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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:caffeine
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Accession:CHEBI:27732 term browser browse the term
Definition:A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Synonyms:related_synonym: 1,3,7-trimethyl-2,6-dioxopurine;   1,3,7-trimethylpurine-2,6-dione;   1,3,7-trimethylxanthine;   1-methyltheobromine;   3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion;   3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione;   7-methyltheophylline;   Coffein;   Formula=C8H10N4O2;   InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3;   InChIKey=RYYVLZVUVIJVGH-UHFFFAOYSA-N;   Koffein;   SMILES=Cn1cnc2n(C)c(=O)n(C)c(=O)c12;   Thein;   anhydrous caffeine;   cafeina;   cafeine;   guaranine;   mateina;   methyltheobromine;   teina;   theine
 alt_id: CHEBI:22982;   CHEBI:3295;   CHEBI:41472
 xref: Beilstein:17705;   CAS:58-08-2;   DrugBank:DB00201;   Drug_Central:463;   Gmelin:103040;   HMDB:HMDB0001847;   KEGG:C07481;   KEGG:D00528;   KNApSAcK:C00001492;   LINCS:LSM-2026
 xref_mesh: MESH:D002110
 xref: MetaCyc:1-3-7-TRIMETHYLXANTHINE;   PDBeChem:CFF;   PMID:10510174;   PMID:10796597;   PMID:10803761;   PMID:10822912;   PMID:10884512;   PMID:10924888;   PMID:10983026;   PMID:11014293;   PMID:11022879;   PMID:11209966;   PMID:11312039;   PMID:11410911;   PMID:11431501;   PMID:11815511;   PMID:11949272;   PMID:12397877;   PMID:12457274;   PMID:12574990;   PMID:12915014;   PMID:12943586;   PMID:14521986;   PMID:14607010;   PMID:15257305;   PMID:15280431;   PMID:15681408;   PMID:15718055;   PMID:15840517;   PMID:16143823;   PMID:16391865;   PMID:16528931;   PMID:16644114;   PMID:16709440;   PMID:16805851;   PMID:16856769;   PMID:17132260;   PMID:17387608;   PMID:17508167;   PMID:17724925;   PMID:17932622;   PMID:17957400;   PMID:18068204;   PMID:18258404;   PMID:18421070;   PMID:18625110;   PMID:18647558;   PMID:19007524;   PMID:19047957;   PMID:19084078;   PMID:19088793;   PMID:19418355;   PMID:19879252;   PMID:20164568;   PMID:20470411;   PMID:22770225;   PMID:7441110;   PMID:7689104;   PMID:8332255;   PMID:8347173;   PMID:8679661;   PMID:9063686;   PMID:9067318;   PMID:9132918;   PMID:9218278;   Reaxys:17705;   Wikipedia:Caffeine


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caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 4:25,150,998...25,209,489 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr10:79,296,681...79,342,749 JBrowse link
G Acan aggrecan decreases expression EXP Caffeine results in decreased expression of ACAN mRNA CTD PMID:29966748 PMID:32663519 NCBI chr 1:132,981,034...133,044,416 JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Caffeine results in decreased expression of ACAT2 mRNA CTD PMID:11793227 NCBI chr 1:47,695,833...47,713,879 JBrowse link
G Ace angiotensin I converting enzyme increases expression
decreases methylation
EXP Caffeine results in increased expression of ACE mRNA; Caffeine results in increased expression of ACE protein
Caffeine results in decreased methylation of ACE promoter
CTD PMID:30423288 NCBI chr10:90,910,316...90,930,437 JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
EXP caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein] CTD PMID:28465162 NCBI chr12:19,407,359...19,413,713 JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression ISO Caffeine results in increased expression of ACIN1 mRNA CTD PMID:11793227 NCBI chr15:28,102,112...28,147,001 JBrowse link
G Acly ATP citrate lyase increases expression EXP Caffeine results in increased expression of ACLY mRNA CTD PMID:30776459 NCBI chr10:85,412,045...85,464,253 JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO Caffeine results in increased expression of ACSL3 mRNA CTD PMID:11793227 NCBI chr 9:80,140,996...80,164,636 JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO Caffeine results in decreased expression of ACSL4 protein CTD PMID:31195006 NCBI chr  X:105,942,794...106,006,573 JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression EXP Caffeine results in increased expression of ACTA2 mRNA CTD PMID:29055810 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Actb actin, beta decreases expression ISO Caffeine results in decreased expression of ACTB protein CTD PMID:31195006 NCBI chr12:11,663,112...11,666,697 JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Caffeine results in increased expression of ACTBL2 protein CTD PMID:31195006 NCBI chr 2:42,858,020...42,860,767 JBrowse link
G Actl6b actin-like 6B increases expression ISO Caffeine results in increased expression of ACTL6B protein CTD PMID:31195006 NCBI chr12:19,124,887...19,141,419 JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:245,237,821...245,256,618 JBrowse link
G Ada adenosine deaminase increases expression EXP Caffeine results in increased expression of ADA protein CTD PMID:6149265 NCBI chr 3:152,398,745...152,422,854 JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 increases expression EXP Caffeine results in increased expression of ADAMTS5 mRNA CTD PMID:31874197 NCBI chr11:25,000,627...25,047,205 JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression EXP Caffeine results in decreased expression of ADARB1 mRNA CTD PMID:20864626 NCBI chr20:11,222,569...11,350,854 JBrowse link
G Adcy5 adenylate cyclase 5 decreases expression EXP Caffeine results in decreased expression of ADCY5 mRNA CTD PMID:26367767 NCBI chr11:65,471,612...65,618,877 JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:18,740,875...18,798,924 JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:24,202,405...24,244,137 JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Caffeine results in increased expression of ADIPOR2 mRNA CTD PMID:22583948 NCBI chr 4:152,524,604...152,588,848 JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
decreases expression
decreases activity
increases expression
ISO
EXP
[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA
Caffeine deficiency results in decreased expression of ADORA1 mRNA
Caffeine results in decreased activity of ADORA1 protein
Caffeine results in decreased expression of ADORA1 mRNA
Caffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]
Caffeine results in increased expression of ADORA1 protein
CTD PMID:3003150 PMID:7996441 PMID:10401785 PMID:12153486 PMID:15708489 PMID:22164264 PMID:23611293 PMID:29107002 PMID:29882086 NCBI chr13:45,658,872...45,695,821 JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
decreases expression
multiple interactions
decreases activity
increases response to substance
affects binding
ISO
EXP
ADORA2A protein affects the susceptibility to Caffeine
Caffeine results in decreased expression of ADORA2A mRNA
Caffeine results in decreased expression of ADORA2A mRNA; Caffeine results in decreased expression of ADORA2A protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]
ADORA2A polymorphism affects the susceptibility to Caffeine
Caffeine results in decreased activity of ADORA2A protein
ADORA2A polymorphism results in increased susceptibility to Caffeine; ADORA2A SNP results in increased susceptibility to Caffeine
Caffeine analog binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to and results in decreased activity of ADORA2A protein; Caffeine binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to ADORA2A protein
ADORA2A protein results in increased susceptibility to Caffeine
CTD PMID:10214707 PMID:11172060 PMID:12077927 PMID:12825092 PMID:15452191 PMID:16221767 PMID:16470403 PMID:16771831 PMID:18305461 PMID:20520601 PMID:21950736 PMID:23611293 PMID:26367767 PMID:30555576 PMID:30825513 NCBI chr20:13,315,848...13,333,386 JBrowse link
G Adora2b adenosine A2B receptor multiple interactions
decreases expression
ISO
EXP
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
Caffeine results in decreased expression of ADORA2B mRNA
CTD PMID:22701600 PMID:26367767 NCBI chr10:46,940,394...46,956,772 JBrowse link
G Agt angiotensinogen increases expression EXP Caffeine results in increased expression of AGT protein CTD PMID:30423288 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
decreases expression
EXP Caffeine results in increased expression of AGTR1A
Caffeine results in decreased expression of AGTR1A mRNA
CTD PMID:25986755 PMID:30423288 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Caffeine results in decreased expression of AGTR2 mRNA; Caffeine results in decreased expression of AGTR2 protein CTD PMID:25986755 PMID:30423288 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Caffeine results in decreased expression of AHCY protein CTD PMID:31195006 NCBI chr 3:143,569,134...143,584,359 JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression ISO Caffeine results in decreased expression of AKAP9 protein CTD PMID:31195006 NCBI chr 4:30,056,738...30,192,716 JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of AKR1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:130,092,945...130,130,277 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects expression
decreases expression
decreases phosphorylation
increases phosphorylation
decreases response to substance
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]
Caffeine affects the expression of AKT1 mRNA
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
Caffeine results in decreased expression of AKT1 mRNA; Caffeine results in decreased expression of AKT1 protein modified form
Caffeine results in decreased phosphorylation of AKT1 protein
AKT1 results in decreased susceptibility to Caffeine
CTD PMID:15126379 PMID:18201823 PMID:21081844 PMID:21561856 PMID:22974838 PMID:29966748 PMID:30528684 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression ISO Caffeine results in decreased expression of ALDH18A1 mRNA CTD PMID:11793227 NCBI chr 1:239,375,657...239,407,967 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] CTD PMID:20230807 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression EXP Caffeine results in increased expression of ALDH9A1 mRNA CTD PMID:20864626 NCBI chr13:79,505,738...79,522,539 JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases expression EXP Caffeine results in decreased expression of ALMS1 mRNA CTD PMID:25868845 NCBI chr 4:118,125,581...118,226,005 JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Caffeine results in decreased expression of ALPL mRNA CTD PMID:30423288 PMID:31874197 NCBI chr 5:149,951,397...150,006,424 JBrowse link
G Ang angiogenin decreases expression ISO Caffeine results in decreased expression of ANG mRNA CTD PMID:11793227 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Caffeine results in decreased expression of ANKRD37 mRNA CTD PMID:20864626 NCBI chr16:46,269,025...46,271,971 JBrowse link
G Anxa11 annexin A11 decreases expression ISO Caffeine results in decreased expression of ANXA11 protein CTD PMID:31195006 NCBI chr16:1,412,373...1,457,814 JBrowse link
G Anxa4 annexin A4 decreases expression ISO Caffeine results in decreased expression of ANXA4 protein CTD PMID:31195006 NCBI chr 4:119,184,378...119,241,183 JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:24,144,595...24,146,785 JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein
Caffeine results in decreased expression of APOA1 mRNA
CTD PMID:16324916 PMID:25868845 NCBI chr 8:46,527,251...46,529,035 JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein
Caffeine results in decreased expression of APOA2 mRNA
CTD PMID:16324916 PMID:25868845 NCBI chr13:83,644,460...83,646,358 JBrowse link
G Apob apolipoprotein B multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein
[Caffeine co-treated with Dietary Fats] results in increased expression of APOB mRNA
Caffeine results in decreased expression of APOB mRNA
CTD PMID:16324916 PMID:25868845 PMID:29800656 NCBI chr 6:30,844,386...30,883,983 JBrowse link
G Apoc1 apolipoprotein C1 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein
Caffeine results in decreased expression of APOC1 mRNA
CTD PMID:16324916 PMID:25868845 NCBI chr 1:79,347,057...79,350,340 JBrowse link
G Apoc2 apolipoprotein C2 multiple interactions
decreases expression
ISO
EXP
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein
Caffeine results in decreased expression of APOC2 mRNA
CTD PMID:16324916 PMID:25868845 NCBI chr 1:79,329,429...79,334,397 JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr 8:46,531,478...46,533,658 JBrowse link
G Apom apolipoprotein M decreases expression EXP Caffeine results in decreased expression of APOM mRNA CTD PMID:25868845 NCBI chr20:3,690,950...3,693,550 JBrowse link
G Arcn1 archain 1 decreases expression ISO Caffeine results in decreased expression of ARCN1 protein CTD PMID:31195006 NCBI chr 8:45,057,617...45,082,224 JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:43,997,983...44,014,543 JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 increases expression ISO Caffeine results in increased expression of ARL6IP1 mRNA CTD PMID:11793227 NCBI chr 1:172,430,475...172,439,990 JBrowse link
G Arrb2 arrestin, beta 2 increases expression EXP Caffeine results in increased expression of ARRB2 mRNA CTD PMID:20864626 NCBI chr10:55,146,887...55,154,854 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Caffeine results in decreased expression of ASNS mRNA CTD PMID:18444173 NCBI chr 4:35,784,995...35,803,474 JBrowse link
G Atg7 autophagy related 7 increases response to substance ISO ATG7 protein results in increased susceptibility to Caffeine; ATG7 results in increased susceptibility to Caffeine CTD PMID:21081844 NCBI chr 4:147,718,663...147,925,656 JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
decreases activity
ISO [[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]
CTD PMID:10531013 PMID:11507241 PMID:15975956 PMID:18347191 PMID:19028473 PMID:19038232 PMID:20734998 PMID:20888899 PMID:22927544 PMID:23274516 PMID:31168028 NCBI chr 8:53,828,741...53,932,773 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects response to substance ISO ATP2A2 protein affects the susceptibility to Caffeine CTD PMID:19328205 NCBI chr12:34,072,710...34,122,142 JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Caffeine results in decreased expression of ATP5MF mRNA CTD PMID:11793227 NCBI chr12:9,421,665...9,428,236 JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V0C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0C mRNA] CTD PMID:20230807 NCBI chr10:13,196,204...13,202,580 JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V1B2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V1B2 mRNA] CTD PMID:20230807 NCBI chr16:20,617,515...20,641,651 JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression EXP Caffeine results in decreased expression of ATPAF1 mRNA CTD PMID:20864626 NCBI chr 5:129,265,789...129,293,556 JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
affects activity
ISO [[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
Caffeine affects the activity of ATR protein
CTD PMID:11507241 PMID:15975956 PMID:18158334 PMID:20734998 NCBI chr 8:96,426,704...96,524,152 JBrowse link
G Atrn attractin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:118,110,320...118,244,326 JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr 7:58,114,306...58,118,230 JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO Caffeine results in increased expression of BASP1 protein CTD PMID:31195006 NCBI chr 2:75,816,130...75,863,801 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Caffeine results in increased expression of BAX protein
[Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA
CTD PMID:12811820 PMID:12907610 PMID:31756439 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] CTD PMID:19028473 NCBI chr 1:77,013,281...77,022,509 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of BCL2L1 mRNA CTD PMID:31756439 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Caffeine inhibits the reaction [aluminum chloride results in decreased expression of BDNF mRNA] CTD PMID:26339337 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein]
