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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:o-cresol
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Accession:CHEBI:28054 term browser browse the term
Definition:A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.
Synonyms:related_synonym: 2-cresol;   2-hydroxy-1-methylbenzene;   2-hydroxytoluene;   2-methylphenol;   Formula=C7H8O;   InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3;   InChIKey=QWVGKYWNOKOFNN-UHFFFAOYSA-N;   SMILES=Cc1ccccc1O;   o-Kresol;   o-Methylphenol;   o-cresylic acid;   ortho-cresol;   orthocresol
 alt_id: CHEBI:10609;   CHEBI:25617
 xref: Beilstein:506917;   CAS:95-48-7;   Gmelin:101619;   HMDB:HMDB0002055;   KEGG:C01542;   KNApSAcK:C00030878
 xref_mesh: MESH:C034047
 xref: PDBeChem:JZ0;   PMID:15687000;   Reaxys:506917;   UM-BBD_compID:c0281;   Wikipedia:O-Cresol


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o-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases expression
ISO Sodium Selenite inhibits the reaction [2-cresol results in increased expression of AKT1 mRNA] CTD PMID:21705299 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin affects binding EXP 2-cresol binds to ALB protein CTD PMID:11334365 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 2-cresol results in increased expression of BAX mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BAX mRNA]
CTD PMID:21705299 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCHE butyrylcholinesterase multiple interactions EXP [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol CTD PMID:22898212 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression
multiple interactions
ISO 2-cresol results in increased expression of BCL2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA]
CTD PMID:21705299 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions ISO 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981
JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 multiple interactions ISO 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044
JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 multiple interactions ISO 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
ISO 2-cresol results in increased expression of PPARG mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA]
CTD PMID:21705299 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PRKCA protein kinase C alpha increases expression
multiple interactions
ISO 2-cresol results in increased expression of PRKCA mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]
CTD PMID:21705299 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO 2-cresol results in increased expression of PTGS2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PTGS2 mRNA]
CTD PMID:21705299 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
4-chloro-2-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor affects binding ISO 4-chloro-2-cresol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions EXP croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24382
    role 24293
      application 23791
        pesticide 18530
          fungicide 11185
            aromatic fungicide 1556
              cresol 124
                o-cresol 13
                  1-(2-methylphenyl)glycerol 0
                  2-[(ethylsulfanyl)methyl]phenol + 1
                  2-methylanisole 0
                  4,6-dinitro-o-cresol 0
                  4-chloro-2-methylphenol 1
                  o-cresol hydrogen sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24382
    subatomic particle 24339
      composite particle 24339
        hadron 24339
          baryon 24339
            nucleon 24339
              atomic nucleus 24339
                atom 24339
                  main group element atom 24188
                    p-block element atom 24188
                      carbon group element atom 23967
                        carbon atom 23924
                          organic molecular entity 23924
                            organic molecule 23803
                              organic cyclic compound 23079
                                carbocyclic compound 21604
                                  benzenoid aromatic compound 19211
                                    benzenes 18749
                                      toluenes 6323
                                        hydroxytoluene 128
                                          cresol 124
                                            o-cresol 13
                                              1-(2-methylphenyl)glycerol 0
                                              2-[(ethylsulfanyl)methyl]phenol + 1
                                              2-methylanisole 0
                                              4,6-dinitro-o-cresol 0
                                              4-chloro-2-methylphenol 1
                                              o-cresol hydrogen sulfate 0
paths to the root