CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (S)-colchicine
Accession: CHEBI:27882
browse the term
Definition: A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Synonyms: exact_synonym: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
related_synonym: (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; 7alphaH-colchicine; Colchicin; Colchicine; Colchisol; Colcin; Colcrys; Colsaloid; Condylon; Formula=C22H25NO6; Goutnil; InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1; InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N; Kolkicin; Mitigare; SMILES=COC1=CC2=C(C(OC)=C1OC)C1=CC=C(OC)C(=O)C=C1[C@H](CC2)NC(C)=O; colchicina; colchicinum
alt_id: CHEBI:3811
xref: Beilstein:2228813; CAS:64-86-8; Chemspider:5933; DrugBank:DB01394; Drug_Central:726; KEGG:C07592; KEGG:D00570; KNApSAcK:C00002327; LINCS:LSM-5199
xref_mesh: MESH:D003078
xref: MetaCyc:CPD-9785; PDBeChem:LOC; PMID:16188942; PMID:17619668; PMID:18787557; PMID:24530796; PMID:28832953; PMID:28912485; PMID:28959419; PMID:30565859; PMID:32025680; PMID:32426001; PMID:32511763; PMID:32837853; PMID:32865380; PMID:33100196; PMID:33166069; Wikipedia:Colchicine
cyclic_relationship: is_enantiomer_of CHEBI:51074
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Abca13
ATP binding cassette subfamily A member 13
affects response to substance
ISO
ABCA13 gene SNP affects the susceptibility to Colchicine
CTD
PMID:25622337
NCBI chr14:89,384,512...89,876,748
Ensembl chr14:89,384,512...89,714,917
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Abcb11
ATP binding cassette subfamily B member 11
affects localization
EXP
Colchicine affects the localization of ABCB11 protein
CTD
PMID:12702492 PMID:15304119
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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Abcb1a
ATP binding cassette subfamily B member 1A
affects transport increases export increases expression multiple interactions decreases response to substance
ISO
ABCB1 protein affects the transport of Colchicine ABCB1 protein results in increased export of Colchicine Colchicine results in increased expression of ABCB1; Colchicine results in increased expression of ABCB1 mRNA [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form] ABCB1 protein results in decreased susceptibility to Colchicine
CTD
PMID:7905786 PMID:11792417 PMID:12711602 PMID:15112361 PMID:15342794 PMID:15725475 PMID:16007523 PMID:24759273
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcc1
ATP binding cassette subfamily C member 1
decreases response to substance
ISO
ABCC1 protein results in decreased susceptibility to Colchicine
CTD
PMID:12067707
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
EXP
[Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]
CTD
PMID:31300867
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcc3
ATP binding cassette subfamily C member 3
affects localization
EXP
Colchicine affects the localization of ABCC3 protein
CTD
PMID:12702492
NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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Abcc4
ATP binding cassette subfamily C member 4
multiple interactions
ISO
Colchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein]
CTD
PMID:18468992
NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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Ace
angiotensin I converting enzyme
multiple interactions decreases activity decreases expression
EXP
carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]; resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein]
CTD
PMID:17135773 PMID:17652827 PMID:18980205 PMID:18992766
NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]
CTD
PMID:14726149 PMID:22446813
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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Ahr
aryl hydrocarbon receptor
decreases activity
ISO EXP
Colchicine results in decreased activity of AHR protein
CTD
PMID:16611024
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Aif1
allograft inflammatory factor 1
decreases expression
EXP
Colchicine results in decreased expression of AIF1 mRNA
CTD
PMID:20624997
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
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Ak1
adenylate kinase 1
decreases expression
EXP
Colchicine results in decreased expression of AK1 mRNA
CTD
PMID:20624997
NCBI chr 3:11,652,143...11,659,135
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Alb
albumin
affects expression multiple interactions
ISO EXP
Colchicine affects the expression of ALB protein Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein]
CTD
PMID:8574231 PMID:23146695
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Apln
apelin
decreases expression
EXP
Colchicine results in decreased expression of APLN mRNA
CTD
PMID:20624997
NCBI chr X:134,856,719...134,866,210
Ensembl chr X:134,856,726...134,866,210
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Atxn1
ataxin 1
decreases expression
ISO
Colchicine results in decreased expression of ATXN1 mRNA
CTD
PMID:24211769
NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814
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Aurkb
aurora kinase B
increases expression
ISO
Colchicine results in increased expression of AURKB mRNA
CTD
PMID:21472861
NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
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Avp
arginine vasopressin
decreases transport
EXP
Colchicine results in decreased transport of AVP protein
CTD
PMID:2453250
NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Colchicine results in increased expression of BAX protein
CTD
PMID:22342440
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
EXP ISO
Colchicine inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] Colchicine results in decreased expression of BCL2 protein
CTD
PMID:22342440 PMID:22446813
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bcl2l1
Bcl2-like 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with Colchicine] results in decreased expression of BCL2L1 protein
CTD
PMID:11749691
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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Bdnf
brain-derived neurotrophic factor
decreases transport
EXP
Colchicine results in decreased transport of BDNF protein
CTD
