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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-colchicine
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Accession:CHEBI:27882 term browser browse the term
Definition:A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Synonyms:exact_synonym: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
 related_synonym: (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;   7alphaH-colchicine;   Colchicin;   Colchicine;   Colchisol;   Colcin;   Colcrys;   Colsaloid;   Condylon;   Formula=C22H25NO6;   Goutnil;   InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1;   InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N;   Kolkicin;   Mitigare;   SMILES=COC1=CC2=C(C(OC)=C1OC)C1=CC=C(OC)C(=O)C=C1[C@H](CC2)NC(C)=O;   colchicina;   colchicinum
 alt_id: CHEBI:3811
 xref: Beilstein:2228813;   CAS:64-86-8;   Chemspider:5933;   DrugBank:DB01394;   Drug_Central:726;   KEGG:C07592;   KEGG:D00570;   KNApSAcK:C00002327;   LINCS:LSM-5199
 xref_mesh: MESH:D003078
 xref: MetaCyc:CPD-9785;   PDBeChem:LOC;   PMID:16188942;   PMID:17619668;   PMID:18787557;   PMID:24530796;   PMID:28832953;   PMID:28912485;   PMID:28959419;   PMID:30565859;   PMID:32025680;   PMID:32426001;   PMID:32511763;   PMID:32837853;   PMID:32865380;   PMID:33100196;   PMID:33166069;   Wikipedia:Colchicine
 cyclic_relationship: is_enantiomer_of CHEBI:51074


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(S)-colchicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca13 ATP binding cassette subfamily A member 13 affects response to substance ISO ABCA13 gene SNP affects the susceptibility to Colchicine CTD PMID:25622337 NCBI chr14:83,873,397...84,376,138
Ensembl chr14:83,873,940...84,375,075 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 affects localization EXP Colchicine affects the localization of ABCB11 protein CTD PMID:12702492 PMID:15304119 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport
increases export
increases expression
multiple interactions
decreases response to substance		 ISO ABCB1 protein affects the transport of Colchicine
ABCB1 protein results in increased export of Colchicine
Colchicine results in increased expression of ABCB1; Colchicine results in increased expression of ABCB1 mRNA
[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]
ABCB1 protein results in decreased susceptibility to Colchicine		 CTD PMID:7905786 PMID:11792417 PMID:12711602 PMID:15112361 PMID:15342794 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Colchicine CTD PMID:12067707 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein] CTD PMID:31300867 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects localization EXP Colchicine affects the localization of ABCC3 protein CTD PMID:12702492 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Colchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein] CTD PMID:18468992 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases activity
decreases expression		 EXP carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]; resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein] CTD PMID:17135773 PMID:17652827 PMID:18980205 PMID:18992766 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP
ISO		 Colchicine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Ache acetylcholinesterase increases activity
multiple interactions		 ISO Colchicine results in increased activity of ACHE protein
amyloid beta-protein (25-35) inhibits the reaction [Colchicine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of ACHE protein]		 CTD PMID:33617922 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:14726149 PMID:22446813 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases activity ISO
EXP		 Colchicine results in decreased activity of AHR protein CTD PMID:16611024 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP Colchicine results in decreased expression of AIF1 mRNA CTD PMID:20624997 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Ak1 adenylate kinase 1 decreases expression EXP Colchicine results in decreased expression of AK1 mRNA CTD PMID:20624997 NCBI chr 3:15,912,431...15,923,045 JBrowse link
G Alb albumin affects expression
multiple interactions		 ISO
EXP		 Colchicine affects the expression of ALB protein
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein]		 CTD PMID:8574231 PMID:23146695 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apln apelin decreases expression EXP Colchicine results in decreased expression of APLN mRNA CTD PMID:20624997 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Colchicine results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Colchicine results in increased expression of AURKB mRNA CTD PMID:21472861 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Avp arginine vasopressin decreases transport EXP Colchicine results in decreased transport of AVP protein CTD PMID:2453250 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Colchicine results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of BAX protein]		 CTD PMID:22342440 PMID:33617922 PMID:33684465 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 Colchicine inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA]
