CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: amphotericin B methyl ester
Accession: CHEBI:277842
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Definition: The methyl ester of amphotericin B.
Synonyms: exact_synonym: methyl (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate
related_synonym: AME; Amphotericin B Me Ester; Formula=C48H75NO17; InChI=1S/C48H75NO17/c1-28-18-16-14-12-10-8-6-7-9-11-13-15-17-19-35(65-47-45(59)42(49)44(58)31(4)64-47)25-39-41(46(60)62-5)38(55)27-48(61,66-39)26-34(52)23-37(54)36(53)21-20-32(50)22-33(51)24-40(56)63-30(3)29(2)43(28)57/h6-19,28-39,41-45,47,50-55,57-59,61H,20-27,49H2,1-5H3/b7-6+,10-8+,11-9+,14-12+,15-13+,18-16+,19-17+/t28-,29-,30-,31+,32+,33+,34-,35-,36+,37+,38-,39-,41+,42-,43+,44+,45-,47-,48+/m0/s1; InChIKey=UAZIZEMIKKIBCA-TYVGYKFWSA-N; Methylamphotericin B; SMILES=[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)OC)O2
xref: Beilstein:6264916; CAS:36148-89-7
xref_mesh: MESH:C017501
xref: PMID:22788845; Reaxys:6264916
G
Havcr1
hepatitis A virus cellular receptor 1
increases expression
ISO
methylamphotericin B results in increased expression of HAVCR1 mRNA
CTD
PMID:22863853
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
G
Lcn2
lipocalin 2
increases expression
ISO
methylamphotericin B results in increased expression of LCN2 mRNA
CTD
PMID:22863853
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Spp1
secreted phosphoprotein 1
increases expression
ISO
methylamphotericin B results in increased expression of SPP1 mRNA
CTD
PMID:22863853
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
G
Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
methylamphotericin B results in increased expression of TIMP1 mRNA
CTD
PMID:22863853
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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