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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:androstane-3,17-diol
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Accession:CHEBI:27727 term browser browse the term
Definition:A 17-hydroxy steroid that has formula C19H32O2.
Synonyms:related_synonym: Androstanediol;   Formula=C19H32O2;   InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12?,13?,14-,15-,16-,17?,18-,19-/m0/s1;   InChIKey=CBMYJHIOYJEBSB-CAHXEBCQSA-N;   SMILES=[H][C@@]12CCC3CC(O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(O)CC[C@@]21[H]
 alt_id: CHEBI:22544;   CHEBI:2713
 xref: Beilstein:9220448;   CAS:25126-76-5;   KEGG:C07632
 xref_mesh: MESH:D015113



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androstane-3,17-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:11158055 PMID:17170221 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Aqp9 aquaporin 9 increases expression EXP Androstane-3,17-diol results in increased expression of AQP9 mRNA; Androstane-3,17-diol results in increased expression of AQP9 protein CTD PMID:17026757 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP Androstane-3,17-diol results in increased expression of CYP11A1 mRNA CTD PMID:21273442 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Androstane-3,17-diol results in increased expression of CYP19A1 mRNA CTD PMID:21273442 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Androstane-3,17-diol results in decreased expression of CYP7B1 mRNA CTD PMID:16630558 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein; Androstane-3,17-diol binds to and results in increased activity of ESR1 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR1 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR1 protein] CTD PMID:17003281 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
affects binding
ISO
EXP
Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein; Androstane-3,17-diol binds to and results in increased activity of ESR2 protein; fulvestrant inhibits the reaction [Androstane-3,17-diol analog binds to and results in increased activity of ESR2 protein]; fulvestrant inhibits the reaction [Androstane-3,17-diol binds to and results in increased activity of ESR2 protein]
Androstane-3,17-diol results in increased activity of ESR2 protein
Androstane-3,17-diol inhibits the reaction [Estradiol binds to ESR2 protein]
Androstane-3,17-diol binds to ESR2 protein
CTD PMID:8650195 PMID:16452668 PMID:17003281 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects binding
multiple interactions
ISO Androstane-3,17-diol binds to HSD11B1 protein
[Androstane-3,17-diol co-treated with NAD] binds to HSD11B1 protein
CTD PMID:25526675 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [Androstane-3,17-diol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 increases chemical synthesis ISO HSD17B12 protein results in increased chemical synthesis of Androstane-3,17-diol CTD PMID:17641292 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases chemical synthesis
increases secretion
EXP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [LHB protein results in increased secretion of Androstane-3,17-diol]; Flurbiprofen inhibits the reaction [LHB protein results in increased chemical synthesis of Androstane-3,17-diol] CTD PMID:24451217 PMID:31184881 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein; arsenite inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; bisphenol A inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; butyl phosphorotrithioate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Chlorpyrifos inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Corticosterone inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; cypermethrin inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Diethylhexyl Phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; enilconazole inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Methoxychlor inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; mono-(2-ethylhexyl)phthalate inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; nonylphenol inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein]; Parathion inhibits the reaction [Androstane-3,17-diol binds to and results in decreased activity of NR1I3 protein] CTD PMID:18832183 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta affects expression ISO Androstane-3,17-diol affects the expression of PRKACB mRNA alternative form; Androstane-3,17-diol affects the expression of PRKACB protein alternative form CTD PMID:16949795 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Rdh16 retinol dehydrogenase 16 increases metabolic processing
multiple interactions
EXP RDH16 protein results in increased metabolism of Androstane-3,17-diol
[RDH16 protein results in increased metabolism of Androstane-3,17-diol] which results in increased chemical synthesis of Dihydrotestosterone
CTD PMID:28535922 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases metabolic processing ISO UGT2B17 protein results in increased metabolism of Androstane-3,17-diol CTD PMID:8798464 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
5alpha-androstane-3alpha,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding EXP 3alpha-androstanediol binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
5alpha-androstane-3beta,17beta-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 affects binding EXP 3beta-androstanediol binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      molecular entity 20058
        polyatomic entity 20018
          heteroatomic molecular entity 19924
            hydroxides 19454
              organic hydroxy compound 19017
                hydroxy steroid 14111
                  3-hydroxy steroid 12157
                    androstane-3,17-diol 15
                      5alpha-androstane-3beta,17alpha-diol + 0
                      5alpha-androstane-3beta,17beta-diol + 1
                      5beta-androstane-3beta,17beta-diol 0
                      androstane-3alpha,17beta-diol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic polycyclic compound 17201
                                  steroid 14380
                                    steroid fundamental parent 14160
                                      androstane 6069
                                        androstanoid 4840
                                          androstane-3,17-diol 15
                                            5alpha-androstane-3beta,17alpha-diol + 0
                                            5alpha-androstane-3beta,17beta-diol + 1
                                            5beta-androstane-3beta,17beta-diol 0
                                            androstane-3alpha,17beta-diol + 1
paths to the root