dihydroactinidiolide inhibits the reaction [Colchicine results in decreased expression of BCL2 protein]		 CTD PMID:22342440 PMID:22446813 PMID:33617922 PMID:33684465 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP [Diethylnitrosamine co-treated with Colchicine] results in decreased expression of BCL2L1 protein CTD PMID:11749691 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases transport EXP Colchicine results in decreased transport of BDNF protein CTD PMID:21310905 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO Colchicine results in decreased expression of BLM mRNA CTD PMID:24211769 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Colchicine results in decreased expression of BTG1 mRNA CTD PMID:24211769 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression ISO Colchicine results in decreased expression of BTG2 mRNA CTD PMID:24211769 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Colchicine results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170 		JBrowse link
G C3 complement C3 increases expression EXP Colchicine results in increased expression of C3 mRNA CTD PMID:20624997 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Capn1 calpain 1 decreases expression EXP Colchicine results in decreased expression of CAPN1 mRNA CTD PMID:18255150 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases cleavage
increases activity		 EXP
ISO		 alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; SB 216763 inhibits the reaction [Colchicine results in increased activity of CASP3 protein]
Colchicine results in increased expression of CASP3 protein
dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of CASP3 protein]
Colchicine results in increased cleavage of CASP3 protein
Colchicine results in increased expression of CASP3 mRNA		 CTD PMID:12941380 PMID:15005753 PMID:16478524 PMID:18255150 PMID:19815060 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases expression EXP Colchicine results in increased expression of CASP8 mRNA CTD PMID:18255150 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Colchicine results in increased activity of CASP9 protein CTD PMID:22342440 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression EXP Colchicine results in increased expression of CAT mRNA CTD PMID:18255150 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Colchicine results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 8:109,722,595...109,741,478
Ensembl chr 8:109,722,557...109,741,472 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Colchicine results in increased expression of CCL2 mRNA CTD PMID:3119359 PMID:20624997 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Colchicine results in increased expression of CCNB1 mRNA; Colchicine results in increased expression of CCNB1 protein CTD PMID:21472861 PMID:27769712 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO
EXP		 Colchicine results in increased expression of CCND1 protein
Colchicine results in increased expression of CCND1 mRNA		 CTD PMID:16495211 PMID:18255150 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Colchicine results in decreased expression of CCNE2 mRNA CTD PMID:24211769 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd14 CD14 molecule increases expression EXP Colchicine results in increased expression of CD14 mRNA CTD PMID:20624997 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP Colchicine results in increased expression of CD44 mRNA CTD PMID:20624997 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd59 CD59 molecule increases mutagenesis ISO Colchicine results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO Colchicine results in decreased expression of CDC25A mRNA CTD PMID:24211769 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Colchicine results in decreased expression of CDC6 mRNA CTD PMID:24211769 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdh1 cadherin 1 affects activity ISO Colchicine affects the activity of CDH1 protein CTD PMID:10413674 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Colchicine results in increased expression of CDK2 mRNA CTD PMID:18255150 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression
multiple interactions		 EXP Colchicine results in increased expression of CDK5 protein
alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]		 CTD PMID:12941380 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression		 EXP
ISO		 Colchicine results in increased expression of CDKN1A mRNA
Colchicine results in increased expression of CDKN1A protein
Colchicine results in decreased expression of CDKN1A mRNA		 CTD PMID:20624997 PMID:24211769 PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Colchicine results in decreased expression of CDKN3 mRNA CTD PMID:20624997 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Celf2 CUGBP, Elav-like family member 2 multiple interactions
increases expression		 ISO 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased expression of CELF2 mRNA] CTD PMID:11478917 NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333 		JBrowse link
G Chaf1a chromatin assembly factor 1 subunit A decreases expression ISO Colchicine results in decreased expression of CHAF1A mRNA CTD PMID:24211769 NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654 		JBrowse link
G Chaf1b chromatin assembly factor 1 subunit B decreases expression ISO Colchicine results in decreased expression of CHAF1B mRNA CTD PMID:24211769 NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO Colchicine results in decreased expression of CLDN1 mRNA CTD PMID:33002524 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein decreases expression ISO Colchicine results in decreased expression of CLN8 mRNA CTD PMID:24211769 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774 		JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Colchicine results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 5:123,069,356...123,080,942
Ensembl chr 5:123,069,371...123,080,199 		JBrowse link
