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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylhydrazine
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Accession:CHEBI:27924 term browser browse the term
Definition:A phenylhydrazine that is the monophenyl derivative of hydrazine.
Synonyms:related_synonym: 1-PHENYLHYDRAZINE;   Formula=C6H8N2;   Hydrazinobenzene;   InChI=1S/C6H8N2/c7-8-6-4-2-1-3-5-6/h1-5,8H,7H2;   InChIKey=HKOOXMFOFWEVGF-UHFFFAOYSA-N;   PhNHNH2;   Phenyldiazane;   Phenylhydrazin;   SMILES=NNc1ccccc1;   hydrazobenzene;   monophenylhydrazine
 alt_id: CHEBI:25995;   CHEBI:44985;   CHEBI:8099
 xref: Beilstein:606080;   CAS:100-63-0;   Gmelin:26849;   KEGG:C02304
 xref_mesh: MESH:C030299
 xref: MetaCyc:PHENYLHYDRAZINE;   PDBeChem:PHZ;   PMID:19627281;   PMID:20585853;   PMID:7144447;   Reaxys:606080;   Wikipedia:Phenylhydrazine


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phenylhydrazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsp alpha hemoglobin stabilizing protein increases expression EXP phenylhydrazine results in increased expression of AHSP mRNA CTD PMID:17082564 NCBI chr 1:182,879,901...182,885,508
Ensembl chr 1:182,880,076...182,885,506
JBrowse link
G Akap10 A-kinase anchoring protein 10 increases expression EXP phenylhydrazine results in increased expression of AKAP10 mRNA CTD PMID:17082564 NCBI chr10:46,545,464...46,608,768
Ensembl chr10:46,551,532...46,608,769
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP phenylhydrazine results in increased expression of AKR1B8 mRNA CTD PMID:17698508 NCBI chr 4:62,997,241...63,009,815 JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP phenylhydrazine results in increased expression of ALAS2 mRNA CTD PMID:17082564 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin multiple interactions EXP Folic Acid inhibits the reaction [phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin]]; phenylhydrazine inhibits the reaction [ALB protein binds to Bilirubin] CTD PMID:33788065 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cbs cystathionine beta synthase decreases activity
multiple interactions
EXP phenylhydrazine results in decreased activity of CBS protein
Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of CBS protein]
CTD PMID:33788065 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased expression of CCND1 mRNA] CTD PMID:30140404 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd7 Cd7 molecule decreases expression EXP phenylhydrazine results in decreased expression of CD7 mRNA CTD PMID:17698508 NCBI chr10:106,304,046...106,306,963
Ensembl chr10:106,304,056...106,306,967
JBrowse link
G Cd8a CD8a molecule decreases expression EXP phenylhydrazine results in decreased expression of CD8A mRNA CTD PMID:17698508 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
JBrowse link
G Ceacam4 CEA cell adhesion molecule 4 increases expression EXP phenylhydrazine results in increased expression of CEACAM10 mRNA CTD PMID:17082564 NCBI chr 1:80,376,667...80,382,943
Ensembl chr 1:80,376,648...80,382,915
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP phenylhydrazine results in increased expression of CHCHD6 mRNA CTD PMID:17698508 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP phenylhydrazine results in increased expression of CREG1 mRNA CTD PMID:17698508 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
JBrowse link
G Ctsb cathepsin B increases expression EXP phenylhydrazine results in increased expression of CTSB mRNA CTD PMID:17698508 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D increases expression EXP phenylhydrazine results in increased expression of CTSD mRNA CTD PMID:17698508 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cul4a cullin 4A affects response to substance ISO CUL4A protein affects the susceptibility to phenylhydrazine CTD PMID:16467204 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP phenylhydrazine results in decreased expression of CYP2C22 mRNA CTD PMID:17082564 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Emb embigin increases expression EXP phenylhydrazine results in increased expression of EMB mRNA CTD PMID:17082564 NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
JBrowse link
