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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-dehydroascorbic acid
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Accession:CHEBI:27956 term browser browse the term
Definition:Dehydroascorbic acid having the L-configuration.
Synonyms:exact_synonym: (5R)-5-[(1S)-1,2-dihydroxyethyl]furan-2,3,4(5H)-trione
 related_synonym: DHAA;   Formula=C6H6O6;   InChI=1S/C6H6O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8H,1H2/t2-,5+/m0/s1;   InChIKey=SBJKKFFYIZUCET-JLAZNSOCSA-N;   L-Dehydroascorbate;   L-threo-2,3-hexodiulosonic acid, gamma-lactone;   L-threo-hexo-2,3-diulosono-1,4-lactone;   SMILES=[H][C@@]1(OC(=O)C(=O)C1=O)[C@@H](O)CO;   dehydro-L-ascorbic acid;   dehydroascorbic acid;   oxidized ascorbic acid;   oxidized vitamin C
 alt_id: CHEBI:21279;   CHEBI:21280;   CHEBI:6210
 xref: Beilstein:84277;   CAS:490-83-5;   Gmelin:51038;   KEGG:C05422;   KNApSAcK:C00007380
 xref_mesh: MESH:D003683
 xref: PMID:15013385;   PMID:18813862;   PMID:23543734;   PMID:9506998;   Reaxys:84277
 cyclic_relationship: is_conjugate_acid_of CHEBI:58539


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L-dehydroascorbic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Dehydroascorbic Acid results in increased expression of BCL2 protein
CTD PMID:20166893 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dehydroascorbic Acid promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dehydroascorbic Acid promotes the reaction [Etoposide results in increased activity of CASP3 protein] CTD PMID:16951922 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of CAT protein; Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Dehydroascorbic Acid affects the localization of CYCS protein CTD PMID:20166893 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; Dehydroascorbic Acid promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Dehydroascorbic Acid promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA] CTD PMID:19683516 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]
Dehydroascorbic Acid inhibits the reaction [Blood Glucose affects the expression of IL1B protein]
CTD PMID:15737438, PMID:16529823 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Dehydroascorbic Acid inhibits the reaction [Blood Glucose affects the expression of PTGS2 protein] CTD PMID:15737438 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases transport
affects uptake
affects transport
ISO
EXP
SLC2A1 protein mutant form results in decreased transport of Dehydroascorbic Acid
SLC2A1 mRNA affects the uptake of Dehydroascorbic Acid
SLC2A1 protein affects the transport of Dehydroascorbic Acid
CTD PMID:11603379, PMID:15590689, PMID:16142743 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases uptake ISO SLC2A2 protein results in increased uptake of Dehydroascorbic Acid CTD PMID:23396969 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a3 solute carrier family 2 member 3 affects transport ISO SLC2A3 protein affects the transport of Dehydroascorbic Acid CTD PMID:15590689 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc2a8 solute carrier family 2 member 8 increases uptake EXP
ISO
SLC2A8 protein results in increased uptake of Dehydroascorbic Acid CTD PMID:23396969 NCBI chr 3:12,020,227...12,029,920
Ensembl chr 3:12,020,229...12,029,877
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of SOD2 protein; Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        cosmetic 1838
          skin lightening agent 1836
            vitamin C 624
              L-dehydroascorbic acid 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carbohydrate acid 757
                                          ketoaldonic acid 627
                                            ascorbic acid 624
                                              dehydroascorbic acid 12
                                                L-dehydroascorbic acid 12
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