G Cp ceruloplasmin increases expression EXP Colchicine results in increased expression of CP mRNA CTD PMID:20624997 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Colchicine results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression		 EXP Colchicine results in decreased expression of CRH protein
Colchicine results in increased expression of CRH mRNA		 CTD PMID:1850078 PMID:2453250 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Colchicine results in increased expression of CXCL1 mRNA CTD PMID:3119359 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP		 Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:16611024 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Colchicine CTD PMID:15914514 PMID:16007523 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Colchicine results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO Colchicine results in decreased expression of DDIT4 mRNA CTD PMID:24211769 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Drd3 dopamine receptor D3 decreases expression EXP Colchicine results in decreased expression of DRD3 mRNA CTD PMID:7878047 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Dusp14 dual specificity phosphatase 14 decreases expression ISO Colchicine results in decreased expression of DUSP14 mRNA CTD PMID:24211769 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Colchicine results in decreased expression of E2F1 mRNA CTD PMID:24211769 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Colchicine results in increased expression of EDNRB mRNA CTD PMID:20624997 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Colchicine results in decreased expression of ENC1 mRNA CTD PMID:24211769 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression EXP Colchicine results in increased expression of EPRS mRNA CTD PMID:20624997 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966 		JBrowse link
G Esm1 endothelial cell-specific molecule 1 decreases expression EXP Colchicine results in decreased expression of ESM1 mRNA CTD PMID:20624997 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Colchicine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G F2 coagulation factor II affects activity ISO Colchicine affects the activity of F2 protein CTD PMID:8574231 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Colchicine results in increased expression of F3 mRNA CTD PMID:20624997 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fas Fas cell surface death receptor increases expression
decreases expression		 ISO Colchicine results in increased expression of FAS mRNA
Colchicine results in decreased expression of FAS protein		 CTD PMID:10675359 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fcgr2b Fc gamma receptor IIb increases expression EXP Colchicine results in increased expression of FCGR2B mRNA CTD PMID:20624997 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fdxr ferredoxin reductase decreases expression ISO Colchicine results in decreased expression of FDXR mRNA CTD PMID:24211769 NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects expression EXP Colchicine affects the expression of FGF2 protein CTD PMID:7714246 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP Colchicine results in increased expression of and affects the localization of FOS protein
Colchicine results in increased expression of FOS mRNA		 CTD PMID:3119359 PMID:7537689 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Colchicine results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 4:156,047,043...156,073,540
Ensembl chr 4:156,046,969...156,073,518 		JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Colchicine results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 4:29,310,303...29,314,701 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Colchicine results in increased expression of GADD45A mRNA CTD PMID:20624997 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression EXP Colchicine results in increased expression of GADD45B mRNA CTD PMID:20624997 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Colchicine results in increased expression of GADD45G mRNA CTD PMID:20624997 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Gas7 growth arrest specific 7 decreases expression EXP Colchicine results in decreased expression of GAS7 mRNA CTD PMID:20624997 NCBI chr10:52,152,728...52,383,276
Ensembl chr10:52,152,493...52,383,276 		JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression ISO Colchicine results in decreased expression of GCH1 mRNA CTD PMID:24211769 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Colchicine results in decreased expression of GDF15 mRNA CTD PMID:24211769 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form] CTD PMID:8824497 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression EXP Colchicine results in increased expression of GPX1 mRNA CTD PMID:18255150 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Colchicine results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP Colchicine results in decreased expression of GSK3B mRNA CTD PMID:18255150 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Colchicine results in decreased expression of HAL mRNA CTD PMID:32741898 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
affects expression		 EXP
ISO		 Colchicine results in increased expression of HMOX1 mRNA
[dihydroactinidiolide co-treated with Colchicine] results in increased expression of HMOX1 mRNA
Colchicine affects the expression of HMOX1 mRNA		 CTD PMID:20624997 PMID:22954530 PMID:33617922 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Colchicine results in increased expression of HSPA5 protein CTD PMID:27358234 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP Colchicine results in increased expression of ICAM1 mRNA CTD PMID:20624997 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Colchicine results in decreased expression of ID3 mRNA CTD PMID:24211769 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases phosphorylation
