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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phenylhydrazine
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Accession:CHEBI:27924 term browser browse the term
Definition:A phenylhydrazine that is the monophenyl derivative of hydrazine.
Synonyms:related_synonym: 1-PHENYLHYDRAZINE;   Formula=C6H8N2;   Hydrazinobenzene;   InChI=1S/C6H8N2/c7-8-6-4-2-1-3-5-6/h1-5,8H,7H2;   InChIKey=HKOOXMFOFWEVGF-UHFFFAOYSA-N;   PhNHNH2;   Phenyldiazane;   Phenylhydrazin;   SMILES=NNc1ccccc1;   hydrazobenzene;   monophenylhydrazine
 alt_id: CHEBI:25995;   CHEBI:44985;   CHEBI:8099
 xref: Beilstein:606080;   CAS:100-63-0;   Gmelin:26849;   KEGG:C02304
 xref_mesh: MESH:C030299
 xref: MetaCyc:PHENYLHYDRAZINE;   PDBeChem:PHZ;   PMID:19627281;   PMID:20585853;   PMID:7144447;   Reaxys:606080;   Wikipedia:Phenylhydrazine


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phenylhydrazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsp alpha hemoglobin stabilizing protein increases expression EXP phenylhydrazine results in increased expression of AHSP mRNA CTD PMID:17082564 NCBI chr 1:199,720,038...199,721,010
Ensembl chr 1:199,720,038...199,721,010
JBrowse link
G Akap10 A-kinase anchoring protein 10 increases expression EXP phenylhydrazine results in increased expression of AKAP10 mRNA CTD PMID:17082564 NCBI chr10:48,150,902...48,210,074
Ensembl chr10:48,150,902...48,210,074
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP phenylhydrazine results in increased expression of AKR1B8 mRNA CTD PMID:17698508 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 increases expression EXP phenylhydrazine results in increased expression of ALAS2 mRNA CTD PMID:17082564 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased expression of CCND1 mRNA] CTD PMID:30140404 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd7 Cd7 molecule decreases expression EXP phenylhydrazine results in decreased expression of CD7 mRNA CTD PMID:17698508 NCBI chr10:110,229,931...110,232,812
Ensembl chr10:110,229,922...110,232,843
JBrowse link
G Cd8a CD8a molecule decreases expression EXP phenylhydrazine results in decreased expression of CD8A mRNA CTD PMID:17698508 NCBI chr 4:99,217,640...99,243,352
Ensembl chr 4:99,239,115...99,243,351
JBrowse link
G Ceacam4 CEA cell adhesion molecule 4 increases expression EXP phenylhydrazine results in increased expression of CEACAM10 mRNA CTD PMID:17082564 NCBI chr 1:81,643,809...81,650,085
Ensembl chr 1:81,643,816...81,650,094
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP phenylhydrazine results in increased expression of CHCHD6 mRNA CTD PMID:17698508 NCBI chr 4:121,340,952...121,565,222
Ensembl chr 4:121,340,952...121,565,212
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression EXP phenylhydrazine results in increased expression of CREG1 mRNA CTD PMID:17698508 NCBI chr13:83,972,186...83,984,675
Ensembl chr13:83,972,212...83,984,675
JBrowse link
G Ctsb cathepsin B increases expression EXP phenylhydrazine results in increased expression of CTSB mRNA CTD PMID:17698508 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D increases expression EXP phenylhydrazine results in increased expression of CTSD mRNA CTD PMID:17698508 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cul4a cullin 4A affects response to substance ISO CUL4A protein affects the susceptibility to phenylhydrazine CTD PMID:16467204 NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP phenylhydrazine results in decreased expression of CYP2C22 mRNA CTD PMID:17082564 NCBI chr 1:259,257,658...259,297,270
Ensembl chr 1:259,257,657...259,287,684
JBrowse link
G Emb embigin increases expression EXP phenylhydrazine results in increased expression of EMB mRNA CTD PMID:17082564 NCBI chr 2:49,682,763...49,733,475
Ensembl chr 2:49,682,754...49,732,253
JBrowse link
G Epo erythropoietin increases expression EXP phenylhydrazine results in increased expression of EPO mRNA CTD PMID:22908232 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor affects response to substance ISO EPOR gene mutant form affects the susceptibility to phenylhydrazine CTD PMID:16511603 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression EXP phenylhydrazine results in increased expression of FABP4 mRNA CTD PMID:17698508 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression EXP phenylhydrazine results in increased expression of FABP5 mRNA CTD PMID:17698508 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression EXP phenylhydrazine results in increased expression of FCGR2B mRNA CTD PMID:17082564 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Flg filaggrin increases expression EXP phenylhydrazine results in increased expression of FLG mRNA CTD PMID:17082564 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Frem2 FRAS1 related extracellular matrix 2 decreases expression EXP phenylhydrazine results in decreased expression of FREM2 mRNA CTD PMID:17082564 NCBI chr 2:142,747,501...142,885,604
