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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:paraoxon
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Accession:CHEBI:27827 term browser browse the term
Definition:An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.
Synonyms:exact_synonym: diethyl 4-nitrophenyl phosphate
 related_synonym: Formula=C10H14NO6P;   InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3;   InChIKey=WYMSBXTXOHUIGT-UHFFFAOYSA-N;   O,O-diethyl O-p-nitrophenyl phosphate;   SMILES=CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O;   diethyl p-nitrophenyl phosphate;   diethyl paraoxon;   ethyl paraoxon;   phosphacol;   phosphoric acid diethyl 4-nitrophenyl ester
 alt_id: CHEBI:25855;   CHEBI:7924
 xref: Beilstein:1915526;   CAS:311-45-5;   Drug_Central:4683;   Gmelin:51821;   KEGG:C06606
 xref_mesh: MESH:D010261
 xref: PMID:24149933;   PMID:24220671;   PMID:24357355;   PMID:24384224;   PMID:24413757;   PMID:24486155;   PMID:24598740;   Reaxys:1915526;   UM-BBD_compID:c0088;   Wikipedia:Paraoxon


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paraoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO Paraoxon results in decreased expression of ABCA1 protein CTD PMID:25250848 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 increases expression ISO Paraoxon results in increased expression of ACBD5 mRNA CTD PMID:24413757 NCBI chr17:89,882,465...89,923,982
Ensembl chr17:89,883,615...89,923,423
JBrowse link
G Ache acetylcholinesterase increases phosphorylation
decreases activity
multiple interactions
increases activity
increases acylation
decreases expression
increases expression
ISO
EXP
Paraoxon results in increased phosphorylation of ACHE protein
Paraoxon results in decreased activity of ACHE protein; Paraoxon results in decreased activity of ACHE protein mutant form
1,4-bis(2-hydroxyiminomethylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Atropine co-treated with Obidoxime Chloride] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Ranitidine affects the reaction [Paraoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
Paraoxon results in increased activity of ACHE protein
Paraoxon results in increased acylation of ACHE protein
Paraoxon results in decreased expression of ACHE mRNA
ACHE protein inhibits the reaction [Paraoxon results in decreased expression of MCL1 polyA tail]; ACHE protein inhibits the reaction [Paraoxon results in increased abundance of Corticosterone]; Atropine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; coumarin inhibits the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; Gallamine Triethiodide promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; HLo 7 inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Paraoxon results in increased phosphorylation of and results in decreased activity of ACHE protein; Propidium promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]; Tubocurarine promotes the reaction [Paraoxon results in increased phosphorylation of ACHE protein]
1,3-bis(2-hydroxyiminomethylpyridinium)propane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1,4-bis(2-hydroxyiminomethylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-((4-(aminocarbonyl)pyridinio)trimethylene)-2-((hydroxyimino)methyl)pyridinium inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 4-(aminocarbonyl)-1-(3-(4-((E)-(hydroxyimino)methyl)pyridinium-1-yl)propyl)pyridinium dibromide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; 4-amino-2-((diethylamino)methyl)phenol analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Paraoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Polyethylene Glycols binds to PON1 protein] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; asoxime chloride affects the reaction [Paraoxon results in decreased activity of ACHE protein]; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Cholinesterase Reactivators inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; diacetylmonoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Fullerenes analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Glucosides inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; HS 3 inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; isonitrosoacetone inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; isonitrosoacetone inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; K075 compound inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; K117 compound inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; K127 compound inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; methamidophos promotes the reaction [Paraoxon results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Paraoxon binds to and results in decreased activity of ACHE protein; Paraoxon promotes the reaction [methamidophos results in decreased activity of ACHE protein]; Paraoxon results in decreased expression of and results in decreased activity of ACHE protein; PON1 protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridine-2-aldoxime analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridine-4-aldoxime analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; RS194B analog inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; RS194B inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; RS41A inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; trimethylene-bis(4-hydroxyiminomethylpyridinium) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