PMID:21310905
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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Blm
BLM RecQ like helicase
decreases expression
ISO
Colchicine results in decreased expression of BLM mRNA
CTD
PMID:24211769
NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
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Btg1
BTG anti-proliferation factor 1
decreases expression
ISO
Colchicine results in decreased expression of BTG1 mRNA
CTD
PMID:24211769
NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
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Btg2
BTG anti-proliferation factor 2
decreases expression
ISO
Colchicine results in decreased expression of BTG2 mRNA
CTD
PMID:24211769
NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
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Btg3
BTG anti-proliferation factor 3
decreases expression
ISO
Colchicine results in decreased expression of BTG3 mRNA
CTD
PMID:24211769
NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
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C3
complement C3
increases expression
EXP
Colchicine results in increased expression of C3 mRNA
CTD
PMID:20624997
NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
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Capn1
calpain 1
decreases expression
EXP
Colchicine results in decreased expression of CAPN1 mRNA
CTD
PMID:18255150
NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
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Casp3
caspase 3
multiple interactions increases activity increases expression increases cleavage
EXP ISO
alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; SB 216763 inhibits the reaction [Colchicine results in increased activity of CASP3 protein] Colchicine results in increased expression of CASP3 mRNA Colchicine results in increased cleavage of CASP3 protein
CTD
PMID:12941380 PMID:15005753 PMID:16478524 PMID:18255150 PMID:19815060 PMID:20300959 PMID:20624997 PMID:22342440
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp8
caspase 8
increases expression
EXP
Colchicine results in increased expression of CASP8 mRNA
CTD
PMID:18255150
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Casp9
caspase 9
increases activity
ISO
Colchicine results in increased activity of CASP9 protein
CTD
PMID:22342440
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cat
catalase
increases expression
EXP
Colchicine results in increased expression of CAT mRNA
CTD
PMID:18255150
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Ccdc51
coiled-coil domain containing 51
decreases expression
ISO
Colchicine results in decreased expression of CCDC51 mRNA
CTD
PMID:24211769
NCBI chr 8:117,812,091...117,830,848
Ensembl chr 8:117,812,099...117,830,868
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Ccl2
C-C motif chemokine ligand 2
increases expression
EXP
Colchicine results in increased expression of CCL2 mRNA
CTD
PMID:3119359 PMID:20624997
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Ccnb1
cyclin B1
increases expression
ISO
Colchicine results in increased expression of CCNB1 mRNA; Colchicine results in increased expression of CCNB1 protein
CTD
PMID:21472861 PMID:27769712
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Ccnd1
cyclin D1
increases expression
ISO EXP
Colchicine results in increased expression of CCND1 protein Colchicine results in increased expression of CCND1 mRNA
CTD
PMID:16495211 PMID:18255150
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Ccne2
cyclin E2
decreases expression
ISO
Colchicine results in decreased expression of CCNE2 mRNA
CTD
PMID:24211769
NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
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Cd14
CD14 molecule
increases expression
EXP
Colchicine results in increased expression of CD14 mRNA
CTD
PMID:20624997
NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
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Cd44
CD44 molecule (Indian blood group)
increases expression
EXP
Colchicine results in increased expression of CD44 mRNA
CTD
PMID:20624997
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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Cd59
CD59 molecule
increases mutagenesis
ISO
Colchicine results in increased mutagenesis of CD59 protein
CTD
PMID:17045307
NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
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Cdc25a
cell division cycle 25A
decreases expression
ISO
Colchicine results in decreased expression of CDC25A mRNA
CTD
PMID:24211769
NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
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Cdc6
cell division cycle 6
decreases expression
ISO
Colchicine results in decreased expression of CDC6 mRNA
CTD
PMID:24211769
NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
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Cdh1
cadherin 1
affects activity
ISO
Colchicine affects the activity of CDH1 protein
CTD
PMID:10413674
NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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Cdk2
cyclin dependent kinase 2
increases expression
EXP
Colchicine results in increased expression of CDK2 mRNA
CTD
PMID:18255150
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Cdk5
cyclin-dependent kinase 5
increases expression multiple interactions
EXP
Colchicine results in increased expression of CDK5 protein alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]
CTD
PMID:12941380
NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression decreases expression
EXP ISO
Colchicine results in increased expression of CDKN1A mRNA Colchicine results in increased expression of CDKN1A protein Colchicine results in decreased expression of CDKN1A mRNA
CTD
PMID:20624997 PMID:24211769 PMID:27358234
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
EXP
Colchicine results in decreased expression of CDKN3 mRNA
CTD
PMID:20624997
NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
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Celf2
CUGBP, Elav-like family member 2
multiple interactions increases expression
ISO
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased expression of CELF2 mRNA]
CTD
PMID:11478917
NCBI chr17:75,259,269...75,660,154
