO |
crocin results in decreased expression of PTGS2 mRNA |
CTD |
PMID:32886819 |
|
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Ptpn4 |
protein tyrosine phosphatase, non-receptor type 4 |
multiple interactions increases expression |
ISO |
MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein] |
CTD |
PMID:35085590 |
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NCBI chr 1:119,580,197...119,765,281
Ensembl chr 1:119,580,197...119,765,343
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein] |
CTD |
PMID:29409856 PMID:32920515 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Smad2 |
SMAD family member 2 |
multiple interactions decreases expression |
ISO |
Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein] |
CTD |
PMID:32259551 |
|
NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034
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G |
Snca |
synuclein, alpha |
multiple interactions |
ISO |
crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein] |
CTD |
PMID:35274200 |
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NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839
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G |
Spry2 |
sprouty RTK signaling antagonist 2 |
increases expression |
ISO |
crocin results in increased expression of SPRY2 protein |
CTD |
PMID:36988377 |
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NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
crocin affects the expression of and affects the phosphorylation of STAT3 protein |
CTD |
PMID:32886819 |
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NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein] |
CTD |
PMID:29409856 PMID:32259551 |
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NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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G |
Tgfbr1 |
transforming growth factor, beta receptor I |
multiple interactions |
ISO |
crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein] |
CTD |
PMID:32259551 |
|
NCBI chr 4:47,353,258...47,414,926
Ensembl chr 4:47,353,222...47,414,931
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein] |
CTD |
PMID:29409856 PMID:32259551 |
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NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO |
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein] crocin results in decreased expression of TNF mRNA |
CTD |
PMID:25637687 PMID:25899501 PMID:26807765 PMID:32886819 PMID:32920515 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Tnfsf11 |
tumor necrosis factor (ligand) superfamily, member 11 |
multiple interactions |
EXP |
[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]] |
CTD |
PMID:30580027 |
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NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
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G |
Tnnt2 |
troponin T2, cardiac |
multiple interactions |
ISO |
crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein] |
CTD |
PMID:26807765 |
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NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998
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G |
Traf6 |
TNF receptor-associated factor 6 |
multiple interactions |
EXP |
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA] |
CTD |
PMID:30580027 |
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NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014
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G |
Trp53 |
transformation related protein 53 |
multiple interactions |
EXP |
crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA] |
CTD |
PMID:31911963 |
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NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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G |
Vgf |
VGF nerve growth factor inducible |
increases expression |
ISO |
crocin results in increased expression of VGF protein |
CTD |
PMID:24401376 |
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NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205
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