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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:o-cresol
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Accession:CHEBI:28054 term browser browse the term
Definition:A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.
Synonyms:related_synonym: 2-cresol;   2-hydroxy-1-methylbenzene;   2-hydroxytoluene;   2-methylphenol;   Formula=C7H8O;   InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3;   InChIKey=QWVGKYWNOKOFNN-UHFFFAOYSA-N;   SMILES=Cc1ccccc1O;   o-Kresol;   o-Methylphenol;   o-cresylic acid;   ortho-cresol;   orthocresol
 alt_id: CHEBI:10609;   CHEBI:25617
 xref: Beilstein:506917;   CAS:95-48-7;   Gmelin:101619;   HMDB:HMDB0002055;   KEGG:C01542;   KNApSAcK:C00030878
 xref_mesh: MESH:C034047
 xref: PDBeChem:JZ0;   PMID:15687000;   Reaxys:506917;   UM-BBD_compID:c0281;   Wikipedia:O-Cresol



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o-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
EXP Sodium Selenite inhibits the reaction [2-cresol results in increased expression of AKT1 mRNA] CTD PMID:21705299 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin affects binding ISO 2-cresol binds to ALB protein CTD PMID:11334365 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP 2-cresol results in increased expression of BAX mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BAX mRNA]
CTD PMID:21705299 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol CTD PMID:22898212 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP 2-cresol results in increased expression of BCL2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA]
CTD PMID:21705299 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP 2-cresol results in increased expression of PPARG mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA]
CTD PMID:21705299 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkca protein kinase C, alpha increases expression
multiple interactions
EXP 2-cresol results in increased expression of PRKCA mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]
CTD PMID:21705299 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP 2-cresol results in increased expression of PTGS2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PTGS2 mRNA]
CTD PMID:21705299 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
4-chloro-2-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP 4-chloro-2-cresol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pesticide 17134
          fungicide 11195
            aromatic fungicide 1550
              cresol 123
                o-cresol 13
                  1-(2-methylphenyl)glycerol 0
                  2-[(ethylsulfanyl)methyl]phenol + 1
                  2-methylanisole 0
                  4,6-dinitro-o-cresol 0
                  4-chloro-2-methylphenol 1
                  o-cresol hydrogen sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                carbocyclic compound 18316
                                  benzenoid aromatic compound 17484
                                    benzenes 17274
                                      toluenes 6311
                                        hydroxytoluene 129
                                          cresol 123
                                            o-cresol 13
                                              1-(2-methylphenyl)glycerol 0
                                              2-[(ethylsulfanyl)methyl]phenol + 1
                                              2-methylanisole 0
                                              4,6-dinitro-o-cresol 0
                                              4-chloro-2-methylphenol 1
                                              o-cresol hydrogen sulfate 0
paths to the root