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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,4-dihydroxyphenylacetaldehyde
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Accession:CHEBI:27978 term browser browse the term
Definition:A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.
Synonyms:exact_synonym: (3,4-dihydroxyphenyl)acetaldehyde
 related_synonym: 2-(3,4-dihydroxyphenyl)ethanal;   DOPAL;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2;   InChIKey=IADQVXRMSNIUEL-UHFFFAOYSA-N;   Protocatechuatealdehyde;   SMILES=[H]C(=O)Cc1ccc(O)c(O)c1
 alt_id: CHEBI:1385;   CHEBI:19888
 xref: CAS:5707-55-1;   FooDB:FDB023227;   HMDB:HMDB0003791;   KEGG:C04043;   KNApSAcK:C00052036
 xref_mesh: MESH:C007430
 xref: MetaCyc:34-DIHYDROXYPHENYLACETALDEHYDE;   PMID:12729575;   PMID:14556942;   PMID:17379813;   PMID:19537779;   Reaxys:1941234;   Wikipedia:3\,4-Dihydroxyphenylacetaldehyde



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3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions
EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa
CTD PMID:21238438 PMID:21514317 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        solvent 16663
          formic acid 8827
            formyl group 8800
              aldehyde 8800
                phenylacetaldehydes 12
                  3,4-dihydroxyphenylacetaldehyde 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            formyl group 8800
                                              aldehyde 8800
                                                phenylacetaldehydes 12
                                                  3,4-dihydroxyphenylacetaldehyde 3
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