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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:apocynin
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Accession:CHEBI:2781 term browser browse the term
Definition:An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Synonyms:exact_synonym: 1-(4-hydroxy-3-methoxyphenyl)ethan-1-one
 related_synonym: 1-(4-Hydroxy-3-methoxyphenyl)ethanone;   4'-hydroxy-3'-methoxyacetophenone;   4-Acetyl-2-methoxyphenol;   4-Hydroxy-3-methoxyphenyl methyl ketone;   Acetoguaiacon;   Acetoguaiacone;   Acetovanillone;   Formula=C9H10O3;   InChI=1S/C9H10O3/c1-6(10)7-3-4-8(11)9(5-7)12-2/h3-5,11H,1-2H3;   InChIKey=DFYRUELUNQRZTB-UHFFFAOYSA-N;   SMILES=COC1=C(O)C=CC(=C1)C(C)=O
 xref: Beilstein:637373;   CAS:498-02-2;   KEGG:C11380;   KNApSAcK:C00002689
 xref_mesh: MESH:C056165
 xref: PDBeChem:I75;   PMID:21848266;   PMID:21954959;   PMID:24870309;   Reaxys:637373;   Wikipedia:Apocynin



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apocynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP acetovanillone inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; acetovanillone inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] CTD PMID:18474546 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased expression of ACTA2 protein] CTD PMID:29760339 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions
decreases activity
ISO
EXP
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein; acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
acetovanillone results in decreased activity of AGT protein
acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
acetovanillone inhibits the reaction [AGT protein results in decreased export of Sodium]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Oxygen]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:14597645 PMID:15502880 PMID:15677497 PMID:16531806 PMID:17224469 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:30366073 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B3 mRNA] CTD PMID:30651350 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein] CTD PMID:26514923 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in decreased expression of ALB protein] CTD PMID:29760339 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA] CTD PMID:24080574 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein] CTD PMID:22288910 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of BAX protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]
CTD PMID:22431579 PMID:29859868 PMID:30366073 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]; acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of BCL2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]
CTD PMID:22431579 PMID:29859868 PMID:30366073 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein] CTD PMID:30366073 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 multiple interactions EXP acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein] CTD PMID:29859868 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of BGLAP mRNA] CTD PMID:24080574 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Casp1 caspase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of CASP1 protein modified form] CTD PMID:26079697 PMID:26901245 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CASP3 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; acetovanillone inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
CTD PMID:20153346 PMID:22147442 PMID:22497828 PMID:24291008 PMID:26522475 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; [acetovanillone results in increased susceptibility to Thioctic Acid] inhibits the reaction [Mitogens results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of CAT mRNA]; acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in decreased activity of CAT protein]] CTD PMID:21983654 PMID:24291008 PMID:29760339 PMID:32298299 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:22414048 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO acetovanillone inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein] CTD PMID:16845898 PMID:19158351 PMID:22414048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]
CTD PMID:10495789 PMID:22414048 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA] CTD PMID:22414048 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO acetovanillone inhibits the reaction [[Oxygen deficiency results in increased abundance of Reactive Oxygen Species] which results in increased expression of CD36 mRNA] CTD PMID:19640849 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdh3 cadherin 3 multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein] CTD PMID:21647593 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL1A2 protein] CTD PMID:16531806 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]; acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:16531806 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO acetovanillone inhibits the reaction [Antimycin A results in decreased phosphorylation of CREB1 protein] CTD PMID:21538410 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA] CTD PMID:22414048 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 PMID:22414048 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein] CTD PMID:22414048 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]
CTD PMID:23270704 PMID:29037473 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of CYBB protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBB protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of CYBB mRNA]
CTD PMID:19878672 PMID:23270704 PMID:24080574 PMID:30797899 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Des desmin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Dmd dystrophin multiple interactions ISO acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP
ISO
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]; acetovanillone inhibits the reaction [EDN1 protein results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]
acetovanillone inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
CTD PMID:17391658 PMID:20977430 PMID:22431579 PMID:24932781 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:23270704 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein] CTD PMID:26514923 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein] CTD PMID:23270704 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [Glucose results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]
acetovanillone inhibits the reaction [Glucose results in increased expression of FN1 protein]
CTD PMID:15086456 PMID:16632126 PMID:22245600 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of FSHB protein] CTD PMID:23270704 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein] CTD PMID:18063801 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of GJA1 protein] CTD PMID:23270704 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO acetovanillone inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein] CTD PMID:25042521 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link