CTD PMID:1609424, PMID:4859365, PMID:8134223, PMID:8783813, PMID:9268605, PMID:9515941, PMID:10421444, PMID:12518340, PMID:12629810, PMID:12974645, PMID:14635269, PMID:15669026, PMID:15669039, PMID:15876422, PMID:16193528, PMID:16193529, PMID:16766477, PMID:16978018, PMID:17005312, PMID:17370251, PMID:18617161, PMID:19105816, PMID:19371630, PMID:20144593, PMID:20227398, PMID:20382137, PMID:20385200, PMID:20412789, PMID:20888407, PMID:20971170, PMID:21673941, PMID:21787676, PMID:21930118, PMID:22093924, PMID:22209767, PMID:22230262, PMID:22414384, PMID:22975155, PMID:23178380, PMID:23220589, PMID:24881594, PMID:25447325, PMID:26210933, PMID:26751814, PMID:26965078, PMID:27132127, PMID:27693733, PMID:28174098, PMID:28603072, PMID:29614332, PMID:30292885, PMID:30312685 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actb actin, beta increases expression ISO Paraoxon results in increased expression of ACTB protein CTD PMID:20931991 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Paraoxon results in increased expression of AHR mRNA CTD PMID:18519978 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akap12 A-kinase anchoring protein 12 decreases expression ISO Paraoxon results in decreased expression of AKAP12 mRNA CTD PMID:24413757 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Alb albumin affects binding
increases hydrolysis
multiple interactions
decreases response to substance
ISO Paraoxon binds to ALB protein
ALB protein results in increased hydrolysis of Paraoxon
ALB protein results in decreased susceptibility to [Paraoxon results in decreased activity of BCHE protein]
ALB protein results in decreased susceptibility to Paraoxon
CTD PMID:15525694, PMID:20211614 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Amot angiomotin decreases expression ISO Paraoxon results in decreased expression of AMOT mRNA CTD PMID:27117976 NCBI chr  X:116,751,231...116,810,238
Ensembl chr  X:116,751,230...116,792,864
JBrowse link
G Apeh acylaminoacyl-peptide hydrolase affects binding ISO Paraoxon binds to APEH protein CTD PMID:31872761 NCBI chr 8:116,862,664...116,871,776
Ensembl chr 8:116,862,625...116,872,215
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Paraoxon results in increased expression of ARHGDIA protein CTD PMID:20931991 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO Paraoxon results in increased expression of ATP5F1B protein CTD PMID:20931991 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Axin2 axin 2 decreases expression ISO Paraoxon results in decreased expression of AXIN2 mRNA CTD PMID:24413757 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased expression of and affects the localization of BAX protein]; Paraoxon results in increased expression of and affects the localization of BAX protein
Paraoxon results in increased expression of BAX mRNA; Paraoxon results in increased expression of BAX protein
CTD PMID:12831782, PMID:28603072, PMID:31493121 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases response to substance
decreases activity
affects binding
ISO
EXP
ALB protein results in decreased susceptibility to [Paraoxon results in decreased activity of BCHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; BCHE protein inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Glucosides inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Paraoxon binds to and results in decreased activity of BCHE protein; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pyridine-4-aldoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pyridoxaloxime analog inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Tiapamil Hydrochloride inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; Trimedoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]
BCHE protein results in decreased susceptibility to Paraoxon
Paraoxon binds to BCHE protein; Paraoxon binds to BCHE protein modified form
Paraoxon results in decreased activity of BCHE mRNA; Paraoxon results in decreased activity of BCHE protein