G Epo erythropoietin increases expression EXP phenylhydrazine results in increased expression of EPO mRNA CTD PMID:22908232 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor affects response to substance ISO EPOR gene mutant form affects the susceptibility to phenylhydrazine CTD PMID:16511603 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP phenylhydrazine results in increased expression of FABP4 mRNA CTD PMID:17698508 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP phenylhydrazine results in increased expression of FABP5 mRNA CTD PMID:17698508 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression EXP phenylhydrazine results in increased expression of FCGR2B mRNA CTD PMID:17082564 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Flg filaggrin increases expression EXP phenylhydrazine results in increased expression of FLG mRNA CTD PMID:17082564 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Frem2 FRAS1 related extracellular matrix 2 decreases expression EXP phenylhydrazine results in decreased expression of FREM2 mRNA CTD PMID:17082564 NCBI chr 2:137,602,784...137,740,785
Ensembl chr 2:137,602,784...137,740,785
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP phenylhydrazine results in increased expression of FTL1 mRNA CTD PMID:17698508 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G G0s2 G0/G1switch 2 decreases expression EXP phenylhydrazine results in decreased expression of G0S2 mRNA CTD PMID:17082564 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G Gcgr glucagon receptor increases expression EXP phenylhydrazine results in increased expression of GCGR mRNA CTD PMID:17698508 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Gfra1 GDNF family receptor alpha 1 increases expression EXP phenylhydrazine results in increased expression of GFRA1 mRNA CTD PMID:17698508 NCBI chr 1:257,315,682...257,552,004 JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP phenylhydrazine results in increased expression of GPNMB mRNA CTD PMID:17082564 PMID:17698508 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO
EXP
SESN2 protein inhibits the reaction [phenylhydrazine results in increased activity of GPT protein]
Folic Acid inhibits the reaction [phenylhydrazine results in increased activity of GPT protein]
CTD PMID:31323261 PMID:33788065 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO phenylhydrazine results in decreased expression of GPX4 protein CTD PMID:31323261 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsn gelsolin affects response to substance ISO GSN protein affects the susceptibility to phenylhydrazine CTD PMID:22271892 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gzmk granzyme K decreases expression EXP phenylhydrazine results in decreased expression of GZMK mRNA CTD PMID:17698508 NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression EXP phenylhydrazine results in increased expression of HBA-A1 mRNA CTD PMID:17082564 NCBI chr10:15,337,265...15,338,121 JBrowse link
G Hbe2 hemoglobin, epsilon 2 increases expression EXP phenylhydrazine results in increased expression of HBE2 mRNA CTD PMID:17082564 NCBI chr 1:158,279,285...158,280,913
Ensembl chr 1:158,279,285...158,280,913
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP phenylhydrazine results in increased expression of HMOX1 mRNA; phenylhydrazine results in increased expression of HMOX1 protein CTD PMID:17082564 PMID:17698508 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP phenylhydrazine results in increased expression of LBP mRNA CTD PMID:17082564 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lgals3 galectin 3 increases expression EXP phenylhydrazine results in increased expression of LGALS3 mRNA CTD PMID:17082564 PMID:17698508 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lgmn legumain increases expression EXP phenylhydrazine results in increased expression of LGMN mRNA CTD PMID:17698508 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480
JBrowse link
G Mt1 metallothionein 1 increases expression EXP phenylhydrazine results in increased expression of MT1A mRNA CTD PMID:17082564 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mthfr methylenetetrahydrofolate reductase multiple interactions
decreases activity
EXP Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTHFR protein] CTD PMID:33788065 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase decreases activity
multiple interactions
EXP phenylhydrazine results in decreased activity of MTR protein
Folic Acid inhibits the reaction [phenylhydrazine results in decreased activity of MTR protein]
CTD PMID:33788065 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA] CTD PMID:30140404 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of phenylhydrazine CTD PMID:15627487 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression EXP phenylhydrazine results in decreased expression of NCK2 mRNA CTD PMID:17082564 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO phenylhydrazine results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