Ensembl chr17:75,352,389...75,654,951
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Chaf1a
chromatin assembly factor 1 subunit A
decreases expression
ISO
Colchicine results in decreased expression of CHAF1A mRNA
CTD
PMID:24211769
NCBI chr 9:11,000,869...11,027,631
Ensembl chr 9:11,001,129...11,027,506
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Chaf1b
chromatin assembly factor 1 subunit B
decreases expression
ISO
Colchicine results in decreased expression of CHAF1B mRNA
CTD
PMID:24211769
NCBI chr11:34,101,248...34,121,371
Ensembl chr11:34,101,197...34,121,378
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Cln8
CLN8, transmembrane ER and ERGIC protein
decreases expression
ISO
Colchicine results in decreased expression of CLN8 mRNA
CTD
PMID:24211769
NCBI chr16:79,828,321...79,838,212
Ensembl chr16:79,828,324...79,838,212
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Coa7
cytochrome c oxidase assembly factor 7
decreases expression
ISO
Colchicine results in decreased expression of COA7 mRNA
CTD
PMID:24211769
NCBI chr 5:127,925,726...127,936,516
Ensembl chr 5:127,925,726...127,936,509
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Cp
ceruloplasmin
increases expression
EXP
Colchicine results in increased expression of CP mRNA
CTD
PMID:20624997
NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
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Cpt2
carnitine palmitoyltransferase 2
decreases expression
ISO
Colchicine results in decreased expression of CPT2 mRNA
CTD
PMID:24211769
NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
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Crh
corticotropin releasing hormone
decreases expression increases expression
EXP
Colchicine results in decreased expression of CRH protein Colchicine results in increased expression of CRH mRNA
CTD
PMID:1850078 PMID:2453250
NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
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Csf2
colony stimulating factor 2
multiple interactions
ISO
Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [Quercetin results in increased secretion of CSF2 protein]
CTD
PMID:18346843
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
Colchicine results in increased expression of CXCL1 mRNA
CTD
PMID:3119359
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO EXP
Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
CTD
PMID:16611024
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
affects metabolic processing
ISO
CYP3A4 protein affects the metabolism of Colchicine
CTD
PMID:15914514 PMID:16007523
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Colchicine results in increased expression of DDIT3 protein
CTD
PMID:27358234
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Ddit4
DNA-damage-inducible transcript 4
decreases expression
ISO
Colchicine results in decreased expression of DDIT4 mRNA
CTD
PMID:24211769
NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
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Drd3
dopamine receptor D3
decreases expression
EXP
Colchicine results in decreased expression of DRD3 mRNA
CTD
PMID:7878047
NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
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Dusp14
dual specificity phosphatase 14
decreases expression
ISO
Colchicine results in decreased expression of DUSP14 mRNA
CTD
PMID:24211769
NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
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E2f1
E2F transcription factor 1
decreases expression
ISO
Colchicine results in decreased expression of E2F1 mRNA
CTD
PMID:24211769
NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
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Ednrb
endothelin receptor type B
increases expression
EXP
Colchicine results in increased expression of EDNRB mRNA
CTD
PMID:20624997
NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
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Enc1
ectodermal-neural cortex 1
decreases expression
ISO
Colchicine results in decreased expression of ENC1 mRNA
CTD
PMID:24211769
NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
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Eprs
glutamyl-prolyl-tRNA synthetase
increases expression
EXP
Colchicine results in increased expression of EPRS mRNA
CTD
PMID:20624997
NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
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Esm1
endothelial cell-specific molecule 1
decreases expression
EXP
Colchicine results in decreased expression of ESM1 mRNA
CTD
PMID:20624997
NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131
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Esr1
estrogen receptor 1
multiple interactions
ISO
Colchicine binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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F2
coagulation factor II
affects activity
ISO
Colchicine affects the activity of F2 protein
CTD
PMID:8574231
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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F3
coagulation factor III, tissue factor
increases expression
EXP
Colchicine results in increased expression of F3 mRNA
CTD
PMID:20624997
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
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Fas
Fas cell surface death receptor
increases expression decreases expression
ISO
Colchicine results in increased expression of FAS mRNA Colchicine results in decreased expression of FAS protein
CTD
PMID:10675359
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Fcgr2b
Fc fragment of IgG receptor IIb
increases expression
EXP
Colchicine results in increased expression of FCGR2B mRNA
CTD
PMID:20624997
NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
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Fdxr
ferredoxin reductase
decreases expression
ISO
Colchicine results in decreased expression of FDXR mRNA
CTD
PMID:24211769
NCBI chr10:103,817,724...103,826,413
Ensembl chr10:103,817,704...103,826,448
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Fgf2
fibroblast growth factor 2
affects expression
EXP
Colchicine affects the expression of FGF2 protein
CTD
PMID:7714246
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
EXP