CTD PMID:30555576 NCBI chr10:86,231,387...86,246,742 JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Caffeine results in decreased expression of BGLAP mRNA CTD PMID:30423288 PMID:31874197 NCBI chr 2:173,838,518...173,839,495 JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 2:24,859,871...24,879,449 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr 4:154,113,198...154,136,353 JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:193,708,164...193,725,348 JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form CTD PMID:21670593 NCBI chr 3:115,020,254...115,051,650 JBrowse link
G C1r complement C1r multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:157,412,718...157,423,483 JBrowse link
G C2cd5 C2 calcium-dependent domain containing 5 increases expression EXP Caffeine results in increased expression of C2CD5 mRNA CTD PMID:20864626 NCBI chr 4:175,969,544...176,055,597 JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression EXP Caffeine results in increased expression of CAD protein CTD PMID:6149265 NCBI chr 6:25,292,133...25,315,176 JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CALM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:119,487,691...119,495,759 JBrowse link
G Calu calumenin decreases expression ISO Caffeine results in decreased expression of CALU mRNA CTD PMID:11793227 NCBI chr 4:57,949,086...57,976,589 JBrowse link
G Cand1 cullin-associated and neddylation-dissociated 1 decreases expression ISO Caffeine results in decreased expression of CAND1 protein CTD PMID:31195006 NCBI chr 7:54,681,114...54,719,002 JBrowse link
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr 1:203,275,912...203,300,848 JBrowse link
G Capn2 calpain 2 decreases expression ISO Caffeine results in decreased expression of CAPN2 protein CTD PMID:31195006 NCBI chr13:94,150,244...94,200,969 JBrowse link
G Casp2 caspase 2 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP2 protein] CTD PMID:16777994 NCBI chr 4:71,149,632...71,167,388 JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity
affects cleavage
ISO
EXP
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein
Caffeine results in decreased expression of CASP3 protein modified form
Caffeine results in increased expression of CASP3 mRNA
Caffeine results in increased cleavage of CASP3 protein
Caffeine results in increased activity of CASP3 protein
[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Caffeine affects the cleavage of CASP3 protein
CTD PMID:12378022 PMID:12395097 PMID:12907610 PMID:15537744 PMID:16522534 PMID:16777994 PMID:18201823 PMID:18283038 PMID:19242509 PMID:19490937 PMID:19815060 PMID:21081844 PMID:21229324 PMID:31874197 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp9 caspase 9 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP9 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
CTD PMID:16522534 PMID:16777994 PMID:20230807 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase multiple interactions
decreases expression
increases expression
ISO
EXP
Caffeine inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein]
Caffeine results in decreased expression of CAT mRNA
Caffeine results in increased expression of CAT protein
[Caffeine co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [Caffeine co-treated with Cadmium Chloride] results in increased expression of CAT protein
CTD PMID:22154906 PMID:23099337 PMID:25868845 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Cav1 caveolin 1 increases expression ISO Caffeine results in increased expression of CAV1 protein CTD PMID:31195006 NCBI chr 4:45,640,624...45,673,708 JBrowse link
G Cav3 caveolin 3 decreases expression EXP Caffeine results in decreased expression of CAV3 mRNA CTD PMID:25868845 NCBI chr 4:145,582,168...145,598,142 JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:134,333,165...134,376,102 JBrowse link
G Ccdc124 coiled-coil domain containing 124 increases expression ISO Caffeine results in increased expression of CCDC124 protein CTD PMID:31195006 NCBI chr16:18,566,745...18,572,564 JBrowse link
G Ccdc174 coiled-coil domain containing 174 decreases expression EXP Caffeine results in decreased expression of CCDC174 mRNA CTD PMID:20864626 NCBI chr 4:124,392,183...124,419,035 JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
decreases expression
ISO Caffeine results in increased expression of CCL3 mRNA
Caffeine results in decreased expression of CCL3 mRNA
CTD PMID:28089782 NCBI chr10:68,451,388...68,452,938 JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
ISO Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein]
Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein]
Caffeine results in increased expression of CCNB1 protein
CTD PMID:9098629 PMID:19038232 PMID:20025956 NCBI chr 2:31,912,190...31,921,163 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:15126379 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Ccnf cyclin F multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CCNF mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNF mRNA] CTD PMID:20230807 NCBI chr10:13,253,073...13,279,140 JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr10:25,176,231...25,182,604 JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:166,416,940...166,428,997 JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Caffeine results in decreased expression of CCT8 protein CTD PMID:31195006 NCBI chr11:26,710,370...26,722,079 JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd59 CD59 molecule increases expression ISO Caffeine results in increased expression of CD59 protein CTD PMID:31195006 NCBI chr 3:90,459,085...90,477,571 JBrowse link
G Cd9 CD9 molecule decreases expression ISO Caffeine results in decreased expression of CD9 protein CTD PMID:31195006 NCBI chr 4:158,256,328...158,289,136 JBrowse link
G Cdc14b cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr17:844,731...934,787 JBrowse link
G Cdc25b cell division cycle 25B increases expression EXP Caffeine results in increased expression of CDC25B mRNA CTD PMID:20864626 NCBI chr 3:118,407,127...118,417,272 JBrowse link
G Cdc25c cell division cycle 25C decreases expression
multiple interactions
ISO Caffeine results in decreased expression of CDC25C protein
Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]
CTD PMID:11835680 PMID:15975956 NCBI chr18:26,335,156...26,356,199 JBrowse link
G Cdh1 cadherin 1 increases expression EXP Caffeine results in increased expression of CDH1 mRNA CTD PMID:20864626 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,148,447...2,305,754 JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of CDK1 protein]; Caffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein
Caffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]
CTD PMID:9098629 PMID:11835680 PMID:15975956 PMID:19038232 NCBI chr20:19,266,226...19,281,417 JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Caffeine results in decreased activity of CDK2 protein CTD PMID:11835680 NCBI chr 7:1,129,878...1,137,431 JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein]
Caffeine results in decreased expression of CDK4 mRNA
CTD PMID:11793227 PMID:15126379 NCBI chr 7:62,885,647...62,889,562 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]
CTD PMID:17977830 PMID:18223691 PMID:18347191 PMID:19735649 PMID:21840268 PMID:22927544 PMID:23274516 PMID:30555576 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
affects expression
increases expression
EXP Caffeine results in decreased expression of CEBPA mRNA
Caffeine affects the expression of CEBPA mRNA
Caffeine results in increased expression of CEBPA mRNA
CTD PMID:23727198 PMID:30423288 PMID:30528684 PMID:30776459 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression EXP Caffeine results in decreased expression of CEBPB mRNA CTD PMID:30528684 NCBI chr 3:156,398,035...156,399,466 JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 1:219,330,295...219,407,760 JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:12,089,025...12,101,828 JBrowse link
G Cfd complement factor D multiple interactions ISO [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr 7:9,813,148...9,814,871 JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
ISO Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein]
Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
Caffeine results in decreased expression of CHEK1 protein modified form
Caffeine results in decreased phosphorylation of CHEK1 protein
CTD PMID:15975956 PMID:18158334 PMID:19261750 PMID:21505179 PMID:21561856 PMID:22403396 PMID:29074359 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
decreases activity
ISO Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]; Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
Caffeine results in decreased activity of CHEK2 protein
CTD PMID:10531013 PMID:15975956 PMID:16777994 PMID:18158334 PMID:19038232 PMID:23274516 NCBI chr12:45,788,823...45,821,382 JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CKMT1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:108,329,859...108,335,760 JBrowse link
G Clic1 chloride intracellular channel 1 increases expression ISO Caffeine results in increased expression of CLIC1 protein CTD PMID:31195006 NCBI chr20:3,764,867...3,773,711 JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:160,031,235...160,094,585 JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:9,712,505...9,719,711 JBrowse link
G Cobl cordon-bleu WH2 repeat protein affects expression EXP Caffeine affects the expression of COBL mRNA CTD PMID:20864626 NCBI chr14:86,828,137...87,060,682 JBrowse link
G Coch cochlin decreases expression EXP Caffeine results in decreased expression of COCH mRNA CTD PMID:20864626 NCBI chr 6:69,031,139...69,045,124 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]
Caffeine results in decreased expression of COL1A1 mRNA
CTD PMID:20230807 PMID:24275088 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Caffeine results in decreased expression of COL2A1 mRNA; Caffeine results in decreased expression of COL2A1 protein CTD PMID:29966748 PMID:32663519 NCBI chr 7:129,098,489...129,127,620 JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:82,568,052...82,587,642 JBrowse link
G Coq8a coenzyme Q8A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COQ8A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COQ8A mRNA] CTD PMID:20230807 NCBI chr13:91,904,731...91,933,588 JBrowse link
G Cort cortistatin decreases expression EXP Caffeine results in decreased expression of CORT protein CTD PMID:25868845 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7A2L mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:11,184,284...11,198,287 JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:16,841,771...16,843,796 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Caffeine results in decreased expression of CPT1A mRNA CTD PMID:30776459 NCBI chr 1:200,564,634...200,627,059 JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO
EXP
Caffeine results in decreased expression of CREB1 mRNA CTD PMID:26367767 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 decreases expression ISO Caffeine results in decreased expression of CRTC2 protein CTD PMID:31195006 NCBI chr 2:175,709,603...175,719,768 JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 decreases expression EXP Caffeine results in decreased expression of CSNK2A2 mRNA CTD PMID:20864626 NCBI chr19:9,556,443...9,596,080 JBrowse link
G Cst3 cystatin C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CST3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:136,336,923...136,340,796 JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA CTD PMID:29447158 NCBI chr 2:246,975,888...247,002,234 JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis
multiple interactions
EXP Caffeine results in increased mutagenesis of CTNNB1 gene
Caffeine inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]
CTD PMID:18283038 PMID:30377735 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA]
CTD PMID:19490937 PMID:20230807 NCBI chr15:37,389,636...37,410,508 JBrowse link
G Ctsd cathepsin D increases expression ISO Caffeine results in increased expression of CTSD protein CTD PMID:31195006 NCBI chr 1:197,527,467...197,539,343 JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:764,370...770,533 JBrowse link
G Cwc25 CWC25 spliceosome-associated protein homolog decreases expression ISO Caffeine results in decreased expression of CWC25 protein CTD PMID:31195006 NCBI chr10:82,735,698...82,760,373 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 4:150,388,326...150,401,173 JBrowse link
G Cyc1 cytochrome c-1 decreases expression ISO Caffeine results in decreased expression of CYC1 mRNA CTD PMID:11793227 NCBI chr 7:108,067,106...108,069,483 JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Caffeine results in decreased expression of CYP11A1 mRNA CTD PMID:24717552 PMID:25868845 NCBI chr 8:58,422,807...58,434,342 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Caffeine results in decreased expression of CYP11B1 mRNA CTD PMID:25868845 PMID:29343424 PMID:30528684 NCBI chr 7:106,838,590...106,845,004 JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Caffeine results in decreased expression of CYP11B2 mRNA CTD PMID:25868845 PMID:29343424 NCBI chr 7:106,808,559...106,814,048 JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP Caffeine results in increased expression of CYP17A1 mRNA CTD PMID:25868845 NCBI chr 1:245,535,462...245,543,148 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Caffeine results in increased expression of CYP19A1 mRNA; Caffeine results in increased expression of CYP19A1 protein CTD PMID:28111094 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Caffeine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing
increases activity
decreases methylation
ISO
EXP
CYP1A2 protein binds to Caffeine
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]
Caffeine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolite
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of Caffeine
Caffeine results in increased activity of CYP1A2 protein
CTD PMID:1302044 PMID:9334905 PMID:11145498 PMID:11376689 PMID:11465391 PMID:11907490 PMID:12433797 PMID:12706856 PMID:14586384 PMID:14586387 PMID:15022032 PMID:15199075 PMID:15286053 PMID:15327588 PMID:15619608 PMID:15659567 PMID:15822860 PMID:15856409 PMID:15980104 PMID:16934051 PMID:18420780 PMID:19215233 PMID:20716633 PMID:24211539 PMID:26599973 PMID:28843594 PMID:31132250 NCBI chr 8:58,075,367...58,082,255 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Caffeine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression
decreases expression
EXP Caffeine results in increased expression of CYP21A1 mRNA
Caffeine results in decreased expression of CYP21A1 mRNA; Caffeine results in decreased expression of CYP21A2 mRNA
CTD PMID:24717552 PMID:25868845 PMID:30528684 NCBI chr20:4,020,217...4,026,923 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 NCBI chr 7:113,882,584...113,891,754 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of Caffeine CTD PMID:1302044 PMID:14586387 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression ISO Caffeine results in increased expression of CYP4B1 mRNA CTD PMID:18444173 NCBI chr 5:129,139,019...129,176,860 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP Caffeine results in decreased expression of CYP7B1 mRNA CTD PMID:20864626 NCBI chr 2:100,502,791...100,669,713 JBrowse link
G Dad1 defender against cell death 1 decreases expression ISO Caffeine results in decreased expression of DAD1 mRNA CTD PMID:11793227 NCBI chr15:27,677,285...27,697,275 JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 decreases expression EXP Caffeine results in decreased expression of DCAF11 mRNA CTD PMID:20864626 NCBI chr15:29,046,744...29,057,450 JBrowse link