affects response to substance
multiple interactions		 ISO Colchicine results in increased phosphorylation of IKBKB protein
IKBKB protein affects the susceptibility to Colchicine
Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]		 CTD PMID:17029595 PMID:20159942 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] CTD PMID:11154858 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression		 EXP
ISO		 Colchicine results in increased expression of IL1B mRNA
Colchicine results in decreased expression of IL1B mRNA		 CTD PMID:20624997 PMID:29594315 PMID:33002524 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 ISO Colchicine results in decreased expression of IL2 protein
[Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA		 CTD PMID:1553933 PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
multiple interactions		 EXP
ISO		 Colchicine results in increased expression of IL6 mRNA
Colchicine results in decreased expression of IL6 mRNA
Colchicine inhibits the reaction [Ethanol results in increased expression of IL6 protein]		 CTD PMID:20624997 PMID:22446813 PMID:33002524 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inha inhibin subunit alpha decreases expression EXP Colchicine results in decreased expression of INHA mRNA CTD PMID:20624997 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Colchicine results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
increases activity		 ISO
EXP		 Colchicine results in increased phosphorylation of JUN protein
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased phosphorylation of JUN protein]; Colchicine results in increased expression of and results in increased phosphorylation of JUN protein
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased activity of JUN protein]; Colchicine results in increased phosphorylation of and results in increased localization of JUN protein		 CTD PMID:12221076 PMID:16478524 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Colchicine results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780 		JBrowse link
G Klf6 Kruppel-like factor 6 increases expression ISO Colchicine results in increased expression of KLF6 mRNA CTD PMID:24211769 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Krt18 keratin 18 decreases expression ISO Colchicine results in decreased expression of KRT18 protein CTD PMID:11259854 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lhx2 LIM homeobox 2 decreases expression ISO Colchicine results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 3:22,113,619...22,143,909
Ensembl chr 3:22,126,007...22,143,908 		JBrowse link
G LOC102548695 zinc finger protein 45-like decreases expression ISO Colchicine results in decreased expression of ZNF45 mRNA CTD PMID:24211769 NCBI chr 1:79,885,875...79,896,601
Ensembl chr 1:79,884,945...79,900,149 		JBrowse link
G LOC683674 similar to Protein C7orf26 homolog decreases expression ISO Colchicine results in decreased expression of C7ORF26 mRNA CTD PMID:24211769 NCBI chr12:11,245,045...11,260,170
Ensembl chr12:11,245,842...11,260,166 		JBrowse link
G Lrp2 LDL receptor related protein 2 affects localization EXP Colchicine affects the localization of LRP2 protein CTD PMID:25588984 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Colchicine results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Colchicine results in increased phosphorylation of MAPK8 protein
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]		 CTD PMID:12221076 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Colchicine results in increased phosphorylation of MAPK9 protein
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein]		 CTD PMID:12221076 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Colchicine results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO Colchicine results in decreased expression of MCM10 mRNA CTD PMID:24211769 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine CTD PMID:11792417 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Colchicine results in decreased expression of MMP9 mRNA CTD PMID:33684465 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Colchicine inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Colchicine results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Colchicine results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Colchicine results in increased expression of MYC mRNA CTD PMID:3119359 PMID:20624997 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myt1 myelin transcription factor 1 increases phosphorylation ISO Colchicine results in increased phosphorylation of MYT1 protein CTD PMID:16611024 NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341 		JBrowse link
G Nbn nibrin increases expression EXP Colchicine results in increased expression of NBN mRNA CTD PMID:20624997 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 affects response to substance ISO NDUFS4 protein affects the susceptibility to Colchicine CTD PMID:21383081 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 decreases localization ISO Colchicine results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [dihydroactinidiolide co-treated with Colchicine] results in increased expression of NFE2L2 mRNA CTD PMID:33617922 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions		 ISO Colchicine results in increased phosphorylation of NFKBIA protein
Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]		 CTD PMID:17029595 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP Colchicine results in increased expression of NOS1 protein CTD PMID:7537689 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA] CTD PMID:23146695 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nptx1 neuronal pentraxin 1 increases expression EXP Colchicine results in increased expression of NPTX1 mRNA CTD PMID:18255150 NCBI chr10:104,811,107...104,820,358
Ensembl chr10:104,811,403...104,820,367 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases degradation
increases activity		 ISO Colchicine results in decreased localization of and results in decreased activity of NR3C1 protein
Colchicine results in increased degradation of NR3C1 protein
Colchicine results in increased activity of NR3C1 protein		 CTD PMID:15744361 PMID:20448266 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nts neurotensin increases expression EXP Colchicine results in increased expression of NTS mRNA CTD PMID:1850078 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Ocln occludin decreases expression ISO Colchicine results in decreased expression of OCLN mRNA CTD PMID:33002524 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases expression		 ISO
EXP		 Colchicine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Colchicine results in increased expression of ODC1 mRNA		 CTD PMID:3119359 PMID:9270009 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression ISO Colchicine results in decreased expression of ORAI3 mRNA CTD PMID:24211769 NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052 		JBrowse link
G Palb2 partner and localizer of BRCA2 decreases expression ISO Colchicine results in decreased expression of PALB2 mRNA CTD PMID:24211769 NCBI chr 1:176,665,076...176,689,053
Ensembl chr 1:176,665,076...176,688,990 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Colchicine results in increased cleavage of PARP1 protein CTD PMID:33684465 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator increases expression
multiple interactions		 EXP Colchicine results in increased expression of PAWR protein
alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein]		 CTD PMID:12941380 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO Colchicine promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Colchicine results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression ISO Colchicine results in decreased expression of PHLDA3 mRNA CTD PMID:24211769 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pidd1 p53-induced death domain protein 1 decreases expression ISO Colchicine results in decreased expression of PIDD1 mRNA CTD PMID:24211769 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699 		JBrowse link
G Plagl1 PLAG1 like zinc finger 1 increases expression EXP Colchicine results in increased expression of PLAGL1 mRNA CTD PMID:20624997 NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228 		JBrowse link
G Plat plasminogen activator, tissue type increases expression EXP Colchicine results in increased expression of PLAT mRNA CTD PMID:20624997 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Colchicine results in increased expression of PLAUR mRNA CTD PMID:20624997 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 decreases expression ISO Colchicine results in decreased expression of PLEKHF1 mRNA CTD PMID:24211769 NCBI chr 1:90,908,304...90,915,862
Ensembl chr 1:90,904,742...90,915,820 		JBrowse link
G Plxnb2 plexin B2 decreases expression ISO Colchicine results in decreased expression of PLXNB2 mRNA CTD PMID:24211769 NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330 		JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Colchicine results in increased secretion of POMC protein CTD PMID:2453250 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D decreases expression ISO Colchicine results in decreased expression of PPM1D mRNA CTD PMID:24211769 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha increases expression ISO Colchicine results in increased expression of PPP1CA protein CTD PMID:16495211 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Colchicine results in increased expression of PPP1R15A mRNA CTD PMID:20624997 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression ISO Colchicine results in decreased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Psmc3ip PSMC3 interacting protein decreases expression ISO Colchicine results in decreased expression of PSMC3IP mRNA CTD PMID:24211769 NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions
increases phosphorylation		 ISO 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein] CTD PMID:11478917 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 decreases expression ISO Colchicine results in decreased expression of PTP4A1 mRNA CTD PMID:24211769 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964 		JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Colchicine results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 8:33,910,461...33,918,716
Ensembl chr 8:33,911,357...33,918,714 		JBrowse link
G Rad51c RAD51 paralog C decreases expression ISO Colchicine results in decreased expression of RAD51C mRNA CTD PMID:24211769 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Ralbp1 ralA binding protein 1 multiple interactions
affects transport		 ISO Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4]
RALBP1 protein affects the transport of Colchicine		 CTD PMID:15386349 NCBI chr 9:105,456,425...105,492,711
Ensembl chr 9:105,456,425...105,492,707 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family decreases expression ISO Colchicine results in decreased expression of RAP2B mRNA CTD PMID:24211769 NCBI chr 2:145,599,714...145,600,265
