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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:griseofulvin
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Accession:CHEBI:27779 term browser browse the term
Definition:An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.
Synonyms:exact_synonym: (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
 related_synonym: Curling factor;   Formula=C17H17ClO6;   Fulcin;   Fulvicin;   Grifulvin;   Grisactin;   Grisovin;   Grysio;   InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1;   InChIKey=DDUHZTYCFQRHIY-RBHXEPJQSA-N;   Lamoryl;   Likuden;   Poncyl;   SMILES=COc1cc(OC)c2C(=O)[C@]3(Oc2c1Cl)[C@H](C)CC(=O)C=C3OC;   Spirofulvin;   Sporostatin;   amudane;   griseofulvina;   griseofulvine;   griseofulvinum
 alt_id: CHEBI:24429;   CHEBI:5546
 xref: Beilstein:95226;   CAS:126-07-8;   DrugBank:DB00400;   Drug_Central:1331;   KEGG:C06686;   KEGG:D00209;   KNApSAcK:C00002398;   LINCS:LSM-5259;   LIPID_MAPS_instance:LMPK13060001
 xref_mesh: MESH:D006118
 xref: MetaCyc:CPD-17786;   PMID:14407521;   PMID:15078340;   PMID:16922553;   PMID:23111828;   PMID:25476923;   PMID:3277037;   PPDB:1807;   Patent:US3069328;   Patent:US3069329;   Reaxys:95226;   VSDB:1807;   Wikipedia:Griseofulvin


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griseofulvin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Griseofulvin results in increased expression of ABCB1A mRNA CTD PMID:8707270 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Griseofulvin results in increased expression of ABCB4 mRNA CTD PMID:8707270 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adrb3 adrenoceptor beta 3 decreases expression ISO Griseofulvin results in decreased expression of ADRB3 mRNA CTD PMID:12735108 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 affects expression
multiple interactions
increases activity
increases expression
ISO Griseofulvin affects the expression of ALAS1 mRNA
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; [Ascorbic Acid co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; Ascorbic Acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]
Griseofulvin results in increased expression of ALAS1 mRNA
CTD PMID:10215191, PMID:12735108, PMID:15793285, PMID:24523661 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Anxa2 annexin A2 increases expression ISO Griseofulvin results in increased expression of ANXA2 mRNA CTD PMID:12735108 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa3 annexin A3 affects expression ISO Griseofulvin affects the expression of ANXA3 mRNA CTD PMID:12735108 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Anxa5 annexin A5 increases expression ISO Griseofulvin results in increased expression of ANXA5 mRNA CTD PMID:12735108 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Anxa6 annexin A6 increases expression ISO Griseofulvin results in increased expression of ANXA6 mRNA CTD PMID:12735108 NCBI chr10:40,320,581...40,375,605
Ensembl chr10:40,320,581...40,375,605
JBrowse link
G Areg amphiregulin increases expression ISO Griseofulvin results in increased expression of AREG protein CTD PMID:19267999 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Btc betacellulin increases expression ISO Griseofulvin results in increased expression of BTC protein CTD PMID:19267999 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO Griseofulvin results in increased activity of CASP3 protein
Griseofulvin results in increased cleavage of CASP3 protein
CTD PMID:23329179, PMID:25412316 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO Griseofulvin results in increased activity of CASP9 protein CTD PMID:23329179 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression ISO Griseofulvin affects the expression of CBR1 mRNA CTD PMID:12735108 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cd14 CD14 molecule affects expression ISO Griseofulvin affects the expression of CD14 mRNA CTD PMID:12735108 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd24 CD24 molecule affects expression ISO Griseofulvin affects the expression of CD24A mRNA CTD PMID:12735108 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Griseofulvin results in increased expression of COL1A1 mRNA CTD PMID:12735108 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Griseofulvin results in increased expression of COL3A1 mRNA CTD PMID:12735108 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain affects expression ISO Griseofulvin affects the expression of COL4A1 mRNA CTD PMID:12735108 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cstb cystatin B increases expression ISO Griseofulvin results in increased expression of CSTB mRNA CTD PMID:12735108 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects expression
multiple interactions
ISO Griseofulvin affects the expression of CYP1A2 mRNA
Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]
CTD PMID:9029748, PMID:12735108 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity
increases expression
ISO Griseofulvin results in increased activity of CYP2A5 protein
Griseofulvin results in increased expression of CYP2A5 mRNA; Griseofulvin results in increased expression of CYP2A5 protein