G Dct dopachrome tautomerase increases expression ISO Caffeine results in increased expression of DCT mRNA CTD PMID:18444173 NCBI chr15:95,062,006...95,100,863 JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DCXR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DCXR mRNA] CTD PMID:20230807 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Ddhd1 DDHD domain containing 1 increases expression EXP Caffeine results in increased expression of DDHD1 mRNA CTD PMID:20864626 NCBI chr15:18,824,389...18,891,036 JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP Caffeine results in decreased expression of DDX31 mRNA CTD PMID:20864626 NCBI chr 3:12,172,829...12,238,392 JBrowse link
G Ddx39a DExD-box helicase 39A decreases expression ISO Caffeine results in decreased expression of DDX39A protein CTD PMID:31195006 NCBI chr19:24,418,743...24,427,422 JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression EXP Caffeine results in decreased expression of DHCR24 mRNA CTD PMID:20864626 NCBI chr 5:121,344,637...121,368,853 JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Caffeine results in decreased expression of DHCR7 mRNA CTD PMID:25868845 NCBI chr 1:199,015,081...199,031,055 JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases expression EXP Caffeine results in increased expression of DHODH protein CTD PMID:6149265 NCBI chr19:37,551,858...37,573,327 JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:55,842,414...55,853,326 JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of DNAJB9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:61,270,385...61,276,795 JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression ISO Caffeine results in increased expression of DNAJC12 protein CTD PMID:31195006 NCBI chr20:25,246,744...25,267,508 JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression EXP Caffeine results in increased expression of DNMT1 mRNA CTD PMID:24717552 NCBI chr 8:19,440,611...19,486,659 JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression EXP Caffeine results in increased expression of DNMT3A mRNA CTD PMID:24717552 NCBI chr 6:26,791,517...26,902,161 JBrowse link
G Dnmt3b DNA methyltransferase 3 beta increases expression EXP Caffeine results in increased expression of DNMT3B mRNA CTD PMID:25868845 PMID:30423288 NCBI chr 3:142,130,592...142,169,124 JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:46,962,243...47,043,870 JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
increases response to substance
multiple interactions
ISO
EXP
DRD2 polymorphism affects the susceptibility to Caffeine
DRD2 protein results in increased susceptibility to Caffeine
Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]
CTD PMID:11172060 PMID:16889759 PMID:18305461 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 decreases expression EXP Caffeine results in decreased expression of DTX4 mRNA CTD PMID:20864626 NCBI chr 1:209,457,719...209,545,163 JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression EXP Caffeine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr 1:197,167,392...197,184,285 JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA] CTD PMID:22403396 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression EXP Caffeine results in increased expression of EBP mRNA CTD PMID:25868845 NCBI chr  X:14,299,427...14,305,826 JBrowse link
G Ebpl EBP like decreases expression EXP Caffeine results in decreased expression of EBPL mRNA CTD PMID:20864626 NCBI chr15:35,508,074...35,531,472 JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression EXP Caffeine results in decreased expression of ECI1 mRNA CTD PMID:20864626 NCBI chr10:13,456,715...13,470,061 JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ECM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:183,287,491...183,292,729 JBrowse link
G Edn1 endothelin 1 increases activity EXP Caffeine results in increased activity of EDN1 protein CTD PMID:1860718 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF1A1 mRNA]
Caffeine results in increased expression of EEF1A1 protein
CTD PMID:20230807 PMID:31195006 NCBI chr 8:79,341,554...79,344,784 JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO Caffeine results in decreased expression of EEF1D protein CTD PMID:31195006 NCBI chr 7:107,581,930...107,596,735 JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma increases expression ISO Caffeine results in increased expression of EEF1G protein CTD PMID:31195006 NCBI chr 1:205,860,713...205,871,319 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA] CTD PMID:20230807 NCBI chr 7:8,533,248...8,538,518 JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA] CTD PMID:20230807 NCBI chr 2:174,681,676...174,690,306 JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNB3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:54,274,506...54,281,951 JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Caffeine results in increased expression of EGR1 mRNA
Caffeine results in decreased expression of EGR1 mRNA
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]
[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA
CTD PMID:10971643 PMID:16771831 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO Caffeine results in increased expression of EHBP1 protein CTD PMID:31195006 NCBI chr14:96,093,327...96,380,502 JBrowse link
G Ehd1 EH-domain containing 1 decreases expression ISO Caffeine results in decreased expression of EHD1 protein CTD PMID:31195006 NCBI chr 1:203,579,850...203,602,226 JBrowse link
G Ehd2 EH-domain containing 2 decreases expression ISO Caffeine results in decreased expression of EHD2 protein CTD PMID:31195006 NCBI chr 1:76,639,568...76,658,747 JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Caffeine results in increased expression of EIF1 mRNA CTD PMID:11793227 NCBI chr10:85,246,751...85,248,842 JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B decreases expression ISO Caffeine results in decreased expression of EIF3B protein CTD PMID:31195006 NCBI chr12:14,196,403...14,220,865 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] CTD PMID:20230807 NCBI chr 2:227,066,519...227,099,261 JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
increases expression
ISO
EXP
Caffeine results in decreased expression of EIF4EBP1 protein modified form
Caffeine results in increased expression of EIF4EBP1 protein
CTD PMID:21081844 NCBI chr16:64,792,595...64,805,984 JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EIF5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807
G Ell elongation factor for RNA polymerase II decreases expression EXP Caffeine results in decreased expression of ELL mRNA CTD PMID:20864626 NCBI chr16:18,845,025...18,891,484 JBrowse link
G Emc6 ER membrane protein complex subunit 6 decreases expression EXP Caffeine results in decreased expression of EMC6 mRNA CTD PMID:20864626 NCBI chr10:57,794,072...57,795,671 JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression EXP Caffeine results in decreased expression of ENDOD1 mRNA CTD PMID:20864626 NCBI chr 8:11,209,123...11,238,680 JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:160,719,951...160,731,337 JBrowse link
G Eppk1 epiplakin 1 decreases expression ISO Caffeine results in decreased expression of EPPK1 protein CTD PMID:31195006 NCBI chr 7:107,816,919...107,842,946 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:91,326,889...91,421,201 JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERP44 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:62,516,550...62,610,762 JBrowse link
G Esyt2 extended synaptotagmin 2 decreases expression EXP Caffeine results in decreased expression of ESYT2 mRNA CTD PMID:20864626 NCBI chr 6:137,219,653...137,312,590 JBrowse link
G Etv3 ETS variant transcription factor 3 increases expression ISO Caffeine results in increased expression of ETV3 protein CTD PMID:31195006 NCBI chr 2:172,965,461...172,980,320 JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Caffeine results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483 JBrowse link
G Ezr ezrin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] CTD PMID:20230807 NCBI chr 1:46,967,961...47,011,505 JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO
EXP
Caffeine results in decreased expression of FABP4 mRNA CTD PMID:23727198 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G Farsa phenylalanyl-tRNA synthetase subunit alpha increases expression ISO Caffeine results in increased expression of FARSA protein CTD PMID:31195006 NCBI chr19:23,291,409...23,300,985 JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP Caffeine results in decreased expression of FAS mRNA CTD PMID:29343424 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
ISO
EXP
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA
Caffeine results in increased expression of FASN mRNA; Caffeine results in increased expression of FASN protein
CTD PMID:28843594 PMID:30776459 NCBI chr10:106,072,093...106,090,259 JBrowse link
G Fastkd3 FAST kinase domains 3 decreases expression EXP Caffeine results in decreased expression of FASTKD3 mRNA CTD PMID:20864626 NCBI chr 1:34,858,342...34,866,988 JBrowse link
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion increases expression ISO Caffeine results in increased expression of FAU protein CTD PMID:31195006 NCBI chr 1:203,350,226...203,351,741 JBrowse link
G Fbln2 fibulin 2 increases expression EXP Caffeine results in increased expression of FBLN2 mRNA CTD PMID:20864626 NCBI chr 4:123,704,289...123,763,857 JBrowse link
G Fbrs fibrosin increases expression EXP Caffeine results in increased expression of FBRS mRNA CTD PMID:20864626 NCBI chr 1:182,090,741...182,104,026 JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of FBXL12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:19,175,864...19,183,373 JBrowse link
G Fbxl19 F-box and leucine-rich repeat protein 19 decreases expression ISO Caffeine results in decreased expression of FBXL19 protein CTD PMID:31195006 NCBI chr 1:182,356,899...182,380,839 JBrowse link
G Fcsk fucose kinase increases expression EXP Caffeine results in increased expression of FCSK mRNA CTD PMID:20864626 NCBI chr19:38,849,130...38,874,497 JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression
increases expression
EXP Caffeine results in decreased expression of FDFT1 mRNA
Caffeine results in increased expression of FDFT1 mRNA
CTD PMID:20864626 PMID:25868845 NCBI chr15:37,412,143...37,440,198 JBrowse link
G Fdx1 ferredoxin 1 decreases expression EXP Caffeine results in decreased expression of FDX1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr 8:52,268,536...52,287,344 JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Caffeine results in increased expression of FHL1 mRNA CTD PMID:20864626 NCBI chr  X:134,555,399...134,614,930 JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression EXP Caffeine results in increased expression of FILIP1L mRNA CTD PMID:20864626 NCBI chr11:42,937,353...43,177,085 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Caffeine results in increased expression of FOS mRNA
[Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]
CTD PMID:10971643 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA] CTD PMID:20230807 NCBI chr20:42,767,733...42,960,903 JBrowse link
G Gale UDP-galactose-4-epimerase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GALE mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GALE mRNA] CTD PMID:20230807 NCBI chr 5:148,193,886...148,198,392 JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO Caffeine results in decreased expression of GANAB protein CTD PMID:31195006 NCBI chr 1:205,793,810...205,813,701 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:157,962,312...157,967,158 JBrowse link
G Gast gastrin increases secretion EXP Caffeine results in increased secretion of GAST protein CTD PMID:19208342 NCBI chr10:85,264,832...85,269,393 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 8:78,629,899...78,668,547 JBrowse link
G Gdf10 growth differentiation factor 10 decreases expression EXP Caffeine results in decreased expression of GDF10 mRNA CTD PMID:20864626 NCBI chr16:9,237,182...9,250,537 JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO
EXP
Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein]
Caffeine inhibits the reaction [aluminum chloride results in increased expression of GFAP protein]
CTD PMID:19882200 PMID:26339337 NCBI chr10:87,852,891...87,861,631 JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] CTD PMID:11907490 NCBI chr10:91,228,102...91,230,079 JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GHITM mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:12,885,551...12,897,887 JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Caffeine results in decreased expression of GJA1 mRNA CTD PMID:28087314 NCBI chr20:35,756,007...35,768,481 JBrowse link
G Glrx glutaredoxin decreases expression ISO Caffeine results in decreased expression of GLRX mRNA CTD PMID:11793227 NCBI chr 2:5,341,873...5,351,686 JBrowse link
G Glt8d1 glycosyltransferase 8 domain containing 1 decreases expression ISO Caffeine results in decreased expression of GLT8D1 mRNA CTD PMID:11793227 NCBI chr16:6,192,269...6,207,227 JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO Caffeine results in decreased expression of GLUD1 mRNA CTD PMID:11793227 NCBI chr16:9,640,312...9,673,961 JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:20,069,923...20,081,005 JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression
increases expression
EXP Caffeine results in decreased expression of GNAI1 protein
Caffeine results in increased expression of GNAI1 mRNA
CTD PMID:15708489 NCBI chr 4:16,813,941...16,898,111 JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Caffeine results in decreased expression of GNAI2 protein CTD PMID:15708489 NCBI chr 8:108,288,401...108,309,009 JBrowse link
G Gnal G protein subunit alpha L increases response to substance ISO GNAL protein results in increased susceptibility to Caffeine CTD PMID:11404425 NCBI chr18:60,622,311...60,762,599 JBrowse link
G Gnaq G protein subunit alpha q decreases expression EXP Caffeine results in decreased expression of GNAQ protein CTD PMID:15998294 NCBI chr 1:213,425,631...213,671,947 JBrowse link
G Gnas GNAS complex locus decreases expression EXP Caffeine results in decreased expression of GNAS protein CTD PMID:15708489 NCBI chr 3:163,071,003...163,136,350 JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:175,333,056...175,346,156 JBrowse link
G Gosr1 golgi SNAP receptor complex member 1 decreases expression EXP Caffeine results in decreased expression of GOSR1 mRNA CTD PMID:20864626 NCBI chr10:61,570,499...61,607,287 JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 decreases expression ISO Caffeine results in decreased expression of GOT2 protein CTD PMID:31195006 NCBI chr19:9,174,304...9,199,995 JBrowse link
G Gpc3 glypican 3 affects expression EXP Caffeine affects the expression of GPC3 mRNA CTD PMID:20864626 NCBI chr  X:131,868,983...132,236,837 JBrowse link
G Gpi glucose-6-phosphate isomerase decreases expression ISO Caffeine results in decreased expression of GPI protein CTD PMID:31195006 NCBI chr 1:86,828,211...86,856,077 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
EXP Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]; fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Caffeine results in increased activity of GPT protein
CTD PMID:11394713 PMID:30776459 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Caffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA] CTD PMID:31756439 NCBI chr 8:109,026,905...109,028,031 JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:39,028,624...39,036,695 JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 NCBI chr 7:9,650,186...9,652,982 JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:92,415,019...93,892,472 JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Caffeine results in decreased expression of GRM1 protein CTD PMID:15998294 NCBI chr 1:5,058,285...5,453,170 JBrowse link