G Gna11 G protein subunit alpha 11 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of GNA11 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNA11 protein] CTD PMID:20691780 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of GNAQ protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein] CTD PMID:20691780 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of GPX1 protein]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:22431579 PMID:29037473 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP acetovanillone inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA] CTD PMID:21983654 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein] CTD PMID:30797899 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased cleavage of GSDMD protein] CTD PMID:30378427 NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 increases expression EXP acetovanillone results in increased expression of GUCY1A1 protein CTD PMID:25217652 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 increases expression EXP acetovanillone results in increased expression of GUCY1B1 protein CTD PMID:25217652 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Gypa glycophorin A multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr19:27,450,311...27,465,940 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
EXP
ISO
acetovanillone results in increased expression of HIF1A protein
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:12595275 PMID:23144690 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] CTD PMID:26079697 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
acetovanillone results in decreased expression of HMOX1 mRNA
CTD PMID:19414066 PMID:20934533 PMID:21690482 PMID:24291008 PMID:26945724 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein] CTD PMID:30366073 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression
ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
acetovanillone results in decreased expression of ICAM1 protein
CTD PMID:10495789 PMID:19417757 PMID:19632255 PMID:20920494 PMID:22414048 More... NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO acetovanillone inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
acetovanillone results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]
CTD PMID:16307444 PMID:30366073 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il18 interleukin 18 multiple interactions ISO acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] CTD PMID:28539244 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO
EXP
acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
acetovanillone inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of IL1B protein modified form]
acetovanillone results in decreased susceptibility to IL1B protein
acetovanillone inhibits the reaction [Ethanol results in increased expression of IL1B protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL1B protein]
CTD PMID:18403674 PMID:19005069 PMID:19281832 PMID:21211511 PMID:21983654 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]
acetovanillone inhibits the reaction [Formaldehyde results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:21983654 PMID:22414048 PMID:22472292 PMID:24631921 PMID:25042521 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]
CTD PMID:16357311 PMID:28202386 PMID:30797899 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO acetovanillone inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of and results in increased expression of JUN protein] CTD PMID:22288910 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lep leptin multiple interactions ISO acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium]; acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein] CTD PMID:16380530 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor multiple interactions ISO acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] CTD PMID:19478208 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of LHB protein] CTD PMID:23270704 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased lipidation of MAP1LC3B protein] CTD PMID:29859868 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:16632126 PMID:20354174 PMID:21391979 PMID:22288910 PMID:23774252 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:16632126 PMID:20354174 PMID:21391979 PMID:22288910 PMID:23774252 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
CTD PMID:20354174 PMID:21391979 PMID:24967690 PMID:26514923 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:21391979 PMID:24967690 PMID:26514923 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA] CTD PMID:22414048 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MLKL protein] CTD PMID:30378427 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 protein]; acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]
CTD PMID:23270704 PMID:23774252 PMID:26514923 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase decreases expression
multiple interactions
ISO
EXP
acetovanillone results in decreased expression of MPO protein
acetovanillone inhibits the reaction [Cisplatin results in increased activity of MPO protein]
CTD PMID:19417757 PMID:24291008 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MSR1 mRNA] CTD PMID:9614211 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF1 protein]
acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of NCF1 protein]; acetovanillone inhibits the reaction [arsenic trioxide affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Glucose results in increased expression of and results in increased activity of NCF1 protein]; acetovanillone inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides affects the localization of NCF1 protein]
acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]; acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 protein]; acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF1 mRNA]
CTD PMID:16380530 PMID:18424721 PMID:19281832 PMID:19878672 PMID:20299304 More... NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [LEP protein results in increased expression of NCF2 protein]
acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NCF2 mRNA]
CTD PMID:16380530 PMID:24080574 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
[acetovanillone co-treated with AGT protein] results in increased expression of and affects the localization of NFE2L2 protein
CTD PMID:24291008 PMID:27983965 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; acetovanillone inhibits the reaction [Glucose results in increased phosphorylation of NFKBIA protein]
CTD PMID:16845898 PMID:17065336 PMID:28202386 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in decreased ubiquitination of NLRP3 protein] CTD PMID:26901245 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
CTD PMID:21983654 PMID:26522475 PMID:28202386 PMID:30797899 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
ISO
EXP
acetovanillone inhibits the reaction [Glucose results in decreased expression of NOS3 protein]
[Cadmium co-treated with acetovanillone] results in increased expression of NOS3 protein; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of NOS3 mRNA]
acetovanillone results in increased expression of NOS3 protein
CTD PMID:19878672 PMID:21983654 PMID:23703608 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX1 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX1 mRNA]]
acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]
CTD PMID:26522475 PMID:29760339 PMID:30797899 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP [acetovanillone co-treated with CAT protein] inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Cyclosporine results in increased expression of NOX4 mRNA]; acetovanillone inhibits the reaction [Ethanol results in increased expression of NOX4 protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of NOX4 mRNA]] CTD PMID:26522475 PMID:29760339 PMID:32298299 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Noxa1 NADPH oxidase activator 1 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXA1 mRNA] CTD PMID:24080574 NCBI chr 3:7,895,488...7,907,011
Ensembl chr 3:7,895,488...7,905,967
JBrowse link
G Noxo1 NADPH oxidase organizer 1 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of NOXO1 mRNA] CTD PMID:24080574 NCBI chr10:13,721,473...13,726,061
