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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:luteolin 7-O-beta-D-glucoside
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Accession:CHEBI:27994 term browser browse the term
Definition:A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Synonyms:exact_synonym: 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
 related_synonym: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside;   2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-one;   7-Glucoluteolin;   7-Glucosylluteolin;   7-O-beta-D-Glucosyl-5,7,3',4'-tetrahydroxyflavone;   Cinaroside;   Cynaroside;   Formula=C21H20O11;   InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1;   InChIKey=PEFNSGRTCBGNAN-QNDFHXLGSA-N;   Luteolin 7-O-glucopyranoside;   Luteolin 7-O-glucoside;   Luteolin 7-monoglucoside;   Luteolin-7-glucoside;   Luteoloside;   SMILES=OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:12251;   CHEBI:20779;   CHEBI:25089;   CHEBI:29061;   CHEBI:6582
 xref: CAS:5373-11-5;   HMDB:HMDB0035588;   KEGG:C03951;   KNApSAcK:C00004266;   LIPID_MAPS_instance:LMPK12110642
 xref_mesh: MESH:C066408
 xref: MetaCyc:LUTEOLIN-7-O-BETA-D-GLUCOSIDE;   PMID:20127879;   PMID:22741463;   PMID:23019878;   PMID:7875536;   Patent:CN101474196;   Patent:US2011207684;   Reaxys:66982;   Wikipedia:Cynaroside
 cyclic_relationship: is_conjugate_acid_of CHEBI:187903;   is_conjugate_acid_of CHEBI:77791



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luteolin 7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [luteolin-7-glucoside co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein CTD PMID:31157476 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:31157476 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein] CTD PMID:31157476 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions ISO luteolin-7-glucoside inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein] CTD PMID:31157476 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il6 interleukin 6 multiple interactions ISO luteolin-7-glucoside inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein] CTD PMID:11123379 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO luteolin-7-glucoside inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein] CTD PMID:11123379 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      chemical role 19565
        antioxidant 15692
          luteolin 7-O-beta-D-glucoside 6
            luteolin 7-O-beta-D-glucoside-4'-(Z-2-methyl-2-butenoate) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19889
                        carbon atom 19894
                          organic molecular entity 19882
                            heteroorganic entity 19593
                              organochalcogen compound 19369
                                organooxygen compound 19262
                                  carbohydrates and carbohydrate derivatives 13979
                                    carbohydrate 13997
                                      monosaccharide 4370
                                        aldose 2717
                                          aldohexose 2365
                                            glucose 2319
                                              D-glucose 2319
                                                D-glucopyranose 1764
                                                  beta-D-glucose 1629
                                                    beta-D-glucoside 1433
                                                      luteolin 7-O-beta-D-glucoside 6
                                                        luteolin 7-O-beta-D-glucoside-4'-(Z-2-methyl-2-butenoate) 0
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