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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:actinomycin D
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Accession:CHEBI:27666 term browser browse the term
Definition:An actinomycin that has formula C62H86N12O16.
Synonyms:exact_synonym: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide
 related_synonym: 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide;   ActD;   Dactinomycin;   Formula=C62H86N12O16;   InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1;   InChIKey=RJURFGZVJUQBHK-IIXSONLDSA-N;   SMILES=[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C;   actinomycin C1;   actinomycin IV
 alt_id: CHEBI:22218;   CHEBI:2446
 xref: Beilstein:4173766;   CAS:50-76-0;   DrugBank:DB00970;   Drug_Central:774;   KEGG:C06770;   KEGG:D00214;   LINCS:LSM-5783
 xref_mesh: MESH:D003609
 xref: Wikipedia:Dactinomycin


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actinomycin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO
EXP
ABCB1 protein results in decreased susceptibility to Dactinomycin
Dactinomycin inhibits the reaction [[Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [[Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1A mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Dactinomycin inhibits the reaction [tetrabromobisphenol A results in increased expression of and results in increased activity of ABCB1A protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]
Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCB1 mRNA]
CTD PMID:1967174 PMID:11455017 PMID:15725475 PMID:18474546 PMID:19813763 PMID:20410605 PMID:30830211 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions EXP Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1B mRNA] CTD PMID:20410605 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases response to substance ISO
EXP
ABCC1 protein results in decreased susceptibility to Dactinomycin CTD PMID:11455017 PMID:12067707 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases response to substance
multiple interactions
EXP
ISO
ABCC2 protein results in decreased susceptibility to Dactinomycin
Dactinomycin inhibits the reaction [Bucladesine results in increased expression of ABCC2 mRNA]
Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCC2 mRNA]
CTD PMID:11408547 PMID:11455017 PMID:26049102 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Daunorubicin results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [Doxorubicin results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein]; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA] CTD PMID:20019844 PMID:21625222 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd3 abhydrolase domain containing 3, phospholipase increases expression ISO Dactinomycin results in increased expression of ABHD3 mRNA CTD PMID:21527772 NCBI chr18:1,892,413...1,946,840
Ensembl chr18:1,892,413...1,946,840
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 multiple interactions EXP Dactinomycin inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA] CTD PMID:10585473 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 multiple interactions ISO Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] CTD PMID:17018608 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of ADRB2 protein]; Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA] CTD PMID:22483689 PMID:24705868 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [Amiodarone results in increased expression of AGT mRNA]
Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]
CTD PMID:16705055 PMID:17214612 PMID:19292980 PMID:23288202 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Dactinomycin inhibits the reaction [TGFB1 protein results in decreased expression of AHR mRNA]
ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
CTD PMID:9145908 PMID:16226227 PMID:25637755 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aicda activation-induced cytidine deaminase multiple interactions ISO [Dactinomycin co-treated with Alpha-Amanitin] inhibits the reaction [Estradiol results in increased expression of AICDA mRNA] CTD PMID:19139166 NCBI chr 4:155,359,909...155,371,104
Ensembl chr 4:155,359,921...155,369,671
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased expression of AIFM1 protein CTD PMID:17707539 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]
PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:14640974 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP Dactinomycin inhibits the reaction [Fish Oils results in increased activity of ALPI protein] CTD PMID:15599000 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084
JBrowse link
G Alx3 ALX homeobox 3 multiple interactions EXP Dactinomycin inhibits the reaction [Folic Acid results in increased expression of ALX3 mRNA] CTD PMID:20534379 NCBI chr 2:210,376,510...210,386,928
Ensembl chr 2:210,381,829...210,386,928
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions EXP Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein] CTD PMID:2860926 PMID:6218830 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of AQP1 mRNA] CTD PMID:22415096 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta increases expression ISO Dactinomycin results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 4:170,913,920...170,932,789
Ensembl chr 4:170,913,923...170,932,618
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]] CTD PMID:16226227 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]; Dactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] CTD PMID:20022965 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of ATG7 protein] CTD PMID:24095927 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Dactinomycin results in decreased expression of and results in increased phosphorylation of ATM protein CTD PMID:31226288 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Dactinomycin results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA] CTD PMID:22020323 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP
ISO
Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAK1 mRNA]
Dactinomycin promotes the reaction [BAK1 protein binds to BAK1 protein]
CTD PMID:21281706 PMID:26670606 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Dactinomycin results in increased expression of BAX mRNA; Dactinomycin results in increased expression of BAX protein
Dactinomycin promotes the reaction [BAX protein binds to BAX protein]
Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNA]
Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]
CTD PMID:10760829 PMID:12927789 PMID:21281706 PMID:21527772 PMID:26670606 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Dactinomycin results in increased expression of BBC3 mRNA; Dactinomycin results in increased expression of BBC3 protein CTD PMID:17581298 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO BCL2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; Dactinomycin inhibits the reaction [IL1B results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Dactinomycin results in decreased expression of BCL2 mRNA; Dactinomycin results in decreased expression of BCL2 protein
