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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acetazolamide
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Accession:CHEBI:27690 term browser browse the term
Definition:A thiadiazole that has formula C4H6N4O3S2.
Synonyms:related_synonym: 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide;   5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE;   Defiltran;   Diacarb;   Diamox;   Diluran;   Formula=C4H6N4O3S2;   Glaupax;   InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9);   InChIKey=BZKPWHYZMXOIDC-UHFFFAOYSA-N;   N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide;   N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide;   N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide;   SMILES=CC(=O)Nc1nnc(s1)S(N)(=O)=O;   acetazolamida;   acetazolamidum
 alt_id: CHEBI:22167;   CHEBI:22168;   CHEBI:2388;   CHEBI:41007
 xref: Beilstein:212994;   CAS:59-66-5;   DrugBank:DB00819;   Drug_Central:56;   Gmelin:365421;   KEGG:C06805;   KEGG:D00218;   LINCS:LSM-5543
 xref_mesh: MESH:D000086
 xref: PDBeChem:AZM;   Patent:US2554816;   Wikipedia:Acetazolamide
 cyclic_relationship: is_conjugate_acid_of CHEBI:50634


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acetazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Acetazolamide results in increased expression of ABCA1 mRNA CTD PMID:19274763 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Akap17a A-kinase anchoring protein 17A increases expression ISO Acetazolamide results in increased expression of AKAP17B mRNA CTD PMID:19274763 NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479
JBrowse link
G Akap9 A-kinase anchoring protein 9 increases expression ISO Acetazolamide results in increased expression of AKAP9 mRNA CTD PMID:19274763 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Ammecr1l AMMECR1 like increases expression ISO Acetazolamide results in increased expression of AMMECR1L mRNA CTD PMID:19274763 NCBI chr18:23,386,114...23,411,177
Ensembl chr18:23,386,903...23,410,920
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A increases expression ISO Acetazolamide results in increased expression of ANP32A mRNA CTD PMID:19274763
G Aqp1 aquaporin 1 decreases expression ISO Acetazolamide results in decreased expression of AQP1 protein CTD PMID:17219999 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Acetazolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268
JBrowse link
G Arid2 AT-rich interaction domain 2 increases expression ISO Acetazolamide results in increased expression of ARID2 mRNA CTD PMID:19274763 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
JBrowse link
G Brd4 bromodomain containing 4 increases expression ISO Acetazolamide results in increased expression of BRD4 mRNA CTD PMID:19274763 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity
multiple interactions
ISO Acetazolamide results in decreased activity of CA12 protein
Acetazolamide binds to and results in decreased activity of CA12 protein
CTD PMID:21851094 PMID:28251759 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Ca13 carbonic anhydrase 13 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA13 protein CTD PMID:28251759 NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525
JBrowse link
G Ca14 carbonic anhydrase 14 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA14 protein CTD PMID:28251759 NCBI chr 2:183,442,263...183,449,207
Ensembl chr 2:183,441,667...183,449,693
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ca4 carbonic anhydrase 4 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA4 protein CTD PMID:28251759 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
JBrowse link
G Ca5a carbonic anhydrase 5A multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5A protein CTD PMID:28251759 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
JBrowse link
G Ca5b carbonic anhydrase 5B multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5B protein CTD PMID:28251759 NCBI chr  X:30,474,697...30,534,797
Ensembl chr  X:30,474,784...30,533,837
JBrowse link
G Ca6 carbonic anhydrase 6 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA6 protein CTD PMID:28251759 NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity
multiple interactions
ISO Acetazolamide results in decreased activity of CA9 protein
Acetazolamide binds to and results in decreased activity of CA9 protein
CTD PMID:21851094 PMID:28251759 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
decreases activity
ISO Acetazolamide binds to and results in decreased activity of CA1 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein] CTD PMID:11430635 PMID:17826101 PMID:19231207 PMID:28117934 PMID:28251759 More... NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO Acetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein] CTD PMID:11430635 PMID:16858005 PMID:17826101 PMID:19231207 PMID:21851094 More... NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car7 carbonic anhydrase 7 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA7 protein CTD PMID:28251759 NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein] CTD PMID:21040473 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cbx3 chromobox 3 increases expression ISO Acetazolamide results in increased expression of CBX3 mRNA CTD PMID:19274763 NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
JBrowse link
G Ccnd2 cyclin D2 increases expression ISO Acetazolamide results in increased expression of CCND2 mRNA CTD PMID:19274763 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Cd47 Cd47 molecule increases expression ISO Acetazolamide results in increased expression of CD47 mRNA CTD PMID:19274763 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Acetazolamide results in increased expression of CIRBP mRNA CTD PMID:19274763 NCBI chr 7:9,533,857...9,538,899 JBrowse link
G Clcn3 chloride voltage-gated channel 3 increases expression ISO Acetazolamide results in increased expression of CLCN3 mRNA CTD PMID:19274763 NCBI chr16:29,127,419...29,200,133
Ensembl chr16:29,127,419...29,200,119
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked increases expression ISO Acetazolamide results in increased expression of DDX3X mRNA CTD PMID:19274763 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Ddx6 DEAD-box helicase 6 increases expression ISO Acetazolamide results in increased expression of DDX6 mRNA CTD PMID:19274763 NCBI chr 8:44,931,127...44,967,773
Ensembl chr 8:44,931,974...44,964,405
JBrowse link
G Dsc2 desmocollin 2 increases expression ISO Acetazolamide results in increased expression of DSC2 mRNA CTD PMID:19274763 NCBI chr18:11,450,392...11,482,476
Ensembl chr18:11,450,390...11,482,392