Colchicine results in increased expression of and affects the localization of FOS protein Colchicine results in increased expression of FOS mRNA
CTD
PMID:3119359 PMID:7537689
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
G
Foxj2
forkhead box J2
decreases expression
ISO
Colchicine results in decreased expression of FOXJ2 mRNA
CTD
PMID:24211769
NCBI chr 4:155,653,446...155,679,815
Ensembl chr 4:155,653,718...155,679,793
G
Fzd1
frizzled class receptor 1
decreases expression
ISO
Colchicine results in decreased expression of FZD1 mRNA
CTD
PMID:24211769
NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
Colchicine results in increased expression of GADD45A mRNA
CTD
PMID:20624997
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
G
Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
EXP
Colchicine results in increased expression of GADD45B mRNA
CTD
PMID:20624997
NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
G
Gadd45g
growth arrest and DNA-damage-inducible, gamma
increases expression
EXP
Colchicine results in increased expression of GADD45G mRNA
CTD
PMID:20624997
NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
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Gas7
growth arrest specific 7
decreases expression
EXP
Colchicine results in decreased expression of GAS7 mRNA
CTD
PMID:20624997
NCBI chr10:54,010,723...54,240,805
Ensembl chr10:54,126,486...54,236,476
G
Gch1
GTP cyclohydrolase 1
decreases expression
ISO
Colchicine results in decreased expression of GCH1 mRNA
CTD
PMID:24211769
NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
G
Gdf15
growth differentiation factor 15
decreases expression
ISO
Colchicine results in decreased expression of GDF15 mRNA
CTD
PMID:24211769
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
G
Gja1
gap junction protein, alpha 1
multiple interactions
EXP
Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]
CTD
PMID:8824497
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
G
Gpx1
glutathione peroxidase 1
increases expression
EXP
Colchicine results in increased expression of GPX1 mRNA
CTD
PMID:18255150
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
G
Grpel1
GrpE-like 1, mitochondrial
decreases expression
ISO
Colchicine results in decreased expression of GRPEL1 mRNA
CTD
PMID:24211769
NCBI chr14:79,458,951...79,464,782
Ensembl chr14:79,458,963...79,464,770
G
Gsk3b
glycogen synthase kinase 3 beta
decreases expression
EXP
Colchicine results in decreased expression of GSK3B mRNA
CTD
PMID:18255150
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
G
Hmox1
heme oxygenase 1
increases expression affects expression
EXP
Colchicine results in increased expression of HMOX1 mRNA Colchicine affects the expression of HMOX1 mRNA
CTD
PMID:20624997 PMID:22954530
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
G
Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Colchicine results in increased expression of HSPA5 protein
CTD
PMID:27358234
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
G
Icam1
intercellular adhesion molecule 1
increases expression
EXP
Colchicine results in increased expression of ICAM1 mRNA
CTD
PMID:20624997
NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
G
Id3
inhibitor of DNA binding 3, HLH protein
decreases expression
ISO
Colchicine results in decreased expression of ID3 mRNA
CTD
PMID:24211769
NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
G
Ifng
interferon gamma
multiple interactions
ISO
[Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
CTD
PMID:29594315
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
G
Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
increases phosphorylation affects response to substance multiple interactions
ISO
Colchicine results in increased phosphorylation of IKBKB protein IKBKB protein affects the susceptibility to Colchicine Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD
PMID:17029595 PMID:20159942
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]
CTD
PMID:11154858
NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
G
Il1b
interleukin 1 beta
increases expression
EXP ISO
Colchicine results in increased expression of IL1B mRNA
CTD
PMID:20624997 PMID:29594315
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
G
Il2
interleukin 2
decreases expression multiple interactions
ISO
Colchicine results in decreased expression of IL2 protein [Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA
CTD
PMID:1553933 PMID:29594315
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
G
Il6
interleukin 6
increases expression multiple interactions
EXP
Colchicine results in increased expression of IL6 mRNA Colchicine inhibits the reaction [Ethanol results in increased expression of IL6 protein]
CTD
PMID:20624997 PMID:22446813
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
G
Inha
inhibin subunit alpha
decreases expression
EXP
Colchicine results in decreased expression of INHA mRNA
CTD
PMID:20624997
NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
G
Isg20l2
interferon stimulated exonuclease gene 20-like 2
decreases expression
ISO
Colchicine results in decreased expression of ISG20L2 mRNA
CTD
PMID:24211769
NCBI chr 2:187,302,192...187,311,677
Ensembl chr 2:187,302,192...187,311,676
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation multiple interactions increases activity
ISO EXP
Colchicine results in increased phosphorylation of JUN protein 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased phosphorylation of JUN protein]; Colchicine results in increased expression of and results in increased phosphorylation of JUN protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein] 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased activity of JUN protein]; Colchicine results in increased phosphorylation of and results in increased localization of JUN protein
CTD
PMID:12221076 PMID:16478524
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Kif20a
kinesin family member 20A
decreases expression
ISO
Colchicine results in decreased expression of KIF20A mRNA
CTD
PMID:24211769
NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
G
Klf6
Kruppel-like factor 6
increases expression
ISO
Colchicine results in increased expression of KLF6 mRNA
CTD
PMID:24211769
NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
G
Krt18
keratin 18