CTD PMID:11726273 PMID:11880364 PMID:12927789 PMID:16492401 PMID:17581298 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO BCL2A1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
increases expression
ISO Dactinomycin results in decreased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Dactinomycin results in increased expression of BCL2L1 protein]
Dactinomycin results in increased expression of BCL2L1 protein; Dactinomycin results in increased expression of BCL2L1 protein alternative form
CTD PMID:9326359 PMID:12430140 PMID:15592511 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of BCL2L11 mRNA] CTD PMID:16166651 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of BDNF mRNA]
Dactinomycin results in decreased expression of BDNF mRNA
CTD PMID:22982731 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of BECN1 protein] CTD PMID:24095927 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Dactinomycin inhibits the reaction [vorinostat results in increased cleavage of BID protein]
Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of BID mRNA]
CTD PMID:11535817 PMID:16166651 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO BIRC3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA; Dactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein]; Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:11592958 PMID:19442826 PMID:24095927 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bsdc1 BSD domain containing 1 increases expression ISO Dactinomycin results in increased expression of BSDC1 mRNA CTD PMID:21527772 NCBI chr 5:147,661,618...147,689,766
Ensembl chr 5:147,661,618...147,689,759
JBrowse link
G C1qbp complement C1q binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Dactinomycin CTD PMID:25354864 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions EXP Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr10:82,129,071...82,197,828
Ensembl chr10:82,129,506...82,197,848
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions EXP Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Casp2 caspase 2 increases cleavage ISO Dactinomycin results in increased cleavage of CASP2 protein CTD PMID:10663630 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases expression
ISO
EXP
[TNF co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP3 protein; Dactinomycin inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP3 protein]
Dactinomycin results in increased cleavage of and results in increased activity of CASP3 protein
[Dactinomycin co-treated with TNF protein] results in increased activity of CASP3 protein
Dactinomycin results in increased activity of CASP3 protein
Dactinomycin results in decreased expression of CASP3 mRNA
CTD PMID:10663630 PMID:16001973 PMID:16492401 PMID:21496118 PMID:22654482 PMID:23300732 PMID:26670606 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
decreases expression
ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP7 protein; [TNF co-treated with Dactinomycin] results in increased activity of CASP7 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP7 protein; Dactinomycin promotes the reaction [TNF results in increased activity of CASP7 protein]
Dactinomycin results in decreased expression of CASP7 mRNA
CTD PMID:16001973 PMID:16492401 PMID:17707539 PMID:21496118 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 decreases expression ISO Dactinomycin results in decreased expression of CASP8 mRNA CTD PMID:16001973 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP9 protein
Dactinomycin results in increased cleavage of CASP9 protein
CTD PMID:17707539 PMID:26670606 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Dactinomycin inhibits the reaction [rosiglitazone results in increased expression of CAV1 mRNA] CTD PMID:15314095 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:15531761 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dactinomycin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:15531761 PMID:16705055 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn4 cellular communication network factor 4 multiple interactions ISO Dactinomycin inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA] CTD PMID:19238344 NCBI chr 7:107,695,227...107,723,759
Ensembl chr 7:107,695,215...107,723,772
JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA] CTD PMID:8550827 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 decreases stability ISO Dactinomycin results in decreased stability of CCND1 mRNA CTD PMID:15610522 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd1d1 CD1d1 molecule multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] CTD PMID:17392484 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [Dactinomycin results in increased expression of and affects the localization of CDKN1A protein]; Dactinomycin results in increased expression of and affects the localization of CDKN1A protein
Dactinomycin results in decreased expression of CDKN1A protein
CTD PMID:12807743 PMID:14601052 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Dactinomycin results in decreased expression of CEBPB mRNA CTD PMID:16001973 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cel carboxyl ester lipase increases expression ISO Dactinomycin results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Dactinomycin results in decreased expression of CFLAR protein CTD PMID:11234897 PMID:14601052 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of CKB protein]; Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of CKB protein] CTD PMID:7839363 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Clmn calmin multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CLMN mRNA] CTD PMID:16688769 NCBI chr 6:128,473,592...128,567,267
Ensembl chr 6:128,473,570...128,567,198
JBrowse link
G Cnmd chondromodulin multiple interactions ISO Dactinomycin inhibits the reaction [hydroquinone results in increased expression of CNMD protein] CTD PMID:19525446 NCBI chr15:61,923,291...61,947,840
Ensembl chr15:61,923,299...61,947,764
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Dactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]
Dactinomycin results in decreased expression of COL1A1 mRNA
CTD PMID:11216681 PMID:18253093 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO Dactinomycin results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Dactinomycin inhibits the reaction [Reactive Oxygen Species results in increased expression of CSF2 protein]
Dactinomycin inhibits the reaction [IL1B results in increased secretion of CSF2 protein]; Dactinomycin inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein]
CTD PMID:9606035 PMID:10645887 PMID:11752025 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]] CTD PMID:23288202 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CYCS mRNA] CTD PMID:21281706 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cygb cytoglobin multiple interactions ISO Dactinomycin inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
ISO Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Lead results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [SB 203580 results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Dactinomycin promotes the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; Dactinomycin promotes the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]
