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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,4-dihydroxyphenylacetaldehyde
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Accession:CHEBI:27978 term browser browse the term
Definition:A phenylacetaldehyde in which the 3 and 4 positions of the phenyl group are substituted by hydroxy groups.
Synonyms:exact_synonym: (3,4-dihydroxyphenyl)acetaldehyde
 related_synonym: 2-(3,4-dihydroxyphenyl)ethanal;   DOPAL;   Formula=C8H8O3;   InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2;   InChIKey=IADQVXRMSNIUEL-UHFFFAOYSA-N;   Protocatechuatealdehyde;   SMILES=[H]C(=O)Cc1ccc(O)c(O)c1
 alt_id: CHEBI:1385;   CHEBI:19888
 xref: CAS:5707-55-1;   KEGG:C04043
 xref_mesh: MESH:C007430
 xref: PMID:12729575;   PMID:14556942;   PMID:17379813;   PMID:19537779;   Reaxys:1941234


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3,4-dihydroxyphenylacetaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein CTD PMID:21238438 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects binding EXP 3,4-dihydroxyphenylacetaldehyde binds to GSTM1 protein CTD PMID:21238438 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Th tyrosine hydroxylase affects binding
decreases activity
multiple interactions
EXP 3,4-dihydroxyphenylacetaldehyde binds to TH protein
3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein
[3,4-dihydroxyphenylacetaldehyde results in decreased activity of TH protein] which results in decreased chemical synthesis of Levodopa
CTD PMID:21238438, PMID:21514317 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        solvent 16489
          formic acid 7885
            formyl group 7851
              aldehyde 7851
                phenylacetaldehydes 12
                  3,4-dihydroxyphenylacetaldehyde 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            formyl group 7851
                                              aldehyde 7851
                                                phenylacetaldehydes 12
                                                  3,4-dihydroxyphenylacetaldehyde 3
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