decreases expression
ISO
Colchicine results in decreased expression of KRT18 protein
CTD
PMID:11259854
NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
G
Lhx2
LIM homeobox 2
decreases expression
ISO
Colchicine results in decreased expression of LHX2 mRNA
CTD
PMID:24211769
NCBI chr 3:22,628,674...22,658,447
Ensembl chr 3:22,640,545...22,658,446
G
LOC102548695
zinc finger protein 45-like
decreases expression
ISO
Colchicine results in decreased expression of ZNF45 mRNA
CTD
PMID:24211769
NCBI chr 1:81,158,743...81,173,245
Ensembl chr 1:81,159,107...81,163,689
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LOC683674
similar to Protein C7orf26 homolog
decreases expression
ISO
Colchicine results in decreased expression of C7ORF26 mRNA
CTD
PMID:24211769
NCBI chr12:13,299,651...13,313,733
Ensembl chr12:13,299,859...13,313,358
G
Lrp2
LDL receptor related protein 2
affects localization
EXP
Colchicine affects the localization of LRP2 protein
CTD
PMID:25588984
NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
G
Lrrc47
leucine rich repeat containing 47
decreases expression
ISO
Colchicine results in decreased expression of LRRC47 mRNA
CTD
PMID:24211769
NCBI chr 5:171,297,850...171,307,682
Ensembl chr 5:171,297,850...171,307,682
G
Mapk8
mitogen-activated protein kinase 8
increases phosphorylation multiple interactions
ISO
Colchicine results in increased phosphorylation of MAPK8 protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]
CTD
PMID:12221076
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
G
Mapk9
mitogen-activated protein kinase 9
increases phosphorylation multiple interactions
ISO
Colchicine results in increased phosphorylation of MAPK9 protein TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein]
CTD
PMID:12221076
NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
G
Mapt
microtubule-associated protein tau
decreases expression
ISO
Colchicine results in decreased expression of MAPT protein
CTD
PMID:16930453
NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
G
Mcm10
minichromosome maintenance 10 replication initiation factor
decreases expression
ISO
Colchicine results in decreased expression of MCM10 mRNA
CTD
PMID:24211769
NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
G
Mgmt
O-6-methylguanine-DNA methyltransferase
multiple interactions
ISO
[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine
CTD
PMID:11792417
NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
G
Mpo
myeloperoxidase
multiple interactions
EXP
Colchicine inhibits the reaction [Ethanol results in increased activity of MPO protein]
CTD
PMID:22446813
NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
G
Mrm2
mitochondrial rRNA methyltransferase 2
decreases expression
ISO
Colchicine results in decreased expression of MRM2 mRNA
CTD
PMID:24211769
NCBI chr12:16,398,749...16,403,656
Ensembl chr12:16,398,749...16,403,656
G
Msh6
mutS homolog 6
decreases expression
ISO
Colchicine results in decreased expression of MSH6 mRNA
CTD
PMID:24211769
NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499
G
Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
EXP
Colchicine results in increased expression of MYC mRNA
CTD
PMID:3119359 PMID:20624997
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
G
Myt1
myelin transcription factor 1
increases phosphorylation
ISO
Colchicine results in increased phosphorylation of MYT1 protein
CTD
PMID:16611024
NCBI chr 3:177,281,365...177,341,550
Ensembl chr 3:177,310,753...177,341,547
G
Nbn
nibrin
increases expression
EXP
Colchicine results in increased expression of NBN mRNA
CTD
PMID:20624997
NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]
CTD
PMID:25257666
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
G
Ndufs4
NADH:ubiquinone oxidoreductase subunit S4
affects response to substance
ISO
NDUFS4 protein affects the susceptibility to Colchicine
CTD
PMID:21383081
NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
G
Nfatc4
nuclear factor of activated T-cells 4
decreases localization
ISO
Colchicine results in decreased localization of NFATC4 protein
CTD
PMID:17044076
NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
G
Nfkbia
NFKB inhibitor alpha
increases phosphorylation multiple interactions
ISO
Colchicine results in increased phosphorylation of NFKBIA protein Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
CTD
PMID:17029595
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
G
Nos1
nitric oxide synthase 1
increases expression
EXP
Colchicine results in increased expression of NOS1 protein
CTD
PMID:7537689
NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]
CTD
PMID:23146695
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
Nptx1
neuronal pentraxin 1
increases expression
EXP
Colchicine results in increased expression of NPTX1 mRNA
CTD
PMID:18255150
NCBI chr10:108,682,637...108,691,592
Ensembl chr10:108,682,638...108,691,367
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666
NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions increases degradation increases activity
ISO
Colchicine results in decreased localization of and results in decreased activity of NR3C1 protein Colchicine results in increased degradation of NR3C1 protein Colchicine results in increased activity of NR3C1 protein
CTD
PMID:15744361 PMID:20448266
NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
G
Nts
neurotensin
increases expression
EXP
Colchicine results in increased expression of NTS mRNA
CTD
PMID:1850078
NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
G
Odc1
ornithine decarboxylase 1
multiple interactions increases expression
ISO EXP
Colchicine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] Colchicine results in increased expression of ODC1 mRNA
CTD
PMID:3119359 PMID:9270009
NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
G
Orai3
ORAI calcium release-activated calcium modulator 3
decreases expression
ISO
Colchicine results in decreased expression of ORAI3 mRNA
CTD
PMID:24211769
NCBI chr 1:199,217,504...199,222,363
Ensembl chr 1:199,217,016...199,222,851
G
Palb2
partner and localizer of BRCA2
decreases expression
ISO
Colchicine results in decreased expression of PALB2 mRNA
CTD
PMID:24211769
NCBI chr 1:192,064,586...192,088,547
Ensembl chr 1:192,064,589...192,088,520
G
Pawr
pro-apoptotic WT1 regulator