Ensembl chr 2:142,747,501...142,885,604
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP phenylhydrazine results in increased expression of FTL1 mRNA CTD PMID:17698508 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G G0s2 G0/G1switch 2 decreases expression EXP phenylhydrazine results in decreased expression of G0S2 mRNA CTD PMID:17082564 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gcgr glucagon receptor increases expression EXP phenylhydrazine results in increased expression of GCGR mRNA CTD PMID:17698508 NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
JBrowse link
G Gfra1 GDNF family receptor alpha 1 increases expression EXP phenylhydrazine results in increased expression of GFRA1 mRNA CTD PMID:17698508 NCBI chr 1:279,203,046...279,572,789 JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP phenylhydrazine results in increased expression of GPNMB mRNA CTD PMID:17082564, PMID:17698508 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO SESN2 protein inhibits the reaction [phenylhydrazine results in increased activity of GPT protein] CTD PMID:31323261 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO phenylhydrazine results in decreased expression of GPX4 protein CTD PMID:31323261 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsn gelsolin affects response to substance ISO GSN protein affects the susceptibility to phenylhydrazine CTD PMID:22271892 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gzmk granzyme K decreases expression EXP phenylhydrazine results in decreased expression of GZMK mRNA CTD PMID:17698508 NCBI chr 2:45,069,136...45,077,154
Ensembl chr 2:45,068,967...45,077,219
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 increases expression EXP phenylhydrazine results in increased expression of HBA-A1 mRNA CTD PMID:17082564 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
JBrowse link
G Hbe2 hemoglobin, epsilon 2 increases expression EXP phenylhydrazine results in increased expression of HBE2 mRNA CTD PMID:17082564 NCBI chr 1:169,000,133...169,001,761
Ensembl chr 1:169,000,133...169,001,761
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP phenylhydrazine results in increased expression of HMOX1 mRNA; phenylhydrazine results in increased expression of HMOX1 protein CTD PMID:17082564, PMID:17698508 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP phenylhydrazine results in increased expression of LBP mRNA CTD PMID:17082564 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lgals3 galectin 3 increases expression EXP phenylhydrazine results in increased expression of LGALS3 mRNA CTD PMID:17082564, PMID:17698508 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lgmn legumain increases expression EXP phenylhydrazine results in increased expression of LGMN mRNA CTD PMID:17698508 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
G Mt1 metallothionein 1 increases expression EXP phenylhydrazine results in increased expression of MT1A mRNA CTD PMID:17082564 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO Ascorbic Acid inhibits the reaction [phenylhydrazine results in decreased expression of MYC mRNA] CTD PMID:30140404 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of phenylhydrazine CTD PMID:15627487 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Nck2 NCK adaptor protein 2 decreases expression EXP phenylhydrazine results in decreased expression of NCK2 mRNA CTD PMID:17082564 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO phenylhydrazine results in increased activity of NFE2L2 protein CTD PMID:30114225, PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nppb natriuretic peptide B multiple interactions
increases expression
EXP Doxorubicin inhibits the reaction [phenylhydrazine results in increased expression of NPPB mRNA] CTD PMID:22908232 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npy neuropeptide Y increases expression EXP phenylhydrazine results in increased expression of NPY mRNA CTD PMID:17082564 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO phenylhydrazine results in increased expression of NR1I3 mRNA CTD PMID:25949234 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Orc1 origin recognition complex, subunit 1 increases expression EXP phenylhydrazine results in increased expression of ORC1 mRNA CTD PMID:17698508 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression EXP phenylhydrazine results in increased expression of PLSCR1 mRNA CTD PMID:17082564 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Psmd6 proteasome 26S subunit, non-ATPase 6 increases expression EXP phenylhydrazine results in increased expression of PSMD6 mRNA CTD PMID:17082564 NCBI chr15:12,407,557...12,416,153
