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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2'-hydroxychalcone
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Accession:CHEBI:27916 term browser browse the term
Definition:A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.
Synonyms:exact_synonym: (2E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
 related_synonym: Formula=C15H12O2;   InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+;   InChIKey=AETKQQBRKSELEL-ZHACJKMWSA-N;   SMILES=Oc1ccccc1C(=O)\\C=C\\c1ccccc1
 alt_id: CHEBI:19265;   CHEBI:840
 xref: CAS:888-12-0;   KEGG:C09321
 xref_mesh: MESH:C013031
 xref: PMID:10953045;   PMID:1453084;   PMID:18961699;   PMID:20957597;   PMID:23427769;   Reaxys:1911344


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2'-hydroxychalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
multiple interactions
ISO 2'-hydroxychalcone results in decreased activity of CYP1A1 protein
2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]
CTD PMID:15596260 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
multiple interactions
ISO 2'-hydroxychalcone results in decreased activity of CYP1B1 protein
2'-hydroxychalcone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1B1 mRNA]
CTD PMID:15596260 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 2'-hydroxychalcone results in increased expression of HMOX1 protein CTD PMID:23942037 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      application 19403
        anti-inflammatory agent 15766
          2'-hydroxychalcone 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      ketone 16833
                                        alpha,beta-unsaturated ketone 8960
                                          enone 8960
                                            chalcones 151
                                              chalcone 103
                                                trans-chalcone 103
                                                  2'-hydroxychalcone 3
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