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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diethyl hydrogen phosphate
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Accession:CHEBI:27708 term browser browse the term
Definition:A dialkyl phosphate having ethyl as the alkyl group.
Synonyms:related_synonym: Diethylphosphate;   Diethylphosphoric acid;   Formula=C4H11O4P;   InChI=1S/C4H11O4P/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3,(H,5,6);   InChIKey=UCQFCFPECQILOL-UHFFFAOYSA-N;   O,O-Diethylphosphoric acid;   SMILES=CCOP(O)(=O)OCC
 alt_id: CHEBI:23712;   CHEBI:4529;   CHEBI:49570
 xref: CAS:598-02-7;   HMDB:HMDB0012209;   KEGG:C06608
 xref_mesh: MESH:C034789
 xref: PDBeChem:DPF;   PMID:17590257;   PMID:20494630;   PMID:22251442;   PMID:23522525;   Reaxys:1704113;   UM-BBD_compID:c0087
 cyclic_relationship: is_conjugate_acid_of CHEBI:140537


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diethyl hydrogen phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO
EXP		 diethyl phosphate results in decreased expression of CYP11A1 mRNA
diethyl phosphate results in decreased expression of CYP11A1 mRNA; diethyl phosphate results in decreased expression of CYP11A1 protein		 CTD PMID:35777568 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Dio1 iodothyronine deiodinase 1 increases expression EXP diethyl phosphate results in increased expression of DIO1 mRNA CTD PMID:31835022 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression EXP diethyl phosphate results in increased expression of DIO2 mRNA CTD PMID:31835022 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 increases expression EXP diethyl phosphate results in increased expression of DIO3 mRNA CTD PMID:31835022 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP diethyl phosphate results in decreased expression of HSD11B1 mRNA CTD PMID:35777568 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects binding ISO diethyl phosphate binds to NR3C1 protein CTD PMID:35777568 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO
EXP		 diethyl phosphate results in increased expression of NR4A1 mRNA; diethyl phosphate results in increased expression of NR4A1 protein CTD PMID:35777568 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases expression EXP diethyl phosphate results in increased expression of NR5A1 mRNA CTD PMID:35777568 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Pomc proopiomelanocortin decreases secretion
multiple interactions
increases expression		 ISO
EXP		 diethyl phosphate results in decreased secretion of POMC protein
Colforsin inhibits the reaction [diethyl phosphate results in decreased secretion of POMC protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [diethyl phosphate results in decreased secretion of POMC protein]; U 0126 inhibits the reaction [diethyl phosphate results in decreased secretion of POMC protein]
diethyl phosphate results in decreased expression of and results in decreased secretion of POMC protein
diethyl phosphate results in increased expression of POMC mRNA		 CTD PMID:35777568 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP diethyl phosphate results in decreased expression of SCARB1 mRNA CTD PMID:35777568 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP diethyl phosphate results in increased expression of SERPINA7 mRNA CTD PMID:31835022 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP diethyl phosphate results in decreased expression of SLC16A10 mRNA CTD PMID:31835022 NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP diethyl phosphate results in decreased expression of SLC22A6 mRNA CTD PMID:31835022 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP
ISO		 diethyl phosphate results in decreased expression of STAR mRNA CTD PMID:35777568 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP diethyl phosphate results in decreased expression of SULT1B1 mRNA CTD PMID:31835022 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Thra thyroid hormone receptor alpha increases expression EXP diethyl phosphate results in increased expression of THRA mRNA CTD PMID:31835022 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta increases expression EXP diethyl phosphate results in increased expression of THRB mRNA CTD PMID:31835022 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression EXP diethyl phosphate results in decreased expression of TSHB protein CTD PMID:31835022 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        biochemical role 19496
          metabolite 19484
            xenobiotic metabolite 15429
              human xenobiotic metabolite 14795
                diethyl hydrogen phosphate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      chalcogen 19515
                        oxygen atom 19520
                          oxygen molecular entity 19490
                            hydroxides 19300
                              oxoacid 18725
                                pnictogen oxoacid 13221
                                  phosphorus oxoacid 12413
                                    phosphoric acids 11427
                                      phosphoric acid 11417
                                        phosphoric acid derivative 11226
                                          phosphate 11225
                                            organic phosphate 11225
                                              alkyl phosphate 4156
                                                dialkyl phosphate 3473
                                                  diethyl hydrogen phosphate 18
paths to the root