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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:androstane-3,17-diol
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Accession:CHEBI:27727 term browser browse the term
Definition:A 17-hydroxy steroid that has formula C19H32O2.
Synonyms:related_synonym: Androstanediol;   Formula=C19H32O2;   InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12?,13?,14-,15-,16-,17?,18-,19-/m0/s1;   InChIKey=CBMYJHIOYJEBSB-CAHXEBCQSA-N;   SMILES=[H][C@@]12CCC3CC(O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(O)CC[C@@]21[H]
 alt_id: CHEBI:22544;   CHEBI:2713
 xref: Beilstein:9220448;   CAS:25126-76-5;   KEGG:C07632
 xref_mesh: MESH:D015113


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androstane-3,17-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c1 aldo-keto reductase family 1, member C1 increases chemical synthesis ISO AKR1C4 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:11158055 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:11158055, PMID:17170221 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Aqp9 aquaporin 9 increases expression EXP Androstane-3,17-diol results in increased expression of AQP9 mRNA; Androstane-3,17-diol results in increased expression of AQP9 protein CTD PMID:17026757 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Androstane-3,17-diol results in increased expression of CYP11A1 mRNA CTD PMID:21273442 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Androstane-3,17-diol results in increased expression of CYP19A1 mRNA CTD PMID:21273442 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Androstane-3,17-diol results in decreased expression of CYP7B1 mRNA CTD PMID:16630558 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein; Androstane-3,17-diol binds to and results in increased activity of ESR1 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein] CTD PMID:17003281 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
affects binding
ISO
EXP
Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein; Androstane-3,17-diol binds to and results in increased activity of ESR2 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR2 protein]
Androstane-3,17-diol results in increased activity of ESR2 protein
Androstane-3,17-diol inhibits the reaction [Estradiol binds to ESR2 protein]
Androstane-3,17-diol binds to ESR2 protein
CTD PMID:8650195, PMID:16452668, PMID:17003281 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects binding
multiple interactions
ISO Androstane-3,17-diol binds to HSD11B1 protein
[Androstane-3,17-diol co-treated with NAD] binds to HSD11B1 protein
CTD PMID:25526675 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [Androstane-3,17-diol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases chemical synthesis ISO HSD17B12 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:17641292 NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases chemical synthesis
increases secretion
EXP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [LHB protein results in increased secretion of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol] CTD PMID:24451217, PMID:31184881 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein; arsenite inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; bisphenol A inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; butyl phosphorotrithioate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Chlorpyrifos inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Corticosterone inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; cypermethrin inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Diethylhexyl Phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Methoxychlor inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; nonylphenol inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Parathion inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein] CTD PMID:18832183 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression ISO Androstane-3,17-diol affects the expression of PRKACB mRNA alternative form; Androstane-3,17-diol affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Rdh16 retinol dehydrogenase 16 increases metabolic processing
multiple interactions
EXP RDH16 protein results in increased metabolism of Androstane-3,17-diol
[RDH16 protein results in increased metabolism of Androstane-3,17-diol] which results in increased chemical synthesis of Dihydrotestosterone
CTD PMID:28535922 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing ISO UGT2B17 protein results in increased metabolism of Androstane-3,17-diol CTD PMID:8798464 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      molecular entity 19787
        polyatomic entity 19697
          heteroatomic molecular entity 19617
            hydroxides 19091
              organic hydroxy compound 18658
                hydroxy steroid 12379
                  3-hydroxy steroid 10006
                    androstane-3,17-diol 16
                      5alpha-androstane-3beta,17alpha-diol + 0
                      5alpha-androstane-3beta,17beta-diol + 0
                      5beta-androstane-3beta,17beta-diol 0
                      androstane-3alpha,17beta-diol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19483
                              organic cyclic compound 19252
                                organic polycyclic compound 16399
                                  steroid 12798
                                    steroid fundamental parent 12413
                                      androstane 4343
                                        androstanoid 2899
                                          androstane-3,17-diol 16
                                            5alpha-androstane-3beta,17alpha-diol + 0
                                            5alpha-androstane-3beta,17beta-diol + 0
                                            5beta-androstane-3beta,17beta-diol 0
                                            androstane-3alpha,17beta-diol + 0
paths to the root

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