increases expression multiple interactions
EXP
Colchicine results in increased expression of PAWR protein alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein]
CTD
PMID:12941380
NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
G
Pelo
pelota mRNA surveillance and ribosome rescue factor
decreases expression
ISO
Colchicine results in decreased expression of PELO mRNA
CTD
PMID:24211769
NCBI chr 2:47,266,758...47,268,526
Ensembl chr 2:47,266,738...47,268,625
G
Phlda3
pleckstrin homology-like domain, family A, member 3
decreases expression
ISO
Colchicine results in decreased expression of PHLDA3 mRNA
CTD
PMID:24211769
NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
G
Pidd1
p53-induced death domain protein 1
decreases expression
ISO
Colchicine results in decreased expression of PIDD1 mRNA
CTD
PMID:24211769
NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
G
Plagl1
PLAG1 like zinc finger 1
increases expression
EXP
Colchicine results in increased expression of PLAGL1 mRNA
CTD
PMID:20624997
NCBI chr 1:7,219,587...7,270,169
Ensembl chr 1:7,252,349...7,259,035
G
Plat
plasminogen activator, tissue type
increases expression
EXP
Colchicine results in increased expression of PLAT mRNA
CTD
PMID:20624997
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
G
Plaur
plasminogen activator, urokinase receptor
increases expression
EXP
Colchicine results in increased expression of PLAUR mRNA
CTD
PMID:20624997
NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
G
Plekhf1
pleckstrin homology and FYVE domain containing 1
decreases expression
ISO
Colchicine results in decreased expression of PLEKHF1 mRNA
CTD
PMID:24211769
NCBI chr 1:94,609,041...94,616,565
Ensembl chr 1:94,609,377...94,610,854
G
Plxnb2
plexin B2
decreases expression
ISO
Colchicine results in decreased expression of PLXNB2 mRNA
CTD
PMID:24211769
NCBI chr 7:130,135,484...130,161,568
Ensembl chr 7:130,135,464...130,151,880
G
Pomc
proopiomelanocortin
increases secretion
EXP
Colchicine results in increased secretion of POMC protein
CTD
PMID:2453250
NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
G
Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
decreases expression
ISO
Colchicine results in decreased expression of PPM1D mRNA
CTD
PMID:24211769
NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
G
Ppp1ca
protein phosphatase 1 catalytic subunit alpha
increases expression
ISO
Colchicine results in increased expression of PPP1CA protein
CTD
PMID:16495211
NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
EXP
Colchicine results in increased expression of PPP1R15A mRNA
CTD
PMID:20624997
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
G
Prkab1
protein kinase AMP-activated non-catalytic subunit beta 1
decreases expression
ISO
Colchicine results in decreased expression of PRKAB1 mRNA
CTD
PMID:24211769
NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
G
Psmc3ip
PSMC3 interacting protein
decreases expression
ISO
Colchicine results in decreased expression of PSMC3IP mRNA
CTD
PMID:24211769
NCBI chr10:89,002,109...89,006,075
Ensembl chr10:89,002,116...89,005,213
G
Ptk2b
protein tyrosine kinase 2 beta
multiple interactions increases phosphorylation
ISO
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein]
CTD
PMID:11478917
NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
G
Ptp4a1
protein tyrosine phosphatase 4A1
decreases expression
ISO
Colchicine results in decreased expression of PTP4A1 mRNA
CTD
PMID:24211769
NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
G
Pus3
pseudouridine synthase 3
decreases expression
ISO
Colchicine results in decreased expression of PUS3 mRNA
CTD
PMID:24211769
NCBI chr 8:36,760,874...36,769,167
Ensembl chr 8:36,766,977...36,769,162
G
Rad51c
RAD51 paralog C
decreases expression
ISO
Colchicine results in decreased expression of RAD51C mRNA
CTD
PMID:24211769
NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472
G
Ralbp1
ralA binding protein 1
multiple interactions affects transport
ISO
Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4] RALBP1 protein affects the transport of Colchicine
CTD
PMID:15386349
NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
G
Rap2b
RAP2B, member of RAS oncogene family
decreases expression
ISO
Colchicine results in decreased expression of RAP2B mRNA
CTD
PMID:24211769
NCBI chr 2:151,685,251...151,685,802
Ensembl chr 2:151,685,251...151,685,802
G
Rassf1
Ras association domain family member 1
increases expression
EXP
Colchicine results in increased expression of RASSF1 mRNA
CTD
PMID:20624997
NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289
G
Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
Colchicine results in decreased phosphorylation of and results in decreased activity of RB1 protein
CTD
PMID:16495211
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
G
Rbm34
RNA binding motif protein 34
decreases expression
ISO
Colchicine results in decreased expression of RBM34 mRNA
CTD
PMID:24211769
NCBI chr19:59,874,745...59,894,981
Ensembl chr19:59,874,752...59,894,937
G
Rfc1
replication factor C subunit 1
decreases expression
ISO
Colchicine results in decreased expression of RFC1 mRNA
CTD
PMID:24211769
NCBI chr14:44,627,528...44,702,205
Ensembl chr14:44,580,216...44,702,203
G
Rgs16
regulator of G-protein signaling 16
decreases expression
ISO
Colchicine results in decreased expression of RGS16 mRNA
CTD
PMID:24211769
NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
G
Rnf113a1
ring finger protein 113A1
decreases expression
ISO
Colchicine results in decreased expression of RNF113A mRNA
CTD
PMID:24211769
NCBI chr X:123,806,922...123,808,049
Ensembl chr X:124,516,949...124,518,077
G
Rnf19b
ring finger protein 19B
decreases expression
ISO
Colchicine results in decreased expression of RNF19B mRNA
CTD
PMID:24211769
NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957
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S100a8
S100 calcium binding protein A8
increases expression
EXP
Colchicine results in increased expression of S100A8 mRNA
CTD
PMID:20624997
NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
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S100a9
S100 calcium binding protein A9
increases expression
EXP
Colchicine results in increased expression of S100A9 mRNA
CTD
PMID:20624997
NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