G Grpr gastrin releasing peptide receptor decreases expression EXP Caffeine results in decreased expression of GRPR mRNA CTD PMID:20864626 NCBI chr  X:30,998,425...31,038,442 JBrowse link
G Grwd1 glutamate-rich WD repeat containing 1 decreases expression EXP Caffeine results in decreased expression of GRWD1 mRNA CTD PMID:20864626 NCBI chr 1:96,301,260...96,306,962 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression EXP Caffeine results in increased expression of GSK3A mRNA CTD PMID:25868845 NCBI chr 1:80,815,843...80,825,732 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
decreases phosphorylation
multiple interactions
ISO Caffeine results in increased phosphorylation of GSK3B protein
Caffeine results in decreased phosphorylation of GSK3B protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]
CTD PMID:15126379 PMID:21229324 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr16:58,482,209...58,525,256 JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Caffeine results in decreased expression of GSTO1 mRNA CTD PMID:11793227 NCBI chr 1:246,721,089...246,731,228 JBrowse link
G H1f0 H1.0 linker histone decreases expression ISO Caffeine results in decreased expression of H1F0 protein CTD PMID:31195006 NCBI chr 7:110,592,834...110,594,694 JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-4 protein CTD PMID:31195006 NCBI chr17:41,486,634...41,487,293 JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-5 protein CTD PMID:31195006 NCBI chr17:42,726,189...42,726,857 JBrowse link
G H1f6 H1.6 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-6 protein CTD PMID:31195006 NCBI chr17:41,427,365...41,428,109 JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP
Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]
[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein
CTD PMID:15537744 PMID:15975956 PMID:16777994 PMID:20888899 PMID:24069304 PMID:26231820 NCBI chr 8:44,671,927...44,673,257 JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 decreases expression EXP Caffeine results in decreased expression of HACD1 mRNA CTD PMID:20864626 NCBI chr17:77,081,508...77,106,114 JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,337,265...15,338,121 JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP Caffeine results in increased expression of HDAC1 mRNA CTD PMID:24717552 NCBI chr 5:141,853,992...141,881,057 JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP Caffeine results in increased expression of HDAC2 mRNA CTD PMID:24717552 NCBI chr20:40,548,250...40,571,609 JBrowse link
G Hdac7 histone deacetylase 7 increases expression EXP Caffeine results in increased expression of HDAC7 mRNA; Caffeine results in increased expression of HDAC7 protein CTD PMID:31306741 NCBI chr 7:128,923,918...128,962,025 JBrowse link
G Hdlbp high density lipoprotein binding protein decreases expression EXP Caffeine results in decreased expression of HDLBP mRNA CTD PMID:25868845 NCBI chr 9:93,948,099...94,018,040 JBrowse link
G Heca hdc homolog, cell cycle regulator increases expression EXP Caffeine results in increased expression of HECA mRNA CTD PMID:20864626 NCBI chr 1:12,525,135...12,575,358 JBrowse link
G Hells helicase, lymphoid specific multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]
Caffeine results in increased expression of HELLS protein
CTD PMID:20025956 PMID:20230807 NCBI chr 1:236,701,704...236,748,239 JBrowse link
G Hhipl2 HHIP like 2 decreases expression ISO Caffeine results in decreased expression of HHIPL2 protein CTD PMID:31195006 NCBI chr13:95,054,685...95,074,609 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of HIF1A mRNA CTD PMID:31756439 NCBI chr 6:92,624,059...92,669,262 JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] CTD PMID:20230807 NCBI chr10:38,989,516...38,993,259 JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Caffeine results in increased expression of H4C9 protein CTD PMID:31195006 NCBI chr17:42,480,467...42,484,912 JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Caffeine results in decreased expression of HMGA1 protein CTD PMID:31195006 NCBI chr20:5,611,088...5,618,755 JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO Caffeine results in decreased expression of HMGA2 protein CTD PMID:31195006 NCBI chr 7:55,877,145...55,998,813 JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO Caffeine results in decreased expression of HMGB1 protein CTD PMID:31195006 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
EXP
ISO
[Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA; Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]
Caffeine results in increased expression of HMGCR mRNA; Caffeine results in increased expression of HMGCR protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]
CTD PMID:29800656 PMID:29958987 PMID:30825513 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression
increases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of HMGCS1 mRNA
Caffeine results in increased expression of HMGCS1 mRNA
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]
CTD PMID:20864626 PMID:25868845 PMID:30825513 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Caffeine results in decreased expression of HNRNPA1 protein CTD PMID:31195006 NCBI chr 7:134,375,318...134,381,610 JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HNRNPC mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:24,779,593...24,809,213 JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Caffeine results in decreased expression of HNRNPDL protein CTD PMID:31195006 NCBI chr14:9,558,079...9,563,654 JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO Caffeine results in decreased expression of HNRNPF protein CTD PMID:31195006 NCBI chr 4:151,083,262...151,104,464 JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Caffeine results in decreased expression of HNRNPH1 protein CTD PMID:31195006 NCBI chr10:34,692,868...34,702,849 JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
EXP
ISO
Caffeine results in decreased expression of HNRNPK mRNA
Caffeine results in increased expression of HNRNPK protein
CTD PMID:25868845 PMID:31195006 NCBI chr17:6,262,936...6,275,001 JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:24,542,777...24,645,715 JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Caffeine results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:81,252,616...81,256,034 JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP Caffeine results in increased expression of HPRT1 protein CTD PMID:6149265 NCBI chr  X:132,736,175...132,768,149 JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] CTD PMID:20230807 NCBI chr 1:196,290,127...196,299,823 JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Caffeine results in increased expression of HSD11B1 mRNA CTD PMID:22583948 PMID:30423288 PMID:30528684 NCBI chr13:104,728,539...104,798,884 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of HSD11B2 mRNA
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
CTD PMID:22583948 PMID:22701600 PMID:30423288 PMID:30528684 NCBI chr19:33,397,656...33,402,899 JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP Caffeine results in decreased expression of HSD17B7 mRNA CTD PMID:20864626 NCBI chr13:82,170,079...82,190,018 JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
decreases expression
EXP Caffeine results in increased expression of HSD3B1 mRNA
Caffeine results in decreased expression of HSD3B1 mRNA
CTD PMID:25868845 PMID:30528684 NCBI chr 2:186,169,864...186,175,984 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] CTD PMID:20230807 NCBI chr 6:129,702,376...129,707,907 JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Caffeine results in decreased expression of HSP90B1 mRNA CTD PMID:25868845 NCBI chr 7:21,110,431...21,124,762 JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Caffeine results in increased expression of HSPA4 protein CTD PMID:31195006 NCBI chr10:37,408,025...37,449,080 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Caffeine results in decreased expression of HSPA9 protein CTD PMID:31195006 NCBI chr18:26,536,131...26,554,294 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression
decreases expression
EXP
ISO
Caffeine results in increased expression of HSPB1 mRNA
Caffeine results in decreased expression of HSPB1 protein
CTD PMID:20864626 PMID:31195006 NCBI chr12:20,794,014...20,795,675 JBrowse link
G Hspb6 heat shock protein family B (small) member 6 increases expression EXP Caffeine results in increased expression of HSPB6 mRNA CTD PMID:20864626 NCBI chr 1:85,806,898...85,809,072 JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:56,589,912...56,593,000 JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Caffeine results in decreased expression of IBSP mRNA CTD PMID:31874197 NCBI chr14:5,439,825...5,452,570 JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Caffeine results in decreased expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression EXP Caffeine results in increased expression of ID3 mRNA CTD PMID:20864626 NCBI chr 5:148,372,784...148,374,353 JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Caffeine results in decreased expression of IDI1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr17:61,629,592...61,637,357 JBrowse link
G Igf1 insulin-like growth factor 1 decreases secretion
multiple interactions
affects expression
decreases activity
decreases expression
ISO
EXP
Caffeine results in decreased secretion of IGF1 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNA
Caffeine affects the expression of IGF1 protein
Caffeine results in decreased activity of IGF1 protein
Caffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 protein
CTD PMID:1995187 PMID:22583948 PMID:24239806 PMID:29343424 PMID:29966748 PMID:30528684 PMID:31756439 NCBI chr 7:22,282,895...22,361,972 JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression
EXP Caffeine results in decreased expression of IGF1R mRNA; Caffeine results in decreased expression of IGF1R protein
Caffeine affects the expression of IGF1R mRNA
CTD PMID:22583948 PMID:29343424 PMID:29966748 PMID:30528684 NCBI chr 1:121,549,839...121,838,545 JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Caffeine results in increased expression of IGFBP1 mRNA CTD PMID:11793227 NCBI chr14:82,047,415...82,052,482 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases expression EXP Caffeine results in increased expression of IKBKB mRNA CTD PMID:20864626 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Il10 interleukin 10 increases expression ISO Caffeine results in increased expression of IL10 mRNA CTD PMID:28089782 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression EXP Caffeine results in increased expression of IL10RB mRNA CTD PMID:20864626 NCBI chr11:30,646,494...30,668,081 JBrowse link
G Il12a interleukin 12A decreases expression ISO Caffeine results in decreased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 2:152,965,769...152,973,035 JBrowse link
G Il12b interleukin 12B multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:26852703 NCBI chr10:28,888,832...28,903,796 JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
ISO
EXP
Caffeine results in decreased expression of IL1B mRNA
Caffeine results in increased expression of IL1B mRNA
CTD PMID:28089782 PMID:29055810 PMID:30776459 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Caffeine results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266 JBrowse link
G Il3 interleukin 3 multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA] CTD PMID:26852703 NCBI chr10:38,405,716...38,408,066 JBrowse link
G Il4r interleukin 4 receptor increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of IL4RA mRNA
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IL4RA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA]
CTD PMID:20230807 PMID:20864626 NCBI chr 1:180,115,061...180,139,981 JBrowse link
G Il5 interleukin 5 increases expression ISO Caffeine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr10:37,874,342...37,877,213 JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of IL6 mRNA
Caffeine results in increased expression of IL6 mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
CTD PMID:23727198 PMID:26852703 PMID:29055810 PMID:30776459 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Ilf3 interleukin enhancer binding factor 3 increases expression ISO Caffeine results in increased expression of ILF3 protein CTD PMID:31195006 NCBI chr 8:19,922,409...19,960,495 JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of IMPDH2 protein CTD PMID:31195006 NCBI chr 8:109,256,705...109,261,365 JBrowse link
G Ino80c INO80 complex subunit C decreases expression EXP Caffeine results in decreased expression of INO80C mRNA CTD PMID:20864626 NCBI chr18:15,378,764...15,398,574 JBrowse link
G Ins2 insulin 2 multiple interactions ISO Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP Caffeine results in decreased expression of INSIG1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr 4:7,315,494...7,323,972 JBrowse link
G Insr insulin receptor decreases expression EXP Caffeine results in decreased expression of INSR mRNA CTD PMID:22583948 NCBI chr12:1,193,193...1,330,976 JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:151,768,621...151,778,521 JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:15,211,882...15,215,323 JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGAM protein] CTD PMID:19882200 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:48,545,998...48,568,904 JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Caffeine results in decreased expression of ITPR1 mRNA CTD PMID:18444173 NCBI chr 4:141,187,377...141,554,240 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation
increases expression
ISO Caffeine results in decreased phosphorylation of JUN protein
Caffeine results in increased expression of JUN protein
CTD PMID:17145898 PMID:20025956 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Kctd14 potassium channel tetramerization domain containing 14 decreases expression EXP Caffeine results in decreased expression of KCTD14 mRNA CTD PMID:20864626 NCBI chr 1:151,761,045...151,766,693 JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression ISO Caffeine results in increased expression of KHSRP protein CTD PMID:31195006 NCBI chr 9:1,862,555...1,872,301 JBrowse link
G Kidins220 kinase D-interacting substrate 220 increases expression EXP Caffeine results in increased expression of KIDINS220 mRNA CTD PMID:20864626 NCBI chr 6:41,618,207...41,706,990 JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KIF3B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:141,758,466...141,798,012 JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Caffeine results in decreased expression of KLF4 mRNA; Caffeine results in decreased expression of KLF4 protein
CTD PMID:20230807 PMID:31306741 NCBI chr 5:70,278,843...70,283,751 JBrowse link
G Krt1 keratin 1 decreases expression ISO Caffeine results in decreased expression of KRT1 protein CTD PMID:31195006 NCBI chr 7:132,976,618...132,981,844 JBrowse link
G Krt18 keratin 18 decreases expression ISO Caffeine results in decreased expression of KRT18 protein CTD PMID:31195006 NCBI chr 7:133,157,486...133,161,162 JBrowse link
G Krt36 keratin 36 decreases expression ISO Caffeine results in decreased expression of KRT36 protein CTD PMID:31195006 NCBI chr10:85,036,594...85,039,959 JBrowse link
