CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: actinomycin D
Accession: CHEBI:27666
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Definition: An actinomycin that has formula C62H86N12O16.
Synonyms: exact_synonym: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide
related_synonym: 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide; ActD; Dactinomycin; Formula=C62H86N12O16; InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1; InChIKey=RJURFGZVJUQBHK-IIXSONLDSA-N; SMILES=[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C; actinomycin C1; actinomycin IV
alt_id: CHEBI:22218; CHEBI:2446
xref: Beilstein:4173766; CAS:50-76-0; DrugBank:DB00970; Drug_Central:774; KEGG:C06770; KEGG:D00214; LINCS:LSM-5783
xref_mesh: MESH:D003609
xref: Wikipedia:Dactinomycin
G
CAPN1
calpain 1
multiple interactions
EXP
Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of CAPN1 mRNA]
CTD
PMID:9728040
NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684
G
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA]
CTD
PMID:9463523
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
G
HSPA5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]
CTD
PMID:16759985
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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