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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxytetracycline
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Accession:CHEBI:27701 term browser browse the term
Definition:A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
Synonyms:exact_synonym: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
 related_synonym: 5-Hydroxytetracycline;   Formula=C22H24N2O9;   InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1;   InChIKey=IWVCMVBTMGNXQD-PXOLEDIWSA-N;   Oxyterracin;   Oxyterracine;   Oxytetracyclin;   Oxytetracycline amphoteric;   Oxytetracycline anhydrous;   SMILES=[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C;   oxitetraciclina;   oxytetracyclinum
 alt_id: CHEBI:25811;   CHEBI:521157;   CHEBI:596903;   CHEBI:7871
 xref: BPDB:503;   Beilstein:2686362;   Beilstein:2714587;   CAS:79-57-2;   DrugBank:DB00595;   Drug_Central:2041;   Gmelin:623487;   HMDB:HMDB0014733;   KEGG:C06624;   KNApSAcK:C00017127;   LIPID_MAPS_instance:LMPK07000005
 xref_mesh: MESH:D010118
 xref: PMID:1650428;   PMID:17386724;   PMID:17638695;   PMID:17870541;   PMID:1833366;   PMID:21136283;   PMID:21488905;   PMID:22013404;   PMID:24247133;   PMID:24281679;   PMID:24290103;   PMID:24362004;   PMID:24510709;   PMID:24607684;   PMID:24853528;   PMID:24983832;   PMID:25019386;   PMID:25035320;   PMID:25081007;   Pesticides:oxytetracycline;   Reaxys:2714587;   VSDB:503;   Wikipedia:Oxytetracycline
 cyclic_relationship: is_tautomer_of CHEBI:133011


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oxytetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Oxytetracycline results in decreased activity of CAT protein CTD PMID:29248593 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Oxytetracycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Oxytetracycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Oxytetracycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Oxytetracycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Oxytetracycline results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Oxytetracycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Oxytetracycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          oxytetracycline 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            organic hydride 18265
                              organic fundamental parent 18265
                                hydrocarbon 17986
                                  cyclic hydrocarbon 17073
                                    arene 17069
                                      polycyclic arene 16887
                                        ortho-fused polycyclic arene 9649
                                          acene 7570
                                            tetracene 7567
                                              tetracyclines 494
                                                oxytetracycline 10
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