G Krt84 keratin 84 decreases expression ISO Caffeine results in decreased expression of KRT84 protein CTD PMID:31195006 NCBI chr 7:132,649,064...132,656,885 JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Caffeine results in increased expression of LAMB1 protein CTD PMID:31195006 NCBI chr 6:47,835,492...47,902,585 JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Caffeine results in decreased expression of LDHA mRNA CTD PMID:11793227 NCBI chr 1:97,371,823...97,381,247 JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP [Caffeine co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; Caffeine promotes the reaction [Dietary Fats results in decreased expression of LDLR mRNA] CTD PMID:29800656 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Lep leptin decreases expression
multiple interactions
ISO
EXP
Caffeine results in decreased expression of LEP mRNA
Caffeine results in decreased expression of LEP mRNA; Caffeine results in decreased expression of LEP protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]
CTD PMID:23727198 PMID:26367767 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Lepr leptin receptor increases expression
decreases expression
EXP Caffeine results in increased expression of LEPR mRNA
Caffeine results in decreased expression of LEPR mRNA
CTD PMID:22583948 PMID:26367767 NCBI chr 5:116,294,409...116,477,904 JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Caffeine results in decreased expression of LMNB1 protein CTD PMID:31195006 NCBI chr18:50,175,861...50,215,210 JBrowse link
G LOC100361457 actin, gamma 1 propeptide-like decreases expression ISO Caffeine results in decreased expression of POTEE protein CTD PMID:31195006 NCBI chr 3:72,977,764...72,979,691 JBrowse link
G LOC100361854 ribosomal protein S26-like increases expression ISO Caffeine results in increased expression of RPS26 protein CTD PMID:31195006 NCBI chr  X:107,822,116...107,822,555 JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:72,033,486...72,046,978 JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of LPL mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA
CTD PMID:23727198 PMID:28843594 NCBI chr16:20,830,055...20,853,855 JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr20:12,091,138...12,118,858 JBrowse link
G Lysmd2 LysM domain containing 2 decreases expression EXP Caffeine results in decreased expression of LYSMD2 mRNA CTD PMID:20864626 NCBI chr 8:76,378,984...76,394,395 JBrowse link
G Mael maelstrom spermatogenic transposon silencer decreases expression ISO Caffeine results in decreased expression of MAEL protein CTD PMID:31195006 NCBI chr13:78,457,073...78,496,657 JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:6,032,172...6,098,308 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases cleavage
multiple interactions
ISO Caffeine results in increased cleavage of MAP1LC3B protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
CTD PMID:30555576 NCBI chr19:49,665,795...49,673,655 JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAP2K7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:2,591,312...2,604,211 JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP3K12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP3K12 mRNA] CTD PMID:20230807 NCBI chr 7:133,630,267...133,648,464 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
decreases phosphorylation
ISO Caffeine results in increased expression of MAPK1 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Caffeine results in decreased phosphorylation of MAPK1 protein
CTD PMID:17145898 PMID:21081844 PMID:22974838 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk15 mitogen-activated protein kinase 15 increases expression EXP Caffeine results in increased expression of MAPK15 mRNA CTD PMID:20864626 NCBI chr 7:107,694,907...107,714,640 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
decreases phosphorylation
ISO Caffeine results in increased expression of MAPK3 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Caffeine results in decreased phosphorylation of MAPK3 protein
CTD PMID:17145898 PMID:21081844 PMID:22974838 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Marchf11 membrane associated ring-CH-type finger 11 decreases expression EXP Caffeine results in decreased expression of MARCHF11 mRNA CTD PMID:20864626 NCBI chr 2:76,898,330...76,999,690 JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MC2R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MC2R mRNA] CTD PMID:20230807 NCBI chr18:62,001,980...62,015,567 JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Caffeine results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314 JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of MDH2 protein CTD PMID:31195006 NCBI chr12:20,894,269...20,907,225 JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression
multiple interactions
EXP Caffeine results in increased expression of MEF2A mRNA; Caffeine results in increased expression of MEF2A protein
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]
CTD PMID:25093688 NCBI chr 1:120,847,874...120,982,488 JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases expression
EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]
Caffeine results in increased expression of MEF2C mRNA; Caffeine results in increased expression of MEF2C protein
CTD PMID:25093688 NCBI chr 2:13,973,299...14,136,065 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Caffeine results in decreased expression of MGST1 mRNA CTD PMID:11793227 NCBI chr 4:171,029,666...171,044,893 JBrowse link
G Micb MHC class I polypeptide-related sequence B multiple interactions ISO Caffeine inhibits the reaction [[Decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein] CTD PMID:18395517 NCBI chr 1:78,495,779...78,513,030 JBrowse link
G Mill1 MHC I like leukocyte 1 multiple interactions ISO Caffeine inhibits the reaction [Resveratrol results in increased expression of MICA protein] CTD PMID:23445485 NCBI chr 1:78,372,138...78,398,932 JBrowse link
G Mir101a microRNA 101a multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 5:115,966,332...115,966,406 JBrowse link
G Mir122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr 1:203,564,946...203,565,055 JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
EXP Caffeine inhibits the reaction [aluminum chloride results in decreased expression of MKI67 protein]
Caffeine results in decreased expression of MKI67 protein
CTD PMID:26339337 PMID:30528684 NCBI chr 1:190,496,319...190,522,983 JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr12:21,542,964...21,577,120 JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP Caffeine results in increased expression of MMP13 mRNA CTD PMID:31874197 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] CTD PMID:20230807 NCBI chr 8:4,848,186...4,855,908 JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 decreases expression EXP Caffeine results in decreased expression of MOGAT1 mRNA CTD PMID:20864626 NCBI chr 9:79,980,963...79,988,513 JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression ISO Caffeine results in increased expression of MOS protein CTD PMID:31195006 NCBI chr 5:16,859,957...16,861,264 JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression EXP Caffeine results in decreased expression of MRM3 mRNA CTD PMID:20864626 NCBI chr10:61,095,920...61,125,421 JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 decreases expression EXP Caffeine results in decreased expression of MRPL19 mRNA CTD PMID:20864626 NCBI chr 4:114,521,824...114,526,053 JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:166,408,962...166,413,492 JBrowse link
G mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:182,082,012...182,086,758 JBrowse link
G Mrps5 mitochondrial ribosomal protein S5 increases expression ISO Caffeine results in increased expression of MRPS5 protein CTD PMID:31195006 NCBI chr 3:114,821,046...114,837,291 JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Caffeine results in decreased expression of MSH2 mRNA CTD PMID:12706856 NCBI chr 6:6,813,793...6,872,960 JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression EXP Caffeine results in decreased expression of MSMO1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr16:24,980,680...24,997,927 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:10,832,009...10,832,783 JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTCH1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:7,389,942...7,413,426 JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:1,639,256...1,683,513 JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like decreases expression EXP Caffeine results in decreased expression of MTHFD2L mRNA CTD PMID:20864626 NCBI chr14:17,089,947...17,170,036 JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity ISO Caffeine results in decreased activity of MTOR protein CTD PMID:21081844 NCBI chr 5:158,884,856...158,994,311 JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase decreases expression EXP Caffeine results in decreased expression of MTRR mRNA CTD PMID:20864626 NCBI chr 1:34,866,991...34,899,425 JBrowse link
G Mutyh mutY DNA glycosylase increases expression EXP Caffeine results in increased expression of MUTYH mRNA CTD PMID:20864626 NCBI chr 5:130,274,034...130,286,149 JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression EXP Caffeine results in decreased expression of MVD mRNA CTD PMID:25868845 NCBI chr19:50,496,366...50,506,389 JBrowse link
G Mvk mevalonate kinase increases expression EXP Caffeine results in increased expression of MVK mRNA CTD PMID:25868845 NCBI chr12:42,141,391...42,158,858 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA] CTD PMID:18283038 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Myh7 myosin heavy chain 7 increases expression
multiple interactions
EXP Caffeine results in increased expression of MYH7 mRNA
Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; Cyclosporine inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]
CTD PMID:25093688 NCBI chr15:28,446,550...28,469,888 JBrowse link
G Myl6b myosin light chain 6B decreases expression ISO Caffeine results in decreased expression of MYL6B protein CTD PMID:31195006 NCBI chr  X:40,572,012...40,572,991 JBrowse link
G Myof myoferlin increases expression ISO Caffeine results in increased expression of MYOF protein CTD PMID:31195006 NCBI chr 1:235,673,666...235,822,413 JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects metabolic processing
ISO NAT2 protein results in increased acetylation of Caffeine
NAT2 gene polymorphism affects the metabolism of Caffeine; NAT2 protein affects the metabolism of Caffeine
CTD PMID:14586384 PMID:14586387 PMID:14747882 PMID:15199075 PMID:15327588 PMID:15558239 PMID:15980104 PMID:24221535 NCBI chr16:22,207,362...22,238,513 JBrowse link
G Ncl nucleolin increases expression ISO Caffeine results in increased expression of NCL protein CTD PMID:31195006 NCBI chr 9:86,999,588...87,008,112 JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NDUFB5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:115,519,248...115,533,589 JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFS4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFS4 mRNA] CTD PMID:20230807 NCBI chr 2:45,951,327...46,061,829 JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Caffeine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347 JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Caffeine results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,641...216,095,276 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:22974838 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:26852703 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nisch nischarin multiple interactions EXP Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr16:6,364,370...6,400,675 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22974838 PMID:26852703 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA CTD PMID:29447158 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin decreases expression EXP Caffeine results in decreased expression of NPHS2 mRNA CTD PMID:25986755 PMID:31306741 NCBI chr13:68,448,720...68,461,312 JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:65,655,099...65,697,464 JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression
EXP Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:15452191 PMID:25093688 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions
EXP Caffeine results in increased expression of NPPB mRNA
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]
CTD PMID:25093688 NCBI chr 5:158,416,813...158,418,175 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Caffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 protein CTD PMID:22583948 PMID:30423288 PMID:30528684 PMID:30776459 PMID:31306741 PMID:32663519 NCBI chr18:31,271,681...31,393,320 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Caffeine results in increased expression of NR3C2 mRNA CTD PMID:22959462 NCBI chr19:30,715,648...31,059,885 JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases methylation
decreases expression
EXP Caffeine results in increased methylation of NR5A1 promoter
Caffeine results in decreased expression of NR5A1 mRNA; Caffeine results in decreased expression of NR5A1 protein
CTD PMID:24717552 NCBI chr 3:22,464,786...22,486,328 JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression EXP Caffeine results in decreased expression of NRF1 mRNA CTD PMID:20864626 NCBI chr 4:58,664,932...58,772,328 JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:88,727,912...88,857,375 JBrowse link
G Nt5e 5' nucleotidase, ecto decreases activity
multiple interactions
EXP Caffeine results in decreased activity of NT5E protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]
CTD PMID:28465162 NCBI chr 8:89,271,046...89,314,918 JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oat ornithine aminotransferase increases expression ISO Caffeine results in increased expression of OAT mRNA CTD PMID:11793227 NCBI chr 1:187,347,862...187,367,644 JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Caffeine results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336 JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Caffeine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:76,766,637...76,776,149 JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 increases expression EXP Caffeine results in increased expression of OXSR1 mRNA CTD PMID:20864626 NCBI chr 8:118,972,754...119,062,102 JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of P3H3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:157,646,238...157,662,035 JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 decreases expression EXP Caffeine results in decreased expression of PAK1 mRNA CTD PMID:29343424 NCBI chr 1:152,111,172...152,226,390 JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions
increases activity
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]
Caffeine results in increased activity of PAK2 protein
CTD PMID:19325779 PMID:20230807 NCBI chr11:68,708,070...68,766,622 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects cleavage
decreases response to substance
multiple interactions
increases cleavage
ISO
EXP
Caffeine affects the cleavage of PARP1 protein
PARP1 protein results in decreased susceptibility to Caffeine
Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 protein
Caffeine results in increased cleavage of PARP1 protein
CTD PMID:16522534 PMID:19242509 PMID:19490937 PMID:21229324 PMID:21840268 PMID:22226932 PMID:30377735 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pax3 paired box 3 decreases expression ISO Caffeine results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042 JBrowse link
G Pcare photoreceptor cilium actin regulator decreases expression ISO Caffeine results in decreased expression of PCARE protein CTD PMID:31195006 NCBI chr 6:23,749,700...23,758,419 JBrowse link
