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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:o-cresol
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Accession:CHEBI:28054 term browser browse the term
Definition:A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene.
Synonyms:related_synonym: 2-cresol;   2-hydroxy-1-methylbenzene;   2-hydroxytoluene;   2-methylphenol;   Formula=C7H8O;   InChI=1S/C7H8O/c1-6-4-2-3-5-7(6)8/h2-5,8H,1H3;   InChIKey=QWVGKYWNOKOFNN-UHFFFAOYSA-N;   SMILES=Cc1ccccc1O;   o-Kresol;   o-Methylphenol;   o-cresylic acid;   ortho-cresol;   orthocresol
 alt_id: CHEBI:10609;   CHEBI:25617
 xref: Beilstein:506917;   CAS:95-48-7;   Gmelin:101619;   HMDB:HMDB0002055;   KEGG:C01542;   KNApSAcK:C00030878
 xref_mesh: MESH:C034047
 xref: PDBeChem:JZ0;   PMID:15687000;   Reaxys:506917;   UM-BBD_compID:c0281;   Wikipedia:O-Cresol


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o-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
EXP Sodium Selenite inhibits the reaction [2-cresol results in increased expression of AKT1 mRNA] CTD PMID:21705299 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding ISO 2-cresol binds to ALB protein CTD PMID:11334365 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP 2-cresol results in increased expression of BAX mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BAX mRNA]
CTD PMID:21705299 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of 2-cresol CTD PMID:22898212 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP 2-cresol results in increased expression of BCL2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of BCL2 mRNA]
CTD PMID:21705299 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP 2-cresol results in increased activity of [GABRG2 protein binds to GABRA1 protein binds to GABRB2 protein] CTD PMID:11399263 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
EXP 2-cresol results in increased expression of PPARG mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PPARG mRNA]
CTD PMID:21705299 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkca protein kinase C, alpha increases expression
multiple interactions
EXP 2-cresol results in increased expression of PRKCA mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PRKCA mRNA]
CTD PMID:21705299 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP 2-cresol results in increased expression of PTGS2 mRNA
Sodium Selenite inhibits the reaction [2-cresol results in increased expression of PTGS2 mRNA]
CTD PMID:21705299 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
4-chloro-2-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP 4-chloro-2-cresol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
ethiofencarb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO croneton inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:26647222 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pesticide 16263
          fungicide 10307
            aromatic fungicide 1482
              cresol 108
                o-cresol 13
                  1-(2-methylphenyl)glycerol 0
                  2-[(ethylsulfanyl)methyl]phenol + 1
                  2-methylanisole 0
                  4,6-dinitro-o-cresol 0
                  4-chloro-2-methylphenol 1
                  o-cresol hydrogen sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      toluenes 6223
                                        hydroxytoluene 112
                                          cresol 108
                                            o-cresol 13
                                              1-(2-methylphenyl)glycerol 0
                                              2-[(ethylsulfanyl)methyl]phenol + 1
                                              2-methylanisole 0
                                              4,6-dinitro-o-cresol 0
                                              4-chloro-2-methylphenol 1
                                              o-cresol hydrogen sulfate 0
paths to the root

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