EXP Doxorubicin inhibits the reaction [phenylhydrazine results in increased expression of NPPB mRNA] CTD PMID:22908232 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Npy neuropeptide Y increases expression EXP phenylhydrazine results in increased expression of NPY mRNA CTD PMID:17082564 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO phenylhydrazine results in increased expression of NR1I3 mRNA CTD PMID:25949234 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP phenylhydrazine results in increased expression of ORC1 mRNA CTD PMID:17698508 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression EXP phenylhydrazine results in increased expression of PLSCR1 mRNA CTD PMID:17082564 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression EXP phenylhydrazine results in increased expression of PSMD6 mRNA CTD PMID:17082564 NCBI chr15:11,102,208...11,112,180
Ensembl chr15:11,102,180...11,205,620
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein]; SESN2 protein inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein] CTD PMID:30626086 PMID:31323261 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression EXP phenylhydrazine results in increased expression of PTPMT1 mRNA CTD PMID:17698508 NCBI chr 3:76,889,922...76,899,427
Ensembl chr 3:76,889,922...76,899,427
JBrowse link
G RGD1306195 similar to RAN protein increases expression EXP phenylhydrazine results in increased expression of RGD1306195 mRNA CTD PMID:17698508 NCBI chr 5:54,456,005...54,457,381
Ensembl chr 5:54,455,893...54,457,677
JBrowse link
G Rhd Rh blood group, D antigen increases expression EXP phenylhydrazine results in increased expression of RHD mRNA CTD PMID:17082564 NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression EXP phenylhydrazine results in increased expression of RIPK3 mRNA CTD PMID:17082564 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression EXP phenylhydrazine results in decreased expression of RT1-BB mRNA CTD PMID:17698508 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP phenylhydrazine results in increased expression of S100A8 mRNA CTD PMID:17082564 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP phenylhydrazine results in increased expression of S100A9 mRNA CTD PMID:17082564 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression EXP phenylhydrazine results in increased expression of SERPINA3N mRNA CTD PMID:17698508 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO SESN2 protein inhibits the reaction [phenylhydrazine results in increased activity of GPT protein]; SESN2 protein inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein] CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression EXP phenylhydrazine results in increased expression of SLC39A14 mRNA CTD PMID:17082564 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression EXP phenylhydrazine results in increased expression of SLC40A1 mRNA CTD PMID:17082564 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Spata48 spermatogenesis associated 48 increases expression EXP phenylhydrazine results in increased expression of SPATA48 mRNA CTD PMID:17698508 NCBI chr14:86,030,577...86,085,644
Ensembl chr14:86,030,655...86,085,644
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP phenylhydrazine results in increased expression of SPINK1 mRNA CTD PMID:17082564 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO phenylhydrazine analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:26549477 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 decreases expression EXP phenylhydrazine results in decreased expression of TNFRSF17 mRNA CTD PMID:17698508 NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP phenylhydrazine results in increased expression of TRIB3 mRNA CTD PMID:17082564 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Ucp2 uncoupling protein 2 affects response to substance ISO UCP2 protein affects the susceptibility to phenylhydrazine CTD PMID:18687678 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP phenylhydrazine results in increased expression of VCAM1 mRNA CTD PMID:17082564 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP Doxorubicin inhibits the reaction [phenylhydrazine results in increased expression of VEGFA mRNA] CTD PMID:22908232 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 decreases expression EXP phenylhydrazine results in decreased expression of ZBTB44 mRNA CTD PMID:17082564 NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        xenobiotic 18441
          phenylhydrazine 73
            4-nitrophenylhydrazine 0
            phenylhydrazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      pnictogen 18837
                        nitrogen atom 18758
                          nitrogen molecular entity 18758
                            hydrazines 10310
                              phenylhydrazines 74
                                phenylhydrazine 73
                                  4-nitrophenylhydrazine 0
                                  phenylhydrazine hydrochloride 0
paths to the root