Dactinomycin results in decreased expression of CYP1A1 mRNA
Dactinomycin inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [NSC 674495 results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Sunitinib results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [T-2 Toxin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]
CTD PMID:1934297 PMID:10359656 PMID:11577022 PMID:11752201 PMID:16093525 PMID:17283379 PMID:17606337 PMID:19901195 PMID:20187624 PMID:20732341 PMID:21262253 PMID:21732638 PMID:23288144 PMID:26318284 PMID:26640276 PMID:31470059 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]; Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA] CTD PMID:21262253 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression
ISO
EXP
Dactinomycin inhibits the reaction [NSC 674495 results in increased expression of CYP1B1 mRNA]
Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of CYP1B1 protein]
Dactinomycin results in decreased expression of CYP1B1 mRNA
Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
CTD PMID:11577022 PMID:11752201 PMID:21867498 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions
increases stability
ISO Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]; Dactinomycin inhibits the reaction [Cyclic AMP results in increased expression of CYP2A5 mRNA]; Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA]
Dactinomycin results in increased stability of CYP2A5 mRNA
CTD PMID:12754101 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA] CTD PMID:9007836 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 multiple interactions ISO Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] CTD PMID:20187624 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA] CTD PMID:17277313 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] CTD PMID:11181506 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP3A23-3A1 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:11181506 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]; Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A4 mRNA] CTD PMID:15795092 PMID:24819614 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A5 mRNA] CTD PMID:24819614 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 multiple interactions ISO Dactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA] CTD PMID:17977009 NCBI chr20:5,049,260...5,052,573
Ensembl chr20:5,049,496...5,052,585
JBrowse link
G Dio3 iodothyronine deiodinase 3 multiple interactions EXP Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein] CTD PMID:18420745 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Dactinomycin results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 1:211,423,022...211,438,533
Ensembl chr 1:211,423,022...211,438,531
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein] CTD PMID:20561571 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Dactinomycin inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA] CTD PMID:20561571 PMID:20716444 PMID:22207076 PMID:25772258 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Efnb2 ephrin B2 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of EFNB2 mRNA] CTD PMID:16688769 NCBI chr16:86,631,151...86,672,050
Ensembl chr16:86,631,064...86,675,049
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of EGFR protein]; Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of EGFR protein] CTD PMID:8888411 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of EGR1 mRNA] CTD PMID:1717835 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 multiple interactions ISO Dactinomycin inhibits the reaction [Norepinephrine results in increased expression of ELOVL3 mRNA]; Dactinomycin inhibits the reaction [rosiglitazone results in increased expression of ELOVL3 mRNA] CTD PMID:17726147 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Dactinomycin results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Dactinomycin results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 1:101,900,731...101,903,948
Ensembl chr 1:101,900,733...101,903,910
JBrowse link
G Epas1 endothelial PAS domain protein 1 increases stability EXP Dactinomycin results in increased stability of EPAS1 protein CTD PMID:23545307 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions
ISO Dactinomycin results in decreased expression of F3 mRNA
Dactinomycin inhibits the reaction [indoleacetic acid results in increased expression of F3 mRNA]
CTD PMID:30324315 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fadd Fas associated via death domain decreases expression ISO Dactinomycin results in decreased expression of FADD mRNA CTD PMID:16001973 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fads3 fatty acid desaturase 3 increases expression ISO Dactinomycin results in increased expression of FADS3 mRNA CTD PMID:21527772 NCBI chr 1:226,091,774...226,108,332
Ensembl chr 1:226,091,774...226,108,332
JBrowse link
G Fbl fibrillarin affects localization ISO Dactinomycin analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr 1:85,103,519...85,112,619
Ensembl chr 1:85,103,519...85,112,619
JBrowse link
G Fcar Fc fragment of IgA receptor multiple interactions ISO Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of FCAR mRNA] CTD PMID:21911031 NCBI chr 1:73,230,392...73,263,462
Ensembl chr 1:73,230,390...73,264,302
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases expression
ISO
EXP
Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
Dactinomycin inhibits the reaction [FGF2 protein results in increased expression of SNCA protein]
Dactinomycin results in decreased expression of FGF2 mRNA
CTD PMID:12562524 PMID:26800359 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 multiple interactions EXP Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA] CTD PMID:12805413 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fhl1 four and a half LIM domains 1 multiple interactions EXP Dactinomycin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Flnc filamin C increases expression ISO Dactinomycin results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 4:56,710,934...56,738,779
Ensembl chr 4:56,711,049...56,738,791
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]
Dactinomycin results in decreased expression of FOS mRNA
Dactinomycin inhibits the reaction [[Cycloheximide co-treated with Cadmium] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA]
CTD PMID:1696944 PMID:7564102 PMID:10381381 PMID:11123204 PMID:11353138 PMID:11568973 PMID:12632255 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of FOSL1 mRNA]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of FOSL1 mRNA]
Dactinomycin results in decreased expression of FOSL1 mRNA
CTD PMID:14565943 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [arsenite results in increased expression of GADD45A mRNA]
Dactinomycin results in increased expression of GADD45A mRNA
CTD PMID:17616671 PMID:21527772 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Galm galactose mutarotase multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of GALM mRNA] CTD PMID:18052213 NCBI chr 6:2,808,988...2,860,742
Ensembl chr 6:2,808,841...2,860,744
