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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heroin
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Accession:CHEBI:27808 term browser browse the term
Definition:A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.
Synonyms:exact_synonym: 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diyl diacetate
 related_synonym: (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester);   3,6-Diacetylmorphine;   7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate;   Diacetylmorphine;   Diamorphine;   Formula=C21H23NO5;   InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1;   InChIKey=GVGLGOZIDCSQPN-PVHGPHFFSA-N;   O,O'-Diacetylmorphine;   SMILES=[H][C@]12C=C[C@H](OC(C)=O)[C@@H]3Oc4c(OC(C)=O)ccc5C[C@H]1N(C)CC[C@@]23c45
 alt_id: CHEBI:24528;   CHEBI:5680
 xref: CAS:561-27-3;   DrugBank:DB01452;   Drug_Central:4412;   KEGG:C06534;   KEGG:D07286
 xref_mesh: MESH:D003932
 xref: PMID:10454516;   PMID:11441925;   PMID:11448454;   PMID:11557911;   PMID:12965116;   PMID:14534521;   PMID:15212982;   PMID:15213301;   PMID:15550572;   PMID:15772255;   PMID:15843500;   PMID:16076083;   PMID:16333714;   PMID:20331562;   PMID:20649590;   PMID:20735218;   PMID:20810225;   PMID:20855171;   PMID:21235340;   PMID:21309955;   PMID:21362452;   PMID:21452028;   PMID:21527184;   PMID:21568984;   PMID:21608377;   PMID:21734607;   PMID:21740578;   PMID:2352148;   PMID:8858977;   PMID:8893832;   PMID:9918543;   Reaxys:99261;   Wikipedia:Heroin



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heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing
ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing
ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Heroin results in decreased expression of BDNF protein
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
Heroin results in decreased expression of BDNF mRNA
CTD PMID:17715210 PMID:25643298 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
affects binding
multiple interactions
increases hydrolysis
ISO CES1 protein results in decreased acetylation of Heroin
Heroin binds to CES1 protein
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
CTD PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175 PMID:9169443 PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
heroin increases phosphorylation of Creb1 protein in brain
CTD
RGD
PMID:25643298 PMID:21362452 RGD:401901181 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Heroin results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Heroin results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases activity ISO Heroin results in increased activity of CYP2D6 protein CTD PMID:35914676 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:56,800,980...56,802,777
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
CTD PMID:16137723 PMID:19169671 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP heroin decreases expression of Fosb protein in brain RGD PMID:21362452 RGD:401901181 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heroin results in increased expression of GPT protein CTD PMID:36502556 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379
JBrowse link
G Pdyn prodynorphin decreases expression
increases expression
ISO
EXP
Heroin results in decreased expression of PDYN mRNA
Heroin results in increased expression of PDYN mRNA
CTD PMID:16710320 PMID:19100723 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:9,580,367...9,609,957
Ensembl chr 6:9,580,217...9,607,772
JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768
JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561
JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:13,710,553...13,715,309
Ensembl chr10:13,704,998...13,715,669
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465
JBrowse link

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  CHEBI ontology 19860
    role 19832
      biological role 19830
        xenobiotic 18737
          morphine 493
            heroin 50
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    main group molecular entity 19804
                      s-block molecular entity 19637
                        hydrogen molecular entity 19618
                          hydrides 19124
                            inorganic hydride 18133
                              pnictogen hydride 18122
                                nitrogen hydride 18030
                                  azane 17837
                                    ammonia 17836
                                      organic amino compound 17836
                                        tertiary amino compound 10144
                                          morphine 493
                                            heroin 50
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