CTD PMID:7543189, PMID:9007836, PMID:9698299, PMID:11038160 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO Griseofulvin affects the expression of CYP2B10 mRNA CTD PMID:12735108 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression ISO Griseofulvin affects the expression of CYP2B13 mRNA CTD PMID:12735108 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects expression ISO Griseofulvin affects the expression of CYP2B9 mRNA CTD PMID:12735108 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects expression ISO Griseofulvin affects the expression of CYP2C29 mRNA CTD PMID:12735108 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Griseofulvin results in decreased expression of CYP7B1 mRNA CTD PMID:12735108 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Eln elastin affects expression ISO Griseofulvin affects the expression of ELN mRNA CTD PMID:12735108 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Ereg epiregulin increases expression ISO Griseofulvin results in increased expression of EREG protein CTD PMID:19267999 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Griseofulvin results in decreased expression of FABP1 mRNA CTD PMID:12735108 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fech ferrochelatase decreases activity
increases expression
multiple interactions
ISO Griseofulvin results in decreased activity of FECH protein
Griseofulvin results in increased expression of FECH mRNA
[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron; heme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]
CTD PMID:10215191, PMID:15078340 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fstl1 follistatin-like 1 affects expression ISO Griseofulvin affects the expression of FSTL1 mRNA CTD PMID:12735108 NCBI chr11:65,791,196...65,845,721
Ensembl chr11:65,782,567...65,845,418
JBrowse link
G G0s2 G0/G1switch 2 decreases expression ISO Griseofulvin results in decreased expression of G0S2 mRNA CTD PMID:12735108 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta affects expression ISO Griseofulvin affects the expression of GADD45B mRNA CTD PMID:12735108 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression
ISO Griseofulvin results in increased expression of and results in increased localization of GJA1 protein
Griseofulvin results in increased expression of GJA1 mRNA
CTD PMID:23329179 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects expression ISO Griseofulvin affects the expression of GSTM2 mRNA CTD PMID:12735108 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hmox1 heme oxygenase 1 increases activity
increases expression
ISO Griseofulvin results in increased activity of HMOX1 protein
Griseofulvin results in increased expression of HMOX1 mRNA; Griseofulvin results in increased expression of HMOX1 protein
CTD PMID:10215191, PMID:15793285, PMID:16309571 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ier3 immediate early response 3 affects expression ISO Griseofulvin affects the expression of IER3 mRNA CTD PMID:12735108 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Griseofulvin results in decreased expression of IGF1 mRNA CTD PMID:12735108 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression ISO Griseofulvin results in decreased expression of IGFALS mRNA CTD PMID:12735108 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression ISO Griseofulvin affects the expression of IGFBP2 mRNA CTD PMID:12735108 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] CTD PMID:11367519 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Inhbc inhibin subunit beta C decreases expression ISO Griseofulvin results in decreased expression of INHBC mRNA CTD PMID:12735108 NCBI chr 7:70,648,005...70,661,475
Ensembl chr 7:70,646,519...70,661,891
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects expression ISO Griseofulvin affects the expression of IQGAP1 mRNA CTD PMID:12735108 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Itgb2 integrin subunit beta 2 affects expression ISO Griseofulvin affects the expression of ITGB2 mRNA CTD PMID:12735108 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Krt18 keratin 18 multiple interactions
increases expression
decreases response to substance
ISO Griseofulvin promotes the reaction [KRT18 protein binds to KRT18 protein]
Griseofulvin results in increased expression of KRT18 mRNA; Griseofulvin results in increased expression of KRT18 protein
KRT18 protein results in decreased susceptibility to Griseofulvin
CTD PMID:7504119, PMID:8770877, PMID:10952237, PMID:12388748 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 increases expression
increases phosphorylation
ISO Griseofulvin results in increased expression of KRT8 mRNA; Griseofulvin results in increased expression of KRT8 protein
Griseofulvin results in increased phosphorylation of KRT8 protein
CTD PMID:7504119, PMID:10952237, PMID:12735108, PMID:20643122 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lamb1 laminin subunit beta 1 decreases expression ISO Griseofulvin results in decreased expression of LAMB1 protein CTD PMID:1573853 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamb2 laminin subunit beta 2 decreases expression
increases expression
ISO Griseofulvin results in decreased expression of LAMB2 protein
Griseofulvin results in increased expression of LAMB2 mRNA
CTD PMID:1573853 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 affects expression ISO Griseofulvin affects the expression of LILRB4 mRNA CTD PMID:12735108 NCBI chr 1:73,393,854...73,399,448
Ensembl chr 1:73,393,850...73,399,579
JBrowse link
G Lpl lipoprotein lipase affects expression ISO Griseofulvin affects the expression of LPL mRNA CTD PMID:12735108 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO Griseofulvin results in increased expression of LY6D mRNA CTD PMID:12735108 NCBI chr 7:115,993,304...115,994,812
Ensembl chr 7:115,993,301...115,994,783
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO Griseofulvin results in increased expression of MAPT mRNA; Griseofulvin results in increased expression of MAPT mRNA alternative form; Griseofulvin results in increased expression of MAPT protein CTD PMID:10051481 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mt1 metallothionein 1 increases expression ISO Griseofulvin results in increased expression of MT1 mRNA CTD PMID:12735108 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Npdc1 neural proliferation, differentiation and control, 1 affects expression ISO Griseofulvin affects the expression of NPDC1 mRNA CTD PMID:12735108 NCBI chr 3:2,624,231...2,630,672