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Sac3d1
SAC3 domain containing 1
decreases expression
ISO
Colchicine results in decreased expression of SAC3D1 mRNA
CTD
PMID:24211769
NCBI chr 1:221,484,210...221,486,669
Ensembl chr 1:221,484,316...221,486,633
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Sct
secretin
multiple interactions
EXP
Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
CTD
PMID:22194894
NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
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Sdc1
syndecan 1
decreases expression
ISO
Colchicine results in decreased expression of SDC1 mRNA
CTD
PMID:24211769
NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
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Sdhaf1
succinate dehydrogenase complex assembly factor 1
decreases expression
ISO
Colchicine results in decreased expression of SDHAF1 mRNA
CTD
PMID:24211769
NCBI chr 1:88,779,476...88,780,425
Ensembl chr 1:90,948,976...90,949,332
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Sele
selectin E
increases expression
EXP
Colchicine results in increased expression of SELE mRNA
CTD
PMID:20624997
NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
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Serpina6
serpin family A member 6
decreases transport
EXP
Colchicine results in decreased transport of SERPINA6 protein
CTD
PMID:16700006
NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
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Serpine1
serpin family E member 1
increases expression
EXP
Colchicine results in increased expression of SERPINE1 mRNA
CTD
PMID:20624997
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Sesn1
sestrin 1
increases expression decreases expression
EXP ISO
Colchicine results in increased expression of SESN1 mRNA Colchicine results in decreased expression of SESN1 mRNA
CTD
PMID:20624997 PMID:24211769
NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
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Sgk1
serum/glucocorticoid regulated kinase 1
decreases expression
ISO
Colchicine results in decreased expression of SGK1 mRNA
CTD
PMID:24211769
NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
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Slbp
stem-loop binding protein
decreases expression
ISO
Colchicine results in decreased expression of SLBP mRNA
CTD
PMID:24211769
NCBI chr14:82,356,916...82,366,368
Ensembl chr14:82,356,916...82,366,368
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Slc1a5
solute carrier family 1 member 5
decreases expression
ISO
Colchicine results in decreased expression of SLC1A5 mRNA
CTD
PMID:24211769
NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
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Spon1
spondin 1
increases expression
EXP
Colchicine results in increased expression of SPON1 mRNA
CTD
PMID:20624997
NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
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Sptan1
spectrin, alpha, non-erythrocytic 1
multiple interactions increases cleavage
ISO
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased cleavage of SPTAN1 protein]
CTD
PMID:16478524
NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
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Srxn1
sulfiredoxin 1
increases expression
ISO
Colchicine results in increased expression of SRXN1 protein
CTD
PMID:27358234
NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
Colchicine deficiency results in decreased activity of and affects the localization of STAT1 protein
CTD
PMID:28086195
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Tat
tyrosine aminotransferase
multiple interactions decreases expression
ISO
pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA]
CTD
PMID:15744361
NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
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Tbc1d4
TBC1 domain family, member 4
multiple interactions affects phosphorylation
EXP
Colchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein] Colchicine affects the phosphorylation of TBC1D4 protein
CTD
PMID:18063688
NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
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Tfpi2
tissue factor pathway inhibitor 2
increases expression
EXP
Colchicine results in increased expression of TFPI2 mRNA
CTD
PMID:20624997
NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
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Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TGFB1 protein]
CTD
PMID:14726149 PMID:22446813 PMID:23146695
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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Thbd
thrombomodulin
increases expression
EXP
Colchicine results in increased expression of THBD mRNA
CTD
PMID:20624997
NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
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Thbs1
thrombospondin 1
increases expression
EXP
Colchicine results in increased expression of THBS1 mRNA
CTD
PMID:20624997
NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
Colchicine binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Colchicine binds to and results in decreased activity of THRB protein
CTD
PMID:25752796
NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
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Tigar
TP53 induced glycolysis regulatory phosphatase
decreases expression
ISO
Colchicine results in decreased expression of TIGAR mRNA
CTD
PMID:24211769
NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Colchicine results in increased expression of TIMP1 mRNA
CTD
PMID:20624997
NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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Tipin
timeless interacting protein
decreases expression
ISO
Colchicine results in decreased expression of TIPIN mRNA
CTD
PMID:24211769
NCBI chr 8:69,753,363...69,768,640
Ensembl chr 8:69,753,373...69,768,305
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Tmem185b
transmembrane protein 185B
decreases expression
ISO
Colchicine results in decreased expression of TMEM185B mRNA
CTD
PMID:24211769
NCBI chr13:35,554,621...35,557,952
Ensembl chr13:35,554,964...35,556,016
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Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO EXP
