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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,4-dihydroxyphenylacetaldehyde
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Accession:CHEBI:27978 term browser browse the term
Definition:A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.
Synonyms:exact_synonym: (3,4-dihydroxyphenyl)acetaldehyde
 related_synonym: 2-(3,4-dihydroxyphenyl)ethanal;   DOPAL;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2;   InChIKey=IADQVXRMSNIUEL-UHFFFAOYSA-N;   Protocatechuatealdehyde;   SMILES=[H]C(=O)Cc1ccc(O)c(O)c1
 alt_id: CHEBI:1385;   CHEBI:19888
 xref: CAS:5707-55-1;   KEGG:C04043
 xref_mesh: MESH:C007430
 xref: PMID:12729575;   PMID:14556942;   PMID:17379813;   PMID:19537779;   Reaxys:1941234


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3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions
EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa
CTD PMID:21238438 PMID:21514317 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        solvent 16636
          formic acid 8817
            formyl group 8789
              aldehyde 8789
                phenylacetaldehydes 12
                  3,4-dihydroxyphenylacetaldehyde 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            formyl group 8789
                                              aldehyde 8789
                                                phenylacetaldehydes 12
                                                  3,4-dihydroxyphenylacetaldehyde 3
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