Ensembl chr 3:2,625,015...2,630,670
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Griseofulvin results in increased expression of NQO1 mRNA CTD PMID:12735108 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Griseofulvin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 affects expression ISO Griseofulvin affects the expression of PAPSS2 mRNA CTD PMID:12735108 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
JBrowse link
G Pf4 platelet factor 4 affects expression ISO Griseofulvin affects the expression of PF4 mRNA CTD PMID:12735108 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression ISO Griseofulvin affects the expression of POR mRNA CTD PMID:12735108 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Griseofulvin results in decreased expression of PPARA mRNA CTD PMID:9548566 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO Griseofulvin results in increased expression of PPARD mRNA CTD PMID:9548566 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Griseofulvin results in increased expression of PPARG mRNA CTD PMID:9548566 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppl periplakin affects expression ISO Griseofulvin affects the expression of PPL mRNA CTD PMID:12735108 NCBI chr10:10,644,572...10,690,223
Ensembl chr10:10,644,572...10,690,223
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO Griseofulvin results in increased expression of RARA mRNA CTD PMID:9548566 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Griseofulvin results in increased expression of RARB mRNA CTD PMID:9548566 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma increases expression ISO Griseofulvin results in increased expression of RARG mRNA CTD PMID:9548566 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Griseofulvin results in decreased expression of RXRA mRNA CTD PMID:9548566 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrg retinoid X receptor gamma decreases expression ISO Griseofulvin results in decreased expression of RXRG mRNA CTD PMID:9548566 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO Griseofulvin results in increased expression of S100A6 mRNA CTD PMID:12735108 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 affects expression ISO Griseofulvin affects the expression of SCD2 mRNA CTD PMID:12735108 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Sele selectin E multiple interactions ISO Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:11367519 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L decreases expression ISO Griseofulvin results in decreased expression of SELL protein CTD PMID:11367519 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Soat1 sterol O-acyltransferase 1 affects expression ISO Griseofulvin affects the expression of SOAT1 mRNA CTD PMID:12735108 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression ISO Griseofulvin affects the expression of SPP1 mRNA CTD PMID:12735108 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgm2 transglutaminase 2 affects expression ISO Griseofulvin affects the expression of TGM2 mRNA CTD PMID:12735108 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Tm4sf4 transmembrane 4 L six family member 4 affects expression ISO Griseofulvin affects the expression of TM4SF4 mRNA CTD PMID:12735108 NCBI chr 2:147,532,032...147,547,254
Ensembl chr 2:147,496,229...147,547,252
JBrowse link
G Tmsb10 thymosin, beta 10 affects expression ISO Griseofulvin affects the expression of TMSB10 mRNA CTD PMID:12735108 NCBI chr 4:100,882,216...100,883,303
Ensembl chr 4:100,882,216...100,883,275
JBrowse link
G Tmsb4x thymosin beta 4, X-linked affects expression ISO Griseofulvin affects the expression of TMSB4X mRNA CTD PMID:12735108 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]] CTD PMID:11154858, PMID:11367519 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase affects expression ISO Griseofulvin affects the expression of UGDH mRNA CTD PMID:12735108 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Griseofulvin affects the expression of UGT1A1 mRNA CTD PMID:12735108 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
multiple interactions
ISO Griseofulvin affects the expression of VCAM1 mRNA
Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
CTD PMID:11154858, PMID:11367519, PMID:12735108 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vcl vinculin affects localization ISO Griseofulvin affects the localization of VCL protein CTD PMID:25412316 NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
JBrowse link
G Wnt3a Wnt family member 3A affects expression ISO Griseofulvin affects the expression of WNT3A mRNA CTD PMID:12735108 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Ybx3 Y box binding protein 3 affects expression ISO Griseofulvin affects the expression of YBX3 mRNA CTD PMID:12735108 NCBI chr 4:165,606,819...165,630,041
Ensembl chr 4:165,606,819...165,630,118
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        antimicrobial agent 17329
          antibacterial agent 13029
            griseofulvin 85
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19483
                              organic cyclic compound 19252
                                organic heterocyclic compound 18422
                                  oxacycle 17197
                                    benzofurans 3225
                                      1-benzofurans 1352
                                        griseofulvin 85
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.