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Dactinomycin results in increased expression of GAPDH mRNA CTD PMID:16001973 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions
increases degradation
ISO Phosphates promotes the reaction [Dactinomycin results in increased degradation of GAS6 mRNA] CTD PMID:20048160 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA]
Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]
CTD PMID:11972604 PMID:24437944 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO Dactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA] CTD PMID:17257620 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
decreases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of GDNF mRNA]
Dactinomycin results in decreased expression of GDNF mRNA
CTD PMID:22982731 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Gfer growth factor, augmenter of liver regeneration increases secretion
multiple interactions
EXP Dactinomycin results in increased secretion of GFER protein
Dactinomycin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of GFER protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Dactinomycin results in increased secretion of GFER protein]
CTD PMID:23073658 NCBI chr10:14,059,347...14,061,703
Ensembl chr10:14,059,347...14,061,703
JBrowse link
G Gpr137b G protein-coupled receptor 137B increases expression ISO Dactinomycin results in increased expression of GPR137B mRNA CTD PMID:21527772 NCBI chr17:90,670,852...90,709,003
Ensembl chr17:90,670,872...90,746,804
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Dactinomycin inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions EXP Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]; Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein] CTD PMID:11665859 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of GSTA1 mRNA] CTD PMID:28483492 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions ISO Dactinomycin inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA] CTD PMID:16243960 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases response to substance EXP GSTP1 protein results in decreased susceptibility to Dactinomycin CTD PMID:11455017 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dactinomycin results in increased expression of H2AX protein CTD PMID:31226288 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions
decreases expression
ISO Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]
Dactinomycin results in decreased expression of HBEGF mRNA
CTD PMID:26800359 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein] CTD PMID:29408570 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:12479793 PMID:19958256 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
ISO
EXP
Dactinomycin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Lipid Peroxides results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]; Dactinomycin results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]
Dactinomycin results in decreased expression of HMOX1 protein
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]
Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]
CTD PMID:8764571 PMID:9747510 PMID:9808084 PMID:11880364 PMID:12763371 PMID:15118350 PMID:15582353 PMID:15588712 PMID:15876423 PMID:15965080 PMID:16647178 PMID:17002867 PMID:18332044 PMID:18357586 PMID:19781563 PMID:20060010 PMID:20833156 PMID:21840424 PMID:24437944 PMID:25239868 PMID:26283888 PMID:26385185 PMID:26968795 PMID:27867098 PMID:30076913 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 multiple interactions
affects localization
ISO Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]
Dactinomycin affects the localization of HNRNPA1 protein
CTD PMID:12754101 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Homer3 homer scaffold protein 3 increases expression ISO Dactinomycin results in increased expression of HOMER3 mRNA CTD PMID:21527772 NCBI chr16:20,880,447...20,890,968
Ensembl chr16:20,881,518...20,890,949
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] CTD PMID:9345283 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Dactinomycin inhibits the reaction [Bexarotene results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA] CTD PMID:31927052 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] CTD PMID:17915553 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO Dactinomycin promotes the reaction [Dronabinol results in decreased activity of HTR3A protein] CTD PMID:20800662 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of ID1 mRNA] CTD PMID:16494909 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Dactinomycin inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA] CTD PMID:16849584 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ier5 immediate early response 5 increases expression ISO Dactinomycin results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr13:72,742,210...72,744,302
Ensembl chr13:72,742,210...72,744,303
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA] CTD PMID:15937643 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dactinomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA]; Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]] CTD PMID:15937643 PMID:16085646 PMID:26278786 PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO IGF1 protein results in decreased susceptibility to Dactinomycin CTD PMID:9525472 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Dactinomycin inhibits the reaction [Zymosan results in increased expression of IL10 mRNA] CTD PMID:17458858 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il11 interleukin 11 multiple interactions ISO Dactinomycin inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Dactinomycin inhibits the reaction [Glucose results in increased secretion of IL17A protein] CTD PMID:18310510 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA] CTD PMID:7564102 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [IL1B results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [IL1B results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [IL1B results in increased secretion of CSF2 protein]
Dactinomycin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA]
CTD PMID:9606035 PMID:11286988 PMID:12512699 PMID:16338976 PMID:16365456 PMID:16492401 PMID:17641275 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Dactinomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il27ra interleukin 27 receptor subunit alpha increases expression ISO Dactinomycin results in increased expression of IL27RA mRNA CTD PMID:21527772 NCBI chr19:25,151,835...25,163,995
Ensembl chr19:25,149,897...25,164,086
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Dactinomycin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with alitretinoin] results in increased expression of SLC27A1 mRNA] CTD PMID:10777552 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of IRF1 mRNA] CTD PMID:16085646 PMID:16636311 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itga2b integrin subunit alpha 2b increases expression ISO Dactinomycin results in increased expression of ITGA2B mRNA CTD PMID:21527772 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Dactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] CTD PMID:15932931 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Dactinomycin results in decreased expression of JUN mRNA
