Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-dehydroascorbic acid
go back to main search page
Accession:CHEBI:27956 term browser browse the term
Definition:Dehydroascorbic acid having the L-configuration.
Synonyms:exact_synonym: (5R)-5-[(1S)-1,2-dihydroxyethyl]furan-2,3,4(5H)-trione
 related_synonym: DHAA;   Formula=C6H6O6;   InChI=1S/C6H6O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-8H,1H2/t2-,5+/m0/s1;   InChIKey=SBJKKFFYIZUCET-JLAZNSOCSA-N;   L-Dehydroascorbate;   L-threo-2,3-hexodiulosonic acid, gamma-lactone;   L-threo-hexo-2,3-diulosono-1,4-lactone;   SMILES=[H][C@@]1(OC(=O)C(=O)C1=O)[C@@H](O)CO;   dehydro-L-ascorbic acid;   dehydroascorbic acid;   oxidized ascorbic acid;   oxidized vitamin C
 alt_id: CHEBI:21279;   CHEBI:21280;   CHEBI:6210
 xref: Beilstein:84277;   CAS:490-83-5;   Gmelin:51038;   KEGG:C05422;   KNApSAcK:C00007380
 xref_mesh: MESH:D003683
 xref: PMID:15013385;   PMID:18813862;   PMID:23543734;   PMID:9506998;   Reaxys:84277
 cyclic_relationship: is_conjugate_acid_of CHEBI:58539


show annotations for term's descendants           Sort by:
 
L-dehydroascorbic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Dehydroascorbic Acid results in increased expression of BCL2 protein
CTD PMID:20166893 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO Dehydroascorbic Acid promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dehydroascorbic Acid promotes the reaction [Etoposide results in increased activity of CASP3 protein] CTD PMID:16951922 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of CAT protein; Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of CAT protein] CTD PMID:20166893 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Dehydroascorbic Acid affects the localization of CYCS protein CTD PMID:20166893 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; Dehydroascorbic Acid promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Dehydroascorbic Acid promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA] CTD PMID:19683516 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]
Dehydroascorbic Acid inhibits the reaction [Blood Glucose affects the expression of IL1B protein]
CTD PMID:15737438 PMID:16529823 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Dehydroascorbic Acid inhibits the reaction [Blood Glucose affects the expression of PTGS2 protein] CTD PMID:15737438 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases transport
affects uptake
affects transport
ISO
EXP
SLC2A1 protein mutant form results in decreased transport of Dehydroascorbic Acid
SLC2A1 mRNA affects the uptake of Dehydroascorbic Acid
SLC2A1 protein affects the transport of Dehydroascorbic Acid
CTD PMID:11603379 PMID:15590689 PMID:16142743 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases uptake ISO SLC2A2 protein results in increased uptake of Dehydroascorbic Acid CTD PMID:23396969 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a3 solute carrier family 2 member 3 affects transport ISO SLC2A3 protein affects the transport of Dehydroascorbic Acid CTD PMID:15590689 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc2a8 solute carrier family 2 member 8 increases uptake EXP
ISO
SLC2A8 protein results in increased uptake of Dehydroascorbic Acid CTD PMID:23396969 NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of SOD2 protein; Cytochalasin B inhibits the reaction [Dehydroascorbic Acid results in increased expression of SOD2 protein] CTD PMID:20166893 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          cofactor 15547
            coenzyme 911
              L-dehydroascorbic acid 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic ester 15889
                                        lactone 11245
                                          gamma-lactone 6749
                                            butenolide 6281
                                              vitamin C 680
                                                L-ascorbic acid 680
                                                  L-dehydroascorbic acid 12
paths to the root