Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-erythroidine
go back to main search page
Accession:CHEBI:27795 term browser browse the term
Definition:An organic heterotetracyclic indole alkaloid isolated from the seeds and other parts of Erythrina species. It differs from the alpha isomer in having the double bond of the dihydropyranone ring located beta,gamma- to the lactone carbonyl group instead of alpha,beta-.
Synonyms:exact_synonym: (4bS,6R)-6-methoxy-1,4,6,10,12,13-hexahydro-3H,5H-pyrano[4',3':3,4]pyrido[2,1-i]indol-3-one
 related_synonym: 12,13-didehydro-13,14-dihydro-alpha-erythroidine;   Formula=C16H19NO3;   InChI=1S/C16H19NO3/c1-19-13-3-2-12-5-7-17-6-4-11-10-20-15(18)8-14(11)16(12,17)9-13/h2-3,5,13H,4,6-10H2,1H3/t13-,16-/m0/s1;   InChIKey=PXWINCSLFXUWBZ-BBRMVZONSA-N;   SMILES=CO[C@@H]1C[C@]23N(CC=C2C=C1)CCC1=C3CC(=O)OC1
 alt_id: CHEBI:10416;   CHEBI:22839
 xref: CAS:466-81-9;   KEGG:C06532;   KNApSAcK:C00001854;   PMID:15437298;   PMID:16550620;   PMID:16898793;   PMID:21018227;   Patent:US2373952;   Patent:US2385266;   Patent:US2407713;   Reaxys:36194


show annotations for term's descendants           Sort by:
 
dihydro-beta-erythroidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:12511591 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atoh1 atonal bHLH transcription factor 1 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of ATOH1 mRNA] CTD PMID:23056257 NCBI chr 4:93,912,068...93,914,163
Ensembl chr 4:93,912,068...93,914,154
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CCND1 mRNA] CTD PMID:23056257 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein] CTD PMID:15231866 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP dihydro-beta-erythroidine affects binding to Chrna2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna2 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
dihydro-beta-erythroidine affects binding [Epibatidine binds to Chrna3 protein]
CTD PMID:9687574 PMID:16129735 PMID:15016836 RGD:2303195, RGD:2303194 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding
ISO
EXP
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrna4 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrna4 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrna4 protein]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of CHRNA4 mRNA]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
CTD PMID:9687574 PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 More... RGD:2303195, RGD:2303194 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases activity
multiple interactions
affects response to substance
ISO
EXP
Dihydro-beta-Erythroidine results in increased activity of CHRNA7 protein mutant form
Dihydro-beta-Erythroidine affects the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]
CHRNA7 protein mutant form affects the susceptibility to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine binds to and results in decreased activity of CHRNA7 protein
CTD PMID:10082212 PMID:19448648 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO
EXP
Carbachol inhibits the reaction [Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [1-Butanol binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased uptake of Calcium]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb2 protein] in rat retina
dihydro-beta-erythroidine affects binding to Chrnb2 protein; dihydro-beta-erythroidine competes with [Epibatidine binds to Chrnb2 protein]
Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [3-(2-(pyrrolidinyl)methoxy)pyridine analog results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
[Dihydro-beta-Erythroidine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in decreased susceptibility to Nicotine; Dihydro-beta-Erythroidine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Dihydro-beta-Erythroidine inhibits the reaction [[pozanicline binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] which results in increased secretion of Acetylcholine]; Dihydro-beta-Erythroidine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]
CTD PMID:10945867 PMID:11600638 PMID:12604691 PMID:14645658 PMID:16569710 More... RGD:2303195, RGD:2303194 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit multiple interactions EXP dihydro-beta-erythroidine affects binding to Chrnb3 protein; dihydro-beta-erythroidine inhibits the reaction [epibatidine affects binding to Chrnb3 protein] in rat retina RGD PMID:16129735 RGD:2303195 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit affects binding
multiple interactions
EXP [CHRNA4 protein binds to CHRNB4 protein] which binds to Dihydro-beta-Erythroidine
Dihydro-beta-Erythroidine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]
CTD PMID:9687574 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO [Mecamylamine co-treated with Dihydro-beta-Erythroidine co-treated with Bungarotoxins] inhibits the reaction [Nicotine results in increased expression of CXCR4 protein] CTD PMID:20457658 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions EXP Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in decreased expression of DNMT1 mRNA] CTD PMID:28555334 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Dihydro-beta-Erythroidine analog inhibits the reaction [Nicotine results in increased expression of GAD1 mRNA] CTD PMID:28555334 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP Dihydro-beta-Erythroidine affects the reaction [Nicotine results in decreased activity of SLC6A3 protein] CTD PMID:23999947 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in increased expression of TNFRSF11B mRNA] CTD PMID:29981921 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of TNFSF11 mRNA] CTD PMID:29981921 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            alkaloid 5680
              indole alkaloid 1856
                beta-erythroidine 17
                  dihydro-beta-erythroidine 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic ester 15884
                                        lactone 11242
                                          delta-lactone 3868
                                            beta-erythroidine 17
                                              dihydro-beta-erythroidine 17
paths to the root