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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetazolamide
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Accession:CHEBI:27690 term browser browse the term
Definition:A thiadiazole that has formula C4H6N4O3S2.
Synonyms:related_synonym: 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide;   5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE;   Defiltran;   Diacarb;   Diamox;   Diluran;   Formula=C4H6N4O3S2;   Glaupax;   InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9);   InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N;   N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide;   N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide;   N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide;   SMILES=CC(=O)Nc1nnc(s1)S(N)(=O)=O;   acetazolamida;   acetazolamidum
 alt_id: CHEBI:22167;   CHEBI:22168;   CHEBI:2388;   CHEBI:41007
 xref: Beilstein:212994;   CAS:59-66-5;   DrugBank:DB00819;   Drug_Central:56;   Gmelin:365421;   KEGG:C06805;   KEGG:D00218;   LINCS:LSM-5543
 xref_mesh: MESH:D000086
 xref: PDBeChem:AZM;   Patent:US2554816;   Wikipedia:Acetazolamide
 cyclic_relationship: is_conjugate_acid_of CHEBI:50634


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acetazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Acetazolamide results in increased expression of ABCA1 mRNA CTD PMID:19274763 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Akap17a A-kinase anchoring protein 17A increases expression ISO Acetazolamide results in increased expression of AKAP17B mRNA CTD PMID:19274763 NCBI chr12:18,527,116...18,531,780
Ensembl chr12:18,526,422...18,531,161
JBrowse link
G Akap9 A-kinase anchoring protein 9 increases expression ISO Acetazolamide results in increased expression of AKAP9 mRNA CTD PMID:19274763 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Ammecr1l AMMECR1 like increases expression ISO Acetazolamide results in increased expression of AMMECR1L mRNA CTD PMID:19274763 NCBI chr18:24,539,530...24,563,576
Ensembl chr18:24,540,659...24,563,576
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Acetazolamide results in increased expression of ANP32A mRNA CTD PMID:19274763 NCBI chr 8:67,295,578...67,333,075
Ensembl chr 8:67,295,727...67,333,247
JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Acetazolamide results in decreased expression of AQP1 protein CTD PMID:17219999 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Acetazolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Arid2 AT-rich interaction domain 2 increases expression ISO Acetazolamide results in increased expression of ARID2 mRNA CTD PMID:19274763 NCBI chr 7:137,680,564...137,798,329
Ensembl chr 7:137,680,530...137,795,655
JBrowse link
G Brd4 bromodomain containing 4 increases expression ISO Acetazolamide results in increased expression of BRD4 mRNA CTD PMID:19274763 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity
multiple interactions
ISO Acetazolamide results in decreased activity of CA12 protein
Acetazolamide binds to and results in decreased activity of CA12 protein
CTD PMID:21851094, PMID:28251759 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Ca13 carbonic anhydrase 13 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA13 protein CTD PMID:28251759 NCBI chr 2:88,282,961...88,314,254
Ensembl chr 2:88,282,961...88,314,254
JBrowse link
G Ca14 carbonic anhydrase 14 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA14 protein CTD PMID:28251759 NCBI chr 2:198,010,142...198,017,635
Ensembl chr 2:198,010,349...198,016,898
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Ca4 carbonic anhydrase 4 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA4 protein CTD PMID:28251759 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067
JBrowse link
G Ca5a carbonic anhydrase 5A multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5A protein CTD PMID:28251759 NCBI chr19:54,731,829...54,761,697
Ensembl chr19:54,731,859...54,761,670
JBrowse link
G Ca5b carbonic anhydrase 5B multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5B protein CTD PMID:28251759 NCBI chr  X:32,232,106...32,291,124
Ensembl chr  X:32,232,142...32,292,072
JBrowse link
G Ca6 carbonic anhydrase 6 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA6 protein CTD PMID:28251759 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity
multiple interactions
ISO Acetazolamide results in decreased activity of CA9 protein
Acetazolamide binds to and results in decreased activity of CA9 protein