Dactinomycin inhibits the reaction [Cadmium results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of JUN mRNA]
CTD PMID:1696944 PMID:11123204 PMID:11353138 PMID:11568973 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif1a kinesin family member 1A increases expression ISO Dactinomycin results in increased expression of KIF1A mRNA CTD PMID:21527772 NCBI chr 9:100,171,851...100,253,626
Ensembl chr 9:100,171,772...100,253,609
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Dactinomycin inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased expression of TNFRSF10B mRNA] CTD PMID:27222248 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt80 keratin 80 increases expression ISO Dactinomycin results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr 7:142,995,715...143,015,932
Ensembl chr 7:142,994,119...143,016,040
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO Dactinomycin results in increased expression of LAMC2 mRNA CTD PMID:21527772 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
decreases expression
ISO Ascorbic Acid inhibits the reaction [Dactinomycin results in decreased expression of LDLR mRNA] CTD PMID:32913121 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin multiple interactions EXP Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lgals3 galectin 3 multiple interactions ISO Dactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein] CTD PMID:21821001 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lgals7 galectin 7 increases expression ISO Dactinomycin results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 1:87,044,823...87,047,223
Ensembl chr 1:87,045,335...87,047,223
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Dactinomycin results in decreased expression of LMNB1 mRNA CTD PMID:16001973 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of MAP1LC3B protein] CTD PMID:24095927 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 decreases expression ISO Dactinomycin results in decreased expression of MAP2K4 mRNA CTD PMID:16001973 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases expression ISO Dactinomycin results in decreased expression of MAP3K7 mRNA CTD PMID:16001973 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
Ensembl chr 9:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
ISO
EXP
PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Dactinomycin results in increased expression of MAPK1 protein
CTD PMID:14640974 PMID:15959627 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
ISO
EXP
PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Dactinomycin results in increased expression of MAPK3 protein
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:14640974 PMID:15959627 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO Dactinomycin results in decreased expression of MCL1 mRNA
Dactinomycin inhibits the reaction [IL1B results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of MCL1 protein]; Quercetin promotes the reaction [Dactinomycin results in decreased expression of MCL1 mRNA]
CTD PMID:16492401 PMID:21750559 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mir21 microRNA 21 multiple interactions ISO Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:19264808 PMID:23052036 PMID:25969534 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir22 microRNA 22 multiple interactions ISO [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] CTD PMID:25969534 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor increases expression ISO Dactinomycin results in increased expression of MLLT11 mRNA CTD PMID:21527772 NCBI chr 2:196,392,936...196,402,106
Ensembl chr 2:196,392,938...196,402,106
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein] CTD PMID:19136476 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of MMP9 mRNA]
Dactinomycin results in decreased expression of MMP9 mRNA
CTD PMID:24956101 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions ISO Dactinomycin inhibits the reaction [Calcitriol results in increased expression of MN1 mRNA] CTD PMID:15890672 NCBI chr12:51,214,192...51,250,230
Ensembl chr12:51,214,192...51,250,230
JBrowse link
G Mrpl41 mitochondrial ribosomal protein L41 multiple interactions ISO Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein] CTD PMID:16024796 NCBI chr 3:2,181,044...2,181,962
Ensembl chr 3:2,181,045...2,181,962
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Dactinomycin inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]]; Dactinomycin inhibits the reaction [Paraquat results in increased expression of MT1 mRNA] CTD PMID:8966720 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA] CTD PMID:17234632 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Dactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA] CTD PMID:15537571 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO
EXP
Dactinomycin results in decreased expression of MYC mRNA
Dactinomycin inhibits the reaction [Cadmium results in increased expression of MYC mRNA]
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of MYC mRNA]
CTD PMID:1696944 PMID:11353138 PMID:16001973 PMID:21527772 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Mylk myosin light chain kinase multiple interactions ISO Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein] CTD PMID:15701621 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Nav2 neuron navigator 2 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of NAV2 mRNA] CTD PMID:16688769 NCBI chr 1:104,575,765...104,941,554
Ensembl chr 1:104,576,589...104,941,552
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA] CTD PMID:19559082 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO [nickel chloride co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA; [Oxygen deficiency co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA CTD PMID:10646848 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions ISO Dactinomycin inhibits the reaction [Tretinoin results in increased expression of NEDD9 mRNA] CTD PMID:16688769 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Dactinomycin results in increased expression of NETO2 mRNA CTD PMID:21527772 NCBI chr19:22,450,579...22,486,530
Ensembl chr19:22,450,030...22,486,531
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Dactinomycin inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFE2L2 mRNA] CTD PMID:22019695 PMID:24632381 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression
multiple interactions
ISO Dactinomycin results in decreased expression of NFKB1 mRNA
[RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]
CTD PMID:11880364 PMID:16001973 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions
decreases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of NGF mRNA]
Dactinomycin results in decreased expression of NGF mRNA
CTD PMID:22982731 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA] CTD PMID:23937860 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Dactinomycin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA] CTD PMID:11286988 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppc natriuretic peptide C multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of NPPC mRNA] CTD PMID:9435603 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [Biological Products results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Dactinomycin promotes the reaction [Chromium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]
Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]
CTD PMID:16243960 PMID:17923278 PMID:18474416 PMID:22570534 PMID:24437944 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Bucladesine results in decreased expression of NR0B1 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of NR0B1 mRNA] CTD PMID:18787026 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] CTD PMID:19593819 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Dactinomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP
ISO
Dactinomycin inhibits the reaction [Clofibrate results in increased expression of NR1I2 protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA]; Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
Dactinomycin inhibits the reaction [ochratoxin A results in decreased expression of NR1I2 mRNA]
CTD PMID:15826607 PMID:20599767 PMID:26341324 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein]; Dactinomycin inhibits the reaction [Dexamethasone binds to NR3C1 protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased degradation of NR3C1 protein] CTD PMID:21569845 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nthl1 nth-like DNA glycosylase 1 decreases expression ISO Dactinomycin results in decreased expression of NTHL1 mRNA CTD PMID:21527772 NCBI chr10:13,996,660...14,002,827
Ensembl chr10:13,996,645...14,002,910
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Dactinomycin inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form] CTD PMID:20678484 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Pappa1 pappalysin 1 multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA] CTD PMID:16338976 NCBI chr 5:80,919,932...81,153,904
Ensembl chr 5:80,920,568...81,150,940
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein; Dactinomycin promotes the reaction [TNF results in increased cleavage of PARP1 protein]; PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]
PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]
CTD PMID:14640974 PMID:16492401 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
EXP
ISO
Dactinomycin results in decreased expression of PCNA protein
Dactinomycin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein]
CTD PMID:15959627 PMID:21533478 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of PLAT mRNA] CTD PMID:11236827 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
ISO Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAU mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of PLAU mRNA]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of PLAU mRNA]
Dactinomycin results in increased expression of PLAU mRNA
CTD PMID:11236827 PMID:21527772 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]; PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:14640974 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]; PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:14640974 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Polh DNA polymerase eta multiple interactions ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA] CTD PMID:25125662 NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132
JBrowse link
G Polr2a RNA polymerase II subunit A decreases phosphorylation
increases phosphorylation
multiple interactions
ISO Dactinomycin results in decreased phosphorylation of POLR2A protein
Dactinomycin results in increased phosphorylation of POLR2A protein
[Dactinomycin co-treated with sodium arsenite] results in increased phosphorylation of POLR2A protein
CTD PMID:8126066 NCBI chr10:56,339,277...56,364,888
Ensembl chr10:56,339,284...56,365,084
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 increases expression ISO Dactinomycin results in increased expression of POMT1 mRNA CTD PMID:21527772 NCBI chr 3:11,253,424...11,271,873
Ensembl chr 3:11,254,026...11,271,872
JBrowse link
G Prdx1 peroxiredoxin 1 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions EXP Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of PRDX6 mRNA]; Dactinomycin inhibits the reaction [Paraquat results in increased expression of PRDX6 mRNA] CTD PMID:12851211 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]
PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]
CTD PMID:14640974 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prl prolactin multiple interactions ISO Dactinomycin inhibits the reaction [PRL protein results in increased expression of SLC30A2 mRNA] CTD PMID:19494234 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Procr protein C receptor increases expression ISO Dactinomycin results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions
ISO Dactinomycin results in decreased expression of PROM1 mRNA
Dactinomycin results in decreased expression of and affects the localization of PROM1 protein
CTD PMID:31226288 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Sodium Fluoride results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
Dactinomycin inhibits the reaction [nickel chloride results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [nickel sulfide results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
Dactinomycin results in decreased expression of PTGS2 mRNA
Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
CTD PMID:9576062 PMID:11286988 PMID:16894348 PMID:17065197 PMID:18513776 PMID:18650268 PMID:19376214 PMID:24967690 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression EXP Dactinomycin results in decreased expression of PTK2 protein CTD PMID:15959627 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression
ISO tetrachlorobenzoquinone promotes the reaction [Dactinomycin results in decreased expression of RAD51 mRNA] CTD PMID:27989139 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression EXP Dactinomycin results in decreased expression of RAF1 protein CTD PMID:15959627 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; RELA protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions ISO Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein] CTD PMID:9203624 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Retsat retinol saturase increases expression ISO Dactinomycin results in increased expression of RETSAT mRNA CTD PMID:21527772 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO Dactinomycin inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB mRNA]; Dactinomycin inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB protein] CTD PMID:23732113 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Ripply3 ripply transcriptional repressor 3 increases expression ISO Dactinomycin results in increased expression of RIPPLY3 mRNA CTD PMID:21527772 NCBI chr11:34,557,679...34,565,776
Ensembl chr11:34,557,679...34,565,776
JBrowse link
G Rnf213 ring finger protein 213 multiple interactions ISO Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA] CTD PMID:26278786 NCBI chr10:108,527,351...108,626,372
Ensembl chr10:108,527,740...108,624,688
JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression ISO Dactinomycin results in increased expression of ROS1 mRNA CTD PMID:16001973 NCBI chr20:33,100,190...33,323,544
Ensembl chr20:33,100,191...33,323,367
JBrowse link
G Rpl34 ribosomal protein L34 increases expression ISO Dactinomycin results in increased expression of RPL34 mRNA CTD PMID:21527772 NCBI chr 2:235,850,281...235,854,021
Ensembl chr 2:235,850,334...235,852,708
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
CTD PMID:14640974 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rras RAS related increases expression ISO Dactinomycin results in increased expression of RRAS mRNA CTD PMID:21527772 NCBI chr 1:101,012,822...101,016,720
Ensembl chr 1:101,012,822...101,016,720
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions ISO Dactinomycin inhibits the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] CTD PMID:16637064 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Dactinomycin inhibits the reaction [ciprofibrate results in increased expression of SCD1 mRNA] CTD PMID:11172741 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1B mRNA] CTD PMID:10942727 NCBI chr 1:191,829,547...191,883,991
Ensembl chr 1:191,829,555...191,884,298
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1G mRNA] CTD PMID:10942727 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Sdc3 syndecan 3 multiple interactions EXP Dactinomycin inhibits the reaction [Estradiol results in increased expression of SDC3 mRNA] CTD PMID:11024013 NCBI chr 5:148,923,098...148,956,404
Ensembl chr 5:148,923,098...148,956,404
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA] CTD PMID:31323261 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sfn stratifin increases expression ISO Dactinomycin results in increased expression of SFN mRNA CTD PMID:21527772 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein] CTD PMID:25128767 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO Dactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein] CTD PMID:21625222 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Dactinomycin affects the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA] CTD PMID:30055241 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions ISO Dactinomycin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA]; Dactinomycin inhibits the reaction [Dopamine results in increased expression of SLC25A14 mRNA] CTD PMID:20600837 NCBI chr  X:135,470,855...135,509,223
Ensembl chr  X:135,470,915...135,509,221
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with alitretinoin] results in increased expression of SLC27A1 mRNA]
Dactinomycin inhibits the reaction [alitretinoin results in increased expression of SLC27A1 mRNA]
CTD PMID:10777552 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of SLC2A2 mRNA] CTD PMID:12787936 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions EXP Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA] CTD PMID:11123204 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Slc30a2 solute carrier family 30 member 2 multiple interactions ISO Dactinomycin inhibits the reaction [PRL protein results in increased expression of SLC30A2 mRNA] CTD PMID:19494234 NCBI chr 5:152,559,577...152,571,800
Ensembl chr 5:152,559,577...152,571,799
JBrowse link
G Slc30a5 solute carrier family 30 member 5 multiple interactions ISO Dactinomycin inhibits the reaction [zinc chloride results in decreased expression of SLC30A5 mRNA] CTD PMID:17234632 NCBI chr 2:30,815,683...30,845,796
Ensembl chr 2:30,815,703...30,846,149
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions ISO Dactinomycin inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA] CTD PMID:21738690 NCBI chr 9:59,947,562...60,070,549
Ensembl chr 9:60,021,534...60,070,552
JBrowse link
G Slc39a4 solute carrier family 39 member 4 multiple interactions ISO Dactinomycin inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA] CTD PMID:18020946 NCBI chr 7:117,675,718...117,682,586
Ensembl chr 7:117,675,720...117,680,004
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of SLC3A2 mRNA] CTD PMID:26621329 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA] CTD PMID:20090884 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Dactinomycin results in decreased expression of SLC7A11 protein CTD PMID:31226288 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a5 solute carrier family 7 member 5 multiple interactions ISO Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of SLC7A5 mRNA] CTD PMID:26621329 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563
JBrowse link
G Snca synuclein alpha multiple interactions EXP Dactinomycin inhibits the reaction [FGF2 protein results in increased expression of SNCA protein] CTD PMID:12562524 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA] CTD PMID:23237828 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [SOD2 protein results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; SOD2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]
Dactinomycin inhibits the reaction [polysaccharide-K results in increased expression of SOD2]
Dactinomycin inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]
CTD PMID:9852137 PMID:11154046 PMID:11880364 PMID:12031898 PMID:14996425 PMID:15683720 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO Dactinomycin results in decreased expression of SOS1 mRNA CTD PMID:16001973 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Dactinomycin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Spata18 spermatogenesis associated 18 increases expression ISO Dactinomycin results in increased expression of SPATA18 mRNA CTD PMID:21527772 NCBI chr14:37,081,529...37,108,245
Ensembl chr14:37,081,427...37,108,341
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]
Dactinomycin inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of SQSTM1 mRNA]
CTD PMID:24095927 PMID:25301941 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO Dactinomycin results in increased expression of STAT1 mRNA CTD PMID:16001973 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stmn3 stathmin 3 increases expression ISO Dactinomycin results in increased expression of STMN3 mRNA CTD PMID:21527772 NCBI chr 3:176,808,016...176,816,108
Ensembl chr 3:176,808,017...176,816,162
JBrowse link
G Stom stomatin increases expression ISO Dactinomycin results in increased expression of STOM mRNA CTD PMID:21527772 NCBI chr 3:14,515,576...14,538,199
Ensembl chr 3:14,514,868...14,538,241
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 mRNA] CTD PMID:16308312 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Dactinomycin results in increased expression of TAP1 mRNA CTD PMID:21527772 NCBI chr20:3,979,302...3,989,669
Ensembl chr20:3,979,035...3,989,669
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP
ISO
Dactinomycin inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] CTD PMID:9398635 PMID:20599767 PMID:28483492 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tcf4 transcription factor 4 multiple interactions EXP Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of TCF4 mRNA] CTD PMID:20459685 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects activity EXP Dactinomycin affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Testin testin gene multiple interactions