Ensembl chr 2:145,599,116...145,603,069 		JBrowse link
G Rassf1 Ras association domain family member 1 increases expression EXP Colchicine results in increased expression of RASSF1 mRNA CTD PMID:20624997 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Colchicine results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:16495211 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rbm34 RNA binding motif protein 34 decreases expression ISO Colchicine results in decreased expression of RBM34 mRNA CTD PMID:24211769 NCBI chr19:54,936,516...54,956,810
Ensembl chr19:54,936,531...54,956,715 		JBrowse link
G Rfc1 replication factor C subunit 1 decreases expression ISO Colchicine results in decreased expression of RFC1 mRNA CTD PMID:24211769 NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Colchicine results in decreased expression of RGS16 mRNA CTD PMID:24211769 NCBI chr13:65,887,788...65,891,232
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Colchicine results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:116,428,037...116,429,164
Ensembl chr  X:116,427,684...116,433,762 		JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Colchicine results in decreased expression of RNF19B mRNA CTD PMID:24211769 NCBI chr 5:141,406,085...141,431,380
Ensembl chr 5:141,406,118...141,431,380 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Colchicine results in increased expression of S100A8 mRNA CTD PMID:20624997 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Colchicine results in increased expression of S100A9 mRNA CTD PMID:20624997 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Sac3d1 SAC3 domain containing 1 decreases expression ISO Colchicine results in decreased expression of SAC3D1 mRNA CTD PMID:24211769 NCBI chr 1:203,414,181...203,416,619
Ensembl chr 1:203,414,187...203,416,604 		JBrowse link
G Sct secretin multiple interactions EXP Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] CTD PMID:22194894 NCBI chr 1:196,382,941...196,383,635
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Sdc1 syndecan 1 decreases expression ISO Colchicine results in decreased expression of SDC1 mRNA CTD PMID:24211769 NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 decreases expression ISO Colchicine results in decreased expression of SDHAF1 mRNA CTD PMID:24211769 NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366
Ensembl chr 1:85,576,041...85,577,366 		JBrowse link
G Sele selectin E increases expression EXP Colchicine results in increased expression of SELE mRNA CTD PMID:20624997 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpina6 serpin family A member 6 decreases transport EXP Colchicine results in decreased transport of SERPINA6 protein CTD PMID:16700006 NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Colchicine results in increased expression of SERPINE1 mRNA CTD PMID:20624997 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sesn1 sestrin 1 increases expression
decreases expression		 EXP
ISO		 Colchicine results in increased expression of SESN1 mRNA
Colchicine results in decreased expression of SESN1 mRNA		 CTD PMID:20624997 PMID:24211769 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression ISO Colchicine results in decreased expression of SGK1 mRNA CTD PMID:24211769 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Slbp stem-loop binding protein decreases expression ISO Colchicine results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr14:77,071,441...77,081,911
Ensembl chr14:77,071,632...77,081,906 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO Colchicine results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Spon1 spondin 1 increases expression EXP Colchicine results in increased expression of SPON1 mRNA CTD PMID:20624997 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions
increases cleavage		 ISO 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased cleavage of SPTAN1 protein] CTD PMID:16478524 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Colchicine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Colchicine deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tat tyrosine aminotransferase multiple interactions
decreases expression		 ISO pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] CTD PMID:15744361 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions
affects phosphorylation		 EXP Colchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein]
Colchicine affects the phosphorylation of TBC1D4 protein		 CTD PMID:18063688 NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression EXP Colchicine results in increased expression of TFPI2 mRNA CTD PMID:20624997 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:14726149 PMID:22446813 PMID:23146695 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbd thrombomodulin increases expression EXP Colchicine results in increased expression of THBD mRNA CTD PMID:20624997 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Colchicine results in increased expression of THBS1 mRNA CTD PMID:20624997 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Colchicine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Colchicine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase decreases expression ISO Colchicine results in decreased expression of TIGAR mRNA CTD PMID:24211769 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Colchicine results in increased expression of TIMP1 mRNA CTD PMID:20624997 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tipin timeless interacting protein decreases expression ISO Colchicine results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 8:64,780,741...64,801,355