CTD PMID:4631366, PMID:12518340, PMID:12629810, PMID:15669026, PMID:16193528, PMID:16213467, PMID:18514178, PMID:18617161, PMID:19272400, PMID:20206154, PMID:20211614, PMID:20227398, PMID:21673941, PMID:22209767, PMID:23178380, PMID:24912784, PMID:27108687, PMID:27693733, PMID:29614332, PMID:31201777 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP
Paraoxon results in decreased expression of BCL2 mRNA
Paraoxon results in decreased expression of BCL2 mRNA; Paraoxon results in decreased expression of BCL2 protein
CTD PMID:27117976, PMID:28603072, PMID:31493121 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp12 caspase 12 multiple interactions
increases expression
ISO Egtazic Acid inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]; Heparin inhibits the reaction [Paraoxon results in increased expression of CASP12 protein]; Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions
ISO
EXP
Paraoxon results in increased activity of CASP3 protein
Paraoxon results in increased expression of CASP3 mRNA; Paraoxon results in increased expression of CASP3 protein
Cyclosporine inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein; Paraoxon results in increased cleavage of and results in increased activity of CASP3 protein
Ro 31-8220 inhibits the reaction [Paraoxon results in increased activity of CASP3 protein]
CTD PMID:11032765, PMID:12831782, PMID:17561261, PMID:29027213, PMID:31493121 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein]; Paraoxon results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:12831782 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP9 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased cleavage of and results in increased activity of CASP9 protein]; Paraoxon results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:12831782 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccdc177 coiled-coil domain containing 177 decreases expression ISO Paraoxon results in decreased expression of CCDC177 mRNA CTD PMID:24413757 NCBI chr 6:104,403,617...104,410,991
Ensembl chr 6:104,406,897...104,409,005
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO Paraoxon results in increased expression of CCR6 mRNA CTD PMID:24413757 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ces1d carboxylesterase 1D decreases activity
affects binding
ISO Paraoxon results in decreased activity of CES1 protein
Paraoxon binds to CES1 protein
CTD PMID:11950785, PMID:25250848, PMID:31872761 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Paraoxon results in decreased activity of CES2 protein CTD PMID:11950785 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Ces3a carboxylesterase 3a decreases activity ISO Paraoxon results in decreased activity of CES3 protein CTD PMID:11950785 NCBI chr19:37,070,705...37,079,411 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression ISO Paraoxon results in decreased expression of CHRM1 mRNA CTD PMID:21787676 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression ISO Paraoxon results in decreased expression of CHRM2 mRNA CTD PMID:21787676 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression ISO Paraoxon results in decreased expression of CHRM3 mRNA CTD PMID:21787676 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
decreases expression
EXP Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 mRNA]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNA4 protein]
Paraoxon results in decreased expression of CHRNA4 mRNA; Paraoxon results in decreased expression of CHRNA4 protein
CTD PMID:21791372 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
decreases expression
EXP Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]]; Atropine promotes the reaction [Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 mRNA]; Mecamylamine inhibits the reaction [Paraoxon results in decreased expression of CHRNB2 protein]
Paraoxon results in decreased expression of CHRNB2 mRNA; Paraoxon results in decreased expression of CHRNB2 protein
CTD PMID:21791372 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Clk1 CDC-like kinase 1 increases expression ISO Paraoxon results in increased expression of CLK1 mRNA CTD PMID:22093924 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995
JBrowse link
G Clk3 CDC-like kinase 3 increases expression ISO Paraoxon results in increased expression of CLK3 mRNA CTD PMID:22093924 NCBI chr 8:62,528,135...62,543,550
Ensembl chr 8:62,528,225...62,542,622
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases activity
ISO Paraoxon inhibits the reaction [CP 55244 binds to CNR1 protein]
Paraoxon results in decreased activity of CNR1 protein
CTD PMID:12243867 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Paraoxon inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:24555085 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Eno1 enolase 1 decreases expression ISO Paraoxon results in decreased expression of ENO1 protein CTD PMID:20931991 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Paraoxon results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F2 coagulation factor II increases activity