Ensembl chr15:12,407,524...12,416,105
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein]; SESN2 protein inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein] CTD PMID:30626086, PMID:31323261 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression EXP phenylhydrazine results in increased expression of PTPMT1 mRNA CTD PMID:17698508 NCBI chr 3:79,734,961...79,743,737
Ensembl chr 3:79,734,961...79,743,737
JBrowse link
G RGD1306195 similar to RAN protein increases expression EXP phenylhydrazine results in increased expression of RGD1306195 mRNA CTD PMID:17698508 NCBI chr 5:54,480,783...54,482,159
Ensembl chr 5:54,480,787...54,482,159
JBrowse link
G Rhd Rh blood group, D antigen increases expression EXP phenylhydrazine results in increased expression of RHD mRNA CTD PMID:17082564 NCBI chr 5:153,197,416...153,232,009
Ensembl chr 5:153,197,459...153,232,687
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression EXP phenylhydrazine results in increased expression of RIPK3 mRNA CTD PMID:17082564 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression EXP phenylhydrazine results in decreased expression of RT1-BB mRNA CTD PMID:17698508 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP phenylhydrazine results in increased expression of S100A8 mRNA CTD PMID:17082564 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP phenylhydrazine results in increased expression of S100A9 mRNA CTD PMID:17082564 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression EXP phenylhydrazine results in increased expression of SERPINA3N mRNA CTD PMID:17698508 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO SESN2 protein inhibits the reaction [phenylhydrazine results in increased activity of GPT protein]; SESN2 protein inhibits the reaction [phenylhydrazine results in increased expression of PTGS2 protein] CTD PMID:31323261 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Slc39a14 solute carrier family 39 member 14 increases expression EXP phenylhydrazine results in increased expression of SLC39A14 mRNA CTD PMID:17082564 NCBI chr15:51,982,872...52,029,841
Ensembl chr15:51,982,982...52,029,816
JBrowse link
G Slc40a1 solute carrier family 40 member 1 increases expression EXP phenylhydrazine results in increased expression of SLC40A1 mRNA CTD PMID:17082564 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Spata48 spermatogenesis associated 48 increases expression EXP phenylhydrazine results in increased expression of SPATA48 mRNA CTD PMID:17698508 NCBI chr14:91,556,782...91,614,099
Ensembl chr14:91,557,601...91,613,540
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP phenylhydrazine results in increased expression of SPINK1 mRNA CTD PMID:17082564 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO phenylhydrazine analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] CTD PMID:26549477 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 decreases expression EXP phenylhydrazine results in decreased expression of TNFRSF17 mRNA CTD PMID:17698508 NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP phenylhydrazine results in increased expression of TRIB3 mRNA CTD PMID:17082564 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Ucp2 uncoupling protein 2 affects response to substance ISO UCP2 protein affects the susceptibility to phenylhydrazine CTD PMID:18687678 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP phenylhydrazine results in increased expression of VCAM1 mRNA CTD PMID:17082564 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP Doxorubicin inhibits the reaction [phenylhydrazine results in increased expression of VEGFA mRNA] CTD PMID:22908232 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Zbtb44 zinc finger and BTB domain containing 44 decreases expression EXP phenylhydrazine results in decreased expression of ZBTB44 mRNA CTD PMID:17082564 NCBI chr 8:32,165,388...32,223,341
Ensembl chr 8:32,165,810...32,217,476
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        xenobiotic 18379
          phenylhydrazine 69
            4-nitrophenylhydrazine 0
            phenylhydrazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      pnictogen 18633
                        nitrogen atom 18532
                          nitrogen molecular entity 18532
                            hydrazines 10284
                              phenylhydrazines 70
                                phenylhydrazine 69
                                  4-nitrophenylhydrazine 0
                                  phenylhydrazine hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.