CTD PMID:21851094, PMID:28251759 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
decreases activity
ISO Acetazolamide binds to and results in decreased activity of CA1 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein] CTD PMID:11430635, PMID:17826101, PMID:19231207, PMID:28117934, PMID:28251759, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO Acetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein] CTD PMID:11430635, PMID:16858005, PMID:17826101, PMID:19231207, PMID:21851094, PMID:28117934, PMID:28251759, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Car7 carbonic anhydrase 7 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA7 protein CTD PMID:28251759 NCBI chr19:636,545...645,935
Ensembl chr19:636,545...645,937
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein] CTD PMID:21040473 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cbx3 chromobox 3 increases expression ISO Acetazolamide results in increased expression of CBX3 mRNA CTD PMID:19274763 NCBI chr 4:81,243,809...81,257,898
Ensembl chr 4:81,244,469...81,257,897
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Acetazolamide results in increased expression of CCND2 mRNA CTD PMID:19274763 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cd47 Cd47 molecule increases expression ISO Acetazolamide results in increased expression of CD47 mRNA CTD PMID:19274763 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Acetazolamide results in increased expression of CIRBP mRNA CTD PMID:19274763 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Acetazolamide results in increased expression of CLCN3 mRNA CTD PMID:19274763 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression ISO Acetazolamide results in increased expression of DDX3X mRNA CTD PMID:19274763 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995
JBrowse link
G Ddx6 DEAD-box helicase 6 increases expression ISO Acetazolamide results in increased expression of DDX6 mRNA CTD PMID:19274763 NCBI chr 8:48,924,768...48,961,394
Ensembl chr 8:48,925,604...48,958,026
JBrowse link
G Dsc2 desmocollin 2 increases expression ISO Acetazolamide results in increased expression of DSC2 mRNA CTD PMID:19274763 NCBI chr18:11,826,705...11,858,801
Ensembl chr18:11,826,706...11,858,754
JBrowse link
G Glg1 golgi glycoprotein 1 increases expression ISO Acetazolamide results in increased expression of GLG1 mRNA CTD PMID:19274763 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Acetazolamide results in increased expression of GLUL mRNA CTD PMID:19274763 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Acetazolamide results in increased expression of HTRA1 mRNA CTD PMID:19274763 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO Acetazolamide results in increased expression of IGF1R mRNA CTD PMID:19274763 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression ISO Acetazolamide results in increased expression of ITPR2 mRNA CTD PMID:19274763 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G LOC102546572 zinc finger protein 709-like increases expression ISO Acetazolamide results in increased expression of ZFP617 mRNA CTD PMID:19274763 NCBI chr 7:15,015,985...15,038,622 JBrowse link
G Mab21l2 mab-21 like 2 decreases expression ISO Acetazolamide results in decreased expression of MAB21L2 mRNA CTD PMID:19274763 NCBI chr 2:185,849,749...185,852,833
Ensembl chr 2:185,850,232...185,852,759
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Acetazolamide results in increased expression of MAP3K1 mRNA CTD PMID:19274763 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Acetazolamide results in decreased expression of MT1 mRNA CTD PMID:19274763 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit increases expression ISO Acetazolamide results in increased expression of NAA15 mRNA CTD PMID:19274763 NCBI chr 2:140,471,437...140,534,259
Ensembl chr 2:140,471,690...140,534,259
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Acetazolamide results in increased expression of NDRG1 mRNA CTD PMID:19274763 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Acetazolamide results in increased expression of NRIP1 mRNA CTD PMID:19274763 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Peg3 paternally expressed 3 increases expression ISO Acetazolamide results in increased expression of PEG3 mRNA CTD PMID:19274763 NCBI chr 1:70,210,810...70,237,450
Ensembl chr 1:70,222,964...70,237,443