multiple interactions
ISO Paraoxon results in increased activity of F2 protein
[Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in decreased expression of F2 mRNA; [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased activity of F2 protein
CTD PMID:30515700 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F2r coagulation factor II (thrombin) receptor multiple interactions ISO [Paraoxon co-treated with Atropine co-treated with Obidoxime Chloride] results in increased expression of F2R protein CTD PMID:30515700 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Paraoxon results in decreased activity of FAAH protein CTD PMID:25447325 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO Paraoxon results in decreased expression of FGFR1 mRNA CTD PMID:24413757 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA] CTD PMID:21787676 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Paraoxon results in decreased expression of GAP43 protein CTD PMID:27939611 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Paraoxon results in increased expression of GCLM mRNA CTD PMID:24413757 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gss glutathione synthetase increases expression ISO Paraoxon results in increased expression of GSS CTD PMID:24486155 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Paraoxon results in increased expression of GSTM2 CTD PMID:24486155 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression ISO Paraoxon results in increased expression of GSTT2 CTD PMID:24486155 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Paraoxon results in decreased expression of H2AC12 protein CTD PMID:20931991 NCBI chr17:44,527,990...44,528,557
Ensembl chr17:44,528,125...44,528,511
JBrowse link
G Hist1h2ak histone cluster 1, H2ak decreases expression ISO Paraoxon results in decreased expression of H2AC4 mRNA CTD PMID:24413757 NCBI chr17:44,840,990...44,841,382
Ensembl chr17:44,840,990...44,841,382
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C increases expression ISO Paraoxon results in increased expression of HNRNPC protein CTD PMID:20931991 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 decreases expression ISO Paraoxon results in decreased expression of HSP90AA1 protein CTD PMID:20931991 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Paraoxon results in decreased expression of HSP90AB1 protein CTD PMID:20931991 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Il2 interleukin 2 decreases response to substance ISO Paraoxon results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 decreases expression ISO Paraoxon results in decreased expression of IL6 mRNA CTD PMID:22093924 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ildr1 immunoglobulin-like domain containing receptor 1 increases expression ISO Paraoxon results in increased expression of ILDR1 mRNA CTD PMID:24413757 NCBI chr11:67,004,042...67,037,115
Ensembl chr11:67,004,042...67,037,115
JBrowse link
G Ilf2 interleukin enhancer binding factor 2 increases expression ISO Paraoxon results in increased expression of ILF2 protein CTD PMID:20931991 NCBI chr 2:189,857,587...189,877,777
Ensembl chr 2:189,857,587...189,877,743
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Paraoxon results in decreased expression of JUN mRNA CTD PMID:27117976 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kirrel2 kirre like nephrin family adhesion molecule 2 increases expression ISO Paraoxon results in increased expression of KIRREL2 mRNA CTD PMID:24413757 NCBI chr 1:88,909,829...88,921,154
Ensembl chr 1:88,910,415...88,920,291
JBrowse link
G Lat2 linker for activation of T cells family, member 2 increases expression ISO Paraoxon results in increased expression of LAT2 mRNA CTD PMID:24413757 NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
JBrowse link
G Lipa lipase A, lysosomal acid type decreases activity ISO Paraoxon results in decreased activity of LIPA protein CTD PMID:25250848 NCBI chr 1:252,816,536...252,959,348
Ensembl chr 1:252,816,527...252,849,904
JBrowse link
G Lmnb2 lamin B2 increases expression ISO Paraoxon results in increased expression of LMNB2 protein CTD PMID:20931991 NCBI chr 7:11,657,870...11,676,936
Ensembl chr 7:11,660,934...11,675,472
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
increases expression
ISO ACHE protein inhibits the reaction [Paraoxon results in decreased expression of MCL1 polyA tail]
Paraoxon results in increased expression of MCL1 protein alternative form
