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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(5-hydroxyindol-3-yl)acetic acid
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Accession:CHEBI:27823 term browser browse the term
Definition:A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Synonyms:exact_synonym: (5-hydroxy-1H-indol-3-yl)acetic acid
 related_synonym: 5-HIAA;   5-Hydroxy-1H-indole-3-acetic acid;   5-Hydroxyindol-3-ylacetic acid;   5-Hydroxyindole-3-acetic acid;   5-Hydroxyindoleacetic acid;   Formula=C10H9NO3;   InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14);   InChIKey=DUUGKQCEGZLZNO-UHFFFAOYSA-N;   SMILES=OC(=O)Cc1c[nH]c2ccc(O)cc12
 alt_id: CHEBI:20585;   CHEBI:2071
 xref: Beilstein:168797;   CAS:54-16-0;   HMDB:HMDB0000763;   KEGG:C05635;   KNApSAcK:C00000104
 xref_mesh: MESH:D006897
 xref: MetaCyc:5-HYDROXYINDOLE_ACETATE;   PMID:11063613;   PMID:11113939;   PMID:22770225;   Reaxys:168797;   Wikipedia:5-Hydroxyindoleacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62622



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(5-hydroxyindol-3-yl)acetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid CTD PMID:2463453 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [MAOA protein results in increased hydroxylation of Serotonin] which results in increased chemical synthesis of Hydroxyindoleacetic Acid CTD PMID:32243540 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Otc ornithine transcarbamylase affects abundance
multiple interactions
ISO OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid
Sodium Benzoate affects the reaction [OTC gene mutant form affects the abundance of Hydroxyindoleacetic Acid]
CTD PMID:3374991 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases abundance ISO TDO2 gene mutant form results in increased abundance of Hydroxyindoleacetic Acid CTD PMID:32871117 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        food additive 15112
          food acidity regulator 11732
            acetic acid 10862
              indole-3-acetic acids 3199
                (5-hydroxyindol-3-yl)acetic acid 4
                  5-hydroxyindoleacetylglycine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organic heteropolycyclic compound 18043
                                    organic heterobicyclic compound 16859
                                      benzopyrrole 9562
                                        indoles 9236
                                          indolyl carboxylic acid 3202
                                            indol-3-yl carboxylic acid 3201
                                              indole-3-acetic acids 3199
                                                (5-hydroxyindol-3-yl)acetic acid 4
                                                  5-hydroxyindoleacetylglycine 0
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