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Acetazolamide results in increased expression of POU2F1 mRNA CTD PMID:19274763 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B increases expression ISO Acetazolamide results in increased expression of PPM1B mRNA CTD PMID:19274763 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Acetazolamide results in increased expression of RBM39 mRNA CTD PMID:19274763 NCBI chr 3:151,691,498...151,724,723
Ensembl chr 3:151,691,514...151,724,654
JBrowse link
G Rbmx RNA binding motif protein, X-linked increases expression ISO Acetazolamide results in increased expression of RBMX mRNA CTD PMID:19274763 NCBI chr  X:159,881,835...159,891,405
Ensembl chr  X:159,884,885...159,891,326
JBrowse link
G Satb1 SATB homeobox 1 increases expression ISO Acetazolamide results in increased expression of SATB1 mRNA CTD PMID:19274763 NCBI chr 9:2,181,135...2,277,949
Ensembl chr 9:2,190,915...2,274,629
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Acetazolamide results in increased expression of SC5D mRNA CTD PMID:19274763 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Schip1 schwannomin interacting protein 1 increases expression ISO Acetazolamide results in increased expression of SCHIP1 mRNA CTD PMID:19274763 NCBI chr 2:172,312,290...173,087,236
Ensembl chr 2:172,312,298...172,459,165
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Acetazolamide results in increased expression of SDC4 mRNA CTD PMID:19274763 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Sema4b semaphorin 4B increases expression ISO Acetazolamide results in increased expression of SEMA4B mRNA CTD PMID:19274763 NCBI chr 1:141,986,145...142,014,400
Ensembl chr 1:141,986,145...142,014,398
JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases expression ISO Acetazolamide results in increased expression of SF3B1 mRNA CTD PMID:19274763 NCBI chr 9:61,594,620...61,634,510
Ensembl chr 9:61,594,620...61,634,510
JBrowse link
G Sfmbt2 Scm-like with four mbt domains 2 increases expression ISO Acetazolamide results in increased expression of SFMBT2 mRNA CTD PMID:19274763 NCBI chr17:71,719,012...71,904,303
Ensembl chr17:71,723,620...71,897,972
JBrowse link
G Shox2 short stature homeobox 2 increases expression ISO Acetazolamide results in increased expression of SHOX2 mRNA CTD PMID:19274763 NCBI chr 2:164,118,175...164,126,783
Ensembl chr 2:164,118,191...164,126,783
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 increases expression ISO Acetazolamide results in increased expression of SMARCC1 mRNA CTD PMID:19274763 NCBI chr 8:118,206,678...118,326,264
Ensembl chr 8:118,206,698...118,325,537
JBrowse link
G Stx3 syntaxin 3 increases expression ISO Acetazolamide results in increased expression of STX3 mRNA CTD PMID:19274763 NCBI chr 1:228,137,781...228,195,004
Ensembl chr 1:228,149,867...228,194,977
JBrowse link
G Styx serine/threonine/tyrosine interacting protein increases expression ISO Acetazolamide results in increased expression of STYX mRNA CTD PMID:19274763 NCBI chr15:19,690,079...19,720,683
Ensembl chr15:19,690,194...19,717,774
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein increases expression ISO Acetazolamide results in increased expression of TIA1 mRNA CTD PMID:19274763 NCBI chr 4:118,207,845...118,238,246
Ensembl chr 4:118,207,862...118,235,218
JBrowse link
G Tmem30b transmembrane protein 30B increases expression ISO Acetazolamide results in increased expression of TMEM30B mRNA CTD PMID:19274763 NCBI chr 6:96,439,607...96,442,682
Ensembl chr 6:96,439,607...96,442,682
JBrowse link
G Trim25 tripartite motif-containing 25 increases expression ISO Acetazolamide results in increased expression of TRIM25 mRNA CTD PMID:19274763 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145
JBrowse link
G Umod uromodulin increases expression ISO Acetazolamide results in increased expression of UMOD protein CTD PMID:2655449 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 increases expression ISO Acetazolamide results in increased expression of WNK1 mRNA CTD PMID:19274763 NCBI chr 4:152,452,211...152,578,469
Ensembl chr 4:152,452,848...152,578,446
JBrowse link
G Zfp322a zinc finger protein 322a increases expression ISO Acetazolamide results in increased expression of ZFP322A mRNA CTD PMID:19274763 NCBI chr17:44,025,036...44,040,900
Ensembl chr17:44,025,267...44,039,284
JBrowse link

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  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            diuretic 1122
              acetazolamide 65
                acetazolamide sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  acetazolamide 65
                                                    acetazolamide sodium 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.