G Pcna proliferating cell nuclear antigen affects expression EXP Caffeine affects the expression of PCNA mRNA; Caffeine affects the expression of PCNA protein CTD PMID:29343424 NCBI chr 3:119,499,039...119,502,911 JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression EXP Caffeine results in decreased expression of PCSK9 mRNA CTD PMID:25868845 NCBI chr 5:121,211,278...121,233,688 JBrowse link
G Pde11a phosphodiesterase 11A decreases expression EXP Caffeine results in decreased expression of PDE11A mRNA CTD PMID:20864626 NCBI chr 3:60,913,562...61,297,154 JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Caffeine results in decreased expression of PDE5A mRNA CTD PMID:20864626 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X decreases expression EXP Caffeine results in decreased expression of PDHX mRNA CTD PMID:20864626 NCBI chr 3:89,372,472...89,396,759 JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PDIA6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:40,062,980...40,080,223 JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:28,014,145...28,067,148 JBrowse link
G Pfkm phosphofructokinase, muscle affects expression ISO Caffeine affects the expression of PFKM protein CTD PMID:25486098 NCBI chr 7:129,221,679...129,259,192 JBrowse link
G Pgk2 phosphoglycerate kinase 2 decreases expression ISO Caffeine results in decreased expression of PGK2 protein CTD PMID:31195006 NCBI chr 9:20,480,367...20,481,933 JBrowse link
G Pgr progesterone receptor increases expression EXP Caffeine results in increased expression of PGR mRNA CTD PMID:20864626 NCBI chr 8:6,073,216...6,131,552 JBrowse link
G Phb prohibitin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA] CTD PMID:20230807 NCBI chr10:80,605,268...80,618,043 JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Caffeine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183 JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PHTF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA] CTD PMID:20230807 NCBI chr 2:191,470,849...191,537,399 JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:196,536,815...196,542,808 JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:74,343,619...74,346,148 JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:8,397,406...8,426,030 JBrowse link
G Pitx2 paired-like homeodomain 2 decreases expression EXP Caffeine results in decreased expression of PITX2 mRNA CTD PMID:20864626 NCBI chr 2:217,717,738...217,737,293 JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting multiple interactions
affects response to substance
ISO PKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]
PKD1 protein affects the susceptibility to Caffeine
CTD PMID:18679710 NCBI chr10:13,573,779...13,621,138 JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 2:218,436,450...218,452,760 JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions
decreases expression
EXP Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]
Caffeine results in decreased expression of PLCB1 protein
CTD PMID:15998294 NCBI chr 3:122,059,968...122,772,896 JBrowse link
G Plec plectin decreases expression ISO Caffeine results in decreased expression of PLEC protein CTD PMID:31195006 NCBI chr 7:107,887,764...107,949,100 JBrowse link
G Plg plasminogen decreases expression EXP Caffeine results in decreased expression of PLG mRNA CTD PMID:25868845 NCBI chr 1:48,325,186...48,367,643 JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Caffeine results in increased expression of PLP1 mRNA CTD PMID:18444173 NCBI chr  X:100,184,039...100,201,035 JBrowse link
G Pls1 plastin 1 increases expression ISO Caffeine results in increased expression of PLS1 protein CTD PMID:31195006 NCBI chr 8:96,316,703...96,426,592 JBrowse link
G Pls3 plastin 3 decreases expression ISO Caffeine results in decreased expression of PLS3 protein CTD PMID:31195006 NCBI chr  X:111,589,193...111,683,908 JBrowse link
G Pnp purine nucleoside phosphorylase increases expression EXP Caffeine results in increased expression of PNP protein CTD PMID:6149265 NCBI chr15:24,170,456...24,178,274 JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:61,329,810...61,391,736 JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Caffeine results in increased secretion of POMC protein alternative form CTD PMID:22959462 NCBI chr 6:26,939,844...26,945,666 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Caffeine results in decreased expression of PPARA mRNA CTD PMID:30776459 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO
EXP
Caffeine results in decreased expression of PPARG mRNA CTD PMID:23727198 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Caffeine results in increased expression of PPARGC1A mRNA CTD PMID:17516843 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression ISO Caffeine results in increased expression of PPFIBP1 protein CTD PMID:31195006 NCBI chr 4:179,807,579...179,951,428 JBrowse link
G Ppial4g peptidylprolyl isomerase A like 4G decreases expression ISO Caffeine results in decreased expression of PPIAL4G protein CTD PMID:31195006 NCBI chr15:74,015,628...74,016,215 JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:9,646,695...9,707,471 JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Caffeine results in decreased expression of PPP2R2B mRNA CTD PMID:18444173 NCBI chr18:34,653,716...35,080,889 JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:72,647,025...72,670,885 JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO Caffeine results in increased expression of PRDX2 protein CTD PMID:31195006 NCBI chr19:23,180,927...23,186,217 JBrowse link
G Prelid1 PRELI domain containing 1 decreases expression ISO Caffeine results in decreased expression of PRELID1 mRNA CTD PMID:11793227 NCBI chr17:9,305,349...9,308,389 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Caffeine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 2:54,240,298...54,275,978 JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Caffeine results in increased expression of PRKAA2 mRNA CTD PMID:22583948 NCBI chr 5:119,807,992...119,879,987 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression ISO
EXP
Caffeine results in decreased expression of PRKACA protein CTD PMID:30825513 NCBI chr19:24,155,081...24,178,430 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression EXP Caffeine results in decreased expression of PRKAR1A mRNA CTD PMID:29343424 NCBI chr10:94,621,042...94,639,534 JBrowse link
G Prkcsh protein kinase C substrate 80K-H increases expression ISO Caffeine results in increased expression of PRKCSH protein CTD PMID:31195006 NCBI chr 8:20,534,787...20,546,493 JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
PRKDC protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]
CTD PMID:18158334 PMID:20888899 NCBI chr11:85,040,790...85,258,357 JBrowse link
G Prmt3 protein arginine methyltransferase 3 decreases expression EXP Caffeine results in decreased expression of PRMT3 mRNA CTD PMID:20864626 NCBI chr 1:99,492,712...99,581,774 JBrowse link
G Prnp prion protein decreases expression ISO Caffeine results in decreased expression of PRNP mRNA CTD PMID:18444173 NCBI chr 3:119,186,073...119,201,513 JBrowse link
G Prorsd1 prolyl-tRNA synthetase associated domain containing 1 decreases expression EXP Caffeine results in decreased expression of PRORSD1 mRNA CTD PMID:20864626 NCBI chr14:103,257,979...103,260,248 JBrowse link
G Prph peripherin decreases expression ISO Caffeine results in decreased expression of PRPH protein CTD PMID:31195006 NCBI chr 7:130,218,149...130,222,136 JBrowse link
G Psma2 proteasome 20S subunit alpha 2 decreases expression ISO Caffeine results in decreased expression of PSMA2 protein CTD PMID:31195006 NCBI chr17:50,554,536...50,564,923 JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression ISO Caffeine results in increased expression of PSMA5 protein CTD PMID:31195006 NCBI chr 2:195,896,369...195,919,733 JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 decreases expression ISO Caffeine results in decreased expression of PSMC3 protein CTD PMID:31195006 NCBI chr 3:77,031,825...77,037,207 JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO Caffeine results in increased expression of PSMC4 protein CTD PMID:31195006 NCBI chr 1:83,349,127...83,357,497 JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:91,187,763...91,193,697 JBrowse link
G Psme3 proteasome activator subunit 3 decreases expression ISO Caffeine results in decreased expression of PSME3 mRNA CTD PMID:11793227 NCBI chr10:86,257,672...86,265,458 JBrowse link
G Ptgfrn prostaglandin F2 receptor inhibitor increases expression EXP Caffeine results in increased expression of PTGFRN mRNA CTD PMID:20864626 NCBI chr 2:188,469,521...188,544,795 JBrowse link
G Ptgr1 prostaglandin reductase 1 decreases expression EXP Caffeine results in decreased expression of PTGR1 mRNA CTD PMID:25868845 NCBI chr 5:73,784,000...73,802,624 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO Caffeine results in decreased expression of PTGS2 protein
Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:21561856 PMID:22974838 PMID:26852703 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pwp2 PWP2, small subunit processome component decreases expression EXP Caffeine results in decreased expression of PWP2 mRNA CTD PMID:20864626 NCBI chr20:10,499,332...10,512,965 JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression EXP Caffeine results in increased expression of QARS1 mRNA CTD PMID:20864626 NCBI chr 8:109,207,705...109,215,738 JBrowse link
G Qrsl1 glutaminyl-tRNA amidotransferase subunit QRSL1 decreases expression EXP Caffeine results in decreased expression of QRSL1 mRNA CTD PMID:20864626 NCBI chr20:47,357,211...47,382,135 JBrowse link
G Rab3ip RAB3A interacting protein increases expression EXP Caffeine results in increased expression of RAB3IP mRNA CTD PMID:20864626 NCBI chr 7:52,531,461...52,575,295 JBrowse link
G Rab5c RAB5C, member RAS oncogene family decreases expression ISO Caffeine results in decreased expression of RAB5C protein CTD PMID:31195006 NCBI chr10:85,642,553...85,666,142 JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:120,461,966...120,510,756 JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 decreases expression EXP Caffeine results in decreased expression of RABGEF1 mRNA CTD PMID:20864626 NCBI chr12:26,459,190...26,503,790 JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 decreases expression EXP Caffeine results in decreased expression of RABL3 mRNA CTD PMID:20864626 NCBI chr11:63,153,281...63,182,240 JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Caffeine results in increased expression of RAC2 protein CTD PMID:31195006 NCBI chr 7:110,101,344...110,128,718 JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:59,461,597...59,469,707 JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAD50 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA] CTD PMID:20230807 NCBI chr10:37,809,353...37,861,309 JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Caffeine results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,759,454...159,772,524 JBrowse link
G Ralgapb Ral GTPase activating protein non-catalytic subunit beta decreases expression ISO Caffeine results in decreased expression of RALGAPB protein CTD PMID:31195006 NCBI chr 3:147,062,443...147,152,090 JBrowse link
G Ran RAN, member RAS oncogene family increases expression ISO Caffeine results in increased expression of RAN protein CTD PMID:31195006 NCBI chr12:27,674,049...27,678,598 JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:75,855,360...75,969,349 JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Caffeine results in decreased phosphorylation of RB1 protein CTD PMID:15126379 PMID:21229324 NCBI chr15:48,371,295...48,502,473 JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:141,655,863...141,675,157 JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:43,912,254...43,939,107 JBrowse link
G Rbm12 RNA binding motif protein 12 decreases expression EXP Caffeine results in decreased expression of RBM12 mRNA CTD PMID:20864626 NCBI chr 3:144,587,548...144,629,950 JBrowse link
G Rbmx RNA binding motif protein, X-linked decreases expression ISO Caffeine results in decreased expression of RBMX protein CTD PMID:31195006 NCBI chr  X:135,305,237...135,314,806 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:22974838 PMID:26852703 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Ren renin increases expression
increases secretion
increases activity
EXP
ISO
Caffeine results in increased expression of REN protein
Caffeine results in increased secretion of REN protein
Caffeine results in increased activity of REN protein
CTD PMID:1860718 PMID:3020089 PMID:3044993 PMID:8244516 PMID:10803761 NCBI chr13:44,796,260...44,807,491 JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RGS2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA] CTD PMID:20230807 NCBI chr13:55,799,749...55,802,354 JBrowse link
G Rhebl1 RHEB like 1 increases expression EXP Caffeine results in increased expression of RHEBL1 mRNA CTD PMID:20864626 NCBI chr 7:130,026,309...130,031,127 JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 decreases expression EXP Caffeine results in decreased expression of RIMS2 mRNA CTD PMID:20864626 NCBI chr 7:70,248,104...70,759,134 JBrowse link
G Rnf166 ring finger protein 166 increases expression EXP Caffeine results in increased expression of RNF166 mRNA CTD PMID:20864626 NCBI chr19:50,529,434...50,539,274 JBrowse link
G Rnh1 ribonuclease/angiogenin inhibitor 1 decreases expression ISO Caffeine results in decreased expression of RNH1 protein CTD PMID:31195006 NCBI chr 1:196,269,293...196,281,763 JBrowse link
G Rpia ribose 5-phosphate isomerase A decreases expression EXP Caffeine results in decreased expression of RPIA mRNA CTD PMID:20864626 NCBI chr 4:102,723,712...102,749,374 JBrowse link
G Rpl10a ribosomal protein L10A decreases expression ISO Caffeine results in decreased expression of RPL10A protein CTD PMID:31195006 NCBI chr20:6,388,800...6,391,358 JBrowse link
G Rpl13 ribosomal protein L13 decreases expression ISO Caffeine results in decreased expression of RPL13 protein CTD PMID:31195006 NCBI chr19:51,153,990...51,156,541 JBrowse link
G Rpl17 ribosomal protein L17 increases expression ISO Caffeine results in increased expression of RPL17 protein CTD PMID:31195006 NCBI chr18:68,581,147...68,584,253 JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:53,610,836...53,613,966 JBrowse link
G Rpl27a ribosomal protein L27a increases expression ISO Caffeine results in increased expression of RPL27A protein CTD PMID:31195006 NCBI chr 1:163,539,732...163,542,771 JBrowse link
G Rpl29 ribosomal protein L29 increases expression ISO Caffeine results in increased expression of RPL29 protein CTD PMID:31195006 NCBI chr 8:107,068,929...107,070,963 JBrowse link
G Rpl36 ribosomal protein L36 increases expression ISO Caffeine results in increased expression of RPL36 protein CTD PMID:31195006 NCBI chr 9:1,441,986...1,447,397 JBrowse link
G Rpl36a ribosomal protein L36a decreases expression ISO Caffeine results in decreased expression of RPL36A protein CTD PMID:31195006 NCBI chr  X:97,766,179...97,768,892 JBrowse link
G Rpl4 ribosomal protein L4 increases expression ISO Caffeine results in increased expression of RPL4 protein CTD PMID:31195006 NCBI chr 8:64,671,177...64,676,301 JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RPL5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:1,843,856...1,850,301 JBrowse link
G Rpl7a ribosomal protein L7a increases expression ISO Caffeine results in increased expression of RPL7A protein CTD PMID:31195006 NCBI chr 3:10,239,026...10,241,703 JBrowse link
G Rpn1 ribophorin I increases expression ISO Caffeine results in increased expression of RPN1 protein CTD PMID:31195006 NCBI chr 4:120,543,667...120,565,069 JBrowse link
G Rpn2 ribophorin II increases expression ISO Caffeine results in increased expression of RPN2 protein CTD PMID:31195006 NCBI chr 3:145,941,787...145,989,271 JBrowse link
