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ONTOLOGY REPORT - ANNOTATIONS


Term:heroin
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Accession:CHEBI:27808 term browser browse the term
Definition:A morphinane alkaloid that is morphine bearing two acetyl substituents on the O-3 and O-6 positions. As with other opioids, heroin is used as both an analgesic and a recreational drug. Frequent and regular administration is associated with tolerance and physical dependence, which may develop into addiction. Its use includes treatment for acute pain, such as in severe physical trauma, myocardial infarction, post-surgical pain, and chronic pain, including end-stage cancer and other terminal illnesses.
Synonyms:exact_synonym: 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diyl diacetate
 related_synonym: (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester);   3,6-Diacetylmorphine;   7,8-Dihydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol diacetate;   Diacetylmorphine;   Diamorphine;   Formula=C21H23NO5;   InChI=1S/C21H23NO5/c1-11(23)25-16-6-4-13-10-15-14-5-7-17(26-12(2)24)20-21(14,8-9-22(15)3)18(13)19(16)27-20/h4-7,14-15,17,20H,8-10H2,1-3H3/t14-,15+,17-,20-,21-/m0/s1;   InChIKey=GVGLGOZIDCSQPN-PVHGPHFFSA-N;   O,O'-Diacetylmorphine;   SMILES=[H][C@]12C=C[C@H](OC(C)=O)[C@@H]3Oc4c(OC(C)=O)ccc5C[C@H]1N(C)CC[C@@]23c45
 alt_id: CHEBI:24528;   CHEBI:5680
 xref: CAS:561-27-3 "ChemIDplus";   CAS:561-27-3 "KEGG COMPOUND";   CAS:561-27-3 "NIST Chemistry WebBook";   DrugBank:DB01452;   Drug_Central:4412 "DrugCentral";   KEGG:C06534;   KEGG:D07286
 xref_mesh: MESH:D003932
 xref: PMID:10454516 "Europe PMC";   PMID:11441925 "Europe PMC";   PMID:11448454 "Europe PMC";   PMID:11557911 "Europe PMC";   PMID:12965116 "Europe PMC";   PMID:14534521 "Europe PMC";   PMID:15212982 "Europe PMC";   PMID:15213301 "Europe PMC";   PMID:15550572 "Europe PMC";   PMID:15772255 "Europe PMC";   PMID:15843500 "Europe PMC";   PMID:16076083 "Europe PMC";   PMID:16333714 "Europe PMC";   PMID:20331562 "Europe PMC";   PMID:20649590 "Europe PMC";   PMID:20735218 "Europe PMC";   PMID:20810225 "Europe PMC";   PMID:20855171 "Europe PMC";   PMID:21235340 "Europe PMC";   PMID:21309955 "Europe PMC";   PMID:21362452 "Europe PMC";   PMID:21452028 "Europe PMC";   PMID:21527184 "Europe PMC";   PMID:21568984 "Europe PMC";   PMID:21608377 "Europe PMC";   PMID:21734607 "Europe PMC";   PMID:21740578 "Europe PMC";   PMID:2352148 "Europe PMC";   PMID:8858977 "Europe PMC";   PMID:8893832 "Europe PMC";   PMID:9918543 "Europe PMC";   Reaxys:99261 "Reaxys";   Wikipedia:Heroin


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heroin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Actn2 actinin alpha 2 JBrowse link 17 66,304,530 66,397,647 RGD:6480464
G Amph amphiphysin JBrowse link 17 48,304,324 48,562,838 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 JBrowse link 3 114,869,478 114,880,218 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Churc1 churchill domain containing 1 JBrowse link 6 99,817,439 99,831,574 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Deaf1 DEAF1 transcription factor JBrowse link 1 214,283,787 214,317,466 RGD:6480464
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 JBrowse link 9 16,845,764 16,848,514 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Eif5a eukaryotic translation initiation factor 5A JBrowse link 10 56,527,075 56,531,615 RGD:6480464
G Enho energy homeostasis associated JBrowse link 5 58,018,039 58,019,836 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Itgb1bp1 integrin subunit beta 1 binding protein 1 JBrowse link 6 43,348,927 43,363,633 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 JBrowse link 3 43,111,258 43,128,391 RGD:6480464
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6480464
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 JBrowse link 13 48,679,726 48,709,663 RGD:6480464
G Pde4dip phosphodiesterase 4D interacting protein JBrowse link 2 199,867,965 200,066,034 RGD:6480464
G Pdyn prodynorphin JBrowse link 3 122,194,327 122,206,671 RGD:6480464
G Pmepa1 prostate transmembrane protein, androgen induced 1 JBrowse link 3 171,295,630 171,342,662 RGD:6480464
G Prepl prolyl endopeptidase-like JBrowse link 6 8,316,861 8,346,293 RGD:6480464
G Septin4 septin 4 JBrowse link 10 74,860,068 74,884,196 RGD:6480464
G Slc25a23 solute carrier family 25 member 23 JBrowse link 9 9,987,988 10,003,599 RGD:6480464
G Slc25a37 solute carrier family 25 member 37 JBrowse link 15 51,125,764 51,168,384 RGD:6480464
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:6480464
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:6480464
G Stxbp6 syntaxin binding protein 6 JBrowse link 6 65,086,483 65,319,527 RGD:6480464
G Sv2a synaptic vesicle glycoprotein 2a JBrowse link 2 198,321,100 198,336,889 RGD:6480464
G Syngr3 synaptogyrin 3 JBrowse link 10 14,051,413 14,056,169 RGD:6480464
G Syt1 synaptotagmin 1 JBrowse link 7 50,084,063 50,638,996 RGD:6480464
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ugcg UDP-glucose ceramide glucosyltransferase JBrowse link 5 76,376,722 76,419,564 RGD:6480464
G Vti1b vesicle transport through interaction with t-SNAREs 1B JBrowse link 6 102,340,261 102,353,612 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        xenobiotic 18187
          morphine 462
            heroin 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    main group molecular entity 19555
                      s-block molecular entity 19336
                        hydrogen molecular entity 19325
                          hydrides 18249
                            inorganic hydride 17113
                              pnictogen hydride 17071
                                nitrogen hydride 16891
                                  azane 16568
                                    ammonia 16565
                                      organic amino compound 16564
                                        tertiary amino compound 8523
                                          morphine 462
                                            heroin 45
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.