CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: benzonitrile
Accession: CHEBI:27991
browse the term
Definition: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a phenyl group.
Synonyms: related_synonym: C6H5-CN; Cyanobenzene; Formula=C7H5N; InChI=1S/C7H5N/c8-6-7-4-2-1-3-5-7/h1-5H; InChIKey=JFDZBHWFFUWGJE-UHFFFAOYSA-N; Phenyl cyanide; SMILES=N#Cc1ccccc1; benzenenitrile; benzoic acid nitrile
alt_id: CHEBI:22725; CHEBI:3033
xref: Beilstein:506893; CAS:100-47-0; Gmelin:2653; KEGG:C09814; MetaCyc:CPD-15582; PMID:24129580; UM-BBD_compID:c0367; Wikipedia:Benzonitrile
G
Cyp2a5
cytochrome P450, family 2, subfamily a, polypeptide 5
increases metabolic processing
EXP ISO
CYP2A5 protein results in increased metabolism of dichlobanil CYP2A6 protein results in increased metabolism of dichlobanil
CTD
PMID:12464242 PMID:20840855
NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
G
Il6
interleukin 6
multiple interactions increases expression
EXP
Dexamethasone inhibits the reaction [dichlobanil results in increased expression of IL6 protein]
CTD
PMID:23921153
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Por
cytochrome p450 oxidoreductase
decreases response to substance
EXP
POR protein results in decreased susceptibility to dichlobanil
CTD
PMID:20840855
NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
G
Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [cyanophos results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing
ISO
CYP1A2 protein results in increased metabolism of perampanel
CTD
PMID:35200000
NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
G
Hmgb1
high mobility group box 1
multiple interactions
ISO
perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein]
CTD
PMID:36669621
NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
G
Il1b
interleukin 1 beta
multiple interactions
ISO
perampanel inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]
CTD
PMID:36669621
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
G
Tlr4
toll-like receptor 4
multiple interactions
ISO
perampanel inhibits the reaction [Kainic Acid results in increased expression of TLR4 protein]
CTD
PMID:36669621
NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
22188
chemical entity
22187
group
22082
pseudohalo group
4677
cyano group
4677
nitrile
4677
benzonitrile
8
2,6-dichlorobenzonitrile
3
2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile
0
3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile
0
4-[(1S,2R)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile
0
4-[(1S,2S)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile
0
4-cyanophenol +
1
benzonitrile oxide
0
perampanel +
4
Path 2
CHEBI ontology
22188
subatomic particle
22180
composite particle
22180
hadron
22180
baryon
22180
nucleon
22180
atomic nucleus
22180
atom
22180
main group element atom
22114
p-block element atom
22114
carbon group element atom
21915
carbon atom
21840
organic molecular entity
21840
organic molecule
21654
organic cyclic compound
21259
carbocyclic compound
19665
benzenoid aromatic compound
18767
benzenes
18558
benzonitrile
8
2,6-dichlorobenzonitrile
3
2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile
0
3-(\{(5R)-3-[3-(1H-imidazol-1-yl)propyl]-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl\}methyl)benzonitrile
0
4-[(1S,2R)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile
0
4-[(1S,2S)-3-(4-fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile
0
4-cyanophenol +
1
benzonitrile oxide
0
perampanel +
4