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ONTOLOGY REPORT - ANNOTATIONS


Term:cisplatin
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Accession:CHEBI:27899 term browser browse the term
Definition:A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Synonyms:exact_synonym: (SP-4-2)-diamminedichloridoplatinum;   (SP-4-2)-diamminedichloroplatinum;   cis-diamminedichloridoplatinum(II)
 related_synonym: Briplatin;   CDDP;   Cismaplat;   Formula=Cl2H6N2Pt;   Formula=H6Cl2N2Pt;   InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2;   InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L;   Lederplatin;   Neoplatin;   Peyrone's chloride;   Peyrone's salt;   Platamine;   Platinex;   Platinol;   Randa;   SMILES=[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H];   [PtCl2(NH3)2];   cis-DDP;   cis-Diamminedichloroplatinum(II);   cis-[PtCl2(NH3)2];   cis-diamminedichloroplatinum;   cis-diammineplatinum(II) dichloride;   cis-dichlorodiammineplatinum(II);   cis-platin;   cisplatine;   cisplatino;   cisplatinum
 alt_id: CHEBI:23314;   CHEBI:3722
 xref: CAS:15663-27-1 "ChemIDplus";   CAS:15663-27-1 "KEGG COMPOUND";   DrugBank:DB00515;   Gmelin:2519 "Gmelin";   HMDB:HMDB0014656;   KEGG:C06911;   KEGG:D00275
 xref_mesh: MESH:D002945
 xref: MetaCyc:CPD0-1392;   MolBase:25;   PMID:10883661 "Europe PMC";   PMID:12537968 "Europe PMC";   PMID:12831510 "Europe PMC";   PMID:12935404 "Europe PMC";   PMID:16327988 "Europe PMC";   PMID:18472761 "Europe PMC";   PMID:1855275 "Europe PMC";   PMID:23554447 "Europe PMC";   PMID:23604226 "Europe PMC";   PMID:23651576 "Europe PMC";   Patent:DE2318020;   Patent:DE2329485;   Reaxys:11324567 "Reaxys";   Wikipedia:Cisplatin


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        reagent 16869
          cross-linking reagent 7295
            cisplatin 7277
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  metal atom 17047
                    transition element atom 16551
                      d-block element atom 16540
                        nickel group element atom 10077
                          platinum 8379
                            platinum molecular entity 8379
                              platinum coordination entity 8379
                                diamminedichloroplatinum 7277
                                  cisplatin 7277
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