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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxytetracycline
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Accession:CHEBI:27701 term browser browse the term
Definition:A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.
Synonyms:exact_synonym: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
 related_synonym: 5-Hydroxytetracycline;   Formula=C22H24N2O9;   InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1;   InChIKey=IWVCMVBTMGNXQD-PXOLEDIWSA-N;   Oxyterracin;   Oxyterracine;   Oxytetracyclin;   Oxytetracycline amphoteric;   Oxytetracycline anhydrous;   SMILES=[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C;   oxitetraciclina;   oxytetracyclinum
 alt_id: CHEBI:25811;   CHEBI:521157;   CHEBI:596903;   CHEBI:7871
 xref: BPDB:503;   Beilstein:2686362;   Beilstein:2714587;   CAS:79-57-2;   DrugBank:DB00595;   Drug_Central:2041;   Gmelin:623487;   HMDB:HMDB0014733;   KEGG:C06624;   KNApSAcK:C00017127;   LIPID_MAPS_instance:LMPK07000005
 xref_mesh: MESH:D010118
 xref: PMID:1650428;   PMID:17386724;   PMID:17638695;   PMID:17870541;   PMID:1833366;   PMID:21136283;   PMID:21488905;   PMID:22013404;   PMID:24247133;   PMID:24281679;   PMID:24290103;   PMID:24362004;   PMID:24510709;   PMID:24607684;   PMID:24853528;   PMID:24983832;   PMID:25019386;   PMID:25035320;   PMID:25081007;   Pesticides:oxytetracycline;   Reaxys:2714587;   VSDB:503;   Wikipedia:Oxytetracycline
 cyclic_relationship: is_tautomer_of CHEBI:133011


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oxytetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Oxytetracycline results in decreased activity of CAT protein CTD PMID:29248593 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Oxytetracycline results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Oxytetracycline results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Oxytetracycline results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Oxytetracycline results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Oxytetracycline results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Oxytetracycline results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Oxytetracycline results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        antimicrobial agent 17945
          oxytetracycline 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    main group molecular entity 19761
                      s-block molecular entity 19612
                        hydrogen molecular entity 19601
                          hydrides 19077
                            organic hydride 18671
                              organic fundamental parent 18671
                                hydrocarbon 18417
                                  cyclic hydrocarbon 17226
                                    arene 17206
                                      polycyclic arene 17033
                                        ortho-fused polycyclic arene 9748
                                          acene 7679
                                            tetracene 7676
                                              tetracyclines 505
                                                oxytetracycline 10
paths to the root