CTD PMID:22093924 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Paraoxon results in decreased activity of NCEH1 protein CTD PMID:16449251, PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nefh neurofilament heavy decreases expression ISO Paraoxon results in decreased expression of NEFH protein CTD PMID:27939611 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nes nestin increases expression ISO Paraoxon results in increased expression of NES mRNA CTD PMID:27117976 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [NR1I3 protein affects the metabolism of Parathion] which affects the chemical synthesis of Paraoxon CTD PMID:20573718 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Paraoxon results in increased expression of ORM1 mRNA CTD PMID:17497759 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Paraoxon results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein]
CTD PMID:29027213 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO Paraoxon results in increased expression of PARP4 mRNA CTD PMID:24413757 NCBI chr15:36,809,362...36,911,167 JBrowse link
G Pcnx4 pecanex 4 increases expression ISO Paraoxon results in increased expression of PCNX4 mRNA CTD PMID:24413757 NCBI chr 6:95,314,867...95,452,631 JBrowse link
G Phb prohibitin decreases expression ISO Paraoxon results in decreased expression of PHB protein CTD PMID:20931991 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pnliprp2 pancreatic lipase related protein 2 decreases activity ISO
EXP
Paraoxon results in decreased activity of PNLIPRP2 protein CTD PMID:9822688, PMID:17401110 NCBI chr 1:279,896,973...279,927,600
Ensembl chr 1:279,896,973...279,927,600
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 multiple interactions
decreases activity
ISO [Paraoxon co-treated with mipafox] results in decreased activity of PNPLA6 protein
Paraoxon results in decreased activity of PNPLA6 protein
CTD PMID:9268605, PMID:19620706 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Pon1 paraoxonase 1 increases activity
decreases response to substance
multiple interactions
increases hydrolysis
affects metabolic processing
increases metabolic processing
affects response to substance
affects hydrolysis
ISO
EXP
Paraoxon results in increased activity of PON1 protein
PON1 results in decreased susceptibility to Paraoxon
[Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Paraoxon; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon; [Ibandronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Pamidronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Risedronic Acid results in increased activity of PON1 protein] which results in increased metabolism of Paraoxon; Fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]
2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to Paraoxon; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to Paraoxon; [Polyethylene Glycols binds to PON1 protein] inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; [Polyethylene Glycols binds to PON1 protein] which results in increased hydrolysis of Paraoxon; Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; lysophosphatidylglycerol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; lysophosphatidylinositol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Oleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Oxygen promotes the reaction [PON1 protein affects the metabolism of Paraoxon]; palmitoleic acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; PON1 protein inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; PON1 protein polymorphism affects the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]
PON1 protein mutant form results in increased hydrolysis of Paraoxon; PON1 protein results in increased hydrolysis of Paraoxon
PON1 protein mutant form results in decreased susceptibility to Paraoxon
PON1 protein affects the metabolism of Paraoxon; PON1 protein polymorphism affects the metabolism of Paraoxon
PON1 protein results in increased metabolism of Paraoxon
PON1 gene polymorphism affects the susceptibility to Paraoxon
PON1 3' UTR SNP affects the hydrolysis of Paraoxon; PON1 intron SNP affects the hydrolysis of Paraoxon; PON1 protein polymorphism affects the hydrolysis of Paraoxon
CTD PMID:9313934, PMID:9746266, PMID:11022865, PMID:11304470, PMID:14668577, PMID:15375178, PMID:15924216, PMID:16052486, PMID:16055108, PMID:16079929, PMID:16175651, PMID:16331452, PMID:16391483, PMID:18519978, PMID:19071155, PMID:19446239, PMID:20176005, PMID:20839225, PMID:21382471, PMID:21629682, PMID:22414384, PMID:23159884, PMID:23223497, PMID:25867687, PMID:27132127, PMID:27256520, PMID:27387541 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases expression ISO Paraoxon results in increased expression of PTK2B mRNA CTD PMID:24413757 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Set SET nuclear proto-oncogene increases expression ISO Paraoxon results in increased expression of SET mRNA CTD PMID:24413757 NCBI chr19:58,420,635...58,422,153