G Rps11 ribosomal protein S11 increases expression ISO Caffeine results in increased expression of RPS11 protein CTD PMID:31195006 NCBI chr 1:95,605,690...95,607,798 JBrowse link
G Rps14 ribosomal protein S14 increases expression ISO Caffeine results in increased expression of RPS14 protein CTD PMID:31195006 NCBI chr18:54,227,854...54,232,638 JBrowse link
G Rps18 ribosomal protein S18 increases expression ISO Caffeine results in increased expression of RPS18 protein CTD PMID:31195006 NCBI chr20:4,931,427...4,935,538 JBrowse link
G Rps19 ribosomal protein S19 decreases expression ISO Caffeine results in decreased expression of RPS19 protein CTD PMID:31195006
G Rps20 ribosomal protein S20 decreases expression ISO Caffeine results in decreased expression of RPS20 protein CTD PMID:31195006 NCBI chr 5:16,819,313...16,820,475 JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO Caffeine results in decreased expression of RPS28 protein CTD PMID:31195006 NCBI chr 7:14,607,801...14,609,170 JBrowse link
G Rps3a ribosomal protein S3a increases expression ISO Caffeine results in increased expression of RPS3A protein CTD PMID:31195006 NCBI chr 2:171,524,685...171,529,054 JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO
EXP
Caffeine results in decreased expression of RPS6 protein modified form CTD PMID:21081844 NCBI chr 5:101,371,716...101,374,576 JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression ISO Caffeine results in decreased expression of RPS6KA3 mRNA CTD PMID:11793227 NCBI chr  X:35,517,306...35,623,296 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO
EXP
Caffeine results in decreased expression of RPS6KB1 protein modified form CTD PMID:21081844 NCBI chr10:71,323,777...71,367,908 JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 6:41,339,858...41,346,774 JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO Caffeine results in increased expression of RRS1 mRNA CTD PMID:11793227 NCBI chr 5:9,733,486...9,735,119 JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:28,283,914...28,368,661 JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression EXP Caffeine results in decreased expression of RUNX2 mRNA CTD PMID:30423288 PMID:31874197 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G Rwdd2b RWD domain containing 2B decreases expression EXP Caffeine results in decreased expression of RWDD2B mRNA CTD PMID:20864626 NCBI chr11:26,665,877...26,677,986 JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases response to substance
multiple interactions
ISO Caffeine results in increased activity of RYR1 protein
RYR1 gene mutant form results in increased susceptibility to Caffeine; RYR1 protein mutant form results in increased susceptibility to Caffeine
[Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium; RYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]
TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]
CTD PMID:14641996 PMID:15210166 PMID:16372898 PMID:16484216 PMID:18719443 PMID:19191329 PMID:21485675 NCBI chr 1:84,292,578...84,423,799 JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]; HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:58,389,925...58,975,641 JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Caffeine results in increased expression of S100A10 protein CTD PMID:31195006 NCBI chr 2:179,221,012...179,229,659 JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Caffeine results in decreased expression of S100A6 protein CTD PMID:31195006 NCBI chr 2:176,100,619...176,102,181 JBrowse link
G Sap18 Sin3A associated protein 18 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SAP18 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SAP18 mRNA] CTD PMID:20230807 NCBI chr15:31,943,228...31,947,534 JBrowse link
G Sc5d sterol-C5-desaturase decreases expression EXP Caffeine results in decreased expression of SC5D mRNA CTD PMID:25868845 NCBI chr 8:42,629,649...42,641,257 JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
increases methylation
EXP Caffeine results in decreased expression of SCARB1 mRNA; Caffeine results in decreased expression of SCARB1 protein
Caffeine inhibits the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 protein]
Caffeine results in increased methylation of SCARB1 promoter
CTD PMID:25868845 PMID:29800656 PMID:29958987 NCBI chr12:31,296,143...31,362,649 JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of SCD1 mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA
CTD PMID:20864626 PMID:28843594 NCBI chr 1:243,269,745...243,282,878 JBrowse link
G Scfd1 sec1 family domain containing 1 decreases expression ISO Caffeine results in decreased expression of SCFD1 mRNA CTD PMID:11793227 NCBI chr 6:68,795,810...68,874,076 JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component decreases expression ISO Caffeine results in decreased expression of SEC13 mRNA CTD PMID:11793227 NCBI chr 4:146,877,739...146,891,130 JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component decreases expression ISO Caffeine results in decreased expression of SEC23A mRNA CTD PMID:11793227 NCBI chr 6:76,658,793...76,706,125 JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SENP6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:80,988,675...81,071,606 JBrowse link
G Septin7 septin 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:23,719,448...23,783,247 JBrowse link
G Serbp1 Serpine1 mRNA binding protein 1 decreases expression ISO Caffeine results in decreased expression of SERBP1 protein CTD PMID:31195006 NCBI chr 4:96,401,587...96,421,816 JBrowse link
G Serpina1 serpin family A member 1 increases expression ISO Caffeine results in increased expression of SERPINA1 mRNA CTD PMID:18444173 NCBI chr 6:122,866,314...122,888,339 JBrowse link
G Serpina6 serpin family A member 6 decreases expression ISO Caffeine results in decreased expression of SERPINA6 mRNA CTD PMID:11793227 NCBI chr 6:122,780,040...122,790,274 JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Caffeine results in increased expression of SFPQ protein
CTD PMID:20230807 PMID:31195006 NCBI chr 5:139,338,034...139,353,476 JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions EXP Caffeine inhibits the reaction [Doxorubicin results in increased secretion of SFRP1 protein] CTD PMID:30377735 NCBI chr16:68,575,763...68,613,905 JBrowse link
G Sh2b2 SH2B adaptor protein 2 increases expression EXP Caffeine results in increased expression of APS mRNA CTD PMID:20864626 NCBI chr12:20,427,057...20,456,845 JBrowse link
G Sharpin SHANK-associated RH domain interactor increases expression EXP Caffeine results in increased expression of SHARPIN mRNA CTD PMID:20864626 NCBI chr 7:108,070,681...108,075,012 JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 decreases expression EXP Caffeine results in decreased expression of SIGMAR1 mRNA CTD PMID:20864626 NCBI chr 5:56,904,155...56,907,012 JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of SIRT1 mRNA; Caffeine results in decreased expression of SIRT1 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]
CTD PMID:30776459 PMID:30825513 NCBI chr20:25,307,143...25,329,260 JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein] CTD PMID:30555576 NCBI chr 1:195,942,066...195,964,472 JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases expression
ISO Caffeine affects the reaction [SLC16A1 protein results in increased uptake of Butyrates]
Caffeine results in increased expression of SLC16A1 mRNA
CTD PMID:19023563 NCBI chr 2:192,123,755...192,144,617 JBrowse link
G Slc17a5 solute carrier family 17 member 5 increases expression EXP Caffeine results in increased expression of SLC17A5 mRNA CTD PMID:20864626 NCBI chr 8:79,394,416...79,429,387 JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions
EXP Caffeine results in decreased activity of SLC1A1 protein
Caffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein]
CTD PMID:23262392 NCBI chr 1:226,549,932...226,631,925 JBrowse link
G Slc25a37 solute carrier family 25 member 37 decreases expression EXP Caffeine results in decreased expression of SLC25A37 mRNA CTD PMID:20864626 NCBI chr15:44,534,280...44,576,697 JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Caffeine results in increased expression of SLC2A1 protein CTD PMID:25486098 NCBI chr 5:132,717,196...132,745,416 JBrowse link
G Slc2a10 solute carrier family 2 member 10 decreases expression ISO Caffeine results in decreased expression of SLC2A10 protein CTD PMID:31195006 NCBI chr 3:154,240,395...154,252,690 JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Caffeine results in increased expression of SLC2A3 protein CTD PMID:25486098 NCBI chr 4:155,960,944...156,026,000 JBrowse link
G Slc30a7 solute carrier family 30 member 7 decreases expression EXP Caffeine results in decreased expression of SLC30A7 mRNA CTD PMID:20864626 NCBI chr 2:203,855,484...203,922,155 JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Caffeine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617 JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Caffeine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937 JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA; [Caffeine co-treated with S 20098] results in decreased expression of SLC6A15 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA; [Fluoxetine co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA CTD PMID:29107002 PMID:29882086 NCBI chr 7:38,553,055...38,607,239 JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases response to substance
affects response to substance
ISO SLC6A3 gene mutant form results in increased susceptibility to Caffeine
SLC6A3 gene polymorphism affects the susceptibility to Caffeine
CTD PMID:11222668 PMID:24403155 NCBI chr 1:29,709,443...29,750,413 JBrowse link
G Slc8b1 solute carrier family 8 member B1 increases expression EXP Caffeine results in increased expression of SLC8B1 mRNA CTD PMID:20864626 NCBI chr12:36,029,759...36,053,087 JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:28,513,130...28,573,665 JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Caffeine results in decreased expression of SMAD2 mRNA; Caffeine results in decreased expression of SMAD2 protein CTD PMID:32663519 NCBI chr18:69,849,884...69,918,926 JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Caffeine results in decreased expression of SMAD3 mRNA
CTD PMID:20230807 PMID:32663519 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Smox spermine oxidase increases expression ISO Caffeine results in increased expression of SMOX mRNA CTD PMID:11793227 NCBI chr 3:118,731,814...118,767,242 JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMPD3 mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:34,162,337...34,245,786 JBrowse link
G Snx3 sorting nexin 3 increases expression EXP Caffeine results in increased expression of SNX3 mRNA CTD PMID:20864626 NCBI chr20:45,992,446...46,025,361 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of SOD1 mRNA CTD PMID:31756439 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of SOD2 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of SOD2 mRNA
CTD PMID:23099337 PMID:31756439 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Caffeine results in decreased expression of SORL1 mRNA CTD PMID:25868845 NCBI chr 8:42,341,704...42,504,435 JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Caffeine results in increased expression of SOWAHA protein CTD PMID:31195006 NCBI chr10:37,641,828...37,645,700 JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Caffeine results in decreased expression of SOX9 mRNA; Caffeine results in decreased expression of SOX9 protein CTD PMID:31874197 PMID:32663519 NCBI chr10:97,806,485...97,811,994 JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Caffeine results in decreased expression of SPP1 mRNA CTD PMID:30423288 NCBI chr14:5,308,885...5,315,120 JBrowse link
G Sqle squalene epoxidase decreases expression
increases expression
EXP
ISO
Caffeine results in decreased expression of SQLE mRNA
Caffeine results in increased expression of SQLE mRNA
CTD PMID:11793227 PMID:20864626 PMID:25868845 NCBI chr 7:90,867,973...90,883,623 JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
decreases expression
EXP
ISO
Caffeine results in increased expression of SQSTM1 mRNA
Caffeine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]
Caffeine results in decreased expression of SQSTM1 protein
CTD PMID:20864626 PMID:21081844 PMID:22927544 NCBI chr10:34,525,517...34,536,685 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Caffeine results in increased expression of SREBF1 mRNA; Caffeine results in increased expression of SREBF1 protein CTD PMID:30776459 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of SREBF2 mRNA; Caffeine results in increased expression of SREBF2 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]
CTD PMID:30825513 NCBI chr 7:113,663,202...113,720,850 JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:93,832,580...93,840,720 JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO Caffeine results in decreased expression of SRSF1 mRNA CTD PMID:11793227 NCBI chr10:72,838,926...72,859,066 JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 increases expression ISO Caffeine results in increased expression of SRSF2 protein CTD PMID:31195006 NCBI chr10:102,052,158...102,055,365 JBrowse link
G Ssc4d scavenger receptor cysteine rich family member with 4 domains increases expression ISO Caffeine results in increased expression of SSC4D protein CTD PMID:31195006 NCBI chr12:20,702,931...20,723,732 JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO Caffeine results in increased expression of ST13 protein CTD PMID:31195006 NCBI chr 7:112,891,007...112,925,727 JBrowse link
G Star steroidogenic acute regulatory protein decreases methylation
increases expression
decreases expression
ISO
EXP
Caffeine results in decreased methylation of STAR promoter
Caffeine results in increased expression of STAR mRNA
Caffeine results in decreased expression of STAR mRNA
Caffeine results in increased expression of STAR mRNA; Caffeine results in increased expression of STAR protein
CTD PMID:22100783 PMID:24717552 PMID:25868845 PMID:30528684 NCBI chr16:66,267,094...66,274,368 JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 decreases expression EXP Caffeine results in decreased expression of STARD4 mRNA CTD PMID:20864626 NCBI chr18:24,814,683...24,830,024 JBrowse link
G Stim1 stromal interaction molecule 1 increases expression EXP Caffeine results in increased expression of STIM1 mRNA CTD PMID:20864626 NCBI chr 1:156,656,246...156,818,777 JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STIP1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA] CTD PMID:20230807 NCBI chr 1:204,209,434...204,228,452 JBrowse link
G Stmn1 stathmin 1 increases expression ISO Caffeine results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:146,680,757...146,687,154 JBrowse link
G Strbp spermatid perinuclear RNA binding protein decreases expression ISO Caffeine results in decreased expression of STRBP mRNA CTD PMID:11793227 NCBI chr 3:21,328,310...21,467,753 JBrowse link
G Stx4 syntaxin 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STX4A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STX4A mRNA] CTD PMID:20230807 NCBI chr 1:182,451,108...182,459,701 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression EXP Caffeine results in increased expression of SULT1A1 mRNA; Caffeine results in increased expression of SULT1A1 protein CTD PMID:21721019 NCBI chr 1:181,272,022...181,276,750 JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression EXP Caffeine results in increased expression of SULT2A1 mRNA; Caffeine results in increased expression of SULT2A1 protein CTD PMID:21721019 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Syt4 synaptotagmin 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SYT4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SYT4 mRNA] CTD PMID:20230807 NCBI chr18:23,036,973...23,046,380 JBrowse link
