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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:veratridine
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Accession:CHEBI:28051 term browser browse the term
Definition:A steroid that has formula C36H51NO11.
Synonyms:exact_synonym: 4beta,12,14,16beta,17,20-hexahydroxy-4alpha,9-epoxycevan-3beta-yl 3,4-dimethoxybenzoate
 related_synonym: Formula=C36H51NO11;   InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1;   InChIKey=FVECELJHCSPHKY-YFUMOZOISA-N;   SMILES=[H][C@@]12CC[C@H](C)CN1C[C@@]1([H])[C@]3(O)C[C@]45O[C@]6(O)[C@H](CC[C@@]4(C)[C@]6([H])CC[C@@]5([H])[C@]3(O)C[C@H](O)[C@]1(O)[C@]2(C)O)OC(=O)c1ccc(OC)c(OC)c1;   Veratrine;   veratridin
 alt_id: CHEBI:27281;   CHEBI:9952
 xref: Beilstein:78875;   CAS:71-62-5;   KEGG:C06544;   KNApSAcK:C00029202
 xref_mesh: MESH:D014701



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veratridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
ISO
EXP
cypermethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]; Permethrin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]
Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]
CTD PMID:11082455 PMID:16166269 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion
EXP nociceptin (1-13) amide inhibits the reaction [Veratridine results in increased secretion of CALCA protein] CTD PMID:17640294 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
cypermethrin inhibits the reaction [Veratridine results in increased expression of FOS mRNA]; Permethrin inhibits the reaction [Veratridine results in increased expression of FOS mRNA] CTD PMID:11082455 PMID:19463813 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions EXP [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Veratridine results in increased secretion of Dopamine] CTD PMID:12907309 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Npy neuropeptide Y multiple interactions
increases expression
EXP Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of NPY mRNA] CTD PMID:2233698 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biophysical role 13085
          membrane transport modulator 12899
            sodium channel modulator 6383
              veratridine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    main group molecular entity 19720
                      s-block molecular entity 19502
                        hydrogen molecular entity 19495
                          hydrides 18855
                            organic hydride 18361
                              organic fundamental parent 18361
                                natural product fundamental parent 13396
                                  alkaloid fundamental parent 2554
                                    steroid alkaloid fundamental parent 13
                                      cevane 5
                                        veratridine 5
paths to the root