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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:heroin
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Accession:CHEBI:27808 term browser browse the term
Definition:A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.
Synonyms:exact_synonym: 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diyl diacetate
 related_synonym: (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester);   3,6-Diacetylmorphine;   7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate;   Diacetylmorphine;   Diamorphine;   Formula=C21H23NO5;   InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1;   InChIKey=GVGLGOZIDCSQPN-PVHGPHFFSA-N;   O,O'-Diacetylmorphine;   SMILES=[H][C@]12C=C[C@H](OC(C)=O)[C@@H]3Oc4c(OC(C)=O)ccc5C[C@H]1N(C)CC[C@@]23c45
 alt_id: CHEBI:24528;   CHEBI:5680
 xref: CAS:561-27-3;   DrugBank:DB01452;   Drug_Central:4412;   KEGG:C06534;   KEGG:D07286
 xref_mesh: MESH:D003932
 xref: PMID:10454516;   PMID:11441925;   PMID:11448454;   PMID:11557911;   PMID:12965116;   PMID:14534521;   PMID:15212982;   PMID:15213301;   PMID:15550572;   PMID:15772255;   PMID:15843500;   PMID:16076083;   PMID:16333714;   PMID:20331562;   PMID:20649590;   PMID:20735218;   PMID:20810225;   PMID:20855171;   PMID:21235340;   PMID:21309955;   PMID:21362452;   PMID:21452028;   PMID:21527184;   PMID:21568984;   PMID:21608377;   PMID:21734607;   PMID:21740578;   PMID:2352148;   PMID:8858977;   PMID:8893832;   PMID:9918543;   Reaxys:99261;   Wikipedia:Heroin


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heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing
ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:48,304,324...48,562,838
Ensembl chr17:48,304,322...48,562,905
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing
ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
CTD PMID:17715210, PMID:25643298 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:114,869,478...114,880,218
Ensembl chr 3:114,869,459...114,881,590
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
increases hydrolysis
multiple interactions
affects binding
ISO CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein
CTD PMID:8930175, PMID:9311626, PMID:12679808, PMID:12773168 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175, PMID:9169443, PMID:25445008 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter] CTD PMID:25643298 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:214,283,787...214,317,466
Ensembl chr 1:214,283,790...214,317,466
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:56,527,075...56,531,615
Ensembl chr10:56,527,085...56,531,483
JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:58,018,039...58,019,836
Ensembl chr 5:58,018,039...58,019,836
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
CTD PMID:16137723, PMID:19169671 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:48,679,726...48,709,663
Ensembl chr13:48,679,774...48,705,575
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:199,867,965...200,066,034
Ensembl chr 2:199,867,972...200,003,443
JBrowse link
G Pdyn prodynorphin decreases expression ISO Heroin results in decreased expression of PDYN mRNA CTD PMID:16710320 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:8,316,861...8,346,293
Ensembl chr 6:8,318,979...8,346,197
JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:74,860,068...74,884,196
Ensembl chr10:74,861,714...74,884,196
JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:9,987,988...10,003,599
Ensembl chr 9:9,988,055...10,001,962
JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:51,125,764...51,168,384
Ensembl chr15:51,128,268...51,168,384
JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:65,086,483...65,319,527
Ensembl chr 6:65,089,318...65,319,527
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:14,051,413...14,056,169
Ensembl chr10:14,051,415...14,056,169
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:76,376,722...76,419,564
Ensembl chr 5:76,386,836...76,419,560
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:102,340,261...102,353,612
Ensembl chr 6:102,339,857...102,353,403
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        xenobiotic 18380
          morphine 463
            heroin 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        tertiary amino compound 8629
                                          morphine 463
                                            heroin 45
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.