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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:physostigmine
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Accession:CHEBI:27953 term browser browse the term
Definition:An indole alkaloid that has formula C15H21N3O2.
Synonyms:exact_synonym: (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate
 related_synonym: Antilirium;   Eserine;   Formula=C15H21N3O2;   InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1;   InChIKey=PIJVFDBKTWXHHD-HIFRSBDPSA-N;   Physostol;   SMILES=[H][C@]12N(C)CC[C@@]1(C)c1cc(OC(=O)NC)ccc1N2C
 alt_id: CHEBI:26108;   CHEBI:8187
 xref: Beilstein:91230;   CAS:57-47-6;   CAS:57-64-7;   DrugBank:DB00981;   Drug_Central:2159;   KEGG:C06535;   KEGG:D00196;   KNApSAcK:C00001757;   LINCS:LSM-2558
 xref_mesh: MESH:D010830


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physostigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
JBrowse link
G Ache acetylcholinesterase decreases activity
affects expression
multiple interactions
increases expression
ISO
EXP
Physostigmine results in decreased activity of ACHE protein
Physostigmine affects the expression of ACHE mRNA
[Corticosterone co-treated with Physostigmine] results in decreased activity of ACHE protein; Physostigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
[Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]] which results in decreased carbamoylation of ACHE protein; ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
asoxime chloride affects the reaction [Physostigmine results in decreased activity of ACHE protein]; asoxime chloride promotes the reaction [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]]; Physostigmine affects the expression of and affects the activity of ACHE protein; Physostigmine affects the reaction [Sarin affects the expression of ACHE mRNA]; Physostigmine affects the reaction [Sarin affects the expression of and affects the activity of ACHE protein]; Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Physostigmine results in increased expression of ACHE protein
CTD PMID:4859365 PMID:11740913 PMID:14644616 PMID:15586889 PMID:19283689 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [Physostigmine results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G App amyloid beta precursor protein increases secretion EXP Physostigmine results in increased secretion of APP protein modified form CTD PMID:7605915 PMID:8624119 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bche butyrylcholinesterase decreases activity
multiple interactions
EXP
ISO
Physostigmine results in decreased activity of BCHE protein
Physostigmine inhibits the reaction [Sarin results in decreased activity of BCHE protein]
CTD PMID:19283689 PMID:32795450 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Physostigmine inhibits the reaction [Corticosterone results in decreased expression of CCL2 mRNA] CTD PMID:28500787 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Physostigmine results in decreased activity of CES2 protein CTD PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chat choline O-acetyltransferase decreases expression
increases expression
EXP Physostigmine results in decreased expression of CHAT protein
Physostigmine results in increased expression of CHAT protein
CTD PMID:22640809 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658 PMID:15733544 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:14645658 PMID:15733544 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of FOS mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of FOS mRNA] CTD PMID:11337201 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein] CTD PMID:28499986 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Physostigmine affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP [1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Physostigmine affects the reaction [Corticosterone affects the expression of IL1B mRNA] CTD PMID:28500787 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in decreased expression of IL6 mRNA CTD PMID:28500787 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Physostigmine inhibits the reaction [Scopolamine promotes the reaction [SK&F 82958 results in increased expression of JUN mRNA]]; Physostigmine inhibits the reaction [SK&F 82958 results in increased expression of JUN mRNA] CTD PMID:11337201 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in decreased expression of LIF mRNA CTD PMID:28500787 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein] CTD PMID:28499986 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein] CTD PMID:28499986 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Osm oncostatin M multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in increased expression of OSM mRNA CTD PMID:28500787 PMID:29846716 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Slc18a3 solute carrier family 18 member A3 increases expression EXP Physostigmine results in increased expression of SLC18A3 protein CTD PMID:22640809 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] CTD PMID:28499986 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Physostigmine results in decreased phosphorylation of STAT3 protein CTD PMID:28500787 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Syp synaptophysin multiple interactions ISO Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein] CTD PMID:28499986 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Corticosterone co-treated with Physostigmine] results in increased expression of TNF mRNA CTD PMID:28500787 PMID:29846716 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
physostigmine salicylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO physostigmine salicylate results in decreased activity of ACHE protein CTD PMID:623676 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link

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  CHEBI ontology 19821
    role 19769
      biological role 19769
        pharmacological role 18847
          neurotransmitter agent 16456
            miotic 71
              physostigmine 27
                physostigmine salicylate 1
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic ester 15884
                                        carbamate ester 7445
                                          physostigmine 27
                                            physostigmine salicylate 1
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