decreases secretion
EXP Dactinomycin inhibits the reaction [Bucladesine results in decreased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]
Dactinomycin results in decreased secretion of TESTIN protein
CTD PMID:11090432 NCBI chr17:4,194,796...4,225,376
Ensembl chr17:4,212,890...4,225,376
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; Dactinomycin inhibits the reaction [TGFB1 protein results in decreased expression of AHR mRNA] CTD PMID:9145908 PMID:16365456 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]; Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA] CTD PMID:17641275 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase multiple interactions ISO Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tmeff2 transmembrane protein with EGF-like and two follistatin-like domains 2 multiple interactions ISO Dactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 mRNA] CTD PMID:23405127 NCBI chr 9:55,379,130...55,673,704
Ensembl chr 9:55,384,100...55,673,829
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
ISO
EXP
[Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]
[Dactinomycin co-treated with TNF protein] results in increased activity of CASP3 protein; Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]
[RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [TNF co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF co-treated with Dactinomycin] results in increased activity of CASP7 protein; [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP7 protein; BCL2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; BCL2A1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; BIRC3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Dactinomycin inhibits the reaction [TNF results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [TNF results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP3 protein]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP7 protein]; Dactinomycin promotes the reaction [TNF results in increased cleavage of PARP1 protein]; HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]; RELA protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; SOD2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]
CTD PMID:9576062 PMID:10100995 PMID:11592958 PMID:11880364 PMID:12479793 PMID:12812920 PMID:15531761 PMID:15701621 PMID:16338976 PMID:16492401 PMID:18845389 PMID:21496118 PMID:22207076 PMID:23300732 PMID:26278786 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP7 protein; [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; [Dactinomycin co-treated with TNFSF10 protein] results in increased expression of AIFM1 protein CTD PMID:17707539 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO Dactinomycin results in increased expression of TNFSF9 mRNA CTD PMID:21527772 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Top1 DNA topoisomerase I increases activity ISO Dactinomycin results in increased activity of TOP1 protein CTD PMID:2164630 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases activity
increases expression
ISO Cadmium Chloride inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Cadmium inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein]; Dactinomycin results in increased expression of and affects the localization of TP53 protein; Dactinomycin results in increased expression of and results in increased activity of TP53 protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]
Dactinomycin results in increased activity of TP53 protein
Dactinomycin results in increased expression of TP53 protein; Dactinomycin results in increased expression of TP53 protein modified form
CTD PMID:10531375 PMID:12807743 PMID:12869419 PMID:12927789 PMID:16024796 PMID:17581298 PMID:20655369 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i11 tumor protein p53 inducible protein 11 multiple interactions
decreases expression
ISO Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]
Dactinomycin results in decreased expression of TP53I11 mRNA
CTD PMID:19333544 NCBI chr 3:82,081,838...82,097,064
Ensembl chr 3:82,081,906...82,097,056
JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions ISO Dactinomycin inhibits the reaction [1,25-dihydroxyvitamin D results in increased expression of TRPV6 mRNA] CTD PMID:16362534 NCBI chr 4:70,918,631...70,934,291
Ensembl chr 4:70,918,632...70,934,295
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Dactinomycin results in increased expression of TUBA4A mRNA CTD PMID:21527772 NCBI chr 9:82,415,599...82,419,918
Ensembl chr 9:82,415,605...82,419,288
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO Dactinomycin inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]; Dactinomycin inhibits the reaction [sulforaphane results in increased expression of TXNRD1 mRNA] CTD PMID:12663510 PMID:15652504 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO Dactinomycin inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]; Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]] CTD PMID:15937643 PMID:30796972 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyr tyrosinase multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]
Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]
CTD PMID:14717847 PMID:15278367 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 multiple interactions ISO Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UBE2L3 mRNA] CTD PMID:26318284 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] CTD PMID:15545831 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]
Dactinomycin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
CTD PMID:10100995 PMID:12892526 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP
Dactinomycin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of VEGFA mRNA]
Dactinomycin inhibits the reaction [Cobalt results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA alternative form]; Dactinomycin inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]
CTD PMID:8344219 PMID:10751333 PMID:11641398 PMID:16386082 PMID:18790786 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of VIM mRNA] CTD PMID:9044050 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vmp1 vacuole membrane protein 1 multiple interactions
decreases expression
ISO [Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA]
Dactinomycin results in decreased expression of VMP1 mRNA
CTD PMID:23052036 PMID:25969534 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Dactinomycin results in decreased expression of XIAP protein CTD PMID:12430140 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        aetiopathogenetic role 18963
          genotoxin 17330
            mutagen 17208
              actinomycin D 296
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        carboacyl group 17410
                                          univalent carboacyl group 17410
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                peptide 9416
                                                  peptide antibiotic 1670
                                                    chromopeptide 296
                                                      actinomycin 296
                                                        actinomycin D 296
paths to the root