Ensembl chr10:13,721,473...13,726,061
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO acetovanillone inhibits the reaction [Glucose results in increased expression of OLR1 mRNA] CTD PMID:19878672 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; acetovanillone inhibits the reaction [zinc chloride results in increased activity of PARP1 protein]
[polyethylene glycol-superoxide dismutase co-treated with acetovanillone] inhibits the reaction [EDN1 protein results in increased expression of and results in increased cleavage of PARP1 protein]
acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]
CTD PMID:15502880 PMID:18509044 PMID:24932781 PMID:29111459 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP acetovanillone inhibits the reaction [Ozone results in increased expression of PCNA protein] CTD PMID:9517619 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB1 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein] CTD PMID:20691780 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in increased expression of PLCB2 protein]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PLCB2 protein] CTD PMID:20691780 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP acetovanillone inhibits the reaction [POMC protein affects the abundance of F2-Isoprostanes] CTD PMID:16053986 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased cleavage of PRKCD protein]
CTD PMID:29859868 PMID:30366073 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP acetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP acetovanillone inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS1 protein] CTD PMID:18414395 PMID:21983654 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP
ISO
acetovanillone inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
acetovanillone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; acetovanillone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]
acetovanillone results in decreased expression of PTGS2 mRNA
CTD PMID:17244722 PMID:18414395 PMID:21983654 PMID:22288910 PMID:23415682 More... NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Pvalb parvalbumin multiple interactions ISO acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] CTD PMID:18063801 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO acetovanillone inhibits the reaction [Ethanol results in increased expression of PYCARD protein] CTD PMID:26079697 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]
acetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]
CTD PMID:19281832 PMID:19608869 PMID:20354174 PMID:23774252 PMID:26930420 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP acetovanillone inhibits the reaction [Palmitic Acid results in increased expression of RUNX2 mRNA] CTD PMID:24080574 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein] CTD PMID:21647593 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Sele selectin E multiple interactions ISO acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SELE protein] CTD PMID:26901245 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA] CTD PMID:22414048 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of SHC1 protein] CTD PMID:23270704 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Snca synuclein alpha multiple interactions EXP acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased phosphorylation of SNCA protein] CTD PMID:29859868 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD1 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]
CTD PMID:21983654 PMID:22431579 PMID:29037473 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of SOD2 protein]; acetovanillone inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]
CTD PMID:21983654 PMID:22431579 PMID:29037473 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP acetovanillone inhibits the reaction [Hydrogen Peroxide deficiency results in decreased expression of STAR protein]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR mRNA]; acetovanillone inhibits the reaction [Oxygen deficiency results in decreased expression of STAR protein] CTD PMID:23270704 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
acetovanillone inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein]
acetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of and results in increased phosphorylation of STAT1 protein]
CTD PMID:18322232 PMID:29859868 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP acetovanillone inhibits the reaction [Mitogens results in increased expression of TGFB1 protein] CTD PMID:29760339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase decreases expression
multiple interactions
EXP acetovanillone results in decreased expression of TH mRNA
acetovanillone analog inhibits the reaction [Chlorpyrifos results in decreased expression of TH protein]
CTD PMID:25217652 PMID:29859868 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO acetovanillone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TJP1 protein]; acetovanillone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TJP1 protein]
acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
CTD PMID:20299304 PMID:21647593 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO
EXP
acetovanillone inhibits the reaction [tert-Butylhydroperoxide results in increased secretion of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CSF2 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of IL6 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
acetovanillone inhibits the reaction [Cisplatin results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Ethanol results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]; acetovanillone inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; acetovanillone inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; acetovanillone promotes the reaction [Thioctic Acid inhibits the reaction [Mitogens results in increased expression of TNF protein]]; Thioctic Acid promotes the reaction [acetovanillone inhibits the reaction [Mitogens results in increased expression of TNF protein]]
acetovanillone results in decreased susceptibility to TNF protein
acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [cobaltous chloride results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; acetovanillone inhibits the reaction [Pyruvaldehyde results in increased expression of TNF protein]; acetovanillone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:10495789 PMID:15795323 PMID:16632126 PMID:19608869 PMID:21211511 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP acetovanillone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of TP53 protein] CTD PMID:22431579 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO acetovanillone inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; acetovanillone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of VCAM1 protein] CTD PMID:19281832 PMID:19632255 PMID:26901245 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP acetovanillone inhibits the reaction [Cocaine results in increased activity of XDH protein] CTD PMID:17217956 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        anti-inflammatory agent 15835
          anti-inflammatory drug 13630
            non-steroidal anti-inflammatory drug 12717
              apocynin 131
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      ketone 16926
                                        methyl ketone 763
                                          acetophenones 148
                                            apocynin 131
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