Colchicine results in decreased expression of TNF protein Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:1553933 PMID:11154858 PMID:22446813 PMID:23146695
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tnfrsf1a
TNF receptor superfamily member 1A
affects response to substance
ISO
TNFRSF1A protein affects the susceptibility to Colchicine
CTD
PMID:20159942
NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
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Tnfsf9
TNF superfamily member 9
decreases expression
ISO
Colchicine results in decreased expression of TNFSF9 mRNA
CTD
PMID:24211769
NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
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Tnni3
troponin I3, cardiac type
increases expression
EXP
Colchicine results in increased expression of TNNI3 protein
CTD
PMID:20624997
NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
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Top3a
DNA topoisomerase III alpha
decreases expression
ISO
Colchicine results in decreased expression of TOP3A mRNA
CTD
PMID:24211769
NCBI chr10:46,980,646...47,018,728
Ensembl chr10:46,981,958...47,018,537
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Tor1a
torsin family 1, member A
decreases expression
ISO
Colchicine results in decreased expression of TOR1A mRNA
CTD
PMID:24211769
NCBI chr 3:9,800,322...9,807,318
Ensembl chr 3:9,800,322...9,807,328
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Tp53
tumor protein p53
multiple interactions
ISO
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein]
CTD
PMID:12221076
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Tpd52l1
TPD52 like 1
increases expression
EXP
Colchicine results in increased expression of TPD52L1 mRNA
CTD
PMID:20624997
NCBI chr 1:28,454,949...28,578,736
Ensembl chr 1:28,454,966...28,576,553
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Traf2
Tnf receptor-associated factor 2
affects response to substance
ISO
TRAF2 protein affects the susceptibility to Colchicine
CTD
PMID:20159942
NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
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Triap1
TP53 regulated inhibitor of apoptosis 1
decreases expression
ISO
Colchicine results in decreased expression of TRIAP1 mRNA
CTD
PMID:24211769
NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897 Ensembl chr12:46,987,404...46,989,897
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Trim26
tripartite motif-containing 26
decreases expression
ISO
Colchicine results in decreased expression of TRIM26 mRNA
CTD
PMID:24211769
NCBI chr20:2,201,685...2,224,481
Ensembl chr20:2,201,683...2,224,463
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Trim32
tripartite motif-containing 32
decreases expression
ISO
Colchicine results in decreased expression of TRIM32 mRNA
CTD
PMID:24211769
NCBI chr 5:81,431,554...81,449,023
Ensembl chr 5:81,431,600...81,442,451
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Trim38
tripartite motif containing 38
decreases expression
ISO
Colchicine results in decreased expression of TRIM38 mRNA
CTD
PMID:24211769
NCBI chr17:43,600,006...43,607,879
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Tuba1b
tubulin, alpha 1B
decreases expression
EXP
Colchicine results in decreased expression of TUBA1B mRNA
CTD
PMID:20624997
NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
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Tuba4a
tubulin, alpha 4A
decreases expression
EXP
Colchicine results in decreased expression of TUBA4A mRNA
CTD
PMID:20624997
NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
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Tubb4b
tubulin, beta 4B class IVb
decreases expression
EXP
Colchicine results in decreased expression of TUBB4B mRNA
CTD
PMID:20624997
NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
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Tubb5
tubulin, beta 5 class I
decreases expression
EXP
Colchicine results in decreased expression of TUBB5 mRNA
CTD
PMID:20624997
NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
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Tubg1
tubulin, gamma 1
decreases expression
EXP
Colchicine results in decreased expression of TUBG1 mRNA
CTD
PMID:20624997
NCBI chr10:89,030,865...89,037,455
Ensembl chr10:89,030,865...89,037,455
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Utp3
UTP3, small subunit processome component
decreases expression
ISO
Colchicine results in decreased expression of UTP3 mRNA
CTD
PMID:24211769
NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
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Vcam1
vascular cell adhesion molecule 1
increases expression multiple interactions
EXP ISO
Colchicine results in increased expression of VCAM1 mRNA Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
CTD
PMID:11154858 PMID:20624997
NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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Vip
vasoactive intestinal peptide
increases expression
EXP
Colchicine results in increased expression of VIP mRNA; Colchicine results in increased expression of VIP protein
CTD
PMID:1850078 PMID:8837219
NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression
ISO
Colchicine results in decreased expression of XPC mRNA
CTD
PMID:24211769
NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
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Zbtb24
zinc finger and BTB domain containing 24
decreases expression
ISO
Colchicine results in decreased expression of ZBTB24 mRNA
CTD
PMID:24211769
NCBI chr20:46,168,149...46,189,806
Ensembl chr20:46,168,177...46,189,806
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Zfp202
zinc finger protein 202
decreases expression
ISO
Colchicine results in decreased expression of ZNF202 mRNA
CTD
PMID:24211769
NCBI chr 8:44,047,586...44,068,990
Ensembl chr 8:44,047,592...44,068,003
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Zfp36l1
zinc finger protein 36, C3H type-like 1
decreases expression
ISO
Colchicine results in decreased expression of ZFP36L1 mRNA
CTD
PMID:24211769
NCBI chr 6:103,308,032...103,313,074
Ensembl chr 6:103,308,045...103,313,074
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