Ensembl chr 8:64,780,828...64,801,352 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO Colchicine results in decreased expression of TJP1 mRNA CTD PMID:33002524 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Colchicine results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr13:30,647,533...30,650,864
Ensembl chr13:30,647,482...30,650,858 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 ISO
EXP		 Colchicine results in decreased expression of TNF protein
Colchicine results in decreased expression of TNF mRNA
Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein]		 CTD PMID:1553933 PMID:11154858 PMID:22446813 PMID:23146695 PMID:33002524 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A affects response to substance ISO TNFRSF1A protein affects the susceptibility to Colchicine CTD PMID:20159942 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf9 TNF superfamily member 9 decreases expression ISO Colchicine results in decreased expression of TNFSF9 mRNA CTD PMID:24211769 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345 		JBrowse link
G Tnni3 troponin I3, cardiac type increases expression EXP Colchicine results in increased expression of TNNI3 protein CTD PMID:20624997 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Top3a DNA topoisomerase III alpha decreases expression ISO Colchicine results in decreased expression of TOP3A mRNA CTD PMID:24211769 NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559 		JBrowse link
G Tor1a torsin family 1, member A decreases expression ISO Colchicine results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 3:14,250,667...14,257,704
Ensembl chr 3:14,250,676...14,257,691 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein] CTD PMID:12221076 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpd52l1 TPD52 like 1 increases expression EXP Colchicine results in increased expression of TPD52L1 mRNA CTD PMID:20624997 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 affects response to substance ISO TRAF2 protein affects the susceptibility to Colchicine CTD PMID:20159942 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 decreases expression ISO Colchicine results in decreased expression of TRIAP1 mRNA CTD PMID:24211769 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Trim26 tripartite motif-containing 26 decreases expression ISO Colchicine results in decreased expression of TRIM26 mRNA CTD PMID:24211769 NCBI chr20:1,708,297...1,731,176
Ensembl chr20:1,709,788...1,731,120 		JBrowse link
G Trim32 tripartite motif-containing 32 decreases expression ISO Colchicine results in decreased expression of TRIM32 mRNA CTD PMID:24211769 NCBI chr 5:79,005,139...79,016,615
Ensembl chr 5:78,999,389...79,022,018 		JBrowse link
G Trim38 tripartite motif containing 38 decreases expression ISO Colchicine results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr17:41,351,857...41,365,021 JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression EXP Colchicine results in decreased expression of TUBA1B mRNA CTD PMID:20624997 NCBI chr 7:130,090,669...130,093,644
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression EXP Colchicine results in decreased expression of TUBA4A mRNA CTD PMID:20624997 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression EXP Colchicine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 NCBI chr 3:8,037,844...8,040,294
Ensembl chr 3:8,037,799...8,040,296 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Colchicine results in decreased expression of TUBB5 mRNA CTD PMID:20624997 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tubg1 tubulin, gamma 1 decreases expression EXP Colchicine results in decreased expression of TUBG1 mRNA CTD PMID:20624997 NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433 		JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Colchicine results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 EXP
ISO		 Colchicine results in increased expression of VCAM1 mRNA
Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]		 CTD PMID:11154858 PMID:20624997 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vip vasoactive intestinal peptide increases expression EXP Colchicine results in increased expression of VIP mRNA; Colchicine results in increased expression of VIP protein CTD PMID:1850078 PMID:8837219 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases expression ISO Colchicine results in decreased expression of XPC mRNA CTD PMID:24211769 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Colchicine results in decreased expression of ZBTB24 mRNA CTD PMID:24211769 NCBI chr20:44,943,302...44,965,329
Ensembl chr20:44,947,297...44,963,963 		JBrowse link
G Zfp202 zinc finger protein 202 decreases expression ISO Colchicine results in decreased expression of ZNF202 mRNA CTD PMID:24211769 NCBI chr 8:40,542,665...40,567,397
Ensembl chr 8:40,542,701...40,563,118 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 decreases expression ISO Colchicine results in decreased expression of ZFP36L1 mRNA CTD PMID:24211769 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        anti-inflammatory agent 15841
          (S)-colchicine 224
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        carboacyl group 17469
                                          univalent carboacyl group 17469
                                            carbamoyl group 17285
                                              carboxamide 17285
                                                acetamides 12410
                                                  colchicine 224
                                                    (S)-colchicine 224
paths to the root