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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:herbacetin
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Accession:CHEBI:27673 term browser browse the term
Definition:A pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities.
Synonyms:exact_synonym: 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
 related_synonym: 3,4',5,7,8-pentahydroxyflavone;   3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;   8-hydroxykaempferol;   Formula=C15H10O7;   InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H;   InChIKey=ZDOTZEDNGNPOEW-UHFFFAOYSA-N;   SMILES=OC1=CC=C(C=C1)C1=C(O)C(=O)C2=C(O1)C(O)=C(O)C=C2O
 alt_id: CHEBI:20809;   CHEBI:2322
 xref: CAS:527-95-7;   KEGG:C02806;   KNApSAcK:C00001048;   LIPID_MAPS_instance:LMPK12113149
 xref_mesh: MESH:C581534
 xref: MetaCyc:CPD-14867;   PMID:23063593;   PMID:24081687;   PMID:26297979;   PMID:26676750;   PMID:26923730;   PMID:29029040;   PMID:29653099;   PMID:30899386;   PMID:31075281;   PMID:31356124;   PMID:31436895;   PMID:31724441;   PMID:32746637;   Wikipedia:Herbacetin


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herbacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA] CTD PMID:36198566 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA] CTD PMID:36198566 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of CASP3 mRNA] CTD PMID:36198566 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein] CTD PMID:36198566 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of FASN protein] CTD PMID:29653099 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of G6PD protein] CTD PMID:29653099 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased activity of GPT protein] CTD PMID:29653099 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein] CTD PMID:36198566 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of HAVCR1 protein] CTD PMID:36198566 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein] CTD PMID:36198566 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein] CTD PMID:36198566 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of LCN2 protein] CTD PMID:36198566 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:36198566 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein] CTD PMID:36198566 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA] CTD PMID:29653099 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO herbacetin inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:29653099 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP herbacetin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein] CTD PMID:36198566 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        anti-inflammatory agent 16695
          herbacetin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            organic molecule 19735
                              organic cyclic compound 19528
                                organic heterocyclic compound 18895
                                  oxacycle 17921
                                    benzopyran 11992
                                      1-benzopyran 11746
                                        flavonoid 7235
                                          anthoxanthin 4588
                                            flavones 4588
                                              hydroxyflavone 4565
                                                flavonols 4432
                                                  7-hydroxyflavonol 4397
                                                    kaempferol 207
                                                      herbacetin 17
paths to the root