Ensembl chr19:58,419,961...58,421,504
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression EXP Paraoxon results in decreased expression of SLC1A1 mRNA; Paraoxon results in decreased expression of SLC1A1 protein CTD PMID:28603072 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression
affects expression
EXP Paraoxon results in increased expression of SLC1A2 mRNA; Paraoxon results in increased expression of SLC1A2 protein
Paraoxon affects the expression of SLC1A2 mRNA; Paraoxon affects the expression of SLC1A2 protein
CTD PMID:27769869, PMID:28603072 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression
affects expression
EXP Paraoxon results in increased expression of SLC1A3 mRNA; Paraoxon results in increased expression of SLC1A3 protein
Paraoxon affects the expression of SLC1A3 mRNA; Paraoxon affects the expression of SLC1A3 protein
CTD PMID:27769869, PMID:28603072 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Paraoxon results in increased expression of SOD2 CTD PMID:24486155 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Syn1 synapsin I decreases expression ISO Paraoxon results in decreased expression of SYN1 protein CTD PMID:27939611 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Syp synaptophysin decreases expression ISO Paraoxon results in decreased expression of SYP protein CTD PMID:27939611 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Paraoxon results in decreased expression of TNF mRNA CTD PMID:22093924 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Paraoxon results in increased expression of TRP53 protein
benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane analog inhibits the reaction [Paraoxon results in increased expression of TRP53 protein]
CTD PMID:12831782 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpm4 tropomyosin 4 increases expression ISO Paraoxon results in increased expression of TPM4 protein CTD PMID:20931991 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Ttc16 tetratricopeptide repeat domain 16 increases expression ISO Paraoxon results in increased expression of TTC16 mRNA CTD PMID:24413757 NCBI chr 3:11,799,788...11,811,600
Ensembl chr 3:11,799,612...11,810,901
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial increases expression ISO Paraoxon results in increased expression of TUFM protein CTD PMID:20931991 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Ube2z ubiquitin-conjugating enzyme E2Z decreases expression ISO Paraoxon results in decreased expression of UBE2Z mRNA CTD PMID:24413757 NCBI chr10:83,869,703...83,888,823
Ensembl chr10:83,869,704...83,888,823
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Paraoxon results in decreased expression of VEGFA mRNA CTD PMID:27117976 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Yap1 Yes1 associated transcriptional regulator decreases expression ISO Paraoxon results in decreased expression of YAP1 mRNA CTD PMID:24413757 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
G Yy2 YY2 transcription factor increases expression ISO Paraoxon results in increased expression of YY2 mRNA CTD PMID:24413757 NCBI chr  X:40,285,923...40,289,545 JBrowse link
G Zfp36 zinc finger protein 36 increases expression ISO Paraoxon results in increased expression of ZFP36 mRNA CTD PMID:22093924 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfyve19 zinc finger FYVE-type containing 19 increases expression ISO Paraoxon results in increased expression of ZFYVE19 protein CTD PMID:20931991 NCBI chr 3:111,013,856...111,021,841
Ensembl chr 3:111,013,856...111,021,841
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pesticide 16430
          insecticide 13828
            organophosphorus insecticide 4202
              organophosphate insecticide 3422
                paraoxon 91
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      chalcogen 19399
                        oxygen atom 19361
                          oxygen molecular entity 19361
                            hydroxides 19107
                              oxoacid 18241
                                pnictogen oxoacid 10179
                                  phosphorus oxoacid 9071
                                    phosphoric acids 7830
                                      phosphoric acid 7830
                                        phosphoric acid derivative 7511
                                          phosphate 7511
                                            organic phosphate 7510
                                              alkyl phosphate 4098
                                                dialkyl phosphate 3432
                                                  aryl dialkyl phosphate 91
                                                    paraoxon 91
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.