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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxytetracycline
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Accession:CHEBI:27701 term browser browse the term
Definition:A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
Synonyms:exact_synonym: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
 related_synonym: 5-Hydroxytetracycline;   Formula=C22H24N2O9;   InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1;   InChIKey=IWVCMVBTMGNXQD-PXOLEDIWSA-N;   Oxyterracin;   Oxyterracine;   Oxytetracyclin;   Oxytetracycline amphoteric;   Oxytetracycline anhydrous;   SMILES=[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C;   oxitetraciclina;   oxytetracyclinum
 alt_id: CHEBI:25811;   CHEBI:521157;   CHEBI:596903;   CHEBI:7871
 xref: BPDB:503;   Beilstein:2686362;   Beilstein:2714587;   CAS:79-57-2;   DrugBank:DB00595;   Drug_Central:2041;   Gmelin:623487;   HMDB:HMDB0014733;   KEGG:C06624;   KNApSAcK:C00017127;   LIPID_MAPS_instance:LMPK07000005
 xref_mesh: MESH:D010118
 xref: PMID:1650428;   PMID:17386724;   PMID:17638695;   PMID:17870541;   PMID:1833366;   PMID:21136283;   PMID:21488905;   PMID:22013404;   PMID:24247133;   PMID:24281679;   PMID:24290103;   PMID:24362004;   PMID:24510709;   PMID:24607684;   PMID:24853528;   PMID:24983832;   PMID:25019386;   PMID:25035320;   PMID:25081007;   Pesticides:oxytetracycline;   Reaxys:2714587;   VSDB:503;   Wikipedia:Oxytetracycline
 cyclic_relationship: is_tautomer_of CHEBI:133011



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oxytetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Oxytetracycline results in decreased activity of CAT protein CTD PMID:29248593 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Oxytetracycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Oxytetracycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Oxytetracycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Oxytetracycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Oxytetracycline results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Oxytetracycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Oxytetracycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        antimicrobial agent 18166
          oxytetracycline 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    main group molecular entity 19866
                      s-block molecular entity 19698
                        hydrogen molecular entity 19684
                          hydrides 19159
                            organic hydride 18714
                              organic fundamental parent 18714
                                hydrocarbon 18440
                                  cyclic hydrocarbon 17255
                                    arene 17235
                                      polycyclic arene 17063
                                        ortho-fused polycyclic arene 9824
                                          acene 7793
                                            tetracene 7790
                                              tetracyclines 503
                                                oxytetracycline 10
paths to the root