JBrowse link
G Glg1 golgi glycoprotein 1 increases expression ISO Acetazolamide results in increased expression of GLG1 mRNA CTD PMID:19274763 NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Acetazolamide results in increased expression of GLUL mRNA CTD PMID:19274763 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression ISO Acetazolamide results in increased expression of HTRA1 mRNA CTD PMID:19274763 NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO Acetazolamide results in increased expression of IGF1R mRNA CTD PMID:19274763 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 increases expression ISO Acetazolamide results in increased expression of ITPR2 mRNA CTD PMID:19274763 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
JBrowse link
G LOC102546572 zinc finger protein 709-like increases expression ISO Acetazolamide results in increased expression of ZFP617 mRNA CTD PMID:19274763 NCBI chr 7:11,846,077...11,868,732 JBrowse link
G Mab21l2 mab-21 like 2 decreases expression ISO Acetazolamide results in decreased expression of MAB21L2 mRNA CTD PMID:19274763 NCBI chr 2:171,946,573...171,949,655
Ensembl chr 2:171,946,573...171,949,655
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Acetazolamide results in increased expression of MAP3K1 mRNA CTD PMID:19274763 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mt1 metallothionein 1 decreases expression ISO Acetazolamide results in decreased expression of MT1 mRNA CTD PMID:19274763 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit increases expression ISO Acetazolamide results in increased expression of NAA15 mRNA CTD PMID:19274763 NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Acetazolamide results in increased expression of NDRG1 mRNA CTD PMID:19274763 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression ISO Acetazolamide results in increased expression of NRIP1 mRNA CTD PMID:19274763 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Peg3 paternally expressed 3 increases expression ISO Acetazolamide results in increased expression of PEG3 mRNA CTD PMID:19274763 NCBI chr 1:67,097,874...67,124,692
Ensembl chr 1:67,097,904...67,124,671
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO Acetazolamide results in increased expression of POU2F1 mRNA CTD PMID:19274763 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B increases expression ISO Acetazolamide results in increased expression of PPM1B mRNA CTD PMID:19274763 NCBI chr 6:9,646,695...9,707,471
Ensembl chr 6:9,655,765...9,707,974
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Acetazolamide results in increased expression of RBM39 mRNA CTD PMID:19274763 NCBI chr 3:144,662,998...144,696,222
Ensembl chr 3:144,663,001...144,696,213
JBrowse link
G Rbmx RNA binding motif protein, X-linked increases expression ISO Acetazolamide results in increased expression of RBMX mRNA CTD PMID:19274763 NCBI chr  X:135,305,237...135,314,806
Ensembl chr  X:135,305,325...135,314,743
JBrowse link
G Satb1 SATB homeobox 1 increases expression ISO Acetazolamide results in increased expression of SATB1 mRNA CTD PMID:19274763 NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Acetazolamide results in increased expression of SC5D mRNA CTD PMID:19274763 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
JBrowse link
G Schip1 schwannomin interacting protein 1 increases expression ISO Acetazolamide results in increased expression of SCHIP1 mRNA CTD PMID:19274763 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Acetazolamide results in increased expression of SDC4 mRNA CTD PMID:19274763 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
JBrowse link
G Sema4b semaphorin 4B increases expression ISO Acetazolamide results in increased expression of SEMA4B mRNA CTD PMID:19274763 NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775
JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases expression ISO Acetazolamide results in increased expression of SF3B1 mRNA CTD PMID:19274763 NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300
JBrowse link
G Sfmbt2 Scm-like with four mbt domains 2 increases expression ISO Acetazolamide results in increased expression of SFMBT2 mRNA CTD PMID:19274763 NCBI chr17:67,934,296...68,128,905
Ensembl chr17:67,935,904...68,128,781
JBrowse link
G Shox2 short stature homeobox 2 increases expression ISO Acetazolamide results in increased expression of SHOX2 mRNA CTD PMID:19274763 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 increases expression ISO Acetazolamide results in increased expression of SMARCC1 mRNA CTD PMID:19274763 NCBI chr 8:110,111,097...110,214,727
Ensembl chr 8:110,111,122...110,214,720
JBrowse link
G Stx3 syntaxin 3 increases expression ISO Acetazolamide results in increased expression of STX3 mRNA CTD PMID:19274763 NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
JBrowse link
G Styx serine/threonine/tyrosine interacting protein increases expression ISO Acetazolamide results in increased expression of STYX mRNA CTD PMID:19274763 NCBI chr15:18,565,214...18,595,797
Ensembl chr15:18,564,633...18,593,524
JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein increases expression ISO Acetazolamide results in increased expression of TIA1 mRNA CTD PMID:19274763 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
JBrowse link
G Tmem30b transmembrane protein 30B increases expression ISO Acetazolamide results in increased expression of TMEM30B mRNA CTD PMID:19274763 NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842
JBrowse link
G Trim25 tripartite motif-containing 25 increases expression ISO Acetazolamide results in increased expression of TRIM25 mRNA CTD PMID:19274763 NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257
JBrowse link
G Umod uromodulin increases expression ISO Acetazolamide results in increased expression of UMOD protein CTD PMID:2655449 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 increases expression ISO Acetazolamide results in increased expression of WNK1 mRNA CTD PMID:19274763 NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905
JBrowse link
G Zfp322a zinc finger protein 322a increases expression ISO Acetazolamide results in increased expression of ZFP322A mRNA CTD PMID:19274763 NCBI chr17:41,773,789...41,789,654
Ensembl chr17:41,773,782...41,790,078
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            diuretic 1131
              acetazolamide 65
                acetazolamide sodium 0
Path 2
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  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  acetazolamide 65
                                                    acetazolamide sodium 0
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