Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:androstane-3,17-diol
go back to main search page
Accession:CHEBI:27727 term browser browse the term
Definition:A 17-hydroxy steroid that has formula C19H32O2.
Synonyms:related_synonym: Androstanediol;   Formula=C19H32O2;   InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12?,13?,14-,15-,16-,17?,18-,19-/m0/s1;   InChIKey=CBMYJHIOYJEBSB-CAHXEBCQSA-N;   SMILES=[H][C@@]12CCC3CC(O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(O)CC[C@@]21[H]
 alt_id: CHEBI:22544;   CHEBI:2713
 xref: Beilstein:9220448;   CAS:25126-76-5;   KEGG:C07632
 xref_mesh: MESH:D015113


show annotations for term's descendants           Sort by:
androstane-3,17-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C2 aldo-keto reductase family 1 member C2 increases chemical synthesis EXP AKR1C2 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:11158055 PMID:17170221 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 increases chemical synthesis EXP AKR1C4 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:11158055 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949 		JBrowse link
G AQP9 aquaporin 9 increases expression ISO Androstane-3,17-diol results in increased expression of AQP9 mRNA; Androstane-3,17-diol results in increased expression of AQP9 protein CTD PMID:17026757 NCBI chr15:58,138,169...58,185,911
Ensembl chr15:58,138,169...58,185,911 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 increases expression ISO Androstane-3,17-diol results in increased expression of CYP11A1 mRNA CTD PMID:21273442 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 increases expression ISO Androstane-3,17-diol results in increased expression of CYP19A1 mRNA CTD PMID:21273442 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP Androstane-3,17-diol results in decreased expression of CYP7B1 mRNA CTD PMID:16630558 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein; Androstane-3,17-diol binds to and results in increased activity of ESR1 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein] CTD PMID:17003281 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions
increases activity
affects binding		 EXP
ISO		 Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein; Androstane-3,17-diol binds to and results in increased activity of ESR2 protein; Fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein]; Fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR2 protein]
Androstane-3,17-diol results in increased activity of ESR2 protein
Androstane-3,17-diol inhibits the reaction [Estradiol binds to ESR2 protein]
Androstane-3,17-diol binds to ESR2 protein		 CTD PMID:8650195 PMID:16452668 PMID:17003281 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 affects binding
multiple interactions		 EXP Androstane-3,17-diol binds to HSD11B1 protein
[Androstane-3,17-diol co-treated with NAD] binds to HSD11B1 protein		 CTD PMID:25526675 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949 		JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 multiple interactions EXP [Androstane-3,17-diol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:53,431,258...53,434,376
Ensembl chr  X:53,431,258...53,434,370 		JBrowse link
G HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 increases chemical synthesis ISO HSD17B12 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:17641292 NCBI chr11:43,556,721...43,856,615
Ensembl chr11:43,680,680...43,856,617 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions
increases chemical synthesis
increases secretion		 ISO 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [LHB protein results in increased secretion of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol] CTD PMID:24451217 PMID:31184881 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein; arsenite inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; bisphenol A inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; butyl phosphorotrithioate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Chlorpyrifos inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Corticosterone inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; cypermethrin inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Diethylhexyl Phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Methoxychlor inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; nonylphenol inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Parathion inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein] CTD PMID:18832183 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta affects expression EXP Androstane-3,17-diol affects the expression of PRKACB mRNA alternative form; Androstane-3,17-diol affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 1:84,078,079...84,238,498
Ensembl chr 1:84,078,062...84,238,498 		JBrowse link
G RDH16 retinol dehydrogenase 16 multiple interactions
increases metabolic processing		 ISO [RDH16 protein results in increased metabolism of Androstane-3,17-diol] which results in increased chemical synthesis of Dihydrotestosterone CTD PMID:28535922 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 increases glucuronidation
increases metabolic processing		 EXP UGT2B15 protein results in increased glucuronidation of Androstane-3,17-diol
UGT2B15 protein results in increased metabolism of Androstane-3,17-diol; UGT2B15 protein SNP results in increased metabolism of Androstane-3,17-diol		 CTD PMID:7835232 PMID:8399210 PMID:12386133 NCBI chr 4:68,646,597...68,670,652
Ensembl chr 4:68,646,597...68,670,652 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing EXP UGT2B17 protein results in increased metabolism of Androstane-3,17-diol CTD PMID:8798464 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
5alpha-androstane-3alpha,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR2 estrogen receptor 2 affects binding ISO 3alpha-androstanediol binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
5alpha-androstane-3beta,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR2 estrogen receptor 2 affects binding ISO 3beta-androstanediol binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      molecular entity 25991
        polyatomic entity 25876
          heteroatomic molecular entity 25527
            hydroxides 24049
              organic hydroxy compound 22060
                hydroxy steroid 15533
                  3-hydroxy steroid 13523
                    androstane-3,17-diol 17
                      5alpha-androstane-3beta,17alpha-diol + 0
                      5alpha-androstane-3beta,17beta-diol + 1
                      5beta-androstane-3beta,17beta-diol 0
                      androstane-3alpha,17beta-diol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic polycyclic compound 18800
                                  steroid 15855
                                    steroid fundamental parent 15629
                                      androstane 6150
                                        androstanoid 4887
                                          androstane-3,17-diol 17
                                            5alpha-androstane-3beta,17alpha-diol + 0
                                            5alpha-androstane-3beta,17beta-diol + 1
                                            5beta-androstane-3beta,17beta-diol 0
                                            androstane-3alpha,17beta-diol + 1
paths to the root