G Taf1d TATA-box binding protein associated factor, RNA polymerase I subunit D decreases expression EXP Caffeine results in decreased expression of TAF1D mRNA CTD PMID:20864626 NCBI chr 8:12,146,511...12,156,647 JBrowse link
G Tbc1d8b TBC1 domain family member 8B increases expression EXP Caffeine results in increased expression of TBC1D8B mRNA CTD PMID:20864626 NCBI chr  X:103,319,181...103,407,137 JBrowse link
G Tbrg4 transforming growth factor beta regulator 4 decreases expression EXP Caffeine results in decreased expression of TBRG4 mRNA CTD PMID:20864626 NCBI chr14:81,481,977...81,490,781 JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Caffeine results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766 JBrowse link
G Tcp1 t-complex 1 increases expression ISO Caffeine results in increased expression of TCP1 protein CTD PMID:31195006 NCBI chr 1:47,829,061...47,836,809 JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase increases activity EXP Caffeine results in increased activity of TDO2 protein CTD PMID:8164501 NCBI chr 2:167,269,581...167,287,511 JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO Caffeine results in decreased expression of TFDP1 mRNA CTD PMID:11793227 NCBI chr16:76,162,040...76,200,871 JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TFRC mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TFRC mRNA] CTD PMID:20230807 NCBI chr11:68,163,413...68,185,257 JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
decreases expression
EXP Caffeine results in increased expression of TGFB1 mRNA
Caffeine results in decreased expression of TGFB1 mRNA; Caffeine results in decreased expression of TGFB1 protein
CTD PMID:29055810 PMID:32663519 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Caffeine results in decreased expression of TGFBR1 mRNA; Caffeine results in decreased expression of TGFBR1 protein CTD PMID:32663519 NCBI chr 5:61,653,773...61,710,777 JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein]; Caffeine promotes the reaction [Methamphetamine results in decreased activity of TH protein] CTD PMID:7996441 PMID:20230807 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of THRSP mRNA CTD PMID:28843594 NCBI chr 1:151,723,415...151,727,740 JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TIRAP mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TIRAP mRNA] CTD PMID:20230807 NCBI chr 8:33,531,724...33,548,508 JBrowse link
G Tlcd1 TLC domain containing 1 decreases expression EXP Caffeine results in decreased expression of TLCD1 mRNA CTD PMID:20864626 NCBI chr10:63,074,469...63,076,502 JBrowse link
G Tm9sf1 transmembrane 9 superfamily member 1 decreases expression ISO Caffeine results in decreased expression of TM9SF1 mRNA CTD PMID:11793227 NCBI chr15:29,127,585...29,135,349 JBrowse link
G Tmcc2 transmembrane and coiled-coil domain family 2 increases expression ISO Caffeine results in increased expression of TMCC2 mRNA CTD PMID:18444173 NCBI chr13:43,794,029...43,831,716 JBrowse link
G Tmed5 transmembrane p24 trafficking protein 5 decreases expression EXP Caffeine results in decreased expression of TMED5 mRNA CTD PMID:20864626 NCBI chr14:1,607,895...1,619,028 JBrowse link
G Tmem69 transmembrane protein 69 decreases expression EXP Caffeine results in decreased expression of TMEM69 mRNA CTD PMID:20864626 NCBI chr 5:130,004,888...130,008,466 JBrowse link
G Tmem97 transmembrane protein 97 decreases expression ISO Caffeine results in decreased expression of TMEM97 mRNA CTD PMID:11793227 NCBI chr10:63,438,228...63,447,311 JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
ISO
EXP
Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Caffeine results in increased expression of TNF mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Caffeine results in decreased expression of TNF mRNA
CTD PMID:22974838 PMID:23727198 PMID:28089782 PMID:29055810 PMID:30776459 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b decreases expression ISO Caffeine results in decreased expression of TNFRSF10A protein CTD PMID:31195006 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 increases expression EXP Caffeine results in increased expression of TNFRSF19 mRNA CTD PMID:20864626 NCBI chr15:35,092,206...35,158,472 JBrowse link
G Tnfsf4 TNF superfamily member 4 increases expression ISO Caffeine results in increased expression of TNFSF4 mRNA CTD PMID:18444173 NCBI chr13:73,723,329...73,746,809 JBrowse link
G Tnk2 tyrosine kinase, non-receptor, 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TNK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNK2 mRNA] CTD PMID:20230807 NCBI chr11:68,114,725...68,154,254 JBrowse link
G Tnks2 tankyrase 2 increases expression EXP Caffeine results in increased expression of TNKS2 mRNA CTD PMID:20864626 NCBI chr 1:234,567,888...234,621,079 JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions
decreases mutagenesis
ISO
EXP
Caffeine results in increased phosphorylation of TP53 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Bortezomib results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of TP53 protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [Cytarabine results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of and results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Caffeine inhibits the reaction [inuviscolide results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of TP53 protein modified form]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; Caffeine inhibits the reaction [tomentosin results in increased phosphorylation of TP53 protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]; Caffeine results in increased phosphorylation of and results in increased activity of TRP53 protein
Caffeine results in decreased mutagenesis of TRP53 gene
Caffeine inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]
CTD PMID:11751435 PMID:12393500 PMID:12811820 PMID:12907610 PMID:15975959 PMID:16024610 PMID:16777994 PMID:17919456 PMID:17977830 PMID:19028473 PMID:19735649 PMID:22226932 PMID:22927544 PMID:23274516 PMID:23523585 PMID:30555576 PMID:31168028 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPH2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPH2 mRNA] CTD PMID:20230807 NCBI chr 7:50,685,694...50,789,424 JBrowse link
G Tpp2 tripeptidyl peptidase 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of TPP2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TPP2 mRNA] CTD PMID:20230807 NCBI chr 9:46,046,712...46,128,157 JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 increases expression EXP Caffeine results in increased expression of TPRA1 mRNA CTD PMID:20864626 NCBI chr 4:121,364,093...121,375,275 JBrowse link
G Trim28 tripartite motif-containing 28 decreases expression ISO Caffeine results in decreased expression of TRIM28 protein CTD PMID:31195006 NCBI chr 1:73,652,441...73,659,388 JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 multiple interactions ISO TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein] CTD PMID:16484216 NCBI chr 2:119,481,313...119,619,333 JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TSC22D1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TSC22D1 mRNA] CTD PMID:20230807 NCBI chr15:51,750,489...51,850,958 JBrowse link
G Tubal3 tubulin, alpha-like 3 increases expression ISO Caffeine results in increased expression of TUBAL3 protein CTD PMID:31195006 NCBI chr17:66,323,733...66,332,423 JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression
multiple interactions
ISO Caffeine results in decreased expression of TXNRD1 mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNA
CTD PMID:18444173 PMID:28843594 NCBI chr 7:20,830,042...20,914,990 JBrowse link
G Tyms thymidylate synthetase decreases expression EXP Caffeine results in decreased expression of TYMS mRNA CTD PMID:20864626 NCBI chr 9:113,313,454...113,329,551 JBrowse link
G Tyw5 tRNA-yW synthesizing protein 5 decreases expression EXP Caffeine results in decreased expression of TYW5 mRNA CTD PMID:20864626 NCBI chr 9:58,961,100...58,979,188 JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases expression ISO Caffeine results in increased expression of UBA1 protein CTD PMID:31195006 NCBI chr  X:1,508,700...1,530,677 JBrowse link
G Ubb ubiquitin B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBB mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA] CTD PMID:20230807 NCBI chr10:47,247,629...47,249,335 JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBC mRNA] CTD PMID:20230807 NCBI chr12:31,238,889...31,243,924 JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UBE2D2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UBE2D2 mRNA] CTD PMID:20230807 NCBI chr18:27,364,665...27,405,589 JBrowse link
G Ubiad1 UbiA prenyltransferase domain containing 1 decreases expression EXP Caffeine results in decreased expression of UBIAD1 mRNA CTD PMID:20864626 NCBI chr 5:158,856,582...158,880,490 JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of UCHL1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UCHL1 mRNA] CTD PMID:20230807 NCBI chr14:41,485,033...41,495,590 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Caffeine results in increased expression of UGT1A1 mRNA CTD PMID:18227147 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Unc13c unc-13 homolog C increases expression ISO Caffeine results in increased expression of UNC13C protein CTD PMID:31195006 NCBI chr 8:74,247,026...74,697,629 JBrowse link
G Uncx UNC homeobox decreases expression ISO Caffeine results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300 JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression ISO Caffeine results in decreased expression of UQCRC2 mRNA CTD PMID:11793227 NCBI chr 1:175,167,933...175,198,499 JBrowse link
G Uros uroporphyrinogen III synthase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UROS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of UROS mRNA] CTD PMID:20230807 NCBI chr 1:188,490,832...188,513,659 JBrowse link
G Usp11 ubiquitin specific peptidase 11 increases expression EXP Caffeine results in increased expression of USP11 mRNA CTD PMID:20864626 NCBI chr  X:1,473,349...1,489,520 JBrowse link
G Utp18 UTP18 small subunit processome component decreases expression EXP Caffeine results in decreased expression of UTP18 mRNA CTD PMID:20864626 NCBI chr10:78,811,879...78,839,338 JBrowse link
G Vcan versican decreases expression EXP Caffeine results in decreased expression of VCAN mRNA CTD PMID:25868845 NCBI chr 2:20,761,718...20,860,637 JBrowse link
G Vcl vinculin increases expression ISO Caffeine results in increased expression of VCL protein CTD PMID:31195006 NCBI chr15:3,265,776...3,355,586 JBrowse link
G Vcp valosin-containing protein decreases expression ISO Caffeine results in decreased expression of VCP protein CTD PMID:31195006 NCBI chr 5:57,210,167...57,229,571 JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Caffeine results in decreased expression of VDAC1 protein CTD PMID:31195006 NCBI chr10:36,532,306...36,559,642 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Caffeine results in increased expression of VEGFA protein
[Caffeine co-treated with bisphenol A] results in decreased expression of VEGFA mRNA; [Caffeine co-treated with bisphenol A] results in decreased expression of VEGFA protein
CTD PMID:20025956 PMID:31756439 NCBI chr 9:14,955,300...14,970,641 JBrowse link
G Vps41 VPS41 subunit of HOPS complex multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of VPS41 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of VPS41 mRNA] CTD PMID:20230807 NCBI chr17:46,063,124...46,227,582 JBrowse link
G Vtn vitronectin decreases expression EXP Caffeine results in decreased expression of VTN mRNA CTD PMID:25868845 NCBI chr10:63,394,732...63,397,812 JBrowse link
G Wbp4 WW domain binding protein 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of WBP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of WBP4 mRNA] CTD PMID:20230807 NCBI chr15:54,862,700...54,890,668 JBrowse link
G Wdr43 WD repeat domain 43 decreases expression EXP Caffeine results in decreased expression of WDR43 mRNA CTD PMID:20864626 NCBI chr 6:23,845,499...23,884,846 JBrowse link
G Wnt4 Wnt family member 4 affects expression EXP Caffeine affects the expression of WNT4 mRNA CTD PMID:20864626 NCBI chr 5:149,513,573...149,535,415 JBrowse link
G Wt1 WT1 transcription factor decreases expression EXP Caffeine results in decreased expression of WT1 mRNA; Caffeine results in decreased expression of WT1 protein CTD PMID:31306741 NCBI chr 3:91,566,540...91,613,653 JBrowse link
G Xdh xanthine dehydrogenase affects metabolic processing ISO XDH protein affects the metabolism of Caffeine CTD PMID:14586384 PMID:14586387 PMID:15199075 PMID:15327588 PMID:15980104 NCBI chr 6:21,530,463...21,592,172 JBrowse link
G Xkr5 XK related 5 decreases expression EXP Caffeine results in decreased expression of XKR5 mRNA CTD PMID:20864626 NCBI chr16:70,874,983...70,892,972 JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression ISO Caffeine results in decreased expression of XRCC5 protein CTD PMID:31195006 NCBI chr 9:73,955,220...74,044,020 JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression ISO Caffeine results in decreased expression of YWHAE protein CTD PMID:31195006 NCBI chr10:60,584,665...60,622,352 JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma increases expression ISO Caffeine results in increased expression of YWHAG protein CTD PMID:31195006 NCBI chr12:20,744,500...20,772,828 JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta multiple interactions ISO Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein] CTD PMID:11835680 NCBI chr 6:40,935,714...40,966,240 JBrowse link
G Zfp276 zinc finger protein (C2H2 type) 276 decreases expression EXP Caffeine results in decreased expression of ZFP276 mRNA CTD PMID:20864626 NCBI chr19:51,291,005...51,304,240 JBrowse link
G Zfp819 zinc finger protein 819 decreases expression EXP Caffeine results in decreased expression of ZFP819 mRNA CTD PMID:20864626 NCBI chr 1:94,027,347...94,085,649 JBrowse link
G Znf48 zinc finger protein 48 decreases expression EXP Caffeine results in decreased expression of ZFP553 mRNA CTD PMID:20864626 NCBI chr 1:181,853,047...181,858,997 JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions
increases response to substance
EXP
ISO
8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine
CTD PMID:11172060 PMID:15641640 PMID:18608257 PMID:19966059 PMID:21195062 NCBI chr20:13,315,848...13,333,386 JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
multiple interactions
ISO DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
CTD PMID:11172060 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368 PMID:10199625 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nts neurotensin multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr 7:37,564,944...37,574,350 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          caffeine 687
            8-(3-chlorostyryl)caffeine 5
            caffeine monohydrate 0
            sodium caffeine benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  organic heteropolycyclic compound 18048
                                    organic heterobicyclic compound 16841
                                      imidazopyrimidine 5604
                                        purines 5602
                                          aminopurine 4422
                                            2-aminopurines 4028
                                              guanine 3992
                                                xanthine 3904
                                                  methylxanthine 1142